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Recent advancement of sonogenetics:A promising noninvasive cellular manipulation by ultrasound

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Genes & Diseases 2024年第5期11卷 163-182页

作者： Jin tang Mingxuan feng Dong Wang liang Zhang Ke Yang Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Engineering Research Center of Stem Cell TherapyChongqing 400014China Department of Ultrasound The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Tongji Medical College Huazhong University of Science and TechnologyWuhanHubei 430074China

Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation ***,a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells,is gaining prominence along with optogenetics,electrogenetics,and *** stimulation with ultrasound,these proteins trigger a cascade of cellular activities and *** traditional ultrasound modalities,sonogenetics offers enhanced spatial selectivity,improving precision and safety in disease *** technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications,including neuromodulation,oncologic treatments,stem cell therapy,and *** current literature predominantly emphasizes ultrasonic neuromodulation,this review offers a comprehensive exploration of *** discuss ultrasound properties,the specific ultrasound-sensitive proteins employed in sonogenetics,and the technique’s potential in managing conditions such as neurological disorders,cancer,and ophthalmic diseases,and in stem cell *** objective is to stimulate fresh perspectives for further research in this promising field.

关键词： Mechanosensitive channel Neuromodulation Sonogenetics Ultrasound Ultrasound-sensitive protein

Risk factors and machine learning prediction models for bronchopulmonary dysplasia severity in the Chinese population

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World Journal of Pediatrics 2023年第6期19卷 568-576页

作者： Wen He Lan Zhang Rui feng Wei-Han Fang Yun Cao Si-Qi Sun Peng Shi Jian-Guo Zhou liang-feng tang Xiao-Bo Zhang Yuan-Yuan Qi Department of Respirology Children’s HospitalFudan University399 Wanyuan RoadShanghai 201102China Department of Neonatology Children’s HospitalFudan UniversityShanghaiChina Shanghai Key Laboratory of Intelligent Information Processing School of Management and StatisticsFudan UniversityShanghaiChina Shanghai Pinghe Bilingual School ShanghaiChina Department of Data Management and Statistics Children’s Hospital of Fudan UniversityShanghaiChina Department of Urology Children’s HospitalFudan UniversityShanghaiChina

Background Bronchopulmonary dysplasia(BPD)is a common chronic lung disease in extremely preterm *** outcome and clinical burden vary dramatically according to *** some prediction tools for BPD exist,they seldom pay attention to disease severity and are based on populations in developed *** study aimed to develop machine learning prediction models for BPD severity based on selected clinical factors in a Chinese *** In this retrospective,single-center study,we included patients with a gestational age<32 weeks who were diagnosed with BPD in our neonatal intensive care unit from 2016 to *** collected their clinical information during the maternal,birth and early postnatal *** factors were selected through univariable and ordinal logistic regression *** models based on logistic regression(LR),gradient boosting decision tree,XGBoost(XGB)and random forest(RF)models were implemented and assessed by the area under the receiver operating characteristic curve(AUC).Results We ultimately included 471 patients(279 mild,147 moderate,and 45 severe cases).On ordinal logistic regression,gestational diabetes mellitus,initial fraction of inspiration O_(2) value,invasive ventilation,acidosis,hypochloremia,C-reactive protein level,patent ductus arteriosus and Gram-negative respiratory culture were independent risk factors for BPD *** the XGB,LR and RF models(AUC=0.85,0.86 and 0.84,respectively)all had good *** We found risk factors for BPD severity in our population and developed machine learning models based on *** models have good performance and can be used to aid in predicting BPD severity in the Chinese population.

关键词： Bronchopulmonary dysplasia Machine learning-Prediction model Preterm

Grain-filling strategies of wheat of contrasting grain sizes under various planting patterns and irrigation levels

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The Crop Journal 2024年第3期12卷 897-906页

作者： Zimeng liang Jingyi feng Jiayu Li Yangyang tang Tiankang He Vinay Nangia Yang Liu College of Agronomy Northwest A&F UniversityYangling 712100ShaanxiChina International Center for Agricultural Research in the Dry Areas Rabat 999055Morocco

In a study comparing grain filling and yield in a large-and a small-grain-size wheat cultivar under two planting patterns and two irrigation regimes,plastic-covered ridge and furrow planting with sprinkler irrigation increased grain filling and yield in both *** largest contributors to grain yield were an extended active grain-filling period in Shuangda 1 and an increased mean grain-filling rate in XN538.

