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Extended Object Model for Product Configuration Design

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International Journal of Automation and computing 2010年第3期7卷 289-294页

作者： Zhi-Wei Xu Ze-Zhong liang Zhong-qi Sheng School of Mechanical Engineering and Automation Northeastern University Shenyang 110004 PRC

This paper presents an extended object model for case-based reasoning （CBR） in product configuration design. In the extended object model, a few methods of knowledge expression are adopted, such as constraints, rules, objects, etc. On the basis of extended object model, case representation model for CBR is applied to product configuration design system. The product configuration knowledge can be represented by the extended object. The model can support all the processes of CBR in product configuration design, such as case representation, indexing, retrieving, and case revising. The presented model is an extension of the traditional object-oriented model by including the relationship class used to express the relation between the cases, constraints class used in the product configuration knowledge representation, index class used in ease retrieving, and solution class used in case revising. Therefore, the product configuration knowledge used in the product configuration design can be represented by using this model. In the end, a metering pump product configuration design system is developed on the basis of the proposed product configuration model to support customized products.

关键词： Mass customization product configuration case-based reasoning (CBR) object-oriented modeling case representation.

Electrical discharge and arc milling with automatic tracking of optimal flushing direction:A novel high-efficiency compound machining method

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Chinese Journal of Aeronautics 2024年第3期37卷 351-364页

作者： Xinlei WU Yonghong LIU Pengxin ZHANG liang qi Dege LI Chi MA Renjie JI College of Mechanical and Electronic Engineering China University of Petroleum(East China)Qingdao 266580China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing 211816China

The arc milling method has the advantages of high machining efficiency and low cost and is independent of the strength and hardness of machined ***,frequent electrode back-offs and the risk of workpiece burning may occur if erosion products are not removed *** this study,it was found that the flushing method of the working medium had a significant impact on the machining performance of arc *** on this,a novel highefficiency compound machining method of electrical discharge and arc milling with automatic tracking of the optimal flushing direction was *** automatic tracking optimizer for external working medium injection was designed to determine the optimal external flushing direction according to the feed *** influence of flushing methods,working mediums,and machining parameters on the machining efficiency,tool electrode wear rate,machining error,and surface integrity of titanium alloys were *** results indicated that better machining performance and environmental friendliness were achieved using the compound flushing method of outer compressed air and inner deionized ***,the automatic tracking flushing method in the opposite direction of the feed direction showed superior results compared to other *** material removal rate with the opposite direction injection could be increased up to 1.62 times that of the same direction,and the relative electrode wear rate could be reduced by 14.76%.This novel method has broad application prospects for machining parts with difficult-to-cut materials in aerospace and military industries.

关键词： Arc milling Dielectric Difficult-to-cut materials Electric discharge machining Erosion Material removal rate

Covalent inhibitor targets KRas^(G12C):A new paradigm for drugging the undruggable and challenges ahead

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Genes & Diseases 2023年第2期10卷 403-414页

作者： Hui-yu Li Wei-liang qi Yu-xiang Wang Ling-hua Meng Division of Anti-tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China College of Pharmacy Nanchang UniversityNanchangJiangxi 330006China

KRAS is one of the most commonly mutated oncogenes in cancers and therapeutics directly targeting the KRas have been *** the different known mutants,KRas^(G12C) has been proved to be successfully targeted *** covalent inhibitors selectively targeting KRas^(G12C) have shown promising efficacy against cancers harboring KRAS G12C mutation in clinical trials and AMG510(sotorasib)has been approved for the treatment of KRAS G12C-mutated locally advanced or metastatic non-small cell lung ***,the overall responsive rate of KRas^(G12C) inhibitors was around 50%in patients with non-small cell lung cancer and the efficacy in patients with colorectal cancer or appendiceal cancer appears to be less *** is of great importance to discover biomarkers to distinguish patients who are likely ***,adaptive resistance would occur inevitably with the persistent administration like other molecularly targeted *** combinatorial regimens have been studied in an effort to potentiate the efficacy of KRas^(G12C) inhibitors in preclinical *** review summarized the recent progress of covalent KRas^(G12C) inhibitors with a focus on identifying biomarkers to predict or monitor the efficacy and proposing rational drug combinations based on elucidation of the mechanisms of drug resistance.

