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Alendronate loaded graphene oxide functionalized collagen sponge for the dual effects of osteogenesis and anti-osteoclastogenesis in osteoporotic rats

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Bioactive Materials 2020年第4期5卷 859-870页

作者： Yuyang Zeng Muran Zhou lifeng chen Huimin Fang Shaokai Liu Chuchao Zhou Jiaming Sun Zhenxing Wang Department of Plastic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Wuhan Clinical Research Center for Superficial Organ Reconstruction Wuhan430022China

Graphene Oxide(GO)-related hydrogels have been extensively studied in hard tissue repair,because GO can not only enhance the mechanical properties of polymers but also promote osteogenic differentiation of mesenchymal stem ***,simple GO-related hydrogels are not ideal for the repair of osteoporotic bone defects as the overactive osteoclasts in ***(Aln)is known to inhibit osteoclasts and may bind to GO through covalent ***,delivering Aln in GO-related hydrogels may be effective to repair osteoporotic bone ***,we developed a control-released system which is constructed by collagen(Col)-GO sponges loaded with Aln(Col-GO-Aln)for osteoporotic bone defect *** vitro,Col-GO-Aln sponges prolonged the release period of Aln,and the sponge containing 0.05%(w/v)GO released Aln faster than sponge with 0.2%***,tartrate-resistant acid phosphatase(TRAP)and F-actin staining demonstrated that Col-GO-Aln sponges effectively inhibited osteoclastogenesis of *** vivo,micro-CT scan showed that the volume of newborn bone in defect site by 0.05%GO sponge was nearly three times larger than that of other ***,the CT and histological examinations of rat femur proved that Col-GO-Aln sponges decreased the number of osteoclasts and suppressed the systemic bone loss in osteoporotic *** findings reveal that the application of GO as carriers of anti-osteoporosis drugs is a viable treatment for *** results also underscore the potential of GO-related hydrogels with Aln-releasing capacity for bone regeneration in osteoporosis.

关键词： Osteoporosis Osteoporotic bone defect Graphene oxide Osteoclast Alendronate

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不同场景下燃料电池汽车氢泄漏的安全研究

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上海汽车 2024年第8期 28-33页

作者：李青曼陈励峰邵峥亚徐国王鹤天张驰庆上海捷氢科技股份有限公司上海201800 上海市消防救援总队上海200051 上海嘉定区消防救援支队上海201899

处于不同停车场环境的燃料电池汽车产生氢泄漏时,氢气的扩散规律会受不同的环境条件影响。为研究燃料电池汽车在泄漏事故中的氢气泄放特征及停车场环境对其扩散的影响,建立了封闭、半封闭、开放、通风4种环境条件的停车场下燃料电池汽... 详细信息

处于不同停车场环境的燃料电池汽车产生氢泄漏时,氢气的扩散规律会受不同的环境条件影响。为研究燃料电池汽车在泄漏事故中的氢气泄放特征及停车场环境对其扩散的影响,建立了封闭、半封闭、开放、通风4种环境条件的停车场下燃料电池汽车氢泄漏的计算模型,分析氢气扩散规律以及氢气浓度随时间和空间的变化规律。结果表明,封闭环境下氢气会由于与空气的挤兑而聚集在车辆正上方的停车场顶部,浓度较高且扩散速度慢;半封闭环境的氢气扩散与封闭环境类似,但氢气聚集浓度明显降低;开放环境下氢气主要聚集在汽车周围,向四周稀释速度较快,相比于封闭与半封闭环境氢气浓度始终比较低;通风环境下氢气会顺着风向向下游扩散,主要聚集在车辆背风处。这些结果可以为燃料电池汽车氢泄漏引起的火灾风险提供参考。

关键词：氢泄漏气体扩散数值模拟燃料电池汽车

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Current status and trends in small nucleic acid drug development:Leading the future

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3802-3817页

作者： Yuxi Miao chen Fu Zhaojin Yu lifeng Yu Yu Tang Minjie Wei Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation China Medical UniversityShenyang 110122China Liaoning Medical Diagnosis and Treatment Center Shenyang 110000China Department of Oncology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China

