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Nutritional screening in a University Hospital:Comparison between Oncologic and Non-Oncologic Patients

Food and Nutrition sciences 2015年第1期6卷 75-82页

作者： selma F.C.Cunha lidiane s.tanaka Roberta G.salomao Danielle M.Macedo Thatiane D.santos Fernanda M.Peria Division of Clinical Nutrition Department of Internal MedicineSchool of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoBrazil Parenteral and Enteral Nutrition Team of Clinical Hospital School of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoBrazil Division of Oncology Department of Internal MedicineSchool of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoBrazil

Background & Aims: We compared the screening nutritional data of patients with malignant and non-malignant disease, and classified their nutritional risk according to the primary tumor’s site. Methods: subjective Global Assessment was applied to 3008 patients within 48 h of admission to a public university. subjects were divided into Oncologic Group (n = 576) or Non-Oncologic Group (n = 2432) according to the presence of neoplasms or other diseases respectively. These data were compared by the t-student test and classic chi-square test, with statistical significance set at p sults: The Oncologic Group presented a higher prevalence of weight loss (60.3% vs. 49.3%), quantitative (40.7% vs. 28.5%) and qualitative (16.4% vs. 7.6%) alterations in the food intake pattern, gastrointestinal symptoms and muscle waste (23.2% vs. 13.2%) as compared to the Non-Oncologic Group. Also, there was a higher prevalence of nutritional disturbances in the Oncologic Group, with 49.5% of the subjects moderately (or suspected to be malnourished) and 12.7% severely mal-nourished. severe malnourishment was mainly observed in patients with head and neck (25%), upper digestive tract (21.9%) and soft tissue and bones (17.9%) tumors. Conclusion: When compared to other hospitalized patients, patients with neoplastic disease were in higher nutritional risk.

关键词： Nutritional screening Malnutrition subjective Global Assessment Hospital setting Neoplasia

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Grain size refinement of magnesium composite alloys by addition of B_2O_3

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中国有色金属学会会刊：英文版 2006年第A03期16卷 1864-1869页

作者：卜乐平 s.tanaka M.TsUsHIDA s.ANDO H.TONDA Graduate school of science and Technology Kumamoto University2-39-1 KurokamiKumamoto 860-8555Japan Machinery and Electronic Engineering Institute Inner Mongolia University of AgricultureHohhot 010018China Department of materials science and Engineering Faculty of EngineeringKumamoyo University2-39-1 KurokamiKumamoto 860-8555Japan

The high performance magnesium alloy was investigated by adding B2O3 in magnesium and magnesium alloys. Experiments include adding B2O3 in Mg, Mg-Al and Mg-RE alloys, respectively, studying the effects of B2O3 on the microstructure, were studied measuring the change of grain size and microhardness of the materials, discussing the change of grain size, morphology and distribution. The results show that adding 3% or 6%(mass fraction) B2O3 in Mg can bring twinning in Mg, adding B2O3 in Mg-Al alloys and Mg-RE alloys can refine the alloy grain size. Adding 3%B2O3 in Mg-6Al alloys can refine the average grain size by about 5μm, with the average hardness increased by 13.3% (53.3-60.4 HV0.03); adding 6%B2O3 in Mg-6Al alloys can refine the average grain size by about 13μm, with the average hardness increased by 15.8% (53.3-61.73 HV0.03); adding 3% and 6%B2O3 into Mg-6RE alloys can refine the grain size by about 5 and 9μm, respectively, with the average hardness decreased to HV0.03 64.66 and HV0.03 57.86, respectively from HV0.03 88.57. In the Mg-6Al alloy the content of aluminum is increased, while in the Mg-6RE alloy the content of oxygen is decreased. It can be concluded that it is beneficial to develop Mg-Al-B-O particle reinforce composite alloys, and it is feasible to develop nanometer crystallization of block material by Mg-B-O-RE.

