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Early morning off in patients with Parkinson's disease:a Chinese nationwide study and a 7-question screening scale

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Translational Neurodegeneration 2020年第3期9卷 370-382页

作者： Chao Han Wei Mao Jing An lifei jiao Piu Chan on behalf of the China Early Morning Off(EMO)Study Group National Clinical Research Center for Geriatric Disorders Xuanwu Hospital of Capital Medical UniversityBeijingChina Department of Neurobiology Neurology and GeriatricsXuanwu Hospital of Capital Medical University45 Changchun RoadBeijing 100053China Beijing Institute of Geriatrics Xuanwu Hospital of Capital Medical University45 Changchun RoadBeijing 100053China Clinical Center for Parkinson's Disease Xuanwu Hospital of Capital Medical University45 Changchun RoadBejjing 100053China Key Laboratories for Neurodegenerative Diseases of the Ministry of Education Xuanwu Hospital of Capital Medical University45 Changchun RoadBeijing 100053China Bejjing Key Laboratory for Parkinson's Disease Xuanwu Hospital of Capital Medical University45 Changchun RoadBeijing 100053China Parkinson Disease Center of Beiing Institute for Brain Disorders Xuanwu Hospital of Capital Medical University45 Changchun RoadBeijing 100053China Advanced Innovative Center for Human Brain Protection Xuanwu Hospital of Capital Medical University45 Changchun RoadBejing 100053China Medical department Lundbeck(Bejjing)Pharmaceutical Co.ItdBeijingChina 不详

Background:Early morning off(EMO)is a common feature of Parkinson's disease(PD).This study aimed to characterize its clinical features and develop a convenient and pragmatic self-assessment instrument in a Chinese nationwide population.Methods:This study was conducted on 942 PD patients admitted to 55 clinic centers for movement disorders between June 2018 and May 2019 in China.Stepwise logistic regression analyses were performed to determine potential risk factors and the most predictive symptoms of EMO,as well as whether EMO was an independent risk factor of functional dependency in daily life.Based on this,a 7-question scale was derived for EMO screening.Diagnostic accuracy of this scale was assessed from the area under the receiver operative characteristic curve(AUROC)and its 95%confidence intervals(CIs).We further calculated sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)for the optimal cutoff point.Results:EMO occurred in 49.2%of PD patients across all disease stages.We identified 7 symptoms most predictive of EMO,including bradykinesia or rigidity,excessive sweating or salivation,ificulty in turning on or getting out of bed,muscle cramp,fatigue or sleepiness,frozen state or freezing gait,and tremor.The resulting 7-item scale was confirmed to be of good discrimination with a relatively large AUROC of 0.83,a relatively high sensitivity of 75.7%,specificity of 77.5%,PPV of 76.5%,and NPV of 76.7%.Nonideal nighttime sleep,long PD duration,advanced H&Y stages,posture instability gait difficulty-dominant or mixed subtypes,and high levodopa dose were independently associated with increased risk of EMO.EMO patients were at 87%higher(OR=1.87,95%C:1.07-3.32)risk of experiencing functional dependency in daily living compared with their counterparts.Conclusions:We demonstrated that EMO is a common feature for PD patients across all disease stages and put forward an EMO-specific screening card of sufficient accuracy and brevity.Meanwhile,we have thrown some light upon potential

关键词： Parkinson's disease Early morning off Motor symptoms Non-motor symptoms Screening scale

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中国石油2023年乙烯业务综述

乙烯工业 2024年第1期36卷 7-12,I0001页

作者：沈洋焦丽菲刘照辉刘晓舟中国石油天然气股份有限公司炼油化工和新材料分公司北京100007

总结了2023年中国石油乙烯业务的发展情况,包括各乙烯生产企业的乙烯产量、乙烯收率、双烯收率、加工损失率和燃动能耗等指标完成情况,以及原料优化、长周期运行、检修和技改技措工作的完成情况。提出了2024年公司乙烯装置长周期优化运... 详细信息

总结了2023年中国石油乙烯业务的发展情况,包括各乙烯生产企业的乙烯产量、乙烯收率、双烯收率、加工损失率和燃动能耗等指标完成情况,以及原料优化、长周期运行、检修和技改技措工作的完成情况。提出了2024年公司乙烯装置长周期优化运行的重点工作安排。

