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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng Gong Haiying liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

CT引导下经皮注射乙酸治疗肾上腺皮质腺瘤3例

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国际护理学杂志 2000年第8期 385-385页

作者： liang hl 段摄霞赵施竹

REAL-VALUED PERIODIC WAVELETS: CONSTRUCTION ANDRELATION WITH FOURIER SERIES

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Journal of Computational Mathematics 1999年第5期17卷 509-522页

作者： Chen, hl liang, XZ Peng, SL Xiao, SL Acad Sinica Inst Math Beijing 100080 Peoples R China Jilin Univ Changchun 130023 Jilin Peoples R China

In this paper, we construct the real-valued periodic orthogonal wavelets. The method presented here is new. The decomposition and reconstruction formulas involve only 4 terms respectively. It demonstrates that the formulas are simpler than that in other kinds of periodic wavelets. Our wavelets are useful in applications since it is real valued. The relation between the periodic wavelets and the Fourier series is also discussed.

关键词： periodic wavelet multiresolution Fourier series linear independence

Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication

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World Journal of Gastroenterology 2000年第1期6卷 134-135页

作者： Kong XB Yang ZK liang LJ Huang JF Lin hl Department of Surgery The First Affiliated HospitalChongqing University of Medical SciencesChongqing 400016China Division of Hepatobiliary Surgery The First Affiliated HospitalSun Yat-Sen University of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Departrnent of Pathology Sun Yat-Sen University of Medical SciencesGuangzhou 510089Guangdong ProvinceChina

INTRODUCTIONMost advanced hepatocellular garcinoma (HCC) isinsensitive to most anticancer drugs which might berelated to the high frequency of expression of themultidrug resistance-1(MDR1) gene and itsproduct,P-glycop... 详细信息

关键词： Subject headings liver neoplasms carcinoma hepatocellular P-glycoprotein multidrug resistance-1 gene immunohistochemistry

Convergent Usage of Amino Acids in Human Cancers as A Reversed Process of Tissue Development

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 147-162页

作者： Yikai Luo Han liang Graduate Program in Quantitative and Computational Biosciences Baylor College of MedicineHoustonTX 77030USA Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Systems Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Genome-and transcriptome-wide amino acid usage preference across different species is a well-studied phenomenon in molecular evolution,but its characteristics and implication in cancer evolution and therapy remain largely ***,we analyzed large-scale transcriptome/proteome profiles,such as The Cancer Genome Atlas(TCGA),the Genotype-Tissue Expression(GTEx),and the Clinical Proteomic Tumor Analysis Consortium(CPTAC),and found that compared to normal tissues,different cancer types showed a convergent pattern toward using biosynthetically low-cost amino *** a pattern can be accurately captured by a single index based on the average biosynthetic energy cost of amino acids,termed energy cost per amino acid(ECPA).With this index,we further compared the trends of amino acid usage and the contributing genes in cancer and tissue development,and revealed their reversed ***,focusing on the liver,a tissue with a dramatic increase in ECPA during development,we found that ECPA represents a powerful biomarker that could distinguish liver tumors from normal liver samples consistently across 11 independent patient cohorts and outperforms any index based on single *** study reveals an important principle underlying cancer evolution and suggests the global amino acid usage as a system-level biomarker for cancer diagnosis.

关键词： Amino acid usage Tissue development Biosynthetic energy Diagnostic biomarker

湿地表层底泥溶解性有机质荧光组分特征及与真菌群落相关性

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光谱学与光谱分析 2025年第1期45卷 191-196页

作者：史传奇李艳孟令波胡钰金梁哈尔滨学院黑龙江省寒区湿地生态与环境研究重点实验室黑龙江哈尔滨150086 北京市农林科学院植