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HTPdb and HTPtools:Exploiting maize haplotypetag polymorphisms for germplasm resource analyses and genomics-informed breeding

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Plant Communications 2022年第4期3卷 54-63页

作者： Yikun Zhao Hongli Tian Chunhui li Hongmei Yi Yunlong zhang Xiaohui li Han Zhao Yongxue Huo Rui Wang Dingming Kang Yuncai Lu Zhihao liu Ziyue liang liwen Xu Yang Yang ling Zhou Tianyu Wang Jiuran Zhao fengge Wang Maize Research Center Beijing Academy of Agriculture&Forestry Sciences(BAAFS)Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular BreedingShuguang Garden Middle Road No.9Beijing 100097China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Jilin Academy of Agricultural Sciences Maize Research InstituteGongzhuling 136100China Provincial Key Laboratory of Agrobiology Institute of Crop Germplasm and BiotechnologyJiangsu Academy of Agricultural SciencesNanjing 210014China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China College of Advanced Agriculture and Ecological Environment Heilongjiang UniversityHarbin 150080China

Along with rapid advances in high-throughput-sequencing technology,the development and application of molecular markers has been critical for the progress that has been made in crop breeding and genetic *** molecular markers should be able to rapidly genotype tens of thousands of breeding accessions with tens to hundreds of *** this study,we developed a multiplex molecular marker,the haplotype-tag polymorphism(HTP),that integrates Maize6H-60K array data from 3,587 maize inbred lines with 6,375 blocks from the recombination block *** applying strict filtering criteria,we obtained 6,163 highly polymorphic HTPs,which were evenly distributed in the ***,we developed a genome-wide HTP analysis toolkit,HTPtools,which we used to establish an HTP database(HTPdb)covering the whole genomes of 3,587 maize inbred lines commonly used in breeding.A total of 172,921 non-redundant HTP allelic variations were *** major HTPtools modules combine seven algorithms(e.g.,chain Bayes probability and the heterotic-pattern prediction algorithm)and a new plotting engine named“BCplot”that enables rapid visualization of the background information of multiple backcross *** was designed for big-data analyses such as complex pedigree reconstruction and maize heterotic-pattern *** HTP-based analytical strategy and the toolkit developed in this study are applicable for high-throughput genotyping and for genetic mapping,germplasm resource analyses,and genomics-informed breeding in maize.

关键词： haplotype tag database maize pedigree reconstruction heterotic-pattern prediction genomicsinformed breeding

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Removal efficiencies of natural and synthetic progesterones in hospital wastewater treated by different disinfection processes

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Frontiers of Environmental Science & Engineering 2022年第10期16卷 11-22页

作者： Jinhui liang Yuchen Luo Benhang li Shiqi liu liansheng Yang Peng Gao li Feng Yongze liu Ziwen Du liqiu zhang Beijing Key Laboratory for Source Control Technology of Water Pollution Engineering Research Center for Water Pollution Source Control and Eco-remediationBeijing Forestry UniversityBeijing 100083China

Progesterones are ubiquitous in hospital wastewater(HWW)with concentrations much higher than those of estrogens and *** ensure that these water systems are safe to use,disinfection is crucial during HWW treatment by providing"front line"defense against biological ***,five disinfection processes,namely,chlorine(Cl_(2)),chlorine dioxide(ClO_(2)),ozone(O_(3)),ultraviolet(UV)),and UV/chlorine(UV/Cl_(2)),were selected to investigate their removal efficiencies for progesterones in primary filtration and secondary biological treatment *** were 61 natural and synthetic progesterones detected in HWW,with the natural progesterones being the main components with a concentration of 845.51 ng/L and contributing to 75.08%of the total *** primary filtration treatment presented insignificant removal effects on the progesterones,while the secondary biological treatment significantly reduced the progesterone content by *** order of removal efficiencies of total progesterones by different disinfection processes was UV/Cl_(2)>Cl_(2)>O_(3)>ClO_(2)>***/Cl_(2)showed the highest removal efficiency against progesterones mainly due to the activation of Cl_(2)by ultraviolet(UV)photolysis,which helps open the heterocyclic,aromatic,and phenolic rings,thus accelerating progesterone *** addition,the removal efficiencies of natural progesterones in the five disinfection processes were higher than those of synthetic progesterones(progesterone derivatives,19-nortestosterone derivatives,and 17α-hydroxyprogesterone derivatives).

