Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer

作     者：Jie Chang Ruirui Yang Lifan Chen Zisheng Fan Jingyi Zhou Hao Guo Yinghui Zhang Yadan Liu Guizhen Zhou Keke Zhang Kaixian Chen Hualiang Jiang Mingyue Zheng Sulin Zhang Jie Chang;Ruirui Yang;Lifan Chen;Zisheng Fan;Jingyi Zhou;Hao Guo;Yinghui Zhang;Yadan Liu;Guizhen Zhou;Keke Zhang;Kaixian Chen;Hualiang Jiang;Mingyue Zheng;Sulin Zhang

作者机构：School of Chinese Materia MedicaNanjing University of Chinese MedicineNanjing 210023China Drug Discovery and Design CenterState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of SciencesBeijing 100049China Shanghai Institute for Advanced Immunochemical Studiesand School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2022年第12卷第5期

页      面：2619-2622页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (81903639 to Sulin Zhang,China) Lingang Laboratory (LG202102-01-02 to Mingyue Zheng,China,LG-QS-202204-01 to Sulin Zhang,China) Shanghai Municipal Science and Technology Major Project (Hualiang Jiang,China) Shanghai Sailing Program (19YF1457800 to Sulin Zhang,China) 

主　　题：ADP-ribosylation factor 1 Breast cancer Demethylzeylasteral Virtual screening 

摘      要：To the Editor:ADP-ribosylation factor 1 (ARF1) plays a critical role in regulating vesicle formation and transport1. The dysregulation of ARF1 expression and/or activity is involved in many human cancers, such as breast cancer2,3. Therefore, ARF1 is one of the promising therapeutic targets for cancer treatment.