检索结果-南通市图书馆

Science China Chemistry 2024年第5期67卷 1384-1396页

作者： Mengfu Dai liangliang Song Liang-An chen Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of New Power BateriesSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Jiangsu Co-lnnovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

1,3-Diene architectures are not only widely present in natural products, pharmaceuticals, and functional organic materials but also serve as versatile building blocks to furnish important functionalized molecules in synthetic chemistry due to conjugated repeating C=C units. Accordingly, various strategies to access substituted 1,3-dienes in a stereoselective manner have been developed. However, chemo-, regio-and stereoselective synthesis of highly substituted 1,3-dienes still remains elusive and challenging. Readily available propargylic esters have emerged as an appealing class of synthetic intermediates for accessing functionalized 1,3-dienes, especially challenging tri-or tetrasubstituted variants, via transition-metal catalysis, including electrophilic metal and redox neutral catalysis. This review, for the first time, systematically highlights recent advances in transitionmetal catalyzed synthesis of substituted 1,3-dienes from propargylic esters, discusses the mechanisms and synthetic utilities, and gives the remaining challenges and potential opportunities in this field.

关键词： 1 3-diene propargylic ester Lewis acid redox catalysis transition metal

Evaluating the Applicability and Health Benefits of the Graded Heat Health Risk Early Warning Model-Jinan City,Shandong Province,China,2022

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2023年第29期5卷 642-646,I0001-I0003页

作者： chen chen Jing Liu Menghan Wang liangliang Cui Tiantian Li China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Key Laboratory of Public Health Safety of Hebei Province College of Public HealthHebei UniversityBaoding CityHebei ProvinceChina Department of Environmental Health Jinan Center for Disease Control and PreventionJinan CityShandong ProvinceChina

What is already known about this topic?The heat health early warning model serves as an effective strategy for reducing health risks related to heatwaves and improving population adaptability.Several high-income countries have taken the lead in conducting research and implementing measures aimed at safeguarding their populations.What is added by this report?The graded heat health risk early warning model(GHREWM)in Jinan City has demonstrated efficacy in safeguarding males,females,individuals aged above 75 years,and those with cardiopulmonary diseases.During the summer of 2022,the warning stage of GHREWM contributed to the prevention of 10.9 deaths per million individuals,concurrently averting health-related economic losses estimated at approximately 227 million Chinese Yuan(CNY).What are the implications for public health practice?The GHREWM has the potential to enhance cities’adaptability to climate change.It is crucial to incorporate additional adverse health endpoint data in the development of early warning models,as this will improve their applicability and protective efficacy.

关键词： income conducting measures

A computational simulation study for techno-economic comparison of conventional and stripping gas methods for natural gas dehydration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2020年第9期28卷 2285-2293页

作者： Muhammad Salman liangliang Zhang Jianfeng chen Research Centerof the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China StateKey Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

In the present work,the conventional natural gas dehydration method(CDM)and stripping gas method(SGM)are technically and economically analyzed,utilizing Aspen HYSYS and Aspen Process Economic Analyzer(APEA),respectively.To optimize the CDM and SGM,the sensitivities of the water content of dry gas,reboiler duty and raw material loss are analyzed against solvent rate and stripping gas rate.The optimized processes are set to achieve a targeted value of water content in dry gas and analyzed at optimized point.The analysis shows that SGM gives 46%lower TEG feed rate,42%lower reboiler duty and 99.97%pure regenerated TEG.Moreover,economic analysis reveals that SGM has 38%lower annual operating cost compared to CDM.According to results,from both technical and economic point of view,SGM is more feasible for natural gas dehydration compared to CDM.

关键词： Natural gas dehydration Technical analysis Parametric optimization Economic study Aspen HYSYS

The risk factors and threshold level of subchronic inhalation exposure of reclaimed water

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 639-650页

作者： Jiayang Kong Yun Lu Yunru Ren Menghao chen Gang Liu liangliang Shi State Key Joint Laboratory of Environment Simulation and Pollution Control State Environment Protection Key Laboratory of Microorganism Application and Risk ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China

