Preparation of baicalin colon-targeted granules and its intervention effect on ulcerative colitis in rats
作者机构：Jiangxi Provincial Key Laboratory of Drug Design and EvaluationSchool of PharmacyJiangxi Science and Technology Normal UniversityNanchang330013China
出 版 物：《Particuology》 (颗粒学报（英文版）)
年 卷 期：2024年第85卷第2期
页 面：13-21页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学]
基 金：supported by Outstanding Youth Foundation of Jiangxi Province(grant No.20224ACB216019) Natural Science Foundation of Jiangxi Province(grant Nos.20202BABL206151 and 20202BABL216026) Doctoral startup fund of Jiangxi Science and Technology Normal University(grant No.2019BSQD015) Department Education Science and Technology Research Project of Jiangxi(grant No.GJ201134) the Open Project of Jiangxi Provincial Key Laboratory of Drug Design and Evaluation(grant No.JKD-KF-2104).
主 题：Plasticizer dry powder coating Colon-targeted granulesIn vivo imaging Ulcerative colitis
摘 要：Baicalin(BA)is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi with excellent antioxidant and anti-inflammatory biological activities.In this study,Eudragit S100 was used as the colonic target material to prepare BA colonic targeting granules(EBCGs)based on plasticizer dry powder coating technology to improve the targeting transportation performance of BA.In vitro studies showed that EBCGs with pH-sensitive properties were successfully prepared by plasticizer dry powder coating,and in vivo animal imaging studies showed that EBCGs could deliver BA to the colon and inhibit the release of BA in the upper gastrointestinal tract(GIT).In vivo studies showed that EBCGs had good therapeutic effects in colitis,which reduced expression levels of tumor necrosis factor alpha(TNF-α)and interleukin-1β(IL-1β)and increased superoxide dismutase(SOD)activities in the colonic tissues of rats with colitis.In conclusion,Eudragit S100 could be used for the preparation of multi-unit oral colon-targeted formulations by plasticizer dry powder coating technology,and our prepared EBCGs had good colon-targeting properties,which could improve the therapeutic effect and provide a potential application for ulcerative colitis(UC).
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