关键词： Plastic-covered ridge and furrow cultivation Sprinkler irrigation Wheat Grain size Grain filling

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Concerted Steric and Electronic Strategy in Thermostable Salicylaldiminato Nickel Catalysts for Ethylene(Co)polymerization

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Chinese Journal of Polymer Science 2024年第8期42卷 1085-1092页

作者： Hong-Yu Ji Hong-liang Mu Chun-feng tang Yu-Xing Zhang Yue Chi Zhong-Bao Jian Key Laboratory of Advanced Structural Materials Ministry of EducationSchool of Materials Science and EngineeringChangchun University of TechnologyChangchun 130012China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Olefin polymerization is one of the most im portant chemical reactions in *** work presents a strategy that emphasizes the synergistic meta/poro-steric hindrance of N-aryl groups and electronic effects in newly synthesized neutral salicylaldiminato nickel *** nickel(Ⅱ)catalysts exhibit exceptional thermostability,ranging from 30℃to 130℃,demonstrating enhanced catalytic activities and broadly regulated polyethylene molecular weights(3-341 kg·mol^(-1))and controlled polymer branch density(2-102 brs/1000C).The preferred catalyst Ni3 with concerted steric and electronic effects enables the production of solid-state semi-crystalline polyethylene materials at temperatures below 90℃.Notably,Ni3 exhibits an impressive tolerance of 110℃and can withstand even the challenging polymerization temperature of 130℃,leading to the production of polyethylene wax and ***,functionalized polyethylene is produced.

关键词： Polyolefin Salicylaldiminato ligand Nickel catalyst Oil Wax

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High-dimensional nonlinear variable separation solutions and novel wave excitations for the(4+1)-dimensional Boiti–Leon–Manna–Pempinelli equation

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Communications in Theoretical Physics 2024年第11期 3-13页

作者： Zu-feng liang Xiao-yan tang Wei Ding Department of Physics Hangzhou Normal University School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications (Ministry of Education) & Shanghai Key Laboratory of PMMP East China Normal University School of Computer Science and Technology Shanghai Normal University

Considering the importance of higher-dimensional equations that are widely applied to real nonlinear problems, many(4 + 1)-dimensional integrable systems have been established by uplifting the dimensions of their corresponding lower-dimensional integrable ***, an integrable(4 + 1)-dimensional extension of the Boiti–Leon–Manna–Pempinelli(4DBLMP) equation has been proposed, which can also be considered as an extension of the famous Korteweg–de Vries equation that is applicable in fluids, plasma physics and so on. It is shown that new higher-dimensional variable separation solutions with several arbitrary lowerdimensional functions can also be obtained using the multilinear variable separation approach for the 4DBLMP equation. In addition, by taking advantage of the explicit expressions of the new solutions, versatile(4 + 1)-dimensional nonlinear wave excitations can be designed. As an illustration, periodic breathing lumps, multi-dromion-ring-type instantons, and hybrid waves on a doubly periodic wave background are discovered to reveal abundant nonlinear structures and dynamics in higher dimensions.

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Exoskeleton active assistance strategy for human muscle activation reduction during linear and circular walking

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Advances in Manufacturing 2024年第3期12卷 484-496页

作者： Wen-Tao Sheng Ke-Yao liang Hai-Bin tang School of Intelligent Manufacturing Nanjing University of Science and TechnologyNanjing210094People’s Republic of China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin150001People’s Republic of China

The exoskeleton is employed to assist humans in various domains including military missions,rehabilitation,industrial operation,and activities of daily living(ADLs).Walking is a fundamental ADL,and exoskeletons are capable of reducing the activation and metabolism of lower extremity muscles through active assistance during *** improve the performance of active assistance strategy,this article proposes a framework using an active hip ***,it correlates to an already established Bayesian-based human gait recognition algorithm,with a particular focus on linear and circular walking within industrial and ADL *** theorizing this strategy for exoskeletons,this study further reveals,in part,the activation characteristics of human hip muscles for the instruction and regulation of active assistance duration and onset *** proposed active assistance strategy provides new insights for enhancing the performance of assistive robots and facilitating human robot interaction within the context of ADLs.

