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Quasilocal Energy for Static Charged Black Holes in String Theory

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Communications in Theoretical Physics 2001年第7期36卷 125-128页

作者： wang Shi-liang JING Ji-liang wang Yong-Jiu Institute of Physics and Physics Department Hunan Normal University Changsha 410081 China Institute of Physics and Physics Department Hunan Normal University Changsha 410081 China Department of Astronomy and Applied Physics University of Science and Technology of China Hefei 230026 China Institute of Physics and Physics Department Hunan Normal University Changsha 410081 China

The Brown-York quasilocal energies of some static charged dilaton black holes are calculated, and then the validity of Martinez's conjecture is explored in string theory. It is shown that the energy is positive and monotonically decreases to the ADM mass at spatial infinity, and the conjecture that the Brown-York quasilocal energy at the outer horizon of black hole reduces to twice of its irreducible mass is still applicable for the static charged black holes in string theory. The result is different from Bose-Naing's one.

关键词： quasilocal energy, black hole, string theory

Derived Born cross sections of e^+e^-annihilation into open charm mesons from CLEO-c measurements

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Chinese Physics C 2018年第4期42卷 69-75页

作者： Xiang-Kun Dong liang-liang wang Chang-Zheng Yuan University of Chinese Academy of Sciences Beijing 100049 China Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

The exclusive Born cross sections of the production of D0, D＋ and Ds＋ mesons in e＋e- annihilation at 13 energy points between 3.970 and 4.260 GeV are obtained by applying corrections for initial state radiation and vacuum polarization to the observed cross sections measured by the CLEO-c experiment. Both the statistical and the systematic uncertainties for the obtained Born cross sections are estimated.

关键词： electron-positron annihilation charm production Born cross section radiative correction

Myeloid-derived Suppressor Cells Activate Liver Natural Killer Cells in a Murine Model in Uveal Melanoma

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Current Medical Science 2022年第5期42卷 1071-1078页

作者： Yuan-yuan wang Shuang-ying LI San-qian CHEN liang-liang wang Zhi-qiang HAN Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Obstetrics and Gynecology Chibi People’s HospitalChibi437300China

Objective Elevated myeloid-derived suppressor cells(MDSCs)in many malignancies are associated with the increased risk for metastases and poor ***,a mouse model of intraocular melanoma was established to explore how MDSCs influence liver *** In this study,murine B16LS melanoma cells were transplanted into the posterior compartment(PC)of the eye of C57BL/6 *** from the liver of naive mice and mice bearing melanoma liver metastasis were isolated using isotonic Percoll centrifugation,examined by flow cytometry for their expression of Gr1,CD11b,F4/80,RAE-1,and Mult-1,and further isolated for MDSCs and natural killer(NK)*** effects of MDSCs on NK cells were tested by coculturing and assessing the ability of NK cells to produce interferon-gamma(IFN-γ)by ELISA and NK cell cytotoxicity by 3H-thymidine incorporation *** impact of IFN-γon liver metastases was examined via selectively depleting IFN-γin *** The results showed that mice with liver metastases had increased levels of CD11b+Gr1+F4/80+as well as CD11b+Gr1+F4/80−*** significantly enhanced the generation of IFN-γtogether with the cytotoxicity of the NK ***,these effects were cell-cell *** IFN-γwas not of a toxic nature to the melanoma cells,it profoundly inhibited B16LS cell *** IFN-γin vivo led to increased liver *** All these findings first revealed that MDSCs accumulated in liver metastasis of intraocular melanoma could activate the NK cells to produce an effective anti-tumor immune ***,the MDSCs’performance in different tumor models would need more investigation to boost current immunotherapy modalities.

关键词： myeloid-derived suppressor cells natural killer cells IFN-γ liver metastases

Quantum key distribution transmitter chip based on hybrid-integration of silica and lithium niobates

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Chinese Physics B 2022年第6期31卷 415-421页

作者： Xiao Li liang-liang wang Jia-shun Zhang Wei Chen Yue wang Dan Wu Jun-Ming An State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of Sciences(CAS)Beijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China

A quantum key distribution transmitter chip based on hybrid-integration of silica planar light-wave circuit(PLC)and lithium niobates(LN)modulator PLC is *** silica part consists of a tunable directional coupler and 400-ps delay line,and the LN part is made up of a Y-branch,with electro-optic modulators on both *** two parts are facet-coupled to form an asymmetric Mach-Zehnder *** successfully encode and decode four BB84 states at 156.25-MHz repetition *** phase-encoding of 0 orπis achieved,with interference fringe visibilities 78.53%and 82.68%for states|+〉and|-〉,*** the aid of an extra off-chip LN intensity modulator,two time-bin states are prepared and the extinction ratios are 18.65 dB and 15.46 dB for states|0〉and|1〉,respectively.

