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Particuology 2016年第2期14卷 83-92页

作者： libin liang Yanmin Wang Zhidong Pana, School of Materials Science and Engineering South China University of Technology Guangzhou 510640 China Guangdong KITO Ceramics Co. Ltd. Foshan 528031 China

The aggregation behavior of submicron-sized particles of praseodymium-doped zirconium silicate, a ceramic pigment, in aqueous suspension was predicted by a modified population balance model, In the model, the collision frequencies were selected to describe evolution of the particle size distribution of the suspension. The collision efficiency was estimated as a function of interaction potential between particles based on Derjaguin-Landau-Verwey-Overbeek theory. The population balance model was modified to predict the stable state of the aggregation by introducing the volume mean size of aggregate to stability ratio. In addition, aggregation of the particles in aqueous suspension in the presence of sodium dodecyl benzene sulfonate or potassium chloride was experimentally investigated. The predicted data （i.e., the final aggregate size, aggregation rate, and particle size distribution） were similar to the experimentalresults.

关键词： Population balance model Aggregation Surface forces Colloidal suspensions Praseodymium-doped zirconium silicate

Beam fanning effect and image storage in Ce:KNSBN crystal

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Chinese Science Bulletin 2007年第8期52卷 1024-1028页

作者： LI PanLai GUO QingLin WANG ZhiJun PANG libin liang BaoLai College of Physics Science & Technology Hebei University Baoding 071002 China

A non-synchronously-numerating experimental system is applied in this *** effect of the incident beam intensity I and the beam incident angleθon beam fanning effect is investigated with a singular beam incident on Ce:KNSBN *** results show that the beam fanning effect strongly depends on I andθ.The threshold effect of I for the beam fanning in Ce:KNSBN crystal is observed,and the threshold intensity of incident beam keeps the same value of 38.2 mW/cm 2 for differentθ,and the steady beam fanning intensity Ifsat reaches a peak atθ=15°under the same *** addition,the effect of the incident beam modulated on the beam fanning noise and holographic storage in Ce:KNSBN crystal is *** the results suggest that the beam fanning noise is effectively suppressed,and the quality of the reappearance image is greatly improved.

关键词： Ce:KNSBN晶体光束扇形散射效应图象存储光折变

TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2

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Protein & Cell 2020年第12期11卷 894-914页

作者： Nan Sun Li Jiang Miaomiao Ye Yihan Wang Guangwen Wang Xiaopeng Wan Yuhui Zhao Xia Wen libin liang Shujie Ma Liling Liu Zhigao Bu Hualan Chen Chengjun Li State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China

Tripartite motif(TRIM)family proteins are important effectors of innate immunity against viral *** we identified TRIM35 as a regulator of TRAF3 *** in or inhibition of TRIM35 suppressed the production of type I interferon(IFN)in response to viral infection.777m35-deficient mice were more susceptible to influenza A virus(IAV)infection than were wild-type ***35 promoted the RIG-Imediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 and the subsequent formation of a signaling complex with VISA and *** PB2 polymerase countered the innate antiviral immune response by impeding the Lys63-linked polyubiquitination and activation of ***35 mediated Lys48-linked polyubiquitination and proteasomal degradation of IAV PB2,thereby antagonizing its suppression of TRAF3 *** in vitro and in vivo findings thus reveal novel roles of TRIM35,through catalyzing Lys63-or Lys48-linked polyubiquitination,in RIG-I antiviral immunity and mechanism of defense against IAV infection.

关键词： influenza A virus PB2 TRIM35 TRAF3 ubiquitination antiviral immunity

Genetic and biological properties of H9N2 avian influenza viruses isolated in central China from2020 to 2022

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Journal of Integrative Agriculture 2024年第8期23卷 2778-2791页

作者： libin liang Yaning Bai Wenyan Huang Pengfei Ren Xing Li Dou Wang Yuhan Yang Zhen Gao Jiao Tang Xingchen Wu Shimin Gao Yanna Guo Mingming Hu Zhiwei Wang Zhongbing Wang Haili Ma Junping Li College of Veterinary Medicine Shanxi Agricultural UniversityJinzhong 030801China Shanxi Provincial Animal Disease Prevention and Control Center Taiyuan 030000China