关键词： Human-robot interaction Hip exoskeleton Muscle activation Walking assistance

Circularly polarized light emission and detection by chiral inorganic semiconductors

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Frontiers of Optoelectronics 2024年第2期17卷 43-49页

作者： Zha Li Wancai Li Dehui Li Wei tang Huageng liang Huaibing Song Chao Chen liang Gao Jiang tang Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China International Health Care Center National Center for Global Health and MedicineTokyo 162‑8655Japan Hepato‑Biliary‑Pancreatic Surgery Division Department of SurgeryThe University of Tokyo HospitalTokyo 113‑8655Japan Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan 430074China

Chiral inorganic semiconductors with high dissymmetric factor are highly desirable,but it is generally difficult to induce chiral structure in inorganic semiconductors because of their structure rigidity and *** this study,we introduced chiral ZnO film as hard template to transfer chirality to CsPbBr_(3) film and PbS quantum dots(QDs)for circularly polarized light(CPL)emission and detection,*** prepared CsPbBr_(3)/ZnO thin film exhibited CPL emission at 520 nm and the PbS QDs/ZnO film realized CPL detection at 780 nm,featuring high dissymmetric factor up to around *** electron transition based mechanism is responsible for chirality transfer.

关键词： High dissymmetric factor Circularly polarized light emission Semiconductor Hard template,Chirality

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Strategy for suppressing abnormal grain growth of ZK60 Mg alloy during solution by pre-compression:A quasi-in-situ study

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Journal of Materials Science & Technology 2024年第4期171卷 115-128页

作者： Zhenxu Wang liang Chen Jianwei tang Cunsheng Zhang Guoqun Zhao Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinanShandong 250061China Department of Mechanical Engineering Kyushu UniversityFukuoka 819-0395Japan

Abnormal grain growth(AGG)easily takes place in Mg alloys during high-temperature solutions,result-ing in deterioration of mechanical ***,the compression prior to solution(pre-compression)was conducted to suppress AGG,and the microstructure evolution as well as suppressing mechanisms was investigated based on quasi-in-situ *** compression along the transverse direction,//ED grains preferentially nucleated and rapidly grew up,and the initial//ED texture was *** grain growth modes of heat-induced and strain-induced grain boundary migrations were *** former was attributed to the high interfacial energy of grain boundaries with large *** latter consumed the adjacent grains with high storage energy,forming abnormal grains with irregular *** compression with a reduction>6%could obviously suppress *** suppressing effects were mainly attributed to weakening the size advantage of//ED grains,increasing nucleation,reducing grain boundary character distribution,and redistributing storage energy *** 12%compression along the transverse direction,30°misorientation of//ED grains and high energy grain boundaries were ***{10-12}tensile twins and{10-15}high index twins induced by com-pression increased the nucleation of static ***,compression introduces high-density dislocations,which also contributed to suppressing AGG behavior during solution.

关键词： Quasi-in-situ analysis Mg alloy Abnormal grain growth Compression Microstructure

Mendelian randomization analysis of causal relationship between cheese intake and diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1905-1910页

作者： Cheng-Ye tang Dong-Yong tang Ying-Qin Yang Yu-Bing liang Hao liang Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Ophthalmology the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Department of Anesthesiology Guangxi Medical University Cancer HospitalNanning 530000Guangxi Zhuang Autonomous RegionChina

AIM:To assess whether there is a possible causal link between the intake of cheese and the risk of diabetic retinopathy(DR)utilizing a two-sample Mendelian randomization(MR)***:The research data were obtained from summary statistics of genome-wide association studies(GWAS).Genetic loci closely related to cheese intake were extracted as instrumental variables(IVs),and DR was the outcome *** data were extracted from individuals of European *** data of cheese intake consisted of 451486 samples with 9851867 single nucleotide polymorphisms(SNPs),while the DR data consisted of 206234 samples with 16380446 ***-one genetic loci closely related to cheese intake were selected as *** analysis was performed by inverse-variance weighted(IVW)method and MR-Egger regression *** causal relationship between cheese intake and DR was evaluated using odds ratios(ORs)and 95%confidence intervals(CIs).Egger-intercept test was used to test horizontal pleiotropy and sensitivity analysis was performed by leave-one-out ***:The P value of the IVW method was less than 0.05,indicating a significant negative correlation between cheese intake and ***-Egger regression showed that the intercept was 0.01 with a standard error of 0.022,and a P-value of 0.634,indicating no evidence of horizontal pleiotropy affecting the IVs related to the exposure ***,heterogeneity tests confirmed the absence of heterogeneity,and the“leave-one-out”sensitivity analysis demonstrated that the results were ***:Cheese intake is causally negatively correlated with the occurrence of DR,and cheese intake could reduce the risk of DR.

关键词： cheese intake diabetic retinopathy Mendelian randomization analysis