关键词：中国石油乙烯综述

Atmospheric Degradation and Performance Recovery of Two-Dimensional MoS2 Field Effect Transistor

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Chinese Journal of Chemistry 2023年第21期41卷 2832-2836页

作者： lifei Sun Zhixing Lu Rui Xu Zhewei Li Guanchen Xu Fengen Chen Zhihai Cheng Liying jiao Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijing100084 China Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-nano Devices Department of PhysicsRenmin University of ChinaBeijing100872 China Advanced Materials Institute Qilu University of Technology(Shandong Academy of Sciences)JinanShandong250000 China

Two-dimensional(2D)transition metal dichalcogenides(TMDCs)showed great potentials in 2D nanoelectronic devices due to their abundant and unique properties.The performance stability of the 2D TMDCs devices turns into one of the keys for their practical applications but has been rarely explored.Here,we investigated stability of MoS_(2)devices in ambient condition and contributed the device performance degradation to the surface oxidation of the contact metals with low work function,which increased the contact barrier and hindered the electron injection.We developed a new approach to recover the performance of the aged devices through the selective doping of contacts with organolithium,which prolonged the lifetime of MoS_(2)devices.Our work not only provides important insights into the stability of 2D TMDCs devices,but also opens up a new avenue for optimizing the performance of 2D MoS_(2)devices.

关键词： MoS_(2) Field effect transistor Atmospheric degradation Performance recovery Semiconductors Doping Oxidation

温胆宁心颗粒对心肌梗死合并抑郁大鼠BDNF/TrkB/PI3K/Akt信号通路的影响研究

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海南医学院学报 2024年第11期30卷 824-832页

作者：吕李飞朱婷婷陈琛沈子涣丁帆王玉玲焦林珂路迎冬崔向宁中国中医科学院广安门医院北京100053

目的:本研究观察温胆宁心颗粒(WDNX)对心肌梗死合并抑郁症大鼠BDNF/TrkB/PI3K/Akt信号通路的影响,探讨其可能的作用机制。方法:通过皮下多点注射异丙肾上腺素和慢性不可预见性轻度应激方法制备心肌梗死合并抑郁症模型大鼠,给予WDNX干预2... 详细信息

目的:本研究观察温胆宁心颗粒(WDNX)对心肌梗死合并抑郁症大鼠BDNF/TrkB/PI3K/Akt信号通路的影响,探讨其可能的作用机制。方法:通过皮下多点注射异丙肾上腺素和慢性不可预见性轻度应激方法制备心肌梗死合并抑郁症模型大鼠,给予WDNX干预28 d后,经胸心脏超声检测心功能变化;根据糖水偏好和旷场实验评估大鼠抑郁状态;采用苏木素-伊红和尼氏染色观察心肌、脑组织病理变化及神经元损伤;最后通过免疫组化和Western blotting技术检测BDNF/TrkB/PI3K/Akt通路的表达水平。结果:与空白组比较,模型组大鼠左室射血分数(LVEF)、左室短轴缩短率(LVFS)显著降低(P<0.01),心肌组织可见大量纤维水肿,胞质疏松,组织边缘可见心肌纤维溶解,伴有少量淋巴细胞浸润;脑组织有明显弥散型损伤,间质肿胀,炎症细胞聚集,形态不规则;尼氏染色观察,模型组神经元数量显著减少,形态不规则,排列松散紊乱,细胞间隙增大,还导致尼氏体形态的固缩,出现病理改变;模型大鼠糖水偏好度、中央区活动时间和中央穿越次数明显降低(P<0.01);与模型组比较,WDNX组LVEF、LVFS显著升高(P<0.01),心肌纤维水肿、胞质疏松、炎症浸润、细胞空洞变性及纤维溶解程度均有改善,脑组织神经元形态较为规则,排列较整齐紧密,神经元数量相对增多,还可恢复尼氏体形态;WDNX组大鼠糖水偏好度、中央区活动时间和中央穿越次数明显增加(P<0.05)。免疫组化染色结果:与空白组比较,模型组大鼠心肌和脑组织(海马、皮层和下丘脑)BDNF蛋白表达明显降低(P<0.01),心肌TrkB、PI3K和Akt蛋白表达均明显降低(P<0.01);与模型组比较,WDNX组心肌和脑组织(海马、皮层和下丘脑)BDNF蛋白表达明显升高(P<0.05),心肌TrkB、PI3K和Akt蛋白表达均明显升高(P<0.01);Western blotting检测结果:与空白组比较,模型组大鼠心肌BDNF、TrkB、PI3K和Akt蛋白表达均明显降低(P<0.01);与模型组比较,WDNX组心肌BDNF、TrkB、PI3K和Akt蛋白表达均明显升高(P<0.05)。结论:温胆宁心颗粒能有效改善心肌梗死合并抑郁大鼠的心肌损伤和抑郁行为,这可能与BDNF/TrkB/PI3K/Akt通路的激活相关。

