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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： Jiayi wang Mengke Zhao Dong Fu Meina wang Chao Han Zhongyue Lv liang wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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Visualization of reticulophagy in living cells using an endoplasmic reticulum-targeted p62 mutant

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Science China(Life Sciences) 2017年第4期60卷 333-344页

作者： liang wang Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China MoE Key Laboratory for Biomedical Photonics Department of Biomedical Engineering Huazhong University of Science and Technology Wuhan 430074 China

Reticulophagy is a type of selective autophagy in which protein aggregate-containing and/or damaged endoplasmic reticulum(ER)fragments are engulfed for lysosomal degradation, which is important for ER homeostasis. Several chemical drugs and mutant proteins that promote protein aggregate formation within the ER lumen can efficiently induce reticulophagy in mammalian ***, the exact mechanism and cellular localization of reticulophagy remain unclear. In this report, we took advantage of the self-oligomerization property of p62/SQSTM1, an adaptor for selective autophagy, and developed a novel reticulophagy system based on an ER-targeted p62 mutant to investigate the process of reticulophagy in living cells. LC3 conversion analysis via western blot suggested that p62 mutant aggregate-induced ER stress triggered a cellular autophagic response. Confocal imaging showed that in cells with moderate aggregation conditions, the aggregates of ER-targeted p62 mutants were efficiently sequestered by autophagosomes, which was characterized by colocalization with the autophagosome precursor marker ATG16L1, the omegasome marker DFCP1, and the late autophagosomal marker LC3/GATE-16. Moreover, time-lapse imaging data demonstrated that the LC3-or DFCP1-positive protein aggregates are tightly associated with the reticular structures of the ER, thereby suggesting that reticulophagy occurs at the ER and that omegasomes may be involved in this process.

关键词： endoplasmic reticulum targeted mutant aggregate puncta homeostasis autophagy Figure lapse

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Performance-Centric Optimization for Racetrack Memory Based Register File on GPUs

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Journal of Computer Science & Technology 2016年第1期31卷 36-49页

作者： Yun liang Shuo wang Center for Energy-Efficient Computing and Applications ( CECA) School of Electrical Engineering and Computer Sciences Peking University Beijing 100871 China

The key to high performance for GPU architecture lies in its massive threading capability to drive a large number of cores and enable execution overlapping among threads. However, in reality, the number of threads that can simultaneously execute is often limited by the size of the register file on GPUs. The traditional SRAM-based register file takes up so large amount of chip area that it cannot scale to meet the increasing demand of GPU applications. Racetrack memory （RM） is a promising technology for designing large capacity register file on GPUs due to its high data storage density. However, without careful deployment of RM-based register file, the lengthy shift operations of RM may hurt the performance. In this paper, we explore RM for designing high-performance register file for GPU architecture. High storage density RM helps to improve the thread level parallelism （TLP）, but if the bits of the registers are not aligned to the ports, shift operations are required to move the bits to the access ports before they are accessed, and thus the read/write operations are delayed. We develop an optimization framework for RM-based register file on GPUs, which employs three different optimization techniques at the application, compilation, and architecture level, respectively. More clearly, we optimize the TLP at the application level, design a register mapping algorithm at the compilation level, and design a preshifting mechanism at the architecture level. Collectively, these optimizations help to determine the TLP without causing cache and register file resource contention and reduce the shift operation overhead. Experimental results using a variety of representative workloads demonstrate that our optimization framework achieves up to 29% （21% on average） performance improvement.

关键词： register file racetrack memory GPU

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Estimation for constant-stress accelerated life test from generalized half-normal distribution

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Journal of Systems Engineering and Electronics 2017年第4期28卷 810-816页

作者： liang wang Yimin Shi School of Mathematics and Statistics Xidian University Department of Applied Mathematics Northwestern Polytechnical University

In the constant-stress accelerated life test, estimation issues are discussed for a generalized half-normal distribution under a log-linear life-stress model. The maximum likelihood estimates with the corresponding fixed point type iterative algorithm for unknown parameters are presented, and the least square estimates of the parameters are also proposed. Meanwhile, confidence intervals of model parameters are constructed by using the asymptotic theory and bootstrap technique. Numerical illustration is given to investigate the performance of our methods.

关键词： accelerated life test maximum likelihood estimation least square method bootstrap technique asymptotic distribution

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Low complexity method for spreading sequence estimation of DSSS signal in non-cooperative communication systems

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Journal of Systems Engineering and Electronics 2009年第1期20卷 41-49页

作者： Chang liang wang Fuping wang Zanji Dept. of Electrical Engineering Tsinghua Univ. Beijing 100084 P. R. China

It is a necessary step to estimate the spreading sequence of direct sequence spread spectrum （DSSS） signal for blind despreading and demodulation in non-cooperative communications. Two innovative and effective detection statistics are proposed to implement the synchronization and spreading sequence estimation procedure. The proposed algorithm also has a low computational complexity with only linear additions and modifications. Theoretical analysis and simulation results show that the algorithm performs quite well in low SNR environment, and is much better than all the existing typical algorithms with a comprehensive consideration both in performance and computational complexity.

关键词： direct sequence spread spectrum detection statistic low complexity.