关键词： quantum key distribution hybrid-integration BB84

Switching On/Off of Guide RNA by Photoinduced Strand Displacement for Functional Control of CRISPR/Cas9

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CCS Chemistry 2024年第5期6卷 1338-1351页

作者： Yang wang Chao-Qun Wu Qiu-Long Zhang Ming Shao Yan Liu liang-liang wang Zun-Yun wang Juan Du liang Xu Central Laboratory Department of the Second Affiliated Hospital School of MedicineThe Chinese University of Hong KongShenzhen&Longgang District People’s Hospital of ShenzhenShenzhen 518172 Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060 MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510275 School of Pharmacy and Medical Technology Putian UniversityPutian 351100

Functional control of CRISPR/Cas9 is essential for precise gene *** engineering of guide RNA(gRNA)provides diverse approaches for conditional control of CRISPR/Cas9 function with a variety of chemical reactive ***,previous investigations into chemically engineering gRNA only unidirectionally regulated the CRISPR/Cas9 function via stimuli-induced caging/decaging ***,we propose a combinatory strategy to engineer the dynamics of gRNA in which photocontrolled strand-displacement reactions coupled with sequence designs of gRNA can achieve lightinduced switching-on/off control of CRISPR/Cas9 *** analysis and cellular gene regulation indicate this approach is capable of both activating and deactivating CRISPR/Cas9 activities using light ***,photocontrolled multiplex modulations of gene expression for opposite regulatory effects have also been achieved simultaneously under the same cellular *** work establishes an essential principle for construction of stimuli-induced switching-on/off modulations of gRNA that can greatly enrich the versatility of conditional control for a variety of CRISPR/Cas9-based applications.

关键词： modified oligonucleotides gene manipulation optical control CRISPR/Cas9 strand displacement

Potential role of microRNA-503 in Icariin-mediated prevention of high glucose-induced endoplasmic reticulum stress

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World Journal of Diabetes 2023年第8期14卷 1234-1248页

作者： Bao-Lin Su liang-liang wang liang-You Zhang Shu Zhang Qiang Li Gang-Yi Chen Department of Nephrology The First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineGuangzhou 510405Guangdong ProvinceChina

BACKGROUND Dysregulated microRNA(miRNA)is crucial in the progression of diabetic nephropathy(DN).AIM To investigate the potential molecular mechanism of Icariin(ICA)in regulating endoplasmic reticulum(ER)stress-mediated apoptosis in high glucose(HG)-induced primary rat kidney cells(PRKs),with emphasis on the role of miR-503 and sirtuin 4(SIRT4)in this *** Single intraperitoneal injection of streptozotocin(65 mg/kg)in Sprague-Dawley rats induce DN in the in vivo hyperglycemic ***-treated PRKs were used as an in vitro HG *** immunofluorescence assay identified isolated *** Counting Kit-8 and flow cytometry analyzed the effect of ICA treatment on cell viability and apoptosis,***-time quantitative polymerase chain reaction and western blot analyzed the levels of ER stressrelated *** luciferase analysis of miR-503 binding to downstream SIRT4 was *** ICA treatment alleviated the upregulated miR-503 expression in vivo(DN)and in vitro(HG).Mechanistically,ICA reduced HG-induced miR-503 overexpression,thereby counteracting its function in downregulating SIRT4 *** regulated the miR-503/SIRT4 axis and subsequent ER stress to alleviate HG-induced PRKs *** ICA reduced HG-mediated inhibition of cell viability,promotion of apoptosis,and ER stress in *** effects involved regulation of the miR-503/SIRT4 *** findings indicate the potential of ICA to treat DN,and implicate miR-503 as a viable target for therapeutic interventions in DN.