关键词： Biomarkers Covalent KRas^(G12C)inhibitors Drug resistance Human cancers KRAS^(G12C)mutation

Electrophilic Halogen Reagents-mediated Halogenation: Synthesis of Halogenated Dihydro-1,3-oxazine Derivatives

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Chemical Research in Chinese Universities 2023年第6期39卷 933-947页

作者： qi liang qiN Yuji WANG Xueqing CHAI Hongli ZHU Weiwei ZHOU Yifeng Department of Pharmacy College of Life SciencesChina Jiliang UniversityHangzhou 310018P.R.China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006P.R.China School of Basic Medical Science Lanzhou UniversityLanzhou 730000P.R.China

Halogenation of N-cinnamylbenzamides and N-[(2H-chromen-3-yl)methyl]benzamides using electrophilic halogen source was *** halogenated dihydro-1,3-oxazine derivatives(45 examples)were synthesized in high to excellent yields(up to 98%yields),as well as halogenated dihydrochromeno-1,3-oxazine derivatives(56 examples,up to 96%yields).The properties of mild conditions,metal-free and high efficiency of the reaction made it a promising strategy in future applications for the construction of carbon-halogen(fluorine,F;chlorine,Cl;bromine,Br;iodine,I)bond and 1,3-oxazine derivatives.

关键词： Carbon halogen bond 1 3-Oxazine Heterocyclization

Nonlinear vibration of iced cable under wind excitation using three-degree-of-freedom model

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Chinese Physics B 2021年第9期30卷 148-158页

作者： Wei Zhang Ming-Yuan Li qi-liang Wu An Xi Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures Beijing University of TechnologyBeijing 100124China College of Mechanical Engineering Beijing University of TechnologyBeijing 100124China School of Artificial Intelligence Tiangong UniversityTianjin 300387China The Fifth Electronic Research Institute of MIIT Guangzhou 510610China

High-voltage transmission line possesses a typical suspended cable structure that produces ice in harsh ***,transversely galloping will be excited due to the irregular structure resulting from the alternation of lift force and drag *** this paper,the nonlinear dynamics and internal resonance of an iced cable under wind excitation are *** the excitation caused by pulsed wind and the movement of the support,the nonlinear governing equations of motion of the iced cable are established using a three-degree-of-freedom model based on Hamilton's *** the Galerkin method,the partial differential equations are then discretized into ordinary differential *** method of multiple scales is then used to obtain the averaged equations of the iced cable,and the principal parametric resonance-1/2 subharmonic resonance and the 2:1 internal resonance are *** numerical simulations are performed to investigate the dynamic response of the iced *** is found that there exist periodic,multi-periodic,and chaotic motions of the iced cable subjected to wind excitation.

关键词： iced cable wind excitation galloping chaotic motion

Effect of Dermabrasion and ReCell on Large Superficial Facial Scars Caused by Burn, Trauma and Acnes

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Chinese Medical Sciences Journal 2016年第3期31卷 173-173,174,175,176,177,178,179页

作者： Pan-xi Yu Wen-qi Diao Zuo-liang qi Jing-long Cai Department No. 16 Plastic Surgery Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100144 China Department of Respiratory Medicine Peking University Third Hospital Beijing 100191 China Department of Dermatology Peking Xiang-Yun Dermatological Hospital Beijing 100068 China

Objective To explore the effects of dermabrasion combined with ReCell on large superficial facial scars caused by burn, trauma and acnes. Methods Nineteen patients with large superficial facial scars were treated by the same surgeon with dermabrasion combined with ReCell？. According to the etiology, patients were classified into post-burning group （n=5）, post-traumatic group （n=7） and post-acne group （n=7）. Fifteen patients completed the follow-ups, 5 patients in each group. Healing time, complication rate, the preoperative and 18-month-post-operative assessments using Patient Satisfaction Score （PSS）, Vancouver Scar Scale （VSS）, and Patient and Observer Scar Assessment Scale （POSAS） of each group were analyzed to compare the effect of the combined therapy on *** The healing time of post-burning group （19.6±4.0 days）, post-traumatic group （15.8±2.6 days）, and post-acne group （11.4±3.1 days） varied remarkably （F=7.701, P=0.007）. The complication rates were 60%, 20%, and 0 respectively. The post-operative POSAS improved significantly in all groups （P〈0.05）, where the most significant improvement was shown in the post-acne group （P〈0.05）. The post-operative PSS and VSS improved only in the post-traumatic group and post-acne group （all P〈0.05）, where the more significant improvement was also shown in the post-acne group （P〈0.05）. Conclusions The combined treatment of dermabrasion and ReCell has remarkable effect on acne scars, moderate effect on traumatic scars and is not suggested for burn scars. POSAS should be applied to assess the therapeutic effects of treatments for large irregular scars.

