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A New Globally Reconstructed Sea Surface Temperature Analysis Dataset since 1900

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Journal of Meteorological Research 2021年第6期35卷 911-925页

作者： lifan chen Lijuan CAO Zijiang ZHOU Dongbin ZHANG Jie LIAO National Meteorological Information Center China Meteorological AdministrationBeijing 100081

A new globally reconstructed sea surface temperature(SST)analysis dataset developed by the China Meteorological Administration(CMA-SST),available on 2°×2°and monthly resolutions since 1900,is described and assessed in this *** dataset has been constructed from a newly developed integrated dataset with denser and wider sampling of in situ SST observations and follows similar analysis techniques to the Extended Reconstructed SST,version 5(ERSST.v5).Assessments show that the larger observation quantity of the input data source is beneficial to making the reconstructed SSTs more realistic than those reconstructed with ICOADS 3.0+GTS(International Comprehensive Ocean-Atmosphere Dataset 3.0 and Global Telecommunication System),especially in China’s offshore sea ***,a specific parameter for bias correction has been upgraded to be self-adaptive to the input data source,and serves as a mediator to improve the accuracy of the reconstructed ***,the reconstructed CMA-SST dataset is comparable to currently congeneric *** biases are similar to those of ERSST.v5,the Centennial Observation-Based Estimates of SST version 2(COBE-SST2),the Hadley Centre Sea Ice and SST dataset version 2(Had ISST2),and the Hadley Centre SST dataset version 3(Had SST3);and more specifically,they are closest to ERSST.v5 and lower than Had ISST2 and Had SST3 at high latitudes of the Southern Hemisphere where in situ observations are ***,its temporal characteristics,such as the year-to-year variations of globally averaged SST anomalies and time series of the Nino-3.4,Atlantic multidecadal oscillation,and Pacific decadal oscillation indices are also a good match to those of congeneric *** the warming rates of CMA-SST are a little higher in many regions over the periods 1900-2019 and 1950-2019,they are found to be acceptable and within the quantified uncertainties of ***,there are noticeable differences in the strength and stability o

关键词： sea surface temperature CMA-SST dataset bias correction reconstruction climate change

Enterprise WeChat Groups： Their Effect on Work-Life Conflict and Life-Work Enhancement

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Frontiers of Business Research in China 2015年第4期9卷 516-535页

作者： Shengming Liu Ye Zhang lifan chen Li Guo Dongling Yu Guanghua School of Management Peking University Beijing 100871 China

Social media technologies have made it increasingly feasible for employees to be connected to work. WeChat, a newly emerging social media platform, is widely used in daily life, yet there is still little understanding of the consequences of the use of WeChat groups in enterprise. Based on boundary theory, we suggested that the use of WeChat groups in enterprise have both pros and cons for employees. We gathered data from an online survey of 202 employees. Results show that posting work-related content in enterprise WeChat groups had a beneficial impact on work for employees but also caused work-life conflict （WLC）. However, posting life-related content in enterprise WeChat groups contributes to employees＇ life-work enhancement （LWE）. Contributions and future study directions of these findings are discussed.

关键词： social media technology WeChat groups boundary theory,work-life conflict life-work enhancement

Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method

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Science China(Life Sciences) 2023年第4期66卷 800-818页

作者： Ping Zhang Junhong Huang Wujian Zheng lifan chen Shurong Liu Anrui Liu Jiayi Ye Jie Zhou Zhirong chen Qiaojuan Huang Shun Liu Keren Zhou Lianghu Qu Bin Li Jianhua Yang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesThe Fifth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510275China Department of Chemistry The University of ChicagoChicagoIL 60637USA Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA

2′-O-methylation(Nm)is one of the most abundant RNA epigenetic modifications and plays a vital role in the post-transcriptional regulation of gene *** Nm mapping approaches are normally limited to highly abundant RNAs and have significant technical hurdles in m RNAs or relatively rare non-coding RNAs(nc RNAs).Here,we developed a new method for enriching Nm sites by using RNA exoribonuclease and periodate oxidation reactivity to eliminate 2′-hydroxylated(2′-OH)nucleosides,coupled with sequencing(Nm-REP-seq).We revealed several novel classes of Nm-containing nc RNAs as well as m RNAs in humans,mice,and *** found that some novel Nm sites are present at fixed positions in different t RNAs and are potential substrates of fibrillarin(FBL)methyltransferase mediated by sno ***,we discovered,for the first time,that Nm located at the 3′-end of various types of nc RNAs and fragments derived from *** approach precisely redefines the genome-wide distribution of Nm and provides new technologies for functional studies of Nm-mediated gene regulation.

