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chinese Chemical Letters 1992年第6期3卷 421-422页

作者： Shi Zhi CHEN Chang Jiu ZHANG liang huang 1. institute of materia medica,{1.,{2., beijing 100029.

Wittig reaction in methanol was investigated, and a possible mechanism was proposed.

关键词： CCH SOLVENT PARTICIPATION OF WITTIG OLEFINATION REACTION IN METHANOL OCH Chen

A NOVEL FREE RADICAL REARRANGEMENT

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chinese Chemical Letters 1992年第4期3卷 257-258页

作者： Shi Zhi CHEN~1, Ming GUO~1, Kai Rong CUI~2.and liang huang~(1*) 1. {2. of materia medica, chinese academy of medical Science, beijing 100050.2. china doping {12. center, beijing 100029

The reaction of benzyloxyethanol with carbon tetrabromide was investigated, and a possible mechanism was proposed.

关键词： Rev A NOVEL FREE RADICAL REARRANGEMENT

Black titanium dioxide nanomaterials for photocatalytic removal of pollutants:A review

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Journal of materials Science & Technology 2022年第17期112卷 239-262页

作者： Ying liang Guohe {1. Xiaying Xin Yao Yao Yongping Li Jianan Yin Xiang Li Yuwei Wu Sichen Gao State Key Joint Laboratory of Environmental Simulation and Pollution control School of EnvironmentBeijing Normal UniversityBeijing 100875China State Key Joint Laboratory of Environmental Simulation and Pollution control China-Canada Center for EnergyEnvironment and Ecology ResearchUR-BNUSchool of EnvironmentBeijing Normal UniversityBeijing 100875China Department of Environmental Systems Engineering University of ReginaReginaSKS4S 0A2Canada State Key Laboratory of Marine Pollution(SKLMP) City University of Hong KongKowloonHong Kong SARChina Faculty of Engineering and Applied Science University of ReginaReginaSaskatchewanS4S 0A2Canada

Semiconductor photocatalysis is one of the most widely used environment-friendly technologies for removing various *** a well-developed photocatalyst,titanium dioxide(TiO_(2.)still has limits in its wide bandgap and rapid recombination rate of photogenerated charge ***,black TiO_(2.appears as a strong candidate in the improvement of sunlight harvesting,because of its excellent absorption capacity and utilization of solar *** extensive applications in both environmental and energy fields,the use of black TiO_(2.as a photocatalyst in pollutant removal is *** primary objective of the review is to comprehensively evaluate the applications of black TiO_(2.in photocatalytic removal of contaminants,including conventional organic contaminants,emerging contaminants,microbes,and heavy *** basic properties,photocatalytic mechanism,and synthesis of black TiO_(2.have been summarized and ***,the stability and recoverability of black TiO_(2.have also been ***,the perspectives of the application of black TiO_(2.in pollutant removal have been further discussed.

关键词： Photocatalysis Back TiO_(2. Ti^(3+)self-doping Nanomaterials Pollutant removal

基于代谢组学和生物信息学的西洋参三七丹参颗粒抗衰老作用及分子机制研究

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中国中药杂志 2024年第7期49卷 1932-1946页

作者：田良良殷志如曹光昭夏裕发张晶晶杨洪军广东药科大学中医药研究院广东广州510006 中国中医科学院中药研究所北京100700 中国中医科学院医学实验中心、中医药防治重大疾病基础研究北京市重点实验室北京100700 漳州片仔癀药业股份有限公司、福建省片仔癀天然医药研发企业重点实验室福建漳州363000 北京脑科学与类脑研究中心北京102206

该研究基于代谢组学、网络药理学和分子对接技术探讨西洋参三七丹参颗粒抗衰老的作用机制。采用腹腔注射D-半乳糖(D-gal)诱导衰老小鼠模型,将小鼠随机分为对照组(control组),模型组(model组),阳性药组(褪黑素组,MT组),西洋参三七丹参颗... 详细信息