关键词：应变分析镁合金金属化合物金属铸造

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MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第3期32卷 463-476页

作者： Hur sUN MAsANORI KAWANO TATsUYA IWAsAKI ICHRO ITONAGA YUTA KUBOTA HROsHI TsUMURA KAZUHRO tanaka Department of Orthopaedic surgery Faculty of MedicineOita UniversityOita879-5503Japan

An important factor in the emergence and progre sion of osteosarcoma(Os)is the dysregulated expression of microRNAs(miRNAs).Transcription factor 7-like 1(TCF7LI),a member of the T cell factor/lymphoid enhancer factor(TCF/LEF)transcription factor family,interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding *** study sought to elucidate the impact of the interaction between miR 3293p and TCF7L1 *** growth and apoptosis of Os and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of ***329-3p was significantly downregulated,while TCF7L1 was considerably up-regulated in all examined Os cell ***,a clinical comparison study was performed using the TCGA ***,the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of Os cells was verified through in vitro and in vivo *** miR 329-3p was transfected into the Os cell line,the expression of TCF7L1 decreased,the proliferation of Os cells was inhibited,the cytoskeleton disintegrated,and the nucleus condensed to fom apoptotic *** expression of proteins that indicate apoptosis increased *** cell cycle was arrested in the G0/G1 phase,and the G1/s transition was *** introduction of miR 3293p also inhibited downstream Cyclin D1 of the Wnt *** experiments indicated that the overexpression of miR-329-3p signi ficanly inhibited the growth of Os xenografts in nude mice,and the expression of TCF7L1 and C-Myc in tumor tssues *** 329-3p was significantly reduced in Os cells and played a suppressive role in tumorigenesis and proliferation by targeting TCF7L1 both in vitro and in *** cell cycle arrest and pathway inhibition were observed upon the regulation of TCF7LI by miR *** these results,it can be inferred that miR.3293p exerts anticancer efects in osteosarcom

关键词： MiR-329-3p TCF7L1 Wnt/β-catenin pathway Osteosarcoma Proliferation

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Development of magnesium composite alloy by a new method combining B_2O_3 addition and melt stirring

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中国有色金属学会会刊：英文版 2006年第A3期16卷 1870-1874页

作者：卜乐平 s.tanaka M.TsUsHIDA s.ANDO H.TONDA Graduate school of science and Technology Kumamoto University2-39-1 KurokamiKumamoto 860-8555Japan Machinery and Electronic Engineering Institute Inner Mongolia University of AgricultureHohhot 010018China Department of Materials science and Engineering Faculty of EngineeringKumamoto University2-39-1 KurokamiKumamoto 860-8555Japan

For developing high performance magnesium alloys, a new method in combination of B2O3 addition and melt stirring was applied. When 0, 3%, 6% and 12%( mass fraction) B2O3 was added into pure Mg, many twins were produced in each alloy. The average grain size of Mg was about 200μm. In Mg-6Al alloy, the grain size is decreased from 50 to 35μm by B2O3 addition. In Mg-6RE (rare earth) alloys, the grain size is decreased from 35 to 15μm. The grain size of Mg-9Al- 6Ti-3B2O3 alloy is about 5μm. The hardness of pure Mg does not change by B2O3 addition. In Mg-6Al alloy, the hardness is increased by addition of 3% B2O3, however, the hardness of Mg-6RE alloy is decreased by B2O3 addition. Addition of B2O3 into Mg-Al, Mg-RE and Mg-Al-Ti alloys makes the fine grain structures, the hardness of Mg-RE alloy is decreased. This strange behavior may be interpreted with existence of many fine pores in the alloy. The mechanical properties of composite Mg-9Al-6Ti with 3%B2O3 are higher than those of AZ91C. The present results demonstrate the potential of this new method for developing high performance magnesium alloys.

关键词：镁合金金属熔炼有色金属金属加工

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Euler Product Expressions of Absolute Tensor Products of Dirichlet L-Functions

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Advances in Pure Mathematics 2024年第6期14卷 451-486页

作者： Hidenori tanaka shin-ya Koyama Department of Biomedical Engineering Toyo University Saitama Japan Department of Mechanical Engineering Toyo University Saitama Japan

In this paper, we calculate the absolute tensor square of the Dirichlet L-functions and show that it is expressed as an Euler product over pairs of primes. The method is to construct an equation to link primes to a series which has the factors of the absolute tensor product of the Dirichlet L-functions. This study is a generalization of Akatsuka’s theorem on the Riemann zeta function, and gives a proof of Kurokawa’s prediction proposed in 1992.