关键词： Progesterones Hospital wastewater Primary filtration treatment effluent Secondary biological treatment effluent Disinfection process

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Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population

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The Journal of Biomedical Research 2014年第4期28卷 262-268页

作者： Fang Zhou Haifeng zhang Wenming Yao Hongbin Mei Dongjie Xu Yanhui Sheng Rong Yang Xiangqing Kong liansheng Wang Jiangang Zou Zhijian Yang Xinli li Department of Cardiology the First Affiliated Hospital of Nanjing Medical University

The purpose of this study was to assess the relationship between arterial stiffness, as measured by brachial-ankle pulse wave velocity （baPWV）, and the presence of the metabolic syndrome （MS） in a Chinese population. A total of 4,445 subjects were enrolled. The prevalence of MS in for the general population, males and females, respectively. our study population was 21.7%, 17.2% and 25.6% With adjustments for age, gender, cigarette smoking, heart rate, total cholesterol, low-density lipoprotein （LDL） cholesterol, and the use of anti-hypertensive drug, the stepwise regression analysis showed that baPWV had a significant relationship with components of MS, including systolic blood pressure （P 〈 0.001）, diastolic blood pressure （P 〈 0.001）, glucose （P 〈 0.001）, highdensity lipoprotein （HDL） cholesterol （P = 0.04）, and triglycerides （P 〈 0.001）, but no relationship with waist circumference （P = 0.25）. With an increase in the number of the MS components, baPWV increased significantly both in women and men. This study indicated that the MS is indeed a risk factor for arterial stiffness. Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease.

关键词： arterial stiffness brachial-ankle pulse wave velocity metabolic syndrome

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泛影葡胺造影剂对非绞窄性小肠梗阻患者行腹腔镜手术时机的判断及对术后疗效的观察

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当代医学 2024年第1期30卷 32-35页

作者：马永强王秋红郑连生段树全王海龙张冬胜李小龙韩唯杰内蒙古科技大学包头医学院第二附属医院消化微创中心内蒙古包头014030

目的研究泛影葡胺造影剂对非绞窄性小肠梗阻患者行腹腔镜手术时机的判断作用及对术后疗效和血清肠脂肪酸结合蛋白(IF-ABP)、二胺氧化酶(DAO)水平的影响。方法选取2019年1月至2021年4月于内蒙古科技大学包头医学院第二附属医院消化微创... 详细信息

目的研究泛影葡胺造影剂对非绞窄性小肠梗阻患者行腹腔镜手术时机的判断作用及对术后疗效和血清肠脂肪酸结合蛋白(IF-ABP)、二胺氧化酶(DAO)水平的影响。方法选取2019年1月至2021年4月于内蒙古科技大学包头医学院第二附属医院消化微创中心诊断为肠梗阻的120例患者作为研究对象,按照随机数字表法分为观察组与对照组,每组60例。对照组给予胃肠减压、抗感染等基础治疗,观察组在对照组基础上行泛影葡胺造影剂下腹腔镜手术,对照组在保守治疗48h无效后行腹腔镜治疗。比较两组治疗指标、非手术治疗疗效评价指标、血清IFABP及DAO水平、术后并发症发生情况。结果观察组非手术治疗成功率高于对照组,排气时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。观察组胃肠减压量少于对照组,首次肛门排便时间、症状缓解时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清IFABP水平均低于治疗前,DAO水平均高于治疗前,且观察组血清IFABP、DAO水平均低于对照组,差异有统计学意义(P<0.05)。随访6个月,两组电解质紊乱、切口感染、再发肠梗阻、腹膜炎发生率比较差异无统计学意义。结论泛影葡胺造影剂对非绞窄性小肠梗阻患者行腹腔镜手术时机的判断准确,可提高非手术治疗成功率,缩短术后排便时间和住院时间,降低IFABP、DAO水平,改善患者肠黏膜缺血状态。

关键词：泛影葡胺造影肠梗阻腹腔镜肠脂肪酸结合蛋白二胺氧化酶

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Diagnostic and prognostic value of minor elevated cardiac troponin levels for percutaneous coronary intervention-related myocardial injury:a prospective,single-center and double-blind study