The H9N2 subtype of avian influenza virus(AIV)is widely prevalent in poultry and wild birds globally,and has become the predominant subtype circulating in poultry in *** H9N2 AIV can directly or indirectly(by serving as a"donor virus")infect humans,posing a significant threat to public ***,there is a lack of in-depth research on the prevalence of H9N2 viruses in Shanxi Province,central *** this study,we isolated 14 H9N2 AIVs from October 2020 to April 2022 in Shanxi Province,and genetic analysis revealed that these viruses belonged to 7 different *** study on animals revealed that the H9N2 strains we identified displayed high transmission efficiency among chicken populations,and exhibited diverse replication abilities within these *** viruses could replicate efficiently in the lungs of mice,with one strain also demonstrating the capacity to reproduce in organs like the brain and *** the cellular level,the replication ability of different H9N2 strains was evaluated using plaque formation assays and multi-step growth curve assays,revealing significant differences in the replication and proliferation efficiency of the various H9N2 viruses at the cellular *** antigenicity analysis suggested that these isolates could be classified into 2 separate antigenic *** research provides crucial data to help understand the prevalence and biological characteristics of H9N2 AIVs in central *** also highlights the necessity of enhancing the surveillance of H9N2 AIVs.

关键词： avian influenza virus H9N2 central China pathogenicity antigenicity

Genetic and pathogenic characterization of new infectious bronchitis virus strains in the GVI-1 and GI-19 lineages isolated in central China

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Journal of Integrative Agriculture 2024年第7期23卷 2407-2420页

作者： Yuhan Yang Dou Wang Yaning Bai Wenyan Huang Shimin Gao Xingchen Wu Ying Wang Jianle Ren Jinxin He Lin Jin Mingming Hu Zhiwei Wang Zhongbing Wang Haili Ma Junping Li libin liang College of Veterinary Medicine Shanxi Agricultural UniversityJinzhong 030801China Shanxi Provincial Animal Disease Prevention and Control Center Taiyuan 030000China

Avian infectious bronchitis(IB)is a highly contagious infectious disease caused by infectious bronchitis virus(IBV),which is prevalent in many countries worldwide and causes serious harm to the poultry *** present,many commercial IBV vaccines have been used for the prevention and control of IB;however,IB outbreaks occur *** this study,two new strains of IBV,SX/2106 and SX/2204,were isolated from two flocks which were immunized with IBV H120 vaccine in central *** and recombination analysis indicated that SX/2106,which was clustered into the GI-19 lineage,may be derived from recombination events of the GI-19 and GI-7 strains and the LDT3-A *** analysis showed that SX/2204 belongs to the GVI-1 lineage,which may have originated from the recombination of the GI-13 and GVI-1 strains and the H120 *** virus cross-neutralization test showed that the antigenicity of SX/2106 and SX/2204 was different from *** experiments found that both SX/2106 and SX/2204 could replicate effectively in the lungs and kidneys of chickens and cause disease and death,and H120 immunization could not provide effective protection against the two IBV *** is noteworthy that the pathogenicity of SX/2204 has significantly increased compared to the GVI-1 strains isolated previously,with a mortality rate up to 60%.Considering the continuous mutation and recombination of the IBV genome to produce new variant strains,it is important to continuously monitor epidemic strains and develop new vaccines for the prevention and control of IBV epidemics.

关键词： infectious bronchitis virus GI-19 lineage GVI-1 lineage complete genome recombination pathogenicity

Generation and application of replication-competent Venus-expressing H5N1,H7N9,and H9N2 influenza A viruses

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Science Bulletin 2018年第3期63卷 176-186页

作者： guangwen wang jie zhang fandi kong qibing li jinliang wang shujie ma yuhui zhao libin liang junping li nan sun lizheng guan yuan zhou chenchen zhou shanyu huang zhigao bu li jiang hualan chen chengjun li State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150069 China