Small nucleic acid drugs,composed of nucleotides,represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based *** agents function by selectively targeting specific genes or their corresponding messenger RNAs(mRNAs),further modulating gene expression and regulating translation-related *** examples within this category include antisense oligonucleotides(ASO),small interfering RNAs(siRNAs),micro-RNAs(miRNAs),and *** emergence of small nucleic acid drugs as a focal point in contemporary biopharmaceutical research is attributed to their remarkable specificity,facile design,abbreviated development cycles,expansive target spectrum,and prolonged *** challenges such as poor stability,immunogenicity,and permeability issues have been addressed through the integration of chemical modifications and the development of drug delivery *** review provides an overview of the current status and prospective trends in small nucleic acid drug *** with a historical context,we introduce the primary classifications and mechanisms of small nucleic acid ***,we delve into the advantages of the *** and Drug Administration(FDA)approved drugs and mainly discuss the challenges encountered during their *** from researching chemical modification and delivery system that efficiently deliver and enrich small nucleic acid drugs to target tissues,promoting endosomal escape is a critical scientific question and important research direction in siRNA drug *** directions in this field will prioritize addressing these challenges to facilitate the clinical transformation of small nucleic acid drugs.

关键词： Small nucleic acid drugs Oligonucleotide drugs siRNA ASO miRNA Aptamer RNAi Drug development

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Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第3期24卷 262-268页

作者： Xinyan WANG Xiuling XU Ting ZHANG Yang JIN Sheng XU lifeng chen Yucheng LAI Ling ZHANG Ruolang PAN Yan YU Department of Gynecology Zhejiang Provincial Hospital of Traditional Chinese Medicinethe First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China Department of Gynecology and Obstetrics Hangzhou Hospital of Traditional Chinese MedicineAffiliated Hangzhou TCM Hospital of Zhejiang Chinese Medical UniversityHangzhou 310005China Department of Gynecology Zhejiang Provincial People’s HospitalAffiliated People’s Hospital of Hangzhou Medical CollegeHangzhou 310014China Key Laboratory of Cell-Based Drug and Applied Technology Development in Zhejiang Province Hangzhou 311122China Institute for Cell-Based Drug Development of Zhejiang Province S-Evans BiosciencesHangzhou 311122China

Endometrial cancer is the most common gynecological malignancy,affecting up to 3%of women at some point during their lifetime(Morice et al.,2016;Li and Wang,2021).Based on the pathogenesis and bio‑logical behavioral characteristics,endometrial cancer can be divided into estrogen-dependent(I)and non-estrogen-dependent(II)types(Ulrich,2011).Type I accounts for approximately 80%of cases,of which the majority are endometrioid carcinomas,and the remaining are mucinous adenocarcinomas(Setiawan et al.,2013).

关键词： endometrial cancer

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Laparoscopy versus open surgery for adnexal masses in pregnancy:A Meta-Analytic Review

Laparoscopy versus open surgery for adnexal masses in pregna...

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2018年浙江省妇科肿瘤学学术年会暨温台妇产科年会

作者： lifeng chen Departments of Gynecology Zhejiang Provincial People’s Hospital

Background:Data regarding the safety and optimal surgical approach to adnexal masses in pregnancy are still *** Objective of this meta-analysis is to investigate and compare the pregnancy outcomes of laparoscopy and open surgery in the treatment of ovarian tumors during *** and Methods:Search was conducted using MEDLINE,EMBASE,and Cochrane Databases from January 1990 to July 2017.A broad search strategy was used to identify studies comparing laparoscopy and open surgery in *** criteria included comparative studies with the quantitative outcomes data on *** authors independently reviewed and assessed for the quality of included studies according the Newcastle-Ottawa *** were extracted for fetal loss,preterm delivery,duration of surgery,blood loss and length hospital ***:Nine retrospective trials were identified involving 985 *** statistical significance was found in fetal loss between laparoscopy and open surgery(P value=0.334).The pooled estimate for preterm labour statistically significant decreased for laparoscopy group(P value=0.014). Reduced operative blood loss was found in laparoscopy group by-83.81 ml(P value=0.015).Duration of operation may be longer in the laparoscopy group,but without statistical significance(P value=0.346).Length of hospital stay was shorter in the laparoscopy group with reduction of 1.95 days(P value <0.001).Conclusion:The available low-grade evidence suggests that laparoscopic surgery might be a feasible alternative for pregnant women with adnexal masses.

