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两种消化内镜水气管道预处理方法的效果比较

护理研究 2024年第3期38卷 530-533页

作者：李良芳张碧雄王森轼黄大辉邓小婵赖艳新南方医科大学附属广东省人民医院(广东省医学科学院) 广东510055

目的:对比两种胃镜水气管道预处理方法的清洗效果和喷嘴堵塞情况。方法:将100条胃镜随机分为对照组和试验组,每组50条。其中试验组内镜使用后经初步擦拭后更换A/W按钮对水气管道和喷嘴进行冲洗,对照组内镜使用后经擦拭后直接使用水气按... 详细信息

目的:对比两种胃镜水气管道预处理方法的清洗效果和喷嘴堵塞情况。方法:将100条胃镜随机分为对照组和试验组,每组50条。其中试验组内镜使用后经初步擦拭后更换A/W按钮对水气管道和喷嘴进行冲洗,对照组内镜使用后经擦拭后直接使用水气按钮进行冲洗。两组内镜均对水气管道采样后使用ATP生物荧光法检测,观察统计内镜喷嘴的堵塞情况和处理时间。结果:预处理后,对照组内镜的ATP值高于试验组,差异有统计学意义(P0.05);对照组床旁预处理时间(30 s)短于试验组(81 s),差异有统计学意义(P<0.05)。结论:更换AW按钮会增加床旁预处理流程的操作步骤和时间,但有利于降低水气管道的生物负载。

关键词：软式内镜水气管道喷嘴生物膜预处理

粤东品清湖表层沉积物有孔虫分布特征及其环境指示意义

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微体古生物学报 2024年第1期41卷 53-64页

作者：张静莹董旭辉冼汉标司子妍谢欣杜恕环李亮芳伍嘉慧广州大学地理科学与遥感学院广州510006 广州大学气候与环境变化研究中心广州510006 中国科学院南海海洋研究所广州510301

有孔虫是海洋环境中一种重要的原生动物,对环境变化响应敏感。潟湖作为海陆交互连接带,生境梯度明显,但目前学术界对此类水体中有孔虫种群的研究报道有限。本文以中国典型潟湖广东省汕尾市品清湖为例,于2021年至2022年间系统调查了该湖... 详细信息

有孔虫是海洋环境中一种重要的原生动物,对环境变化响应敏感。潟湖作为海陆交互连接带,生境梯度明显,但目前学术界对此类水体中有孔虫种群的研究报道有限。本文以中国典型潟湖广东省汕尾市品清湖为例,于2021年至2022年间系统调查了该湖不同区域20个采样点的水环境参数(水深、盐度和pH值等)、沉积物的环境特征(粒度和污染物含量等)及有孔虫的群落组成。结果显示品清湖现今水质大部分均为四类或劣四类,活性磷酸盐和无机氮超标严重;重金属Cu、Zn和Hg浓度相对较高,部分区域浓度达到二类标准。该湖表层沉积物中共鉴定出底栖有孔虫15属35种,以玻璃质壳(Hyaline)为主,瓷质壳(Porcelaneous)次之,胶结质(Agglutinated)含量最低,优势属种为Ammonia aomoriensis, Elphidium advenum, Elphidium hispidulum和Spiroloculina laevigata,丰度及分异度呈现西部入海口高,东部低。统计分析结果显示,影响品清湖有孔虫分布的主要环境因子为水深和水体Cu浓度,分别解释了34.2%和14.9%的有孔虫群落信息。研究结果表明Triloculina trigonula和Quinqueloculina seminula等瓷质壳是水深与盐度变化的有效指示物种,而Spiroloculina laevigata和Ammonia annectens则对水深、盐度和重金属Cu均具有显著指示意义。

关键词：有孔虫群落特征环境因子指示意义品清湖

Mapping out the reaction network of humin formation at the initial stage of fructose dehydration in water

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Green Energy & Environment 2024年第6期9卷 1016-1026页

作者： Xing Fu Yexin Hu Ping Hu Hui li Shuguang Xu liangfang Zhu Changwei Hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengduSichuan610064China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan611137China

The formation of humins hampers the large-scale production of 5-hydroxymethylfurfural(HMF)in ***,a detailed reaction network of humin formation at the initial stage of fructose-to-HMF dehydration in water is delineated by combined experimental,spectroscopic,and theoretical *** bimolecular reaction pathways to build up soluble humins are *** is,the intermolecular etherification of β-furanose at room temperature initiates the C12 path,whereas the C-C cleavage of a-furanose at 130-150℃ leads to C11 path,and that of open-chain fructose at 180℃ to C11' *** successive intramolecular dehydrations and condensations of the as-formed bimolecular intermediates lead to three types of soluble *** show that the C12 path could be restrained by using HCl or AlCl_(3) catalyst,and both the C12 and C110 paths could be effectively inhibited by adding THF as a co-solvent or accelerating heating rate via microwave heating.