The generation and application of replication-competent influenza A virus （IAV） expressing a reporter gene represent a valuable tool to elucidate the mechanism of viral pathogenesis and establish new coun- termeasures to combat the threat of influenza. Here, replication-competent 1AVs with a neuraminidase （NA） segment harboring a fluorescent reporter protein, Venus, were generated in the background of H5N1, H7N9, and H9N2 influenza viruses, the three subtypes of viruses with imminent pandemic poten- tial. All three reporter viruses maintained virion morphology, replicated with similar or slightly reduced titers relative to their parental viruses, and stably expressed the fluorescent signal for at least two pas- sages in embryonated chicken eggs. As a proof of concept, we demonstrated that these reporter viruses, used in combination with a high-content imaging system, can serve as a convenient and rapid tool for the screening of antivirals and host factors involved in the virus life cycle. Moreover. the reporter viruses demonstrated similar growth properties and tissue tropism as their parental viruses in mice, among which the HTN9 NA-Venus virus could potentially be used in ex vivo studies to better understand H7N9 pathogenesis or to develop novel therapeutics.

关键词： Replication-competent Influenza A virus H5N1 H7N9 H9N2 Venus

腋窝小血管弓在腋臭根治术中的解剖标志性意义

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中华整形外科杂志 2021年第2期37卷 192-197页

作者：蔡小辉罗贵月梁利斌重庆市黔江中心医院骨(烧伤整形)科 409000 重庆市黔江中心医院病理科 409000

目的探讨腋窝前、后、内、外4组小血管弓在腋臭根治术中的解剖标志性意义。方法2015年2月至2018年8月,重庆市黔江中心医院对150例(300侧)腋臭患者行腋臭根治术,其中男80例,女70例,10~16岁60例,17~49岁90例。轻度21例,中度43例,重度86例... 详细信息

目的探讨腋窝前、后、内、外4组小血管弓在腋臭根治术中的解剖标志性意义。方法2015年2月至2018年8月,重庆市黔江中心医院对150例(300侧)腋臭患者行腋臭根治术,其中男80例,女70例,10~16岁60例,17~49岁90例。轻度21例,中度43例,重度86例。术前标注腋毛分布区范围,然后选取腋窝中间部位前后襞之间顺皮纹切口切开。锐性解剖出腋窝前、后、内、外侧4组小血管弓,测量血管弓与腋毛分布区边缘的最小距离。在各血管弓外侧1 cm、内侧(紧贴血管弓)、内侧1 cm、内侧2 cm处和腋筋膜表面分别切取直径约1 cm的组织送病理学检测。然后用组织剪彻底剪除腋窝前、后、内、外4组小血管弓所界定范围内的包括腋毛毛囊的浅筋膜组织。对切取组织行HE染色后进行病理学检查,观察有无顶泌汗腺,若有则计数为1,没有则计数为0,统计各处标本诊断为顶泌汗腺的比例并进行卡方检验。术后随访患者,评估手术切口愈合情况和腋臭残留情况。结果150例患者均顺利完成手术,术中发现腋窝前、后、内、外4组小血管弓位置较为恒定。腋窝小血管弓所界定的范围均大于腋毛分布范围,90.00%(270/300)患者腋窝小血管弓距腋毛分布区边缘最小距离超过1.5 cm。术中发现腋窝前、后、内、外4组小血管弓外侧1 cm汗腺组织为0%(0/1200);血管弓内侧(紧贴血管弓)汗腺组织为1.33%(16/1200);血管弓内侧1 cm汗腺组织为100.00%(1200/1200);血管弓内侧2 cm汗腺组织为100.00%(1200/1200);腋筋膜表面汗腺组织为0%(0/1200)。小血管弓内侧顶泌汗腺所占比例与小血管弓外侧比较,差异具有统计学意义(χ2=1621.48,P<0.001)。所有患者术后均切口愈合良好,无血肿形成及皮肤坏死。术后随访6个月至3年,均达到治愈,无一例残留或复发。结论腋窝前、后、内、外4组小血管弓在腋臭根治术中具有解剖标志性意义,对规范腋臭根治术式有推进作用。

关键词：解剖标志臭汗症腋汗腺小血管弓

VxWorks在AFTN网关中的设计和应用

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计算机工程 2005年第20期31卷 127-129页

作者：梁礼斌张军罗喜伶北京航空航天大学电子信息工程学院北京100083

提出了一种基于嵌入式操作系统VxWorks的航空固定电信网(AFTN)网关的设计方案。介绍了AFTN网关的功能,着重描述了系统的设计框架,讨论了实时网关系统的关键技术,包括多任务管理上的协调、网络接口设计和双机热备等。

