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中国物理学报 1951年第3期 197-206页

作者： C.T.KWEI P.H.liang J.H.moh W.CHOW Ionosphere Laboratory Wuhan University Wuchang Wuchang at the Institute of Geophysics and Mctcorology Academia Sinica

From data obtained during the eclipse and on control days,the effective coefficient of recombinationfor F-2 layer is found to be 4×10-10cm3/electron per sec.The magnitude of α is apparently afunction of the height of the layer which becomes lower with increasing latitude.Solar eruptionsmay be associated with two of the discontinuities of the eclipse curve.The thickness of the F-2 layerbecame compressed and dropped as a whole during the eclipse,possibly due to air movement causedby lowering of temperature.The sporadic E layer was not influenced by the change of solar radiation,and must be due to other causes.

关键词： THE F-2 REGION OF THE IONOSPHERE AT WUCHANG DURING THE SOLAR ECLIPSE OF MAY 9,1948 AT

Acute-on-Chronic Liver Failure Precipitated by Severe Acute Respiratory Syndrome Coronavirus 2 Infection in a Patient with Hepatitis B Virus-Related Cirrhosis: A Case Report

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Infectious Diseases & Immunity 2021年第3期1卷 169-173页

作者： Wanling Chen Qiran Zhang Shijun Li Ruiting liang Haiqun liang Yiqi Yu Chao Qiu Jiannan Lv Wenhong Zhang Department of Infectious Disease Beihai People’s HospitalGuangxi 536006China Department of Infectious Disease National Medical Center for Infectious DiseasesShanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseHuashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China National Clinical Research Center for Aging and Medicine Huashan HospitalFudan UniversityShanghai 200040China Key Laboratory of Medical Molecular Virology(MOE/moh)Shanghai Medical College Fudan UniversityShanghai 200040China

We present a case of acute-on-chronic liver failure(ACLF)in a patient with hepatitis B virus(HBV)-related decompensated cirrhosis and coronavirus disease 2019(COVID-19).A 58-year-old woman with HBV-related and decompensated cirrhosis without any anti-viral treatment previously was admitted to the hospital due to a confirmed severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.On admission,she was in stable condition.Thoracic computed tomography(CT)and laboratory findings showed no significant abnormalities.Entecavir was initiated promptly for HBV,while antiviral therapy and supportive treatment were initiated for COVID-19.Her lung infection exacerbated after 10days of recurrent fever despite treatments,and there were signs of HBV reactivation.ACLF and multiple organ dysfunction syndrome developed rapidly from day 10 to day 19.The patient’s clinical deterioration was also consistent with pneumonia progression and elevated interleukin 6 levels.SARS-CoV-2 likely precipitated ACLF in cirrhotic patients,either by inducing HBV flare or serving as an acute insult directly.This study discussed the underlying mechanisms of this process and management details.Monitoring HBV status is necessary,and inflammatory parameters might be valuable.HBV suppression should be initiated early,and variceal hemorrhage primary prevention might be beneficial in COVID-19 patients with cirrhosis.

关键词： Acute-on-chronic liver failure Decompensated cirrhosis SARS-CoV-2 infection

Host restriction factors for hepatitis C virus

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World Journal of Gastroenterology 2016年第4期22卷 1477-1486页

作者： li-ya zhou lei-liang zhang moh Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176China

Host-hepatitis C virus(HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.

关键词： Hepatitis C virus Host restriction factor Interferon Entry Replication Propagation

A Metal Oxide Heterostructure for Resistive Random Access Memory Devices

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Chinese Physics Letters 2013年第4期30卷 197-200页

作者：廖昭亮陈东敏 Department of Physics and Astronomy Louisianan State UniversityBaton RougeLA 70810USA Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871

We propose and investigate a metal oxide heterostructure(moh)based resistive switching(RS)device.The driving mechanism of resistive switching(RS)in an moh is more directly related to oxygen ion/vacancy migration around their interface.The performance of an moh-based RS device depends on the oxygen mobility,oxygen vacancy concentration as well as its relation to the resistivity.An enhanced ratio of high resistance state to low resistance state can be achieved if the two involved metal oxides are mutually complemental metal oxides in which one of them has larger resistivity with increasing concentration of vacancy while the other one is the reverse.

关键词： resistance vacancy resistivity

The Malaysian cataract surgery registry:incidence and risk factors of postoperative infectious endophthalmitis over a 7-year period

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1685-1690页

作者： Yong Zheng Wai Fiona Lee Min Chew mohamad Aziz Salowi Chai liang Ang Yong Yuin Chong Tassha Hilda Adnan Pik-Pin Goh Department of Ophthalmology Hospital Tuanku Jaafar Seremban Department of Ophthalmology Hospital Selayang Department of Ophthalmology Faculty of Medicine University Sultan Zainal Abidin Department of Emergency Medicine Hospital Teluk Intan Faculty of Medicine MAHSA University Clinical Research Centre Hospital Kuala Lumpur

AIM：To report the incidence,risk factors and visual outcomes for postoperative endophthalmitis（POE）based on 7-year data from the Malaysian Ministry of Health Cataract Surgery Registry（moh CSR）.METHODS：Data was collected from the web-based moh CSR.All consecutive cataract surgery patients from 1st June 2008 to 31st December 2014 were identified.Exclusion criteria were traumatic cataract or previous ocular surgery.Demographic data,ocular co-morbidities,intraoperative details and postoperative visual acuity（VA）at final ophthalmological follow-up were noted.All eyes were taken for analysis.Subjects with POE were compared against subjects with no POE for risk factor assessment using multiple logistic regressions.RESULTS：A total of 163 503 subjects were screened.The incidence of POE was 0.08%（131/163 503）.Demographic POE risk factors included male gender（OR：2.121,95%CI：1.464-3.015）and renal disease（OR：2.867,95%CI：1.503-5.467）.POE risk increased with secondary causes of cataract（OR：3.562,95%CI：1.740-7.288）,uveitis（OR：11.663,95%CI：4.292-31.693）and diabetic retinopathy（OR：1.720,95%CI：1.078-2.744）.Intraoperative factors reducing POE were shorter surgical time（OR：2.114,95%CI：1.473-3.032）,topical or intracameral anaesthesia（OR：1.823,95%CI：1.278-2.602）,posterior chamber intraocular lens（PCIOL;OR：4.992,95%CI：2.689-9.266）and foldable IOL（OR：2.276,95%CI：1.498-3.457）.POE risk increased with posterior capsule rupture（OR：3.773,95%CI：1.915-7.432）and vitreous loss（OR：3.907,95%CI：1.720-8.873）.Postoperative VA of 6/12 or better was achieved in 15.27%（20/131）subjects with POE.CONCLUSION：This study concurs with other studies regarding POE risk factors.Further strengthening of moh CSR data collection process will enable deeper analysis and optimization of POE treatment.

关键词： cataract endophthalmitis eye infection surgery

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

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Protein & Cell 2018年第11期9卷 945-965页

作者： Ping Wang Zunpeng Liu Xiaoqian Zhang Jingyi Li liang Sun Zhenyu Ju Jian Li Piu Chan Guang-Hui Liu Weiqi Zhang Moshi Song Jing Qu National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of BiophysicsChinese Academy of Sciences Beijing 100101 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing100101 China State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China National Clinical Research Center for Geriatric Disorders Xuanwu Hospital of Capital Medical University Beijing 100053China Institute of Stem cell and Regeneration Chinese Academy of Sciences Beijing 100101 China The moh Key Laboratory of Geriatrics Beijing Hospital National Center of Gerontology Beijing 100730 China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine JinanUniversity Guangzhou 510632 China

Vascular cell functionality is critical to blood vessel homeostasis. Constitutive NF-κB activation in vascular cells results in chronic vascular inflammation, leading to various cardiovascular diseases. However, how NF-κB regulates human blood vessel homeostasis remains largely elusive. Here, using CRISPR/Cas9-mediated gene editing, we generated RelA knockout human embryonic stem cells （hESCs） and differentiated them into various vascular cell derivatives to study how NF- KS modulates human vascular cells under basal and inflammatory conditions. Multi-dimensional phenotypic assessments and transcriptomic analyses revealed that RelA deficiency affected vascular cells via modulatinginflammation, survival, vasculogenesis, cell differentia- tion and extracellular matrix organization in a cell type- specific manner under basal condition, and that RelA protected vascular cells against apoptosis and modu- lated vascular inflammatory response upon tumor necrosis factor a （TNFa） stimulation. Lastly, further evaluation of gene expression patterns in IKBo knockout vascular cells demonstrated that IKBa acted largely independent of RelA signaling. Taken together, our data reveal a protective role of NF-κB/ReiA in modulating human blood vessel homeostasis and map the human vascular transcriptomic landscapes for the discovery of novel therapeutic targets.

关键词： NF-κB RelA Stem cell Inflammation Apoptosis

A single-cell transcriptomic atlas of primate pancreatic islet aging

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National Science Review 2021年第2期8卷 17-31页

作者： Jingyi Li Yuxuan Zheng Pengze Yan Moshi Song Si Wang liang Sun Zunpeng Liu Shuai Ma Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Weiqi Zhang Guang-Hui Liu Fuchou Tang Jing Qu Gene Expression Laboratory Salk Institute for Biological Studies Ministry of Education Key Laboratory of Cell Proliferation and Differentiation National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences Beijing Institute for Brain Disorders Advanced Innovation Center for Human Brain ProtectionNational Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical University The moh Key Laboratory of Geriatrics Beijing HospitalNational Center of Gerontology Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking University State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences Institute for Stem Cell and Regeneration Chinese Academy of Sciences State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences Beijing Advanced Innovation Center for Genomics Biomedical Pioneering Innovation CenterCollege of Life SciencesPeking University CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences University of Chinese Academy of Sciences China National Center for Bioinformation

Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine cells age heterogeneously, complicating the efforts to unravel the molecular drivers underlying endocrine aging. To overcome these obstacles, we undertook single-cell RNA sequencing of pancreatic islet cells obtained from young and aged non-diabetic cynomolgus monkeys. Despite sex differences and increased transcriptional variations, aged β-cells showed increased unfolded protein response(UPR) along with the accumulation of protein aggregates. We observed transcriptomic dysregulation of UPR components linked to canonical ATF6 and IRE1 signaling pathways, comprising adaptive UPR during pancreatic aging. Notably, we found aging-related β-cell-specific upregulation of HSP90 B1, an endoplasmic reticulum-located chaperone, impeded high glucose-induced insulin secretion. Our work decodes aging-associated transcriptomic changes that underlie pancreatic islet functional decay at single-cell resolution and indicates that targeting UPR components may prevent loss of proteostasis,suggesting an avenue to delaying β-cell aging and preventing aging-related diabetes.

关键词： islet β-cell aging single-cell RNA sequencing primate

Low-dose quercetin positively regulates mouse healthspan

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Protein & Cell 2019年第10期10卷 770-775页

作者： Lingling Geng Zunpeng Liu Si Wang Shuhui Sun Shuai Ma Xiaoqian Liu Piu Chan liang Sun Moshi Song Weiqi Zhang Guang-Hui Liu Jing Qu Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Genomics and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Laboratory of Biomacromolecules CAS Center for Excellenee in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China The moh Key Laboratory of Geriatrics Beijing HospitalNational Center of GerontologyBeijing 100730China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Brain Disorders Beijing 100069China

Dear Editor,Aging is the leading risk factor for many chronic diseases,accounting for almost 60%of all deaths worldwide.How to achieve healthy aging,alleviate aging-related diseases,and extend healthspan has become a main topic of biomedical research(He et al.,2019).Geroprotective compounds,such as metformin and rapamycin,have been shown to improve both healthspan and lifespan in mice(Martin-Montalvo et al.,2013;Bitto et al.,2016),whereas nicotinamide partially improves healthspan in mice(Mitchell et al.,2018).

关键词： al. protective diseases

Chemical screen identifies a geroprotective role of quercetin in premature aging

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Protein & Cell 2019年第6期10卷 417-435页

作者： Lingling Geng Zunpeng Liu Weiqi Zhang Wei Li Zeming Wu Wei Wang Ruotong Ren Yao Su Peichang Wang liang Sun Zhenyu Ju Piu Chan Moshi Song Jing Qu Guang-Hui Liu Advaneed Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital of Capital Medical University Beijing 100053 China National Laboratory of Biomacromolecules CAS Center for Excellenee in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Stem cell and Regeneration Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Jinan University Guangzhou 510632 China The moh Key Laboratory of Geriatrics Beijing Hospital National Center of Gerontology Beijing 100730 China

Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders.

关键词： Quercetin Stem cell Aging Werner syndrome Hutchinson-Gilford progeria syndrome