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A mini-review and perspective on ferroptosis-inducing strategies in cancer therapy

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Chinese Chemical Letters 2019年第4期30卷 847-852页

作者： Shuaifei Wang hongwei liao Fangyuan Li Daishun Ling Institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou Institute of Innovative Medicine College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Biomedical Engineering of the Ministry of Education College of Biomedical Engineering & Instrument Science Zhejiang University

Ferroptosis, as a new type of cell death caused by lipid peroxidation, has attracted much attention since it was first identified in 2012. A lot of progress has been made in unraveling its mechanisms and therapeutic potential as a target for cancer therapy. Hitherto, there are mainly two strategies widely adopted for designing ferroptosis-inducing agents, which include increasing the intracellular reactive oxygen species(ROS) level by Fenton reaction, and inactivating the glutathione peroxidase 4(GPX4). In this mini-review,we summarize the recent advances in ferroptosis-based anticancer treatments with a highlight on nanomaterials, and discuss the current challenges faced by those agents from the perspective of in vivo applications. Moreover, by generalizing ferroptosis induced by excess iron ions to cell death caused by the polyvalent metal-mediated oxidative burden, we introduce a new paradigm of cancer treatment by exploiting various polyvalent metals to disrupt the vulnerable redox balance in cancer cells, which may greatly diversify our arsenal to combat cancer.

关键词： Ferroptosis Fenton reaction Reactive oxygen species Lipid peroxidation Glutathione peroxidase 4

Building State-owned Assets Supervision System and Conducting Mixed Ownership Reforms to Reinforce Each Other’s Collaboration

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Frontiers of Business Research in China 2022年第1期16卷 70-87页

作者： liao hongwei LIU Yongfei Center for China Public Sector Economy Research Jilin UniversityChangchun 130012China School of Economics Jilin UniversityChangchun 130012China

Improving the state-owned assets supervision system(SOASS)can effectively get over the defects of systems and mechanisms and further promote the reform of mixed ownership of state-owned enterprises(SOEs);and the deepening of the reform can advance the change of the SOASS to the supervision on *** analyzing the relationship between the SOASS and the reform of mixed ownership of state-owned enterprises,we have found that collaborative promotion of the change of the SOASS to the supervision on capital and promotion of the reform of mixed ownership can do good to ameliorating the corporate management mechanism,improving the market-oriented management mechanism of enterprises and completing the medium-and long-term incentive mechanisms,*** enhance business operation *** to such prevailing problems as relative dispersion and vagueness of the policies relating to deepening the reform of SOEs,inconsistent progress of the reform of state-owned assets(SOAs)and SOEs,and corporate reform focusing on apprence,improving the SOASS and deepening collaborative development of the reform of mixed ownership of SOEs are hindered by some *** construct and improve the SOASS and the reform of mixed ownership collaboratively,we should make efforts to promote the reform in the following five aspects,namely,placing importance to policy coordination,boosting synchronism of the reform of SOAs and SOEs at different levels and in different areas to coordinate the nationwide reform of SOAs and SOEs,facilitating reform of the mechanism of enterprises of mixed ownership through mixed capital,and promoting the SOASS and stimulating classified monitoring and reform of mixed ownership based on classified reform of SOEs.

关键词： state-owned assets supervision system(SOASS) state-owned enterprises(SOEs) reform of mixed ownership corporation for state-owned capital investment and operation

Dynamic supraparticles for the treatment of age-related diseases

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Science Bulletin 2019年第24期64卷 1850-1874页

作者： hongwei liao Zeyu Liang Nan Wang Min Wei Ying Chen Fangyuan Li Daishun Ling Institute of Pharmaceutics and Hangzhou Institute of Innovative Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Biomedical Engineering of the Ministry of Education College of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhou 310058China