关键词： Dirichlet L-Function Absolute Tensor Product (Kurokawa Tensor Product) Euler Product

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Flow Rate Measurement of Gravity Infusion set and Functional Evaluation of Drop Counter: A Pilot study

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Journal of Biomedical science and Engineering 2024年第7期17卷 129-135页

作者： Rina sakai shuichi tanaka Kaya Murakami Tomomi Mizuhashi Kazuhiro Yoshida Masanobu Ujihira Department of Medical Engineering and Technology Kitasato University School of Allied Health Sciences Sagamihara Japan Faculty of Medical Engineering Gunma University of Health and Welfare Maebashi Japan Kitasato University Graduate school of Medical sciences Sagamihara Japan

Developing a novel drop counter by introducing the Internet of Things concept has been vigorously conducted in recent years. Understanding the newly introduced drop counter’s flow rate control accuracy and flow rate count feature is essential for improving safety in infusion management. This study aimed to verify if the new drop counters could secure accurate flow rate and drip count by conducting actual flow rate measurements using gravimetry and functional evaluation. A drop counter was attached to each drip chamber of the infusion set, and an IV drip was conducted at the 100 ml/h flow rate. The weight of discharged physiological saline was measured to plot trumpet curves. Next, three different types of drop counters were evaluated to determine if they maintained drip count accuracy according to the changes in their position angles. The flow rate errors in all conditions indicated trumpet-like curves, exhibiting an overall error range within ±10% in all observation windows. Although every drop counter successfully detected and measured dripping, it was challenging in some counters to detect dripping when the drip chamber was tilted. In comparing adult and pediatric IV sets, the adult IV set was found to be less likely to detect dripping in the angled position. No significant differences in results were confirmed between high and low flow rates, suggesting that the drop count function would not be affected by the flow rate in the ranges of typical infusion practices. Doppler sensors have a wide range of measurements and high sensitivity;the dripping was detected successfully even when the drip chamber was tilted, probably due to the advantages of these sensors. In contrast, miscounts occurred in those equipped with infrared sensors, which could not detect light intensity changes in tilted positions. Understanding the tendencies in flow rate errors in infusion can be valuable information for infusion management.

关键词： Gravity Infusion set Drop Counter IV Fluids Flow Rate Trumpet Curves

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Haplotype-based phylogenetic analysis and population genomics uncover the origin and domestication of sweetpotato

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Molecular Plant 2024年第2期17卷 277-296页

作者： Mengxiao Yan Ming Li Yunze Wang Xinyi Wang M-Hossein Moeinzadeh Dora G.Quispe-Huamanquispe Weijuan Fan Yijie Fang Yuqin Wang Haozhen Nie Zhangying Wang Aiko tanaka Bettina Heider Jan F.Kreuze Godelieve Gheysen Hongxia Wang Martin Vingron Ralph Bock Jun Yang shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai 201602China College of Life sciences Chongqing Normal UniversityChongqing 401331China Biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural SciencesChengdu 610061China College of Life sciences Shanghai Normal UniversityShanghai 200234China Department of Computational Molecular Biology Max Planck Institute for Molecular GeneticsIhnestraBe 63-7314195 BerlinGermany Department of Biotechnology Ghent University9000 GhentBelgium Guangdong Provincial Key Laboratory of Crops Genetics and Improvement Crop Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Graduate school of Bioagricultural sciences Nagoya UniversityChikusaNagoya 464-8601Japan international Potato Center(CIP) LimaPeru CAs Center for Excellence of Molecular Plant sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany

The hexaploid sweetpotato(lpomoea batatas)is one of the most important root crops ***,its genetic origin remains controversial,and its domestication history remains *** this study,we used a range of genetic evidence and a newly developed haplotype-based phylogenetic analysis to identify two probable progenitors of *** diploid progenitor was likely closely related to lpomoea ae-quatoriensis and contributed the B,subgenome,IbT-DNA2,and the lineage 1 type of chloroplast genome to *** tetraploid progenitor of sweetpotato was most likely *** 4x,which donated the B2 subgenome,IbT-DNA1,and the lineage 2 type of chloroplast *** most likely originated from reciprocal crosses between the diploid and tetraploid progenitors,followed by a subsequent whole-genome *** addition,we detected biased gene exchanges between the subgenomes;the rate of B,to B2 subgenome conversions was nearly three times higher than that of B2 to B subgenome *** analyses revealed that genes involved in storage root formation,maintenance of genome stabil-ity,biotic resistance,sugar transport,and potassium uptake were selected during the speciation and domestication of *** study sheds light on the evolution of sweetpotato and paves the way forimprovementofthiscrop.

关键词： sweetpotato origin gene conversion domestication IbT-DNA HPA

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