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The Journal of Biomedical Research 2014年第2期28卷 98-107页

作者： Min zhang Huiwei He Ze-Mu Wang Zhihui Xu Ningtian Zhou Zhengxian Tao Bo Chen Chunjian li Tiebing Zhu Di Yang liansheng Wang Zhijian Yang Department of Gardiology the First Affiliated Hospital of Nanjing Medical University Department of Geriatrics the Second Affiliated Hospital of Nanjing Medical University Department of Geriatrics the First Affiliated Hospital of Nanjing Medical University

Cardiac troponin-I （cTnI） and -T （cTnT） are sensitive and specific markers of myocardial injury. However, the role of increased cTnI and cTnT in percutaneous coronary intervention （PCI）-related myocardial injury remains controversial. In this prospective, single-center and double-blind study, we aimed to determine the diagnostic and prognostic value of cTnI as well as cTnT （cTns） in PCI-related myocardial injury in a Chinese population. A total of 1,008 patients with stable angina pectoris and non-ST-segment elevation acute coronary syndrome were recruited. The levels of cTnI and cTnT were examined before and after PCI. All patients were followed up for 26± 9 months to observe the incidence of major adverse cardiac events （MACEs）. Our results showed that post- PCI cTnI and/or cTnT levels were increased to more than the 99^th percentile upper reference limit （URL） in 133 （13.2%） patients, among which 22 （2.2%） were more than 5 × 99^th percentile URL. By univariate analysis, an elevation in cTns after PCI was not an independent predictor of increased MACEs, HR 1.35 （P = 0.33, 95% CI： 0.74-2.46）. In conclusion, our data demonstrate that the incidence of PCI-related myocardial injury is not common in a Chinese population and minor elevated cTns levels may not be a sensitive prognostic marker for MACEs.

关键词： percutaneous coronary intervention (PCI) troponins PCI-related myocardial injury major adversecardiac events diagnosis prognosis

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Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia

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Neuroscience Bulletin 2019年第6期35卷 1102-1105页

作者： liansheng Zhao Huijuan Wang Yamin zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan liwen Tan Qi Chen Guigang Yang Tianlan Lu lifang Wang Fuquan zhang Jianli Yang Keqing li Luxian Lv Qingrong Tan Yinfei li Hua Yu Hongyan zhang Xin Ma Fude Yang lingjiang li Chuanyue Wang Huiyao Wang Xiaojing li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai zhang Chao Chen Tao li Chinese Antipsychotics Pharmacogenomics Consortium Psychiatric Laboratory and Mental Health Center the State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China West China Brain Research Center West China Hospital of Sichuan UniversityChengdu 610041China The National Engineering Research Center for Miniaturized Detection Systems College of Life ScienceNorthwest UniversityXi'an 710069China Shaanxi lifegen Co. LtdXi'an 712000China Biomolecular Science Research Centre Sheffield Hallam UniversitySheffield S11WBUK Peking University Sixth Hospital(Institute of Mental Health) Beijing 100083China National Clinical Research Center for Mental Disorders and Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100871China Second Xiangya Hospital Central South UniversityChangsha 410011China Beijing Anding Hospital Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100088China Beijing HuiLongGuan Hospital Beijing 102200China Wuxi Mental Health Center Nanjing Medical UniversityWuxi 214121China Institute of Mental Health Tianjin Anding HospitalTianjin 300222China Tianjin Medical University General Hospital Tianjin Medical UniversityTianjin 300052China Hebei Mental Health Center Baoding 071000China Second Affiliated Hospital of Xinxiang Medical University Xinxiang 453003China Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi'an 710032China Huaxi Biobank West China Hospital of Sichuan UniversityChengdu 610041China 不详

Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia.