关键词： 2′-O-methylation MgR exoribonuclease periodate oxidation epitranscriptome transcriptome

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Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2619-2622页

作者： Jie Chang Ruirui Yang lifan chen Zisheng Fan Jingyi Zhou Hao Guo Yinghui Zhang Yadan Liu Guizhen Zhou Keke Zhang Kaixian chen Hualiang Jiang Mingyue Zheng Sulin Zhang School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China

To the Editor:ADP-ribosylation factor 1 (ARF1) plays a critical role in regulating vesicle formation and transport1. The dysregulation of ARF1 expression and/or activity is involved in many human cancers, such as brea... 详细信息

关键词： ADP-ribosylation factor 1 Breast cancer Demethylzeylasteral Virtual screening

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基于生态进化的科研人才生命周期仿真研究

中国科技论坛 2018年第11期 133-140页

作者：陈力凡北京大学光华管理学院北京100871

本文借鉴生命周期理论的生态进化规律,将科研人才成长过程看成是不同科研人才从各自的角度开展研究,提升创新能力的动态竞争过程,构建了科研人才成长模型,并进行了仿真分析。结果表明,科研人才成长的最终稳定状态只与科研影响力相关,达... 详细信息

本文借鉴生命周期理论的生态进化规律,将科研人才成长过程看成是不同科研人才从各自的角度开展研究,提升创新能力的动态竞争过程,构建了科研人才成长模型,并进行了仿真分析。结果表明,科研人才成长的最终稳定状态只与科研影响力相关,达到稳定所需的时间与科研生产力、初始团队相关。并提出了通过优化考核体系、搭建成长平台、注重引育青年人才等方式促进科研人才成长。

关键词：科研人才生命周期生态进化仿真

Targeting STING oligomerization with licochalcone D ameliorates STING-driven inflammatory diseases

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Science China Life Sciences 2024年第12期67卷 2664-2677页

作者： Yinghui Zhang Yadan Liu Bing Jiang lifan chen Jie Hu Buying Niu Jie Chang Zisheng Fan Jingyi Zhou Yajie Wang Dan Teng Ning Ma Xiaofeng Wang Ruirui Yang Mingyue Zheng Sulin Zhang Drug Discovery and Design Center State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences University of Chinese Academy of Sciences School of Chinese Materia Medica Nanjing University of Chinese Medicine Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology Shanghai Tech University School of Physical Science and Technology Shanghai Tech University School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences State Key Laboratory of Pharmaceutical Biotechnology Nanjing University

The development of STING inhibitors for the treatment of STING-related inflammatory diseases continues to encounter significant challenges. The activation of STING is a multi-step process that includes binding with c GAMP, self-oligomerization, and translocation from the endoplasmic reticulum to the Golgi apparatus, ultimately inducing the expression of IRF3 and NF-κB-mediated interferons and inflammatory cytokines. It has been demonstrated that disruption of any of these steps can effectively inhibit STING activation. Traditional structure-based drug screening methodologies generally focus on specific binding sites. In this study, a Transformer CPI model based on protein primary sequences and independent of binding sites is employed to identify compounds capable of binding to the STING protein. The natural product Licochalcone D(Lico D) is identified as a potent and selective STING inhibitor. Lico D does not bind to the classical ligandbinding pocket; instead, it covalently modifies the Cys148 residue of STING. This modification inhibits STING oligomerization, consequently suppressing the recruitment of TBK1 and the nuclear translocation of IRF3 and NF-κB. Lico D treatment ameliorates the inflammatory phenotype in Trex1-/-mice and inhibits the progression of DSS-induced colitis and AOM/DSS-induced colitis-associated colon cancer(CAC).In summary, this study reveals the potential of Lico D in treating STING-driven inflammatory diseases. It also demonstrates the utility of the Transformer CPI model in discovering allosteric compounds beyond the conventional binding pockets.