关键词： Carbohydrates 5-hydroxymethylfurfural Reaction network Soluble humins Tautomer

Salivary microbiota may predict the presence of esophageal squamous cell carcinoma

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Genes & Diseases 2022年第4期9卷 1143-1151页

作者： Junmin Wei Ruifeng li Yanxian Lu Fan Meng Bohong Xian Xiaorong Lai Xiayi lin Yu Deng Dongyang Yang Huabin Zhang liangfang li Xiaosong Ben Guibin Qiao Wanwei liu Zijun li Guangdong Provincial Institute of Geriatrics Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080PR China The Second School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdong 510515PR China Wuhan No.1 Hospital WuhanHubei 430022PR China The First Affiliated Hospital Gannan Medical UniversityGanzhouJiangxi 341000PR China Medicine-Oncology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080PR China Department of Gastroenterology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080PR China Department of Thoracic Surgery Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080PR China Concord Medical Center Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080PR China

The aim is to explore the predictive value of salivary bacteria for the presence of esophageal squamous cell carcinoma (ESCC). Saliva samples were obtained from 178 patients with ESCC and 101 healthy controls, and allocated to screening and verification cohorts, respectively. In the screening phase, after saliva DNA was extracted, 16S rRNA V4 regions of salivary bacteria were amplified by polymerase chain reaction (PCR) with high-throughput sequencing. Highly expressed target bacteria were screened by Operational Taxonomic Units clustering, species annotation and microbial diversity assessment. In the verification phase, the expression levels of target bacteria identified in the screening phase were verified by absolute quantitative PCR (Q-PCR). Receiver operating characteristic (ROC) curves were plotted to investigate the predictive value of target salivary bacteria. LEfSe analysis revealed higher proportions of Fusobacterium, Streptococcus and Porphyromonas, and Q-PCR assay showed significantly higher numbers of Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in patients with ESCC, when compared with healthy controls (all P livarius, Fusobacterium nucleatum, Porphyromonas gingivalis and the combination of the three bacteria for predicting patients with ESCC were 69%, 56.5%, 61.8% and 76.4%, respectively. The sensitivities corresponding to cutoff value were 69.3%, 22.7%, 35.2% and 86.4%, respectively, and the matched specificity were 78.4%, 96.1%, 90.2% and 58.8%, respectively. These highly expressed Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in the saliva, alone or in combination, indicate their predictive value for ESCC.

关键词： Esophageal squamous cell carcinoma(ESCC) Predictive value Quantitative polymerase chain reaction(Q-PCR) Receiver operating characteristic(ROC)curves Salivary bacteria

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论美国批判性服务学习

全球教育展望 2019年第7期48卷 58-71页

作者：李良方山东师范大学教育学部

批判性服务学习是美国服务学习的新发展,代表着服务学习的未来发展方向。批判性服务学习是在与传统服务学习的相对比较中形成的,二者存在显著性差异。批判性服务学习能够为参与者赋权增能,追求社会正义,指向社会变革,并蕴含批判性。“... 详细信息

批判性服务学习是美国服务学习的新发展,代表着服务学习的未来发展方向。批判性服务学习是在与传统服务学习的相对比较中形成的,二者存在显著性差异。批判性服务学习能够为参与者赋权增能,追求社会正义,指向社会变革,并蕴含批判性。“关注社会变革”、“质疑权力分配”、“创建真实的合作关系”是批判性服务学习的三大基本目标。批判性服务学习的潜在价值端赖于高质量的实施。引导学生对自我身份进行反思与澄清,鼓励学生对社会正义问题进行批判性反思,通过学生所提供服务为社区增能是实施批判性服务学习需要关注的三个方面。

关键词：美国批判性服务学习传统服务学习社会正义

Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing

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Nano Research 2024年第10期17卷 8904-8925页

作者： Zhongyuan Guo Audrey T.Zhu Ronnie H.Fang liangfang Zhang Aiiso Yufeng li Family Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA

The continued development of clustered regularly interspaced short palindromic repeats(CRISPR)technology has the potential to greatly impact clinical medicine,particularly for disease diagnosis and *** high demand for the in vivo delivery of CRISPR-based therapies,significant challenges *** include rapid degradation by enzymes,inefficient disease site targeting,and the risk of undesired off-target *** platforms,with their tailorable properties,have been engineered to efficiently package CRISPR payloads in various formats,including as plasmid DNA,mRNA,and ribonucleoprotein complexes,for in vivo *** them,recombinant adeno-associated viruses,virus-like particles,and lipid nanoparticles have displayed exceptional *** review will discuss the development of these and other nanocarriers for in vivo CRISPR-based genome editing.