关键词： Icariin MicroRNA-503 Sirtuin 4 Endoplasmic reticulum stress Diabetic nephropathy Kidney damage

Electron-beam induced degradation of bisphenol A

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Nuclear Science and Techniques 2011年第5期22卷 277-281页

作者： XU Gang REN Hua WU Ming-Hong LIU Ning YUAN Qing TANG liang wang liang Shanghai Applied Radiation Institute Shanghai University Shanghai 200444 China

E-beam degradation of bisphenol A(BPA) was carried out,under reductive condition of ethanol-water solution and oxidative condition of acetonitrile-water *** degradation efficiency is higher in oxidative condition than that in reductive condition,and increases with the dose but decreased with increasing initial *** BPA radiolysis follows the pseudo-first-order *** H_2O_2,or neutral condition,does not benefit BPA degradation in oxidative *** radiolysis was used to investigate mechanism of the BPA *** rate constant for BPA reaction with OH(1.85×10^(10) L·mor^(-1)·s^(-1)) is about an order of magnitude higher than that with e_(aq)^-(1.80×l0~9 L·mor^(-1)·s^(-1)).The degradation products were analyzed by ion *** molecules such as formic acid and acetic acid were detected,indicating that ^-OH attacks the BPA *** work is of significance for the practical E-beam treatment of waste water containing BPA.

关键词：电子束诱导降解效率双酚A 乙醇水溶液氧化条件反应速率常数还原条件一级动力学

Simulation study of BESⅢwith stitched CMOS pixel detector using AcTs

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Nuclear Science and Techniques 2023年第12期34卷 264-270页

作者： Yi Liu Xiao‑Cong Ai Guang‑Yan Xiao Ya‑Xuan Li Ling‑Hui Wu liang‑liang wang Jia‑Ning Dong Ming‑Yi Dong Qing‑Lin Geng Min Luo Yan Niu An‑Qing wang Chen‑Xu wang Meng wang Lei Zhang liang Zhang Rui‑Kai Zhang Yao Zhang Ming‑Gang Zhao Yang Zhou School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Physics Nanjing UniversityNanjing 210093China School of Physics Nankai UniversityTianjin 300071China Institute of High Energy Physics Chinese Academy of Sciences19B Yuquan RoadShijingshan DistrictBeijing 100049China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China University of Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China School of Information Science and Engineering Harbin Institute of TechnologyWeihai 264209China

The reconstruction of the tracks of charged particles with high precision is crucial for HEP experiments to achieve their physics *** BESⅢdrift chamber,which is used as the tracking detector of the BESⅢexperiment,has suffered from aging effects resulting in degraded tracking performance after operation for approximately 15 *** preserve and enhance the tracking performance of BESⅢ,one of the proposals is to add one layer of a thin cylindrical CMOS pixel sensor based on state-of-the-art stitching technology between the beam pipe and the drift *** improvement in the tracking performance of BESⅢwith such an additional pixel detector compared to that with only the existing drift chamber was studied using the modern common tracking software Acts,which provides a set of detector-agnostic and highly performant tracking algorithms that have demonstrated promising performance for a few high-energy physics and nuclear physics experiments.

关键词： BESⅢtracking detector CMOS pixel sensor Track reconstruction Common tracking software

High efficiency,small size,and large bandwidth vertical interlayer waveguide coupler

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Chinese Physics B 2022年第2期31卷 329-335页

作者： Shao-Yang Li liang-liang wang Dan Wu Jin You Yue wang Jia-Shun Zhang Xiao-Jie Yin Jun-Ming An Yuan-Da Wu State Key Laboratory of Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

Since the advent of three-dimensional photonic integrated circuits,the realization of efficient and compact optical interconnection between layers has become an important development direction.A vertical interlayer coupler between two silicon layers is presented in this *** coupling principle of the directional coupler is analyzed,and the traditional method of using a pair of vertically overlapping inverse taper structures is *** the coupling of two rectangular waveguide layers,a pair of nonlinear tapers with offset along the transmission direction is *** the coupling of two ridge waveguide layers,a nonlinear taper in each layer is used to achieve high coupling *** simulation results show that the coupling efficiency of the two structures can reach more than 90%in a wavelength range from 1500 nm to 1650 ***,the crosstalk is reduced to less than-50 d B by using multimode waveguides at *** vertical interlayer coupler with a nonlinear taper is expected to realize the miniaturization and dense integration of photonic integrated chips.

关键词： silicon photonics vertical coupling nonlinear tapers three-dimensional integration