该研究基于代谢组学、网络药理学和分子对接技术探讨西洋参三七丹参颗粒抗衰老的作用机制。采用腹腔注射D-半乳糖(D-gal)诱导衰老小鼠模型,将小鼠随机分为对照组(control组),模型组(model组),阳性药组(褪黑素组,MT组),西洋参三七丹参颗粒低、中、高剂量组(XSD-L、XSD-M、XSD-H组)。进行旷场实验,免疫荧光检测细胞周期阻滞蛋白(p1.)和磷酸化组蛋白H2.变异体(phosphorylated histone family 2. variant,γH2.X)在脑组织中的表达,酶联免疫吸附法(ELISA)测定小鼠脑组织中炎症因子白细胞介素-1.(interleukin-1.,IL-1.)和白细胞介素-6(interleukin-6,IL-6)表达水平。对control组、model组、XSD-H组的小鼠血清进行代谢组学分析得到代谢过程及代谢物;通过网络药理学预测西洋参三七丹参颗粒有效化学成分和潜在靶点,构建“药物-有效化学成分-关键靶点”网络图,进行基因本体论(Gene Ontology,GO)分析、京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)分析以及蛋白-蛋白互作(protein-protein interaction,PPI)网络构建,阐明西洋参三七丹参颗粒抗衰老的作用机制。结果表明,西洋参三七丹参颗粒能明显改善D-gal小鼠衰老程度,显著改善D-gal小鼠总运动距离和平均运动速度,减少休息时间;显著降低D-gal小鼠IL-6和IL-1.的蛋白水平;明显降低p1.和γH2.X的表达;与model组相比,XSD-H组显著上调了66个差异代谢物(differential metabolites,DMs),下调了91.DMs;筛选出4条关键代谢途径(色氨酸代谢、甘油磷脂代谢、嘧啶代谢、赖氨酸降解)和1.种潜在生物标志物(赖氨酸、色氨酸、吲哚乙醛、磷脂酰胆碱、溶血磷脂酰胆碱、3-羟基邻氨基苯甲酸、褪黑素等);网络药理学方法筛选出西洋参三七丹参颗粒的主要活性成分58个,关键靶点62.;GO功能富集分析发现与基因表达的正向调控、药物反应等;KEGG通路富集筛选到涉及糖尿病并发症相关的AGE-RAGE信号通路、缺氧诱导因子-1.号通路等;并通过PPI网络以及分子对接筛选出STAT3、MAPK1.MAPK1.、EGFR、FOS、STAT1.6个潜在核心靶点。

关键词：西洋参三七丹参颗粒代谢组学网络药理学分子对接衰老

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Genomic,transcriptomic,and epigenomic analysis of a medicinal snake,Bungarus multicinctus,to provides insights into the origin of Elapidae neurotoxins

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2234-2249页

作者： Jiang Xu Shuai Guo Xianmei Yin Mingqian Li He Su Xuejiao Liao Qiushi Li liang Le Shiyu Chen Baosheng Liao Haoyu Hu Juan Lei Yingjie Zhu Xiaohui Qiu Lu Luo Jun Chen Ruiyang Cheng Zhenzhan Chang Han Zhang Nicholas Chieh Wu Yiming Guo Dianyun Hou Jin Pei Jihai Gao Yan Hua Zhihai {1. Shilin Chen institute of Herbgenomics State Key Laboratory of Southwest Chinese Medicine ResourcesPharmacy CollegeChengdu University of Traditional Chinese MedicineChengdu 611137China institute of {1. {2. medica China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Cancer Prevention and Therapy Combining Traditional chinese and Western Medicine of Zhejiang Province Zhejiang Academy of Traditional Chinese MedicineTongde Hospital of Zhejiang ProvinceHangzhou 310012China Guangdong Provincial Hospital of chinese Medicine(the Second Clinical {1. College of Guangzhou University of chinese Medicine Guangdong Provincial Hospital of Traditional Chinese Medicine)Guangzhou 510006China Pharmacy College Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pathology Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA beijing Engineering Research {1. of Pediatric Surgery Engineering and Transformation CenterBeijing Children's HospitalNational Center for Children's HealthCapital Medical UniversityBeijing 100045China School of Basic medical {1. Peking UniversityBeijing 100191China School of chinese {1. {2. Tianjin University of Traditional Chinese MedicineTianjin 300193China School of Life and Environmental sciences the University of SydneyNSW2006Australia University of Pittsburgh Kenneth P.Dietrich School of Arts and SciencesPittsburghPA 15260USA Agricultural College Henan University of Science and TechnologyLuoyang 471000China Guangdong Provincial Key Laboratory of Silviculture Protection and UtilizationGuangdong Academy of ForestryGuangzhou 510520China