Inhalation of reclaimed water is known to cause lung infammation,and free endotoxins have been shown to be a major risk factor for acute exposure.Subchronic exposure has also been shown to induce infammatory responses with visible tissue damage.However,subchronic risk factors have yet to be identified,and a threshold for the protection of occupational populations during urban reuse is necessary.In this study,potential risk factors in reclaimed water were examined by subchronic exposure with fractionated reclaimed water,and the health risk threshold was tested with a series of diluted reclaimed water.Accordingly,following a 12-week exposure,macromolecules and microorganisms were found to be two major risk factors in reclaimed water that could cause pulmonary infammation,including increased proportion of polymorphonuclear leukocytes in bronchoalveolar fuid,formation of inducible bronchus-associated lymphoid tissue,and elevation of Immunoglobulin A levels.Moreover,infammation persisted after a 4-week recovery period.The calculated threshold of reclaimed water exposure for mice was 31.8 Endotoxin Unit(EU)/(kg·day)under when exposed to 50%additional relative humidity from reclaimed water at 25℃ for 2 hr/day.Meanwhile,the subchronic threshold estimate for humans under the same exposure conditions was found to be 12.2 EU/(kg·day),corresponding to endotoxin levels of 61.7 EU/mL in reclaimed water.The threshold level of endotoxin was lower than that in most non-potable reclaimed water.The findings of this study suggest that occupational exposure of reclaimed water can serve as a potential risk to workers.

关键词： Reclaimed water Inhalation exposure Risk factor Threshold Infammation Endotoxin

A haemorrhagic cholecystitis presenting as obstructive jaundice

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2021年第2期10卷 299-300页

作者： Xin chen liangliang Yu Department of Gastroenterology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina

A 63-year-old female suffered right upper quadrant pain for 5 days,and icteric sclera for 3 days.Her Laboratory examinations revealed a normal blood routine and abnormal bilirubin levels:total bilirubin 222.0μmol/L,direct bilirubin 131.8μmol/L.Stool occult blood was negative.Abdomen/pelvis CT(Panel A)and MRCP(Panel B)showed cholecystolithiasis and lower choledocholithiasis.

关键词： routine cholecystitis jaundice

The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第3期36卷 299-302页

作者： Yuncheng Zhu Liangliang Chen Haifeng Ji Maomao Xi Yiru Fang Yi Li Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Shanghai Changning Mental Health Center(Affiliated to East China Normal University) Shanghai 200335China Institute of Burns Tongren Hospital of Wuhan University(Wuhan Third Hospital)Wuhan 430000China Affiliated Wuhan Mental Health Center Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430012China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 201108China

Dear Editor,Since the middle of December 2019,human-to-human transmission of novel coronavirus pneumonia(NCP,also called COVID-19)has occurred among close contacts[1].After the outbreak on January 21,2020,it was swiftly included among the Class B infectious diseases stipulated in the Law of the People’s Republic of China on the Prevention and Control of Infectious Diseases,and measures for prevention and control of Class A infectious diseases were adopted.At 21:27 on February 12,2020,the China News Network updated information to include epidemic data from the National Health Commission and official channels in Hong Kong,Macao,and Taiwan regions:the highest death rate was in Wuhan City(Table 1).Overload of inpatients at hospitals may play a negative role in the overall therapeutic effect and contribute to the death rate.

关键词： prevention Taiwan measures

Sugemule-10:Source of prescription and modern clinical application

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2022年第3期14卷 376-384页

作者： Xiangmei chen liangliang Hadanbaoligao Zhang Buriebao Xiulan Wang Wurihan Tai Affiliated Hospital of Inner Mongolia Minzu University Tongliao 028005China NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine(Mongolian Medicine) Tongliao 028000China National and Local Joint Engineering Research Center for Mongolian Medicine Research and Development(Development and Reform Commission) Tongliao 028000China Key Laboratory of Mongolian Medicine R&D Engineering Ministry of EducationTongliao 028000China Mongolian Medicine Research and Health Science Center of Inner Mongolia Minzu University Tongliao 028000China

Sugemule-10,one of the traditional Mongolian medicine(TMM)formulae,is derived from Four Medical Classics(Vol.4)and composed of 10 Mongolian medicines.It is used to treat kidney cold,low back pain,urinary obstruction,kidney/bladder stones,and is the main prescription for kidney cold.The current research on Sugemule-10 is mostly focused on its clinical efficacy,and few papers are available upon its historical changes.Therefore,we systematically reviewed Sugemule-10 from the aspects of prescription source,prescription interpretation,efficacy evolution,and modern clinical applications.