关键词： clustered regularly interspaced short palindromic repeats(CRISPR) in vivo gene editing nanocarriers recombinant adeno-associated viruses(rAAVs) virus-like particle(VLP) lipid nanoparticle(LNP)

Methane and nitrous oxide emissions from municipal wastewater treatment plants in China:A plant-level and technology-specific study

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Environmental Science and Ecotechnology 2024年第4期20卷 123-130页

作者： Haiyan li liangfang You He Du Bowen Yu Lu Lu Bo Zheng Qiang Zhang Kebin He Nanqi Ren School of Civil and Environmental Engineering Harbin Institute of TechnologyShenzhen518055China Shenzhen Key Laboratory of Ecological Remediation and Carbon Sequestration Institute of Environment and EcologyTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing100084China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China

Wastewater treatment is an important source of greenhouse gases(GHGs).Yet large uncertainties remain in the quantification of GHG emissions from municipal wastewater treatment plants(MWWTPs)in China.A high-resolution and technology-specific emission inventory is still lacking to support mitigation strategies of *** we develop a plant-level and technology-based MWWTP emission inventory for China covering 8703 plants and 19 treatment technology categories by compiling and harmonizing the most up-to-date facility-level ***'s methane(CH_(4))and nitrous oxide(N_(2)O)emissions from MWWTPs in 2020 are estimated to be 150.6 Gg and 22.0 Gg,respectively,with the uncertainty range of-30%to 37%and-30%to 26%at 95%confidence *** find an emission inequality across cities,with the richest cities emitting two times more CH_(4)and N_(2)O per capita from municipal wastewater treatment than the poorest *** emitted CH_(4)and N_(2)O are dominated by Anaerobic/Anoxic/Oxic-,Sequencing Batch Reactor-,Oxidation Ditch-,and Anoxic/Oxic-based MWWTPs of less than 20 years *** the relatively young age structure of China's MWWTPs,the committed emissions highlight the importance of reducing on-site GHG emissions by optimization of operating conditions and innovation *** emission differences among our estimates,previous studies,and the Intergovernmental Panel on Climate Change guidelines are largely attributed to the uncertainties in emission factors,implying the urgent need for more plant-integrated measurements to improve the accuracy of emission accounting.

关键词： Methane Nitrous oxide Emissions Municipal wastewater treatment plants

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道德量化评价的批判与超越

教育发展研究 2018年第15期38卷 117-124页

作者：李良方李福春山东师范大学教育学部博士研究生济南250014 济南大学教育与心理科学学院济南250022

道德量化评价被寄予了优化道德评价机制、推动学校道德教育改革与发展的厚望。量化文化的强势发展促使道德量化评价发展愈演愈烈。道德量化评价把学生的德性结构用数量描述,看似"客观""精确",却存在异化道德评价的问题,需要对其进行批... 详细信息

道德量化评价被寄予了优化道德评价机制、推动学校道德教育改革与发展的厚望。量化文化的强势发展促使道德量化评价发展愈演愈烈。道德量化评价把学生的德性结构用数量描述,看似"客观""精确",却存在异化道德评价的问题,需要对其进行批判与超越。要走出道德量化评价的困境,应秉持人文主义价值取向,采取既符合道德本质特征又符合学校道德教育核心价值的合格性评价。

关键词：道德量化评价批判超越

Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： Xiaozhong Chen Wei Wang Qingfeng Zou Xiaodong Zhu Qin lin Yi Jiang Yan Sun liangfang Shen lin Wang Guorong Zou Xiaoyan lin Shaojun lin Minying li Ying Wang Ruilian Xu Rui Ao Rensheng Wang Haifeng lin Shuang Huang Tingting Xu Wenting li Mengying Xia Yu Xia Zhongmin Wang Baiyong li Jingao li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in China enrolled adult patients with metastatic nasopharyngeal carcinoma(NPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NPC patients,supporting further clinical development as third-line treatment of metastatic NPC.

关键词： metastatic nasopharyngeal supporting