关键词： dermabrasion ReCell scars Patient and Observer Scar Assessment Scale

Gold-Nanoparticles/Boron-Doped-Diamond Composites as Surface-Enhanced Raman Scattering Substrates

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Chinese Physics Letters 2020年第6期37卷 107-110页

作者： Ai-qi Zhang qi-liang Wang Ying Gao Shao-Heng Cheng Hong-Dong Li State Key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China

By vacuum sputtering and annealing processes of gold(Au)films on boron-doped diamond(BDD)surfaces,Aunanoparticles/BDD(AuNP/BDD)composite substrates were prepared as surface-enhanced Raman scattering(SERS)*** SERS performances of the substrate were investigated using methylene blue molecule as a *** the AuNPs having an average diameter of 20 nm,high performance of SERS was achieved at an enhancement factor of 9×10~5,arising from the synergistic effect of electromagnetic enhancement from Au NPs and chemical enhancement from *** AuNP/BDD substrate is demonstrated to be highly sensitive,reproducible,stable,and reusable for the SERS *** to the facile preparation process and controllable surface morphology,the AuNP/BDD substrates are favorable as a high performance SERS platform performed in practical applications.

关键词： boron synergistic annealing

CHAUS:Scalable VM-Based Channels for Unbounded Streaming

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Journal of Computer Science & Technology 2017年第6期32卷 1288-1304页

作者： Yu Zhang Yu-Fen Yu Hui-Fang Cao Jian-Kang Chen qi-liang Zhang School of Computer Science and Technology University of Science and Technology of China Hefei 230027 China

Stream processing is a special form of the dataflow execution model that offers extensive opportunities for optimization and automatic parallelism. A streaming application is represented by a graph of computation stages that communicate with each other via FIFO channels. In shared-memory environment, an FIFO channel is classically a com- mon, fixed-size synchronized buffer shared between the producer and the consumer. As the number of concurrent stage workers increases, the synchronization overheads, such as contention and waiting times, rise sharply and severely impair application performance. In this paper, we present a novel multithreaded model which isolates memory between threads by default and provides a higher level abstraction for scalable unicast or multicast communication between threads -- CHAUS （Channel for Unbounded Streaming）. The CHAUS model hides the underlying synchronization details, but requires the user to declare producer-consumer relationship of a channel in advance. It is the duty of the runtime system to ensure reliable data transmission at data item granularity as declared. To achieve unbounded buffer for streaming and reduce the synchronization overheads, we propose a virtual memory based solution to implement a scalable CHAUS channel. We check the programmability of CHAUS by successfully porting dedup and ferret from PARSEC as well as implementing MapReduce library with Phoenix-like API. The experimental results show that workloads built with CHAUS run faster than those with Pthreads, and CHAUS has the best scalability compared with two Pthread versions. There are three workloads whose CHAUS versions only spend no more than 0.17x runtime of Pthreads on both 16 and 32 cores.

关键词： streaming thread model pipeline parallelism unbounded channel virtual memory

Re-Os isotope dating of pyrite from the footwall mineralization zone of the Xinqiao deposit,Tongling,Anhui Province:Geochronological evidence for submarine exhalative sedimentation

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Chinese Science Bulletin 2011年第35期56卷 3860-3865页

作者： GUO WeiMin LU JianJun JIANG ShaoYong ZHANG Rongqing qi liang State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University Nanjing 210093 China State Key Laboratory o fOre Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China

The Xinqiao deposit is located in the Tongling area,Anhui *** deposit is dominantly composed of stratiform sulfide orebodies,which are restricted to the transitional zone from clastic rocks to carbonates at the base of the Late Carboniferous Huanglong *** are discordant veinlets or networks of mineralization in the footwall rocks below the stratiform sulfide *** underlying discordant mineralization zones coexist with conformable stratiform sulfide orebodies,which are considered to be the most representative features of massive sulfide deposits formed by submarine exhalative *** study reports a pyrite 187Re-187Os isotopic age of 319±13 Ma(MSWD=16) for the footwall mineralization *** isochron age is consistent with the interval of strata hosting the conformable stratiform sulfide orebody,and provides direct geochronological evidence for Carboniferous exhalative sedimentary mineralization.

关键词：海底喷流沉积同位素年代学矿化带同位素定年下盘安徽铜陵新桥证据