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早期胃癌内镜黏膜下剥离术后迟发性出血风险预警模型研究

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护理管理杂志 2024年第4期24卷 310-314,335页

作者：唐月莲陈丽峰王欣燕黄晓莉黎钢李伟红浙江中医药大学附属湖州中医院肿瘤消化科湖州市313000 湖州市中心医院消化内科 313000 湖州市中心医院内镜中心 313000

目的探讨影响早期胃癌患者内镜黏膜下剥离术后迟发性出血的危险因素,建立风险预警模型并进行验证。方法选取2020年1月至2023年1月在医院行内镜黏膜下剥离术的早期胃癌患者180例为研究对象,依据患者是否发生术后迟发性出血将其分为术后... 详细信息

目的探讨影响早期胃癌患者内镜黏膜下剥离术后迟发性出血的危险因素,建立风险预警模型并进行验证。方法选取2020年1月至2023年1月在医院行内镜黏膜下剥离术的早期胃癌患者180例为研究对象,依据患者是否发生术后迟发性出血将其分为术后迟发性出血组和非术后迟发性出血组。并对其临床资料进行单因素和多因素回归分析,得出独立预测因素,基于此构建列线图风险模型,并对该模型进行预测效能的评价。结果180例患者中,术后迟发性出血发生率为18.33%。单因素分析结果显示,患者病灶部位、病灶直径、浸润深度、长期服用抗血栓药物、活检次数、溃疡和瘢痕、手术时间、术中出血量、D-二聚体、血小板计数、血浆凝血酶原时间和活化部分凝血活酶时间是影响早期胃癌患者内镜黏膜下剥离术后发生术后迟发性出血的主要因素,其中,病灶部位位于贲门、长期服用抗血栓药物、溃疡和瘢痕、手术时间和活化部分凝血活酶时间是独立危险因素(P<0.05)。模型C-index指数为0.992,与1000次Bootstrap内部验证的C-index指数0.990较为接近,模型校正曲线总体趋势接近理想曲线。结论早期胃癌患者行内镜黏膜下剥离术后迟发性出血的发生受多重因素共同影响,根据危险因素建立的风险预警模型具有较好的预测效能,有助于临床护理人员识别早期胃癌患者内镜黏膜下剥离术后迟发性出血高危患者。

关键词：早期胃癌内镜黏膜下剥离术迟发性出血风险预警模型

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Y-chromosome evidence for no independent origin of modern human in China

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Chinese Science Bulletin 2001年第11期46卷 935-937页

作者： KE Yuehai SU Bing LI Hongyu chen lifeng QI Chunjian GUO Xinjun HUANG Wei JIN Jianzhong LU Daru JIN Li Institute of Genetics and Morgan-Tan International Center for Life Science Fudan UniversityShanghai 200433China Kunming Institute of Zoology Chinese Academy of SciencesKunming 650031China Human Genetics Center University of Texas-HoustonHouston 77225USA Department of Biotechnology Suzhou UniversitySuzhou 215007China TSBIO Science&Technology Co. LtdHangzhou 310013China National Human Genome Center at Shanghai Shanghai 201203China

East Asia is one of the few regions in the world where a large number of human fossils have been unearthed. The continuity of hominid fossils in East Asia, particularly in China has been presented as strong evidence supporting an independent origin of modern humans in this area. To search for such evidence of a possible independent origin of modern humans in China, a total of 9988 male individuals were sampled across China. Three Y-chromosome biallelic markers (M89, M130 and YAP), which were located at the non-re-combinant region of Y-chromosome, were typed among the samples. Our result showed that all the individuals carry a mutation at one of the three loci. The three mutations (M89T, M130T, YAP+) coalesce to another mutation (M168T), which was originally derived from Africa about 31000 to 79000 years ago. In other words, all Y-chromosome samples from China, with no exception, were originally derived from a lineage of African origin. Hence, we conclude that even a very minor contribution of in situ hominid origin in China cannot be supported by the Y-chromosome evidence.