关键词：温胆宁心颗粒心肌梗死抑郁症脑源性神经营养因子大鼠

Multi-bright-dark soliton solutions to the AB system in nonlinear optics

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Communications in Theoretical Physics 2022年第4期74卷 23-30页

作者： Yunyun Zhai lifei Wei Xianguo Geng jiao Wei School of Mathematics and Statistics Zhengzhou University100 Kexue RoadZhengzhouHenan 450001China

The AB system is the basic integrable model to describe unstable baroclinic wave packets in geophysical fluids and the propagation of mesoscale gravity flows in nonlinear optics. On the basis of the spectral analysis of a Lax pair and the inverse scattering method, we establish the Riemann–Hilbert problem of the AB system. Then, the inverse problems are formulated and solved with the aid of the Riemann–Hilbert problem, from which the potentials can be reconstructed according to the asymptotic expansion of the sectional analytic function and the related symmetry relations. As an application, we obtain the multi-bright-dark soliton solutions to the AB system in the reflectionless case and discuss the dynamic behavior of elastic soliton collisions by choosing appropriate free parameters.

关键词： AB system multi-soliton structures Riemann-Hilbert problem

Growth of single-walled carbon nanotubes from Ag15 cluster catalysts

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Science Bulletin 2016年第12期61卷 917-920页

作者： Dake Hu Xin He lifei Sun Guanchen Xu Liying jiao Liang Zhao The Key Laboratory of Organic Optoelectronics and Molecular Engineering Ministry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084China The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084China

Chirality-specific growth of single-walled carbon nanotubes(SWNTs) remains a challenge for their practical applications in electronics. Here, we explored the surface growth of SWNTs by utilizing the atomic-precise silver cluster complex [Ag_(15){1,3,5–(C:C)_3–C_6H_3}_2(Py[8])_3–(CF_3SO_3)_3](CF_3SO_3)_6(Py[8] is abbreviation for octamethylazacalix[8]pyridine) as a catalyst precursor. The diameters of most acquired SWNTs distributed in the range of 1.2–1.4 nm, which is suitable for making high performance field-effect transistors. The high quality of the obtained SWNTs was evidenced by Raman spectroscopy and electrical measurements. Successful growth of high quality SWNTs in this study foresees that rational design of metal-organic complexes as growth catalysts can open up a new avenue for the controllable synthesis of SWNTs.

关键词：单壁碳纳米管催化剂前体表面生长簇合物金属有机配合物场效应晶体管 SWNTs 电子应用

Growth of large-area aligned pentagonal graphene domains on high-index copper surfaces

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Nano Research 2016年第7期9卷 2182-2189页

作者： Kailun Xia Vasilii I. Artyukhov lifei Sun Jingying Zheng Liying jiao Boris I. Yakobson Yingying Zhang Department of Chemistry Tsinghua University Beijing 100084 China Center for Nano and Micro Mechanics Tsinghua University Beijing 100084 China Department of Materials Science and Nano Engineering Rice University Houston TX 77005 USA

Single-crystal graphene domains grown by chemical vapor deposition （CVD） intrinsically tend to have a six-fold symmetry; however, several factors can influence the growth kinetics, which can in turn lead to the formation of graphene with different shapes. Here we report the growth of oriented large-area pentagonal single-crystal graphene domains on Cu foils by CVD. We found that high-index Cu planes contributed selectively to the formation of pentagonal graphene. Our results indicated that lattice steps present on the crystalline surface of the underlying Cu promoted graphene growth in the direction perpendicular to the steps and finally led to the disappearance of one of the edges forming a pentagon. In addition, hydrogen promoted the formation of pentagonal domains. This work provides new insights into the mechanism of graphene growth.