关键词： cGAS-STING signaling STING inhibitor TransformerCPI model Licochalcone D inflammatory diseases

EFFECTS OF B^+ IMPLANTATION ON MECHANICAL PROPERTIES AND MICROSTRUCTURE OF POLYCRYSTALLINE Ni

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Acta Metallurgica Sinica(English Letters) 1993年第2期6卷 86-91页

作者： chen lifan BA Tu SHI Changxu State Key Laboratory for Fatigue and Fracture of Materials,Institute of Metal Research,Academia Sinica,Shenyang,China Doctorate Student.Institute of Physics.Academia Sinica,Beijing 100080,China Inst of Metal Research Acad Sinica Sheyang China

50 keV B^+ ions was implanted to polycrvstalline with 50 keV B^+ to a dose o/ 3x 10~17 ions/cm^2 at room *** specimens with and without B^+implantation were tested in micro-hardness and load or unload tensile fatigue under stress-controlled eondition. The surface layer structure was observed with IMA,SEM and TEM before and after implantation and/or *** B^+ implanted surface region consists of amorphous Ni-B phase,Ni_3B and Ni_4B_3 second phases,and damage *** corresponding measurements indicate that both surface micro-hardness and endurance limit of the specimens have increased after *** with unimplanted specimens under the same fa- tigue condition,all implanted specimens show the smallest overall fatigue *** cyclic loading at room temperature can lead to migration of implanted B^+ out surface layer and reerystallization of amorphous Ni-B phase,Possible strengthening *** these ex- perimental results were discussed.

关键词： ion implantation fatigue polycrystalline Ni implanted layer

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基坑支护结构计算方法的比较分析

地下空间与工程学报 2019年第S1期15卷 100-104,174页

作者：沈印陈丽凡上海市政工程设计研究总院(集团)有限公司上海200096 武汉市青山区(化工区)水务局武汉430080

对于基坑支护结构的计算方法,目前较流行的是按照增量法的计算原理,采用简化的平面弹性抗力法计算,而普遍认为总量法计算值偏小。本文进一步探讨了总量法与增量法的计算模式原理。同时利用有限元软件分别构建了基于两种计算方法的有限... 详细信息

对于基坑支护结构的计算方法,目前较流行的是按照增量法的计算原理,采用简化的平面弹性抗力法计算,而普遍认为总量法计算值偏小。本文进一步探讨了总量法与增量法的计算模式原理。同时利用有限元软件分别构建了基于两种计算方法的有限元模型。通过对实际算例的计算,证实了在荷载施加正确的前提下,两种计算方法计算结果是一致的,且总量法更具优势。在此基础上,本文还对现行规范建议的三维空间计算方法与传统的平面计算方法进行了对比。从对比结果得出,距离支撑较远的支护桩的位移宜利用空间计算方法计算,以及冠梁及腰梁的尺寸对于增加支撑对支护桩的作用、改善支护桩变形来说,基本不起作用。

关键词：基坑支护结构总量法增量法三维计算

生物多样性与传染性疾病的关系:进展、挑战与展望

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生物多样性 2020年第11期28卷 1376-1390页

作者：刘向陈立范周淑荣兰州大学草地农业生态系统国家重点实验室/生态学创新研究院兰州730000 上海健康医学院文理教学部上海201318 海南大学林学院海口570228

在全球生物多样性快速丧失的背景下,理解生物多样性如何影响传染性疾病风险具有重要意义。大量研究表明,宿主多样性对传染性疾病可能存在稀释效应(即疾病风险随宿主生物多样性的增加而降低),但是也有放大效应或者没有影响的证据。本文... 详细信息

在全球生物多样性快速丧失的背景下,理解生物多样性如何影响传染性疾病风险具有重要意义。大量研究表明,宿主多样性对传染性疾病可能存在稀释效应(即疾病风险随宿主生物多样性的增加而降低),但是也有放大效应或者没有影响的证据。本文首先介绍了关于生物多样性与传染性疾病关系的研究进展,以及该领域的热点研究问题,包括宿主多样性–疾病关系的格局和空间依赖性、稀释效应的体系依赖性和系统发育稀释效应等。随后,介绍了相关研究伴随的争议和批判,主要集中在:稀释效应发生的普遍性、生物多样性–疾病关系实验研究的发表偏好性以及部分疾病生态学家对生物多样性和传染性疾病之间简单数字关系的过分关注。最后指出稀释效应与物种共存、全球变化对稀释效应的影响、进化与稀释效应、稀释效应在政策制定中的应用等领域可能是今后的主要研究方向。

关键词：疾病生态学生态系统服务放大效应病原体宿主稀释效应