关键词： clinical application prescription interpretation prescription source Sugemule-10

Selenophene-Flanked Diketopyrrolopyrrole Based Conjugated Polymers for Ambipolar Field-Effect Transistors

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2020年第10期38卷 1075-1080页

作者： Dandan Shi Xiaobo Yu Liangliang Chen Daoliang chen Zitong Liu Xisha Zhang Guanxin Zhang Deqing Zhang Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsCAS Center of Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBejjing 100049China

Summary of main observation and conclusion The development of selenophene-flanked DPP(SeDPP)based copolymers,especially for the ambipolar ones,lags behind other aromatic group flanked DPP-based polymers.Herein,we report two new ambipolar SeDPP-based conjugated polymers.One is the alternating polymer PSeDPPFT with normal SeDPP and 3,4-difluorothiophene units.The other is PSeFDFT,in which the electron acceptor unit is replaced by a new SeDPP derivative,referred as to half-fused SeDPP.The more planar structure of half fused SeDPP endows the backbone of PSeFDFT with good rigidity and planarity.Both polymers exhibit ambipolar transporting properties in air.The PSeFDFT based fleld-effect transistors(FETs)display higher and more balanced ambipolar properties with μnave of 0.27 cm2·V-1·s-1,μe ave of 0.18 cm2·V-1·s-1,and μh ave/μeave of 1.5 than those of PSeDPPFT(μhave=0.11cm2·V-1·s-1,μeave=0.042cm2·V-1·s-1,and μh/μe=2.6).This is attributed to the more planar structure,lower LUMO level,higher HOMO level,and better interchain packing orientations of PSeFDFT by comparing with PSeDPPFT.Therefore,a new molecular design strategy to modulate the hole and electron transporting properties is proposed for conjugated D-A polymers.

关键词： planar conjugated fused

Preparation of baicalin colon-targeted granules and its intervention effect on ulcerative colitis in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第2期85卷 13-21页

作者： Yongqing Huang Yuxin Zhou Yao Shen Jin Wang liangliang Zhou Zhenhua chen Jiangxi Provincial Key Laboratory of Drug Design and Evaluation School of PharmacyJiangxi Science and Technology Normal UniversityNanchang330013China

Baicalin(BA)is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi with excellent antioxidant and anti-inflammatory biological activities.In this study,Eudragit S100 was used as the colonic target material to prepare BA colonic targeting granules(EBCGs)based on plasticizer dry powder coating technology to improve the targeting transportation performance of BA.In vitro studies showed that EBCGs with pH-sensitive properties were successfully prepared by plasticizer dry powder coating,and in vivo animal imaging studies showed that EBCGs could deliver BA to the colon and inhibit the release of BA in the upper gastrointestinal tract(GIT).In vivo studies showed that EBCGs had good therapeutic effects in colitis,which reduced expression levels of tumor necrosis factor alpha(TNF-α)and interleukin-1β(IL-1β)and increased superoxide dismutase(SOD)activities in the colonic tissues of rats with colitis.In conclusion,Eudragit S100 could be used for the preparation of multi-unit oral colon-targeted formulations by plasticizer dry powder coating technology,and our prepared EBCGs had good colon-targeting properties,which could improve the therapeutic effect and provide a potential application for ulcerative colitis(UC).

关键词： Plasticizer dry powder coating Colon-targeted granulesIn vivo imaging Ulcerative colitis

Colonization of Bacillus cereus NJSZ-13,a species with nematicidal activity in Masson pine(Pinus massoniana Lamb.)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2020年第3期31卷 1025-1033页

作者： liangliang Li Jiajin Tan Fengmao chen Dejun Hao College of Forestry Nanjing Forestry UniversityCo-Innovation Center for Sustainable Forestry in Southern ChinaNanjing 210037People’s Republic of China

Bacillus cereus NJSZ-13,an endophytic bacterium with nematicidal activity,was isolated from stems of healthy Pinus elliottii Engelm.Colonization of P.massoniana Lamb.by endophytic B.cereus was studied using scanning electron microscopy and confocal laser scanning microscopy.After the plasmid p GFP78 containing the green fluorescent protein(GFP)gene was transformed into the NJSZ-13 strain,the NJSZ-13:gfp showed the same nematicidal activity and growth curve as the wild-type strain,and the plasmid p GFP78 was stably maintained in strain NJSZ-13 for at least 96 h of bacterial cultivation on medium without antibiotics.After inoculation into Masson pine roots,colonization of the NJSZ-13:gfp strain in plant roots and stems was visualized using confocal laser scanning and the strain was enumerated in inoculated roots and stems.These results suggest that NJSZ-13:gfp is an efficient colonizer of Masson pine and can transfer vertically from roots to stems.

关键词： Bacillus cereus Endophytes Green fluorescent protein Plasmid stability Colonization