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Controlling the effect of a distant extremely thick igneous rock in overlying strata on coal mine disasters

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Mining Science and Technology 2010年第4期20卷 510-515页

作者： wang liang School of Safety Engineering China University of Mining & Technology Xuzhou 221116 China National Engineering Research Center for Coal & Gas Control China University of Mining & Technology Xuzhou 221008 China

Based on theoretical analysis, similarity simulation tests, numerical simulation analysis and field observations, we analyzed rock collapse and rules of fraction evolution of overlying rocks and studied the rules in controlling the effect of an extremely thick igneous rock, found above a main mining coal seam in an area prone to coal mine disasters in the Haizi Coal Mine. The results show that this igneous rock, called a "main key stratum", will not subside nor break for a long time, causing lower fractures and bed separations not to close. The presence of igneous rock plays an important role in rock bursts, mine floods, gas outburst and surface subsidence in coal mines. By analyzing the rules in controlling the effect of this igneous rock, we provide useful references for safety and high efficiency mining in coal mines under special geological conditions.

关键词： extremely thick igneous rock separation rock burst mine flood gas outburst surface subsidence

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New routes for the construction of strong metal-support interactions

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Science China Chemistry 2022年第11期65卷 2051-2057页

作者： Hai wang liang wang Feng-Shou Xiao Key Lab of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China College of Chemistry Zhengzhou UniversityZhengzhou 450001China

Supported metal nanoparticles(NPs)on solid carriers are highly efficient catalysts in many industrial ***,the sintering and/or leaching of metal NPs occurred under harsh reaction conditions that caused the catalyst *** metal-support interactions(SMSIs)serve as an effective method to stabilize the metal NPs against sintering and leaching,which have been extensively *** addition to the classical route to construct SMSIs via high-temperature reduction treatments,new routes have emerged recently to extend the scope of catalysts with SMSIs and optimized their catalytic *** this review,we briefly summarize these routes that avoid the high-temperature reduction treatments for the construction of *** significant advantages in stabilizing metal NPs,modulating the geometric/electronic structure of metal species,and the mechanism on the SMSI formation are particularly ***,the current challenges and developing trends in the construction of SMSIs for achieving more efficient catalysts are outlooked.

关键词： strong metal-support interaction supported catalyst metal nanoparticles heterogeneous catalysis

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PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES OF TWO-ARM LINEAR AND FOUR-ARM STAR-SHAPED POLY(ε-CAPROLACTONE)S WITHα-CYCLODEXTRIN

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Chinese Journal of Polymer Science 2006年第3期24卷 245-252页

作者： Lu wang Jing-liang wang 董常明 Department of Polymer Science ＆ Engineering School of Chemistry and Chemical Technology Shanghai Jiao Tong University Shanghai 200240 China

Both four-ann star-shaped poly（ε-caprolactone）（4sPCL） and two-ann linear PCL （2LPCL） were synthesized and their inclusion complexation with α-cyclodextrin （α-CD） were studied. The inclusion complexes （ICs） formed between the PCL polymers and α-CD were characterized by ^1H-NMR, DSC, TGA, WAXD, and FT-1R, respectively. Both branch ann number and molecular weight of the PCL polymers have apparent effect on the stoichiometry （CL：CD, mol：mol） of these ICs. All these analytical results indicate that the branch arms of the PCL polymers are incorporated into the hydrophobic α-CD cavities and their original crystalline properties are completely suppressed. Moreover, the inclusion complexation between two-ann linear or four-ann star-shaped PCL polymers and α-CD not only enhances the thermal stability of the guest PCL polymers but also improves that of α-CD.

关键词： Inclusion complexes Linear poly(ε-caprolactone) Star-shaped poly(ε-caprolactone) Thermal stability.

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INVESTIGATION AND APPLICATION OF LAWS OF TWO DIMENSIONAL TRANSFORMATION OF SANDY BEACHES UNDER WAVE ACTION

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China Ocean Engineering 1990年第4期5卷 447-457页

作者： wang, liang Hohai Univ Nanjing China

Based on previous research results and experimental studies, this paper indicates the important factors affecting two-dimensional transformation of sandy beaches, especially the characteristic slope and sediment transport factor. A discrimination criterion of transformation type of sandy beaches is derived by applying the theory of wave energy dissipation rate. This criterion is closely examined with a lot of data and can be used to forecast the transformation of sandy beaches under the action of varying wave climates.

关键词： Energy Conservation Water Waves Wave Effects

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Underwater Pulse Waveform Recognition Based on Hash Aggregate Discriminant Network

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Journal of Ocean University of China 2024年第3期23卷 654-660页

作者： wang Fangchen ZHONG Guoqiang wang liang College of Computer Science and Technology Ocean University of ChinaQingdao 266100China College of Marine Technology Ocean University of ChinaQingdao 266100China

Underwater pulse waveform recognition is an important method for underwater object *** existing works focus on the application of traditional pattern recognition methods,which ignore the time-and space-varying characteristics in sound propagation channels and cannot easily extract valuable waveform *** propagation channels in seawater are time-and space-varying convolutional *** the extraction of the waveform features of underwater acoustic signals,the effect of high-accuracy underwater acoustic signal recognition is identified by eliminating the influence of time-and space-varying convolutional channels to the greatest extent *** propose a hash aggregate discriminative network(HADN),which combines hash learning and deep learning to minimize the time-and space-varying effects on convolutional channels and adaptively learns effective underwater waveform features to achieve high-accuracy underwater pulse waveform *** the extraction of the hash features of acoustic signals,a discrete constraint between clusters within a hash feature class is *** constraint can ensure that the influence of convolutional channels on hash features is *** addition,we design a new loss function called aggregate discriminative loss(AD-loss).The use of AD-loss and softmax-loss can increase the discriminativeness of the learned hash *** results show that on pool and ocean datasets,which were collected in pools and oceans,respectively,by using acoustic collectors,the proposed HADN performs better than other comparative models in terms of accuracy and mAP.

关键词： convolutional channel hash aggregate discriminative network aggregate discriminant loss waveform recognition

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