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一种刚柔耦合模块化月球科考站的构型设计与分析

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科学技术与工程 2024年第17期24卷 7438-7447页

作者：黄鑫宋嘉乐朱一鸣曾可意余双梁宁李欣中山大学航空航天学院深圳518107

月球探测是中国的战略性项目,其最后一步也是最关键的一步就是月球科考站的建设。为了能给月球科考站的建设提供一些经验,针对月球科考站的建设问题,提出了一种刚柔耦合的充气式展开的月球科考站构型设计方案,并介绍了各层的设计用途及... 详细信息

月球探测是中国的战略性项目,其最后一步也是最关键的一步就是月球科考站的建设。为了能给月球科考站的建设提供一些经验,针对月球科考站的建设问题,提出了一种刚柔耦合的充气式展开的月球科考站构型设计方案,并介绍了各层的设计用途及其功能。采用有限元软件ABAQUS进行仿真分析,研究了提出的科考站构型在月面上无月震影响下的静载工况,以及有月震影响下的动载工况的工作情况。结果表明:所提出的科考站各层结构在这两种工况下都能维持较好的力学性能,说明所提出的科考站构型具有较好的可行性,可以为相关领域的工程设计提供一些参考。

关键词：月球科考站构型设计功能分析有限元分析

PCHE细小多通道内天然气沸腾两相流分配特性数值分析

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工业加热 2024年第2期53卷 24-30页

作者：刘佳伦林金鹏宁亮唐凌虹西安石油大学新能源学院陕西西安710065

印刷电路板式换热器具有体积小、结构紧凑、换热效率高等特点,在天然气生产工艺中应用前景极为广阔,在PCHE换热过程中,冷、热侧通道内工质往往发生沸腾相变,各子通道间普遍存在汽液两相流分配不均问题,严重降低换热效率。对此,以换热器... 详细信息

印刷电路板式换热器具有体积小、结构紧凑、换热效率高等特点,在天然气生产工艺中应用前景极为广阔,在PCHE换热过程中,冷、热侧通道内工质往往发生沸腾相变,各子通道间普遍存在汽液两相流分配不均问题,严重降低换热效率。对此,以换热器封头和12个细小通道为建模对象,采用天然气汽液两相混合物为工质,通过Aspen Plus软件获得其物性数据,基于VOF模型追踪相界面运动位置,构建适用于预测分析PCHE内天然气两相流分配特性的三维非稳态数值模型,并开展了相关数值研究。结果表明,相比于单相液态天然气,当换热器入口混入汽相工质变为汽液两相混合物时,各子通道间工质的质量流量相对标准偏差由0.0004增加到0.036,两者相差近100倍,分配不均现象明显加剧。导致该现象的主要原因在于来流汽相工质明显倾向于进入距离换热器入口最近的若干通道,使得这些通道的汽相流量显高于其他通道,各通道汽相工质流量分配特性整体上呈现明显的“峰值分布”,但是,随着换热器入口汽相工质流速的不断增大,各通道间汽相工质的流量分配不均现象逐渐缓和,而液相工质的流量分配特性发生明显恶化。

关键词：印刷电路板式换热器并联细小多通道天然气汽液两相流流量分配

吹扫捕集-气相色谱-质谱法快速测定生活饮用水中82种挥发性有机物

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环境卫生学杂志 2024年第6期14卷 514-519页

作者：王璐蔡德玲梁宁黄晶杨滨银阿克苏地区疾病预防控制中心阿克苏843000 中华人民共和国拱北海关技术中心

目的建立吹扫捕集-气相色谱-质谱联用(P&T-GC-MS)法测定生活饮用水中三氯甲烷、四氯化碳等82种挥发性有机物(volatile organic compounds,VOCs)的分析方法。方法生活饮用水经吹扫捕集技术进行富集,经DB-624色谱柱分离,GC-MS选择扫描模... 详细信息

目的建立吹扫捕集-气相色谱-质谱联用(P&T-GC-MS)法测定生活饮用水中三氯甲烷、四氯化碳等82种挥发性有机物(volatile organic compounds,VOCs)的分析方法。方法生活饮用水经吹扫捕集技术进行富集,经DB-624色谱柱分离,GC-MS选择扫描模式进行分析,以保留时间和特征离子定性,内标法定量。结果82种VOCs在1.0~20.0μg/L浓度范围内的线性关系良好,R^(2)均大于0.990(1,1-二氯丙酮为0.988除外),方法检出限为0.02~2.69μg/L,定量限为0.07~8.95μg/L,回收率72.3%~122.6%,相对标准偏差为0.29%~11.48%。应用该方法测定80份不同水样,结果检出8种痕量VOCs。结论本方法灵敏、准确,操作简便,适用于生活饮用水中82种VOCs的同时检测。

关键词：气相色谱-质谱法饮用水挥发性有机物吹扫捕集

真空脱水技术在乙二醇再生回收系统脱水单元的应用探索

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四川化工 2024年第2期27卷 19-22,27页

作者：梁宁杨勇杜洋洋李春辉中海石油深海开发有限公司白云天然气作业公司广东深圳518000

贫乙二醇含水量是衡量乙二醇再生回收技术水平的重要指标之一。随着海洋天然气的勘探和开发进程加快,乙二醇再生的方式也从常压脱水向更节能的真空脱水方向发展。以某深水天然气开采平台配置的乙二醇再生回收系统为研究对象,针对乙二醇... 详细信息

贫乙二醇含水量是衡量乙二醇再生回收技术水平的重要指标之一。随着海洋天然气的勘探和开发进程加快,乙二醇再生的方式也从常压脱水向更节能的真空脱水方向发展。以某深水天然气开采平台配置的乙二醇再生回收系统为研究对象,针对乙二醇脱水过程中出现的重沸器热量供给不足、重沸器结垢、海水出水温度过高等一系列问题,提出真空脱水技术应用改造方案,并对脱水单元主要设备进行了刚度和失稳校核。改造实施后的现场试运行结果表明,真空脱水技术在乙二醇再生回收系统脱水单元中具有重要的应用价值和显著的节能效果,预计节能量可达1267.47 tce/a,是乙二醇再生回收技术改进的有益探索。

关键词：乙二醇再生回收系统问题描述真空脱水技术应用方案节能

Experimental study of retinoic acid on improving iodide uptake in MCF-7 breast cancer cells

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Nuclear Science and Techniques 2005年第4期16卷 221-224页

作者： FU Hong-liang WU Jing-Chuan DU Xue-liang LI Jia-ning WU Zhen ZOU Ren-Jian Department of Nuclear Medicine Xinhua Hospital Shanghai Second Medical University Shanghai 200092

The study aims to investigate the effect of retinoic acid on the iodide uptake of MCF-7 cells and its mechanism. The iodide uptake and expression of hNIS(human sodium/iodide symporter)mRNA in the breast cancer MCF-7 cells were compared individually before and after the intervention of all-trans retinoic acid (ATRA) with the iodide uptake assay and RT-PCR. The following results are obtained: (1) when treated with all-trans retinoic acid in the concentration of 1.0 μmol/L, the capacity of iodide uptake of MCF-7 cells reached about 1.5 times of the basal state; (2) 12 h after the intervention of 1.0 μmol/L ATRA,the hNISmRNA expression of the MCF-7 cells reached maximum. The study shows that all-trans retinoic acid has the effect to improve the iodide uptake of the MCF-7 cells and this effect may result from its up-regulation of the hNISmRNA expression.

关键词： MCF-7 碘化物乳腺癌放射性疗法

A carbon nanoparticle-peptide fluorescent sensor custom-made for simple and sensitive detection of trypsin

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Journal of Pharmaceutical Analysis 2020年第5期10卷 482-489页

作者： Shanshan Hou Tingting Feng Na Zhao Jiaxin Zhang Huibin Wang ning liang Longshan Zhao School of Pharmacy Shenyang Pharmaceutical UniversityShenyangLiaoning Province110016China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyangLiaoning Province110016China Institute of Pharmaceutical and Food Engineering Shanxi University of Chinese MedicineJinzhongShanxi Province030619China

Herein,we report a novel sensor to detect trypsin using a purpose-designed fluorescein-labelled peptide with negatively charged carbon nanoparticles(CNPs)modified by acid *** fluorescence of the fluorescein-labelled peptide was quenched by *** sensor reacted with trypsin to cleave the peptide,resulting in the release of the dye moiety and a substantial increase in fluorescence intensity,which was dose-and time-dependent,and trypsin could be quantified ***,the biosensor has led to the development of a convenient and efficient fluorescent method to measure trypsin activity,with a detection limit of 0.7 mg/*** method allows rapid determination of trypsin activity in the normal and acute pancreatitis range,suitable for point-of-care ***,the applicability of the method has been demonstrated by detecting trypsin in spiked urine samples.

关键词： Carbon nanoparticles Fluorescence quenching F€orster resonance energy transfer(FRET) Fluorescein-labelled peptide Trypsin assay

对转喷水推进器前后叶轮能量配比对其性能影响的数值研究

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船舶 2024年第3期35卷 30-42页

作者：梁宁王赟冯若凡曹琳琳吴大转浙江大学能源工程学院杭州310012

面向新型舰船高效推进系统的研制需求,将对转叶轮形式与喷水推进技术相结合,以更高能量密度的能量转化模型代替传统模式。该文采用计算流体力学的数值模拟方法,对基本参数相似、前后叶轮能量配比不同的2种推进方案开展了定常内流场分析... 详细信息

面向新型舰船高效推进系统的研制需求,将对转叶轮形式与喷水推进技术相结合,以更高能量密度的能量转化模型代替传统模式。该文采用计算流体力学的数值模拟方法,对基本参数相似、前后叶轮能量配比不同的2种推进方案开展了定常内流场分析与非定常叶轮干涉特性研究,结果表明:2种能量配比的对转喷水推进器推进效率基本相同,适应航速范围广、高效区宽;前叶轮起到了整流作用,降低了进口流道流场不均匀性对后叶轮的影响;增加后转子负载,减小前叶轮负载的能量配比方式有利于对转喷水推进器非定常性能的提升,推进器叶轮激振力与压力脉动幅值下降明显。

关键词：喷水推进器对转叶轮能量配比水动力性能激振力压力脉动

Hypoxia-inducible factor-1α induces the epithelial-mesenchymal transition of human prostatecancer cells

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Chinese Medical Journal 2006年第9期119卷 713-718页

作者： LUO Yong HE Da-lin ning liang SHEN Shu-lin LI Lei LI Xiang Department of Urology First Hospital of Xi＇an Jiaotong University Xi＇an 710061 China

Background Hypoxia-inducible factor- 1α （HIF- 1α） is a transcriptional factor that could improve the stimulation of angiogenesis and the metabolic adaptation of tumor cells to hypoxia. A recent study showed that HIF- 1α could induce colon cancer cells epithelial-mesenchymal transition （EMT）. However, no evidence indicates a similar correlation in human prostate cancer cells. This study was designed to evaluate the effect of HIF- 1α over-expression on the EMT in human prostate cancer cells. Methods We selected the appropriate cell line for HIF- 1α induction from those EMT negative prostate cell lines through vimentin gene detection by RT-PCR. As the result, LNCaP cell line is the best one for further experiment. LNCaP cells were transfected with recombinant plasmid pcDNA3.1 （-）/HIF- 1α and pcDNA3.1 （-） control vector by Lipofectamine 2000 system. The positive cell colonies were confirmed by indirect immunofluorescence labeling. Then Transwell polycarbonate filter was used to analyze the invasive potency. The expression of EMT associated proteins, E-cadherin and vimentin, was detected by Western blotting. Results Among four of the EMT negative cell lines, LNCaP was the only one expressed the vimentin gene but not the associated protein. The expression level of HIF- 1α in LNCaP/HIF- 1α was distinctly higher than that in LNCaP/pcDNA3.1 and LNCaP. The cell numbers of LNCaP/HIF- 1α that penetrated through the Transwell filter were higher than that of LNCaP/pcDNA3.1 and LNCaP. Compared with the LNCaP/pcDNA3.1 and LNCaP cells, the expression of vimentin was up-regulated in LNCaP/HIF- 1α, whereas the expression of E-cadherin was down-regulated.Conclusions Over-expression of HIF- 1α stimulates the invasion potency of human prostate carcinoma cells through EMT pathway. The expression of E-cadherin and vimentin, playing established roles in EMT, could be regulated by HIF- 1α in human prostate cancer cell line.

关键词： prostate cancer epithelial-mesenchymal transition hypoxia-inducible factor- 1α

Evaluation of outcomes reported in randomized controlled trials for herbal remedies for adults with chronic hepatitis C

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Journal of Traditional Chinese Medical Sciences 2019年第2期6卷 115-121页

作者： Yuqian Yan ning liang Shibing liang Yuxin Sun Nicola Robinson Jianping Liu Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Shanxi University of Chinese Medicine Taiyuan 030619China School of Health and Social Care London South Bank UniversityLondon SE10AAUnited Kingdom

Background:Herbal remedies have been widely utilized in treating chronic hepatitis C (CHC) *** appropriate outcomes to reflect both beneficial and harmful effects is a crucial step in designing randomized controlled trials (RCTs).This study evaluated the outcomes reported in RCTs on herbal remedies for CHC with comparison to the core outcomes recommended by the Cochrane Hepato-Biliary Group (CHBG),to check the consistency of the outcomes and to provide recommendation for future ***:A systematic literature search was conducted in Western and Chinese databases to identify RCTs on herbal remedies for adults with *** each trial,all the outcomes reported in the results section were *** between trial outcomes and CHBG core outcomes were evaluated and summarized with descriptive ***:A total of 116 RCTs involving 9154 participants were included;27 outcomes were *** reported outcomes included alanine aminotransferase (64 trials,55.2%),adverse events (58 trials,50.0%),and end-of-treatment virological response (50 trials,43.1%).All trials indicated that the herbal remedies under investigation had a positive effect and was markedly more effective than the *** half of the trials reported that the combination of herbal medicine and antiviral drugs could ameliorate adverse *** few trials reported primary core outcomes relating survival and quality of *** most frequently reported core outcomes are non-serious adverse events (54 trials,46.6%),viral response (27 trials,23.3%),and biochemical response (24 trials,20.7%).Conclusion:The variation and inconsistency in trial outcomes impedes research synthesis efforts,and indicate the need for comparable outcomes through the development of core outcome sets in *** low concordance of outcome reporting could be improved by following CHBG core outcomes recommendation.

关键词： Chronic hepatitis C Herbal Core outcome set Randomized controlled trial Cochrane Hepato-Biliary Group