Age-related diseases(ARDs) are arising as a major threat to public health in our fast-aging *** development of nanomedicine has sparked much optimism toward ARDs management by improving drug delivery and controlled drug release. However, effective treatments for ARDs, such as cancer and Alzheimer’s diseases(AD), are still lacking, due to the complicated pathological features of ARDs including multifactorial pathogenesis, intricate disease microenvironment, and dynamic symptom manifestation. Recently, dynamic supraparticles(DS), which are reversibly self-assembled functional nanoparticles, have provided a novel strategy for combating ARDs. Besides the intrinsic advantages of nanomedicine including multifunctional and multitarget, DS are capable of dynamic structural reconfiguration upon certain stimulation, creating another layer of maneuverability that allows programmed response to the spatiotemporal alterations of ARDs during progression and treatment. In this review,we will overview the challenges faced by ARDs management, and discuss the unique opportunities brought by DS. Then, we will summarize the designed synthesis of DS for ARDs treatment. Finally, we will dissect the therapeutic targets in ARDs that can be exploited by DS, and present the encouraging advances in this field. Hopefully, this review will bridge our knowledge of the design principle of DS and ARDs management, which may inspire the future development of potent theranostic agents to improve the healthcare.

关键词： Dynamic supraparticles Age-related diseases Nanomedicine Stimuli-responsive

Impacts of hydrogen dilution on growth and optical properties of a-SiC:H films

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Science China(Technological Sciences) 2004年第3期47卷 327-334页

作者： HU Zhihua liao Xianbo DIAO hongwei KONG Guanglin ZENG Xiangbo XU Yanyue State Key Laboratory for Surface Physics Institute of Semiconductors & Center for Condensed Materials Physics Chinese Academy of Sciences Beijing 100083 China School of Energy and Environmental Sciences Yunnan Normal University Kunming 650092China State Key Laboratory for Surface Physics Institute of Semiconductors & Center for Condensed Materials Physics Chinese Academy of Sciences Beijing 100083 China State Key Laboratory for Surface Physics Institute of Semiconductors & Center for Condensed Materials Physics Chinese Academy of Sciences Beijing 100083 China State Key Laboratory for Surface Physics Institute of Semiconductors & Center for Condensed Materials Physics Chinese Academy of Sciences Beijing 100083 China State Key Laboratory for Surface Physics Institute of Semiconductors & Center for Condensed Materials Physics Chinese Academy of Sciences Beijing 100083 China State Key Laboratory for Surface Physics Institute of Semiconductors & Center for Condensed Materials Physics Chinese Academy of Sciences Beijing 100083 China

Hydrogenated amorphous silicon-carbon (a-SiC:H) films were deposited by plasma enhanced chemical vapor deposition (PECVD) with a fixed methane to silane ratio ([CH4]/[SiH4]) of 1.2 and a wide range of hydrogen dilution (RH=[H2]/[SiH4 + CH4]) values of 12, 22, 33, 102 and 135. The impacts of RH on the structural and optical properties of the films were investigated by using UV-VIS transmission, Fourier transform infrared (FTIR) absorption, Raman scattering and photoluminescence (PL) measur- ements. The effects of high temperature annealing on the films were also probed. It is found that with increasing hydrogen dilution, the optical band gap increases, and the PL peak blueshifts from ～1.43 to 1.62 Ev. In annealed state, the room temperature PL peak for the low RH samples disappears, while the PL peak for the high RH samples appears at ～2.08 Ev, which is attributed to nanocrystalline Si particles confined by Si-C and Si-O bonds.

关键词： amorphous silicon carbon, hydrogen dilution, nanocrystalline silicon.

Design of flower transplanting mechanisms based on double planet carrier non-circular gear train with complete rotation kinematic pair

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International Journal of Agricultural and Biological Engineering 2022年第3期15卷 9-15页

作者： Xiong Zhao Xingxiao Ma hongwei liao Yongsen Xiong Yadan Xu Jianneng Chen Faculty of Mechanical Engineering and Automation Zhejiang Sci-Tech UniversityHangzhou 310018China Key Laboratory of Crop Harvesting Equipment Technology of Zhejiang Province Jinhua 321017ZhejiangChina Hangzhou Vocational&Technical College Hangzhou 310018China