The many-banded krait,Bungarus multicinctus,has been recorded as the animal resource of JinQianBaiHuaShe in the chinese *** of its venoms classified chief phyla of modern animal ***,the evolutionary origin and diversification of its neurotoxins as well as biosynthesis of its active compounds remain largely unknown due to the lack of its high-quality ***,we present the 1.58 Gbp genome of *** assembled into 1. chromosomes with contig/scaffold N50 of 7.53 Mbp/1.9.8 *** bungarotoxin-coding genes were clustered within genome by family and found to be associated with ancient local *** truncation of glycosylphosphatidylinositol anchor in the 3'-terminal of a LY6E paralog released modern three-finger toxins(3FTxs)from membrane tethering before the Colubroidea *** expansion and mutations diversified and recruited these *** the cobra/krait divergence,the modern unit-B ofβ-bungarotoxin emerged with an extra cysteine residue.A subsequent point substitution in unit-A enabled theβ-bungarotoxin covalent *** *** gene expression,chromatin topological organization,and histone modification characteristics were featured by transcriptome,proteome,chromatin conformation capture sequencing,and *** results highlighted that venom production was under a sophisticated *** findings provide new insights into snake neurotoxin research,meanwhile will facilitate antivenom development,toxin-driven drug discovery and the quality {1. of JinQianBaiHuaShe.

关键词： Medicinal snake Neurotoxin origin Antivenoms Gene regulation Chromatin

《中国药典》2.2.年版中药材基原修订探赜

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中国中药杂志 2021年第10期46卷 2617-2622页

作者：赵维良依泽黄琴伟周建良陈士林杭州师范大学药学院浙江杭州311121 浙江省食品药品检验研究院浙江杭州310052 中国中医科学院中药研究所北京100700

《中国药典》2.2.年版对2.1.年版9种药材的基原作了修订。修订系基于对2.1.年版全部收载药材的植物、动物或矿物基原进行筛查后发现问题的研究和考证。其中泽泻、决明子、薏苡仁、苦地丁和禹州漏芦的植物基原中文名均与拉丁学名不对应,... 详细信息

《中国药典》2.2.年版对2.1.年版9种药材的基原作了修订。修订系基于对2.1.年版全部收载药材的植物、动物或矿物基原进行筛查后发现问题的研究和考证。其中泽泻、决明子、薏苡仁、苦地丁和禹州漏芦的植物基原中文名均与拉丁学名不对应,也与实际药用基原名称不匹配,泽泻并存在基原植物遗漏情况;虫白蜡昆虫基原的中文名及所属科名有混淆,石膏的矿物基原的族名有误,白矾的矿物基原明矾石、皂矾(绿矾)的矿物基原水绿矾的族名均缺失。针对这些问题进行了药材及其基原的实地调研和文献考证,探究了这些问题存在的根源。对由于药材基原植物中文名和拉丁学名不对应,而出现由中文名和拉丁学名各自代表的不同基原植物的情况,则根据研究考证确定正确的基原和正确的中文名或拉丁学名;另根据分类学,对科名有混淆的,探究正确的名称;族名缺失的,考证得出正确的族名,最终确定了《中国药典》2.2.年版基原修订的科学依据和正确结果。