关键词： Y-chromosome haplotype SNPs modern human origin Chinese.

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Structure and electrical characteristics of Nb-doped SrTiO3 substrates

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Chinese Science Bulletin 2006年第16期51卷 2035-2037页

作者： HUANG Yanhong LUE Huibin GUO Haizhong LIU lifeng HE Meng chen Zhenghao ZHOU Yueliang ZHAO Kun JIN Kuijuan YANG Guozen Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China

The studies on structure and electrical characteristic of Nb-doped SrTiO3 (SNTO) substrates by XRD, Hall measurements, R-T and SEM, show that the SNTO substrates with the same Nb-doping concentration have different electrical properties be- cause of the nonuniformity of Nb-doping. The uni- formly doped high-quality substrates are extremely important for fabricating multilayer structure and de- vices. In addition, the experimental results also pro- vide us with SEM method to judge the uniformity of conducting material.

关键词：铌掺杂 SrTiO3 激光晶体电性能

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Effects of Reinforcement Content and Homogenization Treatment on the Microstructure and Mechanical Properties of in‑situ TiB_(2)/2219Al Composites

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1421-1437页

作者： Linwei Li Donghu Zhou Kai Zhao lifeng Jiang Huijun Kang Enyu Guo Feng Mao Zongning chen Tongmin Wang Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315000China National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials Henan University of Science and TechnologyLuoyang 471003China Longmen Laboratory Luoyang 471000China

Obtaining an appropriate grain size is crucial for Al alloys or Al matrix composites prior to processing,as it significantly influences the mechanical properties of components and workability during the manufacturing ***_(2)particles are exceptional grain refiners in Al and serve as excellent reinforcement particles for particulate-reinforced aluminum matrix ***,the optimal particle content for achieving excellent refinement and strengthening effects depends on the matrix composition and requires further ***,homogenization is essential for mitigating the element segregation in the *** it is anticipated that adding suitable particles can effectively inhibit undesired grain growth during homogenization,comprehensive investigations on this aspect are currently ***,TiB_(2)/2219Al matrix composites with varying reinforcement contents(0,1,3,5 wt%)were fabricated through traditional casting followed by homogenization treatment to address these research *** effects of reinforcement content and homogenization treatment on the microstructure and mechanical properties of in-situ TiB_(2)/2219Al composites were *** results demonstrate a gradual strengthening of the refining effect with increasing particle ***,composites containing 3 wt%TiB_(2)particles exhibit superior comprehensive mechanical properties in both as-cast and homogenized ***,potential orientation relationships are observed and calculated between undissolved Al_(2)Cu eutectic phase and submicron or nanometer-sized TiB_(2)particles,resulting in a mixture structure with enhanced bonding *** mixture structure is continuously distributed along grain boundaries during solidification,forming a three-dimensional cellular network that acts as primary retarding forces for grain growth during ***,the established homogenization kinetic equations were further utilized to an

关键词： TiB_(2)/2219Al matrix composite Reinforcement content Homogenization treatment Homogenization kinetic Cellular structure Mechanical property

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氢燃料电池系统静电产生机理及危害分析

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上海汽车 2024年第10期 34-37页

作者：郁召锋梁晓燕黄赟陈励峰徐振邵峥亚徐国上海捷氢科技股份有限公司上海201800 普陀区消防救援支队上海200333 上海市消防救援总队上海200051 上海嘉定区消防救援支队上海201899

文章介绍了氢燃料电池系统静电产生的机理及静电积累的潜在危害,并通过典型案例分析,加深大家对氢燃料电池系统中静电的危害的认识,为提前识别并抑制静电产生提供参考及借鉴。

关键词：氢燃料电池系统静电放电接地

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