In view of the problems of the existing mechanisms based on 2R open-chain planetary gear train for seedling transplanting,such as the bad tracking flexibility,low positioning accuracy,and high structure design difficulties of the mechanisms based on 3R open-chain planetary gear train for seedling *** this paper,a transplanting mechanism based on the solution domain synthesis of a 3R open-chain-based complete rotation kinematic pair,a gear train with a single cycle integral rotating pair,is *** Burmester curve equation is derived from the given transplanting trajectory and four exact poses corresponding to each other on the rotation ***,the open-chain road model of the 3R complete rotation kinematic pair is obtained under the constraint governed by the judgment condition of the hinge integral rotating ***,combined with our developed in-house optimization software,the solution to the optimal parameters for the transplanting mechanism can be optimized according to the target ***,the feasibility of the design method is verified by transplanting testing,where kale seedlings with ages of about 20 d and heights of about 80-120 mm are *** experimental results show that the actual motion trajectory of the prototype is basically identical to the theoretical trajectory,validating the feasibility of transplanting mechanism design,parts processing,and test-bed *** the statistical analysis,the average success rate of transplanting is 90.625%,and the reliability of designed mechanism is *** study provides a promising solution for the seedling transplanting of two-planet scaffold pots.

关键词： 3R open-chain planetary gear train complete rotation kinematic pair precise manipulation plug seedling

Design and experiment of double planet carrier planetary gear flower transplanting mechanism

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International Journal of Agricultural and Biological Engineering 2021年第2期14卷 55-61页

作者： Xiong Zhao hongwei liao Xingxiao Ma Li Dai Gaohong Yu Jianneng Chen Faculty of Mechanical Engineering and Automation Zhejiang Sci-Tech UniversityHangzhou 310018China Key Laboratory of Zhejiang Transplanting Equipment Technology Hangzhou 310018China

At present,there is a lack of miniaturized and highly reliable plug seedling transplanting mechanism in flowerpots planting operation,in order to meet the needs of large displacement and high vertical uprightness for flower transplanting,the paper combined the transmission characteristics of the non-circular gear planetary gear train with the swing flexibility of the cam gear and proposed a double planet carrier planetary gear transplanting *** linkage of the mechanism performs variable speed rotation relative to the first planet carrier,the linkage serves as the second planet carrier,and the transplanting arm performs variable speed swing relative to the linkage.A mathematical model of a single planetary carrier mechanism was first established using the method of open linkage group solution domain synthesis,then established the kinematic equations of the second planet carrier and the transplanting *** two parts are combined to form the mathematical solution model of the proposed *** initial trajectory was planned according to the trajectory requirements of seedlings planting operation,the non-circular gear pitch curve in the first planet carrier was obtained and the length of the first planet carrier is 120 *** using the key points’angular deviation between the initial trajectory and the improved trajectory to obtain the cam parameters which driving the transplant arm,consequently determined the length of the second planet carrier is 69.25 mm and the length of the transplant arm is 112.4 ***,the prototype of the mechanism was manufactured,and the test verified the correctness of the design method of the double planet carrier planetary gear flower potting transplanting *** transplanting success rate of this mechanism reached 94.43%,and the plug seedlings planted in flowerpots had high *** research can provide a reference for the automatic development of research on flower transplanting machines.

关键词： flower transplanting double planet carrier planetary gear mechanism non-circular plug seedling

mc-Si:H/c-Si solar cell prepared by PECVD

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Rare Metals 2006年第Z1期25卷 176-179页

作者： XU Ying liao Xianbo DIAO hongwei Li Xudong ZENG Xiangbo LIU Xiaoping WANG Minhua WANG Wenjing State Laboratory for Surface Physics Institute of Semiconductors and Center for Condensed Matter Physics Chinese Acad-bmy of Sciences Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China State Laboratory for Surface Physics Institute of Semiconductors and Center for Condensed Matter Physics Chinese Acad-bmy of Sciences Beijing 100083 China State Laboratory for Surface Physics Institute of Semiconductors and Center for Condensed Matter Physics Chinese Acad-bmy of Sciences Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China State Laboratory for Surface Physics Institute of Semiconductors and Center for Condensed Matter Physics Chinese Acad-bmy of Sciences Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China

Hetero-junction solar cells with an mc-Si:H window layer were achieved. The open voltage is increased while short current is decreased with increasing the mc-Si:H layer′s thickness of emitter layer. The highest of Voc of 597 mV has obtained. When fixed the thickness of 30 nm, changing the N type from amorphous silicon layer to micro-crystalline layer, the efficiency of the hetero-junction solar cells is increased. Although the hydrogen etching before deposition enables the c-Si substrates to become rough by AFM images, it enhances the formation of epitaxial-like micro-crystalline silicon and better parameters of solar cell can be obtained by implying this process. The best result of efficiency is 13.86% with the Voc of 549.8 mV, Jsc of 32.19 mA·cm-2 and the cell′s area of 1 cm2.

关键词： solar cell hetero-junction amorphous silicon plasma enhanced CVD

A K~+-sensitive AND-gate dual-mode probe for simultaneous tumor imaging and malignancy identification

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National Science Review 2022年第7期9卷 127-136页

作者： Qiyue Wang Fangyuan Li Zeyu Liang hongwei liao Bo Zhang Peihua Lin Xun Liu Shen Hu Jiyoung Lee Daishun Ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical Sciences Zhejiang University World Laureates Association (WLA) Laboratories Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational Medicine Shanghai Jiao Tong University Department of Obstetrics The Second Affiliated Hospital of Zhejiang University School of Medicine

Although molecular imaging probes have the potential to non-invasively diagnose a tumor,imaging probes that can detect a tumor and simultaneously identify tumor malignancy remain ***,we demonstrate a potassium ion(K+) sensitive dual-mode nanoprobe(KDMN) for non-invasive tumor imaging and malignancy identification,which operates via a cascaded ’AND’ logic gate controlled by inputs of magnetic resonance imaging(MRI) and fluorescence imaging(FI) *** encapsulate commercial K~+ indicators into the hollow cavities of magnetic mesoporous silica nanoparticles,which are subsequently coated with a K+-selective membrane that exclusively permits the passage of K+while excluding other *** KDMN can readily accumulate in tumors and enhance the MRI contrast after systemic *** information of the tumor lesion is thus accessible via MRI and forms the first layer of the ’AND’ ***,the KDMN selectively captures K+and prevents interference from other cations,triggering a K~+-activated FI signal as the second layer of the ’AND’ gate in the case of a malignant tumor with a high extracellular K~+*** dual-mode imaging approach effectively eliminates false positive or negative diagnostic results and allows for non-invasive imaging of tumor malignancy with high sensitivity and accuracy.

关键词： dual-mode imaging probe fluorescence imaging MRI tumor malignancy identification potassium ion

A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy

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Nano-Micro Letters 2022年第6期14卷 282-293页

作者： Xi Hu Nan Wang Xia Guo Zeyu Liang Heng Sun hongwei liao Fan Xia Yunan Guan Jiyoung Lee Daishun Ling Fangyuan Li Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058People’s Republic of China Frontiers Science Center for Transformative Molecules State Key Laboratory of Oncogenes and Related GenesSchool of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Department of Clinical Pharmacy The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003People’s Republic of China WLA Laboratories Shanghai 201203People’s Republic of China Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roWonmi-guBucheon-SiGyeonggi-do 14662Republic of Korea

The structural change-mediated catalytic activity regulation plays a significant role in the biological functions of natural ***,there is virtually no artificial nanozyme reported that can achieve natural enzyme-like stringent spatiotemporal structure-based catalytic activity ***,we report a subnanostructural transformable gold@ceria(STGC-PEG)nanozyme that performs tunable catalytic activities via near-infrared(NIR)light-mediated sub-nanostructural *** gold core in STGC-PEG can generate energetic hot electrons upon NIR irradiation,wherein an internal sub-nanostructural transformation is initiated by the conversion between CeO;and electron-rich state of CeO;-x,and active oxygen vacancies generation via the hot-electron ***,the sub-nanostructural transformation of STGC-PEG enhances peroxidase-like activity and unprecedentedly activates plasmon-promoted oxidase-like activity,allowing highly efficient low-power NIR light(50 m W cm;)-activated photocatalytic therapy of *** atomic-level design and fabrication provide a platform to precisely regulate the catalytic activities of nanozymes via a light-mediated sub-nanostructural transformation,approaching natural enzyme-like activity control in complex living systems.

关键词： Nanozymes Sub-nanostructural transformation Catalytic activity Reactive oxygen species Photocatalytic therapy