关键词：中国药典基原修订泽泻决明子薏苡仁苦地丁禹州漏芦虫白蜡

Hsp90β inhibitors prevent GLT-1.degradation but have no beneficial efficacy on absence epilepsy

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中国药理学与毒理学杂志 2018年第9期32卷 724-724页

作者： PENG Yu-chen WANG Shan ZHANG Yong huang Long-jian ZHOU Yu-jun WANG Xiao-{1. PENG Ying State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China

OBJECTIVE To examine whether1. AAG and STA9090 have anticonvulsant activity in absence *** For the acute seizure study,each group of mice received VPA(dissolved in saline) 1.0 mg·kg-1.1. AAG(dissolved in 50 μL DMSO) 2. mg·kg-1.or STA9090(dissolved in 2. μL DMSO) 50 mg·kg-1.by oral gavage *** control group received DMSO *** minutes after oral gavage,PTZ 80 mg·kg-1.was intraperitoneal injected to induce acute *** number of seizures refers to the total number of epileptic mice after PTZ *** latency was defined by the time elapsed from PTZ injection to the occurrence of the first *** levels of Hsp90β,GLT-1.GFAP and 2. S proteasome β1.in the cortex and hippocampus were detected by Western *** The mortality were60% for 1. AAG and 43% for STA9090,and the mortality of valproate group dropped to 2.%which decreased by 33.3% compared to model *** latency of valproate group obviously prolonged compared to model group(P1. AAG and STA9090 had no significant differences in seizure *** result of Western blotting has shown that inhibition of Hsp90β significantly reduced expressions of both membrane and cytosolic Hsp90β in the hippocampus and cortex of each group of ***,the expressions of GLT-1.and GFAP did not show the significant difference in the cortex and *** expression of 2. S proteasome β1.had not been obviously changed in the cortex and hippocampus among the *** 1. AAG and STA9090 did not have anticonvulsant activity and did not increase the stability of GLT-1.by disrupting proteasome-dependent GLT-1.degradation in PTZ induced mice of absence epilepsy.

关键词： Hsp90β inhibitor epilepsy GLT-1 absence epilepsy

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-1.

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1585-1600页

作者： Yiyue Ge Tingzhong Tian Suling huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Cheng{1. Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui {1. Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng institute for Interdisciplinary Information {1. Tsinghua UniversityBeijingChina NHC Key laboratory of Emeric Pathogenic Microbiology Jiangsu Provincial Center for Diseases Control and PreventionNanjingJiangsu ProvinceChina Shanghai institute of {1. {2. Chinese Academy of SciencesShanghaiChina Silexon Al Technology Co. Ltd.NanjingJiangsu ProvinceChina Department of Computer Science University of Illinois at Urbana-ChampaignIllinoisILUSA School of Pharmaceutical sciences Tsinghua UniversityBeijingChina School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhanHubei ProvinceChina institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Automation Tsinghua UniversityBeijingChina Inner Mongolia Alashan League Organization Establishment Committee Office Electronic Support center AlashanInner MongoliaChina Convalife(Shanghai)Co. Ltd.ShanghaiChina Advanced Innovation center for Human Brain Protection Beijing Tiantan HospitalCapital Medical UniversityBeijingChina beijing Advanced Innovation {1. for Structural Biology Tsinghua-Peking Joint Center for Life SciencesDepartment of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijingChina center for Global Health Nanjing Medical UniversityNanjingJiangsu ProvinceChina

The global spread of severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2.1.(COVID-1.).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against *** in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1.PARP1.inhibitor,CVL2.0},currently in Phase I clinical trial,may be repurposed to treat *** in vitro assays revealed that CVL2.0} can exhibit effective inhibitory activity against SARS-CoV-2.replication without obvious cytopathic *** addition,we showed that CVL2.0} can interact with the nucleocapsid(N)protein of SARS-CoV-2.and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2.infection.