关键词： VxWorks AFTN网关实时系统多任务

盐度和pH值对不同规格西施舌耗氧率和排氨率的影响

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海洋湖沼通报 2023年第6期45卷 100-108页

作者：罗杰王中铎曹伏君梁李彬广东海洋大学水产学院南海水产经济动物增养殖广东普通高校重点实验室广东湛江524025 湛江东海岛经济开发区彩丰渔业专业合作社广东湛江524074

在盐度12、17、22、27、32、37和pH值5.0、6.0、7.0、8.0、9.0、10.0条件下,采用实验生态学方法,研究了大(L)、中(M)、小(S)3种规格西施舌对耗氧率和排氨率的影响。结果表明:(1)盐度对西施舌耗氧率有显著影响(p<0.05),对排氨率有极显著... 详细信息

在盐度12、17、22、27、32、37和pH值5.0、6.0、7.0、8.0、9.0、10.0条件下,采用实验生态学方法,研究了大(L)、中(M)、小(S)3种规格西施舌对耗氧率和排氨率的影响。结果表明:(1)盐度对西施舌耗氧率有显著影响(p<0.05),对排氨率有极显著影响(p<0.01)。当盐度12~22时西施舌的耗氧率随着盐度的增大而上升,并在盐度22时达最大值,之后随盐度的升高而降低;而排氨率在盐度为27时达到最大值,然后随盐度的升高而降低;(2)pH对西施舌的耗氧率和排氨率均有显著影响(p<0.05);随着pH的升高,西施舌的耗氧率和排氨率呈现先升高后降低的趋势,并在pH=8时达最大值后逐渐降低;(3)在相同盐度或pH条件下,各规格西施舌的耗氧率、排氨率均随单位体质量的增大而减小,单位体质量对西施舌耗氧率、排氨率影响极为显著(p<0.01);(4)盐度实验中,3种规格西施舌O∶N比值的变化范围为5.733~7.543,总体上是随着盐度增大呈现先上升后下降的趋势;随着pH的升高,O∶N的变化与盐度变化相似,范围为5.722~6.574,并在pH=7时达到最大值;O∶N随着个体的增大而增加;盐度或pH的变化对西施舌O∶N比值变化不大。

关键词：西施舌盐度 pH值耗氧率排泄率

微创介入中智能化光学辅助技术与激光消融治疗的研究进展

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中国激光 2023年第15期50卷 73-89页

作者：梁利斌李亮高婷婷王广志丁辉万明习张镇西西安交通大学生命科学与技术学院生物医学工程系生物医学信息工程教育部重点实验室陕西西安710049 南京医科大学生物医学工程与信息学院江苏南京211100 清华大学医学院生物医学工程系北京100084 西安交通大学生命科学与技术学院生物医学信息工程教育部重点实验室生物医学光子学与传感研究所陕西西安710049

微创介入治疗近年来发展迅速,具有重要临床价值。然而,微创条件下手术视野与操作范围受限,手术结果高度依赖医生经验。为解决这一问题,临床关注的焦点是如何实现手术信息的可视化、手术定量信息的获取和治疗范围的精准控制。光学辅助与... 详细信息

微创介入治疗近年来发展迅速,具有重要临床价值。然而,微创条件下手术视野与操作范围受限,手术结果高度依赖医生经验。为解决这一问题,临床关注的焦点是如何实现手术信息的可视化、手术定量信息的获取和治疗范围的精准控制。光学辅助与激光消融技术在解决该问题上发挥了重要作用。增强现实技术提供新的可视化方式,光学追踪与传感为术中提供多维的定量信息,而激光消融则提供了精准治疗的途径。同时,光学技术与计算机视觉、人工智能、材料科学等多学科结合,推动微创介入朝着智能化、精准化、个性化的方向发展。聚焦于微创介入中的光学辅助与激光消融技术,主要从增强现实、光学追踪与感知、激光消融三方面,对相关研究进展进行综述。

关键词：医用光学增强现实光学追踪与感知激光消融微创介入