关键词： pentagonal graphene,copper foil,high index plane,chemical vapor deposition,large area

Metallic and ferromagnetic MoS2 nanobelts with vertically aligned edges

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Nano Research 2015年第9期8卷 2946-2953页

作者： Guanchen Xu Xinsheng Wang Yupeng Sun Xiao Chen Jingying Zheng lifei Sun Liying jiao Jinghong Li Department of Chemistry Tsinghua University Beijing 100084 China Key Laboratory of Colloid and Interface Chemistry Shandong University Jinan 250100 China

Edge effects are predicted to significantly impact the properties of low dimensional materials with layered structures. The synthesis of low dimensional materials with copious edges is desired for exploring the effects of edges on the band structure and properties of these materials. Here we developed an approach for synthesizing MoS2 nanobelts terminated with vertically aligned edges by sulfurizing hydrothermally synthesized MoO3 nanobelts in the gas phase through a kinetically driven process; we then investigated the electrical and magnetic properties of these metastable materials. These edge-terminated MoS2 nanobelts were found to be metallic and ferromagnetic, and thus dramatically different from the semiconducting and nonmagnetic two-dimensional （2D） and three-dimensional （3D） 2H-MoS2 materials. The transitions in electrical and magnetic properties elucidate the fact that edges can tune the properties of low dimensional materials. The unique structure and properties of this one-dimensional （1D） MoS2 material will enable its applications in electronics, spintronics, and catalysis.

关键词： MoS2 two-dimensional (2D)atomic crystal,nanobelt,edge effect,metallic,ferromagnetic

Unveiling the planar deformation mechanisms for improved formability in pre-twinned AZ31 Mg alloy sheet at warm temperature

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Journal of Magnesium and Alloys 2023年第12期11卷 4659-4678页

作者： Xiaohuan Pan lifei Wang Pengbin Lu Hua Zhang Guangsheng Huang Liuwei Zheng Bin Xing Weili Cheng Hongxia Wang Wei Liang Kwang Seon Shin Shanxi Key Laboratory of Advanced Magnesium-Based Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China National Engineering Laboratory for Industrial Big-data Application Technology Chongqing Innovation Center of Industrial Big-Data Co.Ltd.Chongqing 400707China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute for Advanced Studies in Precision Materials Yantai UniversityYantai 264005China National Engineering Research Center for Magnesium Alloys College of Materials Science&EngineeringChongqing UniversityChongqing 400044China Magnesium Technology Innovation Center School of Materials Science and EngineeringSeoul National University1 Gwanak-roGwanak-guSeoul 08826South Korea

To investigate the role of pre-twins in Mg alloy sheets during warm planar deformation, the stretch forming is conducted at 200 ℃. Results suggest the formability of the pre-twinned AZ31 Mg alloy sheet is enhanced to 11.30 mm. The mechanisms for the improved formability and the deformation behaviors during the planar stretch forming are systematically investigated based on the planar stress states. The Schmid factor for deformation mechanisms are calculated, the results reveal that planar stress states extremely affect the Schmid factor for {10-12}twinning. The detwinning is activated and the prismatic slip is enhanced in the pre-twinned sheet, especially under the planar extension stress state in the outer region. Consequently, the thickness-direction strain is accommodated better. The dynamic recrystallization(DRX) type is continuous DRX(CDRX) regardless of the planar stress state. However, the CDRX degree is greater under the planar extension stress state.Some twin lattices deviate from the perfect {10-12} twinning relation due to the planar compression stress state and the CDRX. The basal texture is weakened when the planar stress state tends to change the texture components.

关键词： AZ31 Mg alloy sheet Planar stretch forming Planar stress states Continuous dynamic recrystallization {10-12}tensile twinning