关键词： drugs Dopamine Schizophrenia

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某通廊结构的检测鉴定

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工业建筑 2008年第Z1期38卷 1076-1078页

作者：李奉阁张金玲内蒙古科技大学建筑与土木工程学院包头014010 包头市建筑设计研究院有限责任公司包头014010

某通廊经过50年的使用,已发生不同程度的损伤。结构材料逐渐老化,构件出现不同程度的开裂、钢筋锈蚀、混凝土疏松剥落及碳化,结构的可靠度下降,严重影响了结构的安全和正常使用。通过对通廊结构进行的现场检测、结构计算分析和可靠性鉴... 详细信息

某通廊经过50年的使用,已发生不同程度的损伤。结构材料逐渐老化,构件出现不同程度的开裂、钢筋锈蚀、混凝土疏松剥落及碳化,结构的可靠度下降,严重影响了结构的安全和正常使用。通过对通廊结构进行的现场检测、结构计算分析和可靠性鉴定评级,提出了加固处理方案。对该类结构的检测鉴定具有一定的参考。

关键词：通廊检测鉴定加固

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R134a中润滑油对强化管外池沸腾传热影响的实验研究

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西安交通大学学报 2008年第5期42卷 519-523页

作者：费继友张定才李连生西安交通大学能源与动力工程学院

对3根高效强化管（E21、E22、E23）在饱和温度为5℃和10℃的工况下进行了水平管外含油R134a池沸腾传热的实验研究．实验结果表明：相对于光滑管，强化管E21、E22和E23的管内传热系数强化倍率分别为3．703、3．035和2．709；在蒸发温度为... 详细信息

对3根高效强化管（E21、E22、E23）在饱和温度为5℃和10℃的工况下进行了水平管外含油R134a池沸腾传热的实验研究．实验结果表明：相对于光滑管，强化管E21、E22和E23的管内传热系数强化倍率分别为3．703、3．035和2．709；在蒸发温度为5℃时，在不同的流速下，含油率为100X10。的外表面传热系数比含油率为50×10^-6的传热系数增加了3．7％～7．2％，而在10℃时增加了0．8％～10．9％．研究结果对于制冷系统中蒸发器的设计具有一定的参考作用．

关键词：强化管含油R134a 沸腾传热实验研究

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功能梯度截顶圆锥壳的热弹性弯曲精确解

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力学学报 2008年第2期40卷 185-193页

作者：张靖华李世荣马连生兰州理工大学理学院工程力学系兰州730050

研究了功能梯度材料截顶圆锥壳在横向机械载荷与非均匀热载荷同时作用下的变形问题.基于经典线性壳体理论推导出了以横向剪力和中面转角为基本未知量的功能梯度薄圆锥壳轴对称变形的混合型控制方程.假设功能梯度圆锥壳的材料性质为沿厚... 详细信息

研究了功能梯度材料截顶圆锥壳在横向机械载荷与非均匀热载荷同时作用下的变形问题.基于经典线性壳体理论推导出了以横向剪力和中面转角为基本未知量的功能梯度薄圆锥壳轴对称变形的混合型控制方程.假设功能梯度圆锥壳的材料性质为沿厚度方向按照幂函数连续变化的形式.然后采用解析方法求解,得到了问题的精确解.分别就两端简支和两端固支边界条件,给出了圆锥壳的变形随其载荷、材料参数等变化的特征关系曲线,重点分析和讨论了载荷参数与材料梯度变化参数对变形的影响.

关键词：功能梯度材料截顶圆锥壳热弹性弯曲精确解

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缺铁性贫血规范化诊治的若干问题

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中华医学杂志 2021年第40期101卷 3266-3270页

作者：李莉娟张连生兰州大学第二医院血液科甘肃省血液病重点实验室兰州730030

缺铁性贫血(IDA)在我国发病率较高,儿童、老年人和妊娠期妇女等人群尤为高发。IDA可伴发于多种疾病,累及各个系统,对免疫和神经系统可造成不可逆的损害。然而,能及时接受治疗的IDA患者不足患病人数的20%。IDA亟需重视并加以规范诊治和... 详细信息

缺铁性贫血(IDA)在我国发病率较高,儿童、老年人和妊娠期妇女等人群尤为高发。IDA可伴发于多种疾病,累及各个系统,对免疫和神经系统可造成不可逆的损害。然而,能及时接受治疗的IDA患者不足患病人数的20%。IDA亟需重视并加以规范诊治和多学科协作。本文系统回顾了近年来IDA的相关临床研究,重点阐述了IDA的危害、治疗中所面临的难点以及静脉铁剂的发展和最新研究进展,旨在为IDA的及时诊断与合理治疗提供指导建议。

关键词：贫血,缺铁性静脉铁剂,新型多学科联合诊疗

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