关键词： prevention respiratory acute

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无公害银柴胡栽培技术

中国实验方剂学杂志 2019年第16期25卷 120-127页

作者：黄旗凯沈亮刘志香开国银浙江中医药大学药学院杭州310053 中国中医科学院中药研究所中药鉴定与安全性检测评估重点实验室北京100700

银柴胡作为中国传统的常用中药,已有几百年的药用历史,收载于历版《中国药典》。味甘,性微温。归肝、胃经。有清虚热,除疳热的作用。用于阴虚发热,骨蒸劳热,小儿疳热等病证。为乌鸡白凤丸等中药制剂的原料药。近年来人们对其需求日益增... 详细信息

银柴胡作为中国传统的常用中药,已有几百年的药用历史,收载于历版《中国药典》。味甘,性微温。归肝、胃经。有清虚热,除疳热的作用。用于阴虚发热,骨蒸劳热,小儿疳热等病证。为乌鸡白凤丸等中药制剂的原料药。近年来人们对其需求日益增多,而野生资源被长期过度采挖,导致野生银柴胡的资源严重匮乏,难以满足日益增长的国内外市场需求。人工栽培面积虽逐渐扩大,但银柴胡人工栽培品的品质与野生品差异较大。同时,生产过程中不合理使用农药、化肥所导致的农药残留、金属超标等问题,以及市场上伪品众多,严重影响银柴胡药材的品质、疗效和用药安全,由此银柴胡的无公害栽培技术尤为重要,无公害栽培是促进银柴胡产业健康发展的有效方式。该文综述了银柴胡无公害生产应具备的产地环境、种植方法、田间管理、合理施肥灌水等农艺措施,以及无公害防治病虫害的方法等无公害种植技术,从而构建规范化的银柴胡无公害生产体系,有效指导银柴胡的规范化生产栽培,促进银柴胡种植产业的健康可持续发展。

关键词：银柴胡栽培技术产地环境品种鉴定田间管理合理施肥综合防治

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无公害中药材产地环境质量标准探讨

中国实验方剂学杂志 2018年第23期24卷 1-7页

作者：孟祥霄沈亮黄林芳熊超陈士林中国中医科学院中药研究所北京100700 中国医学科学院&北京协和医科大学药用植物研究所北京100193

无公害中药材栽培体系是解决中药材农药残留（简称农残）和重金属超标、药材品质下降的技术体系。种植基地作为无公害中药材生产不可或缺的物质基础,其环境质量标准制定是中药材质量控制中的重要一环。现阶段无公害中药材产地环境标准缺... 详细信息

无公害中药材栽培体系是解决中药材农药残留（简称农残）和重金属超标、药材品质下降的技术体系。种植基地作为无公害中药材生产不可或缺的物质基础,其环境质量标准制定是中药材质量控制中的重要一环。现阶段无公害中药材产地环境标准缺失,中药材无序种植、农残和重金属超标等问题导致其有效性和安全性受到较大质疑。该文通过总结我国无公害农产品产地环境质量标准的发展进程及研究现状,结合中药材种植方法,借鉴已有成熟标准,建立了无公害中药材产地环境质量标准;同时提出运用＂药用植物全球产地生态适宜性区划信息系统＂,以药材野生分布区、道地产区及主产区样点的气候和土壤因子信息为依据,对栽培选地进行科学预测,得出潜在的无公害中药材生态适宜产区,最终达到降低药材农残及重金属含量,提高药材品质,生产无公害中药材的目的。建立无公害中药材产地环境质量标准对于指导中药材生产、推进中医药事业健康发展具有重要意义。

关键词：无公害中药材产地环境标准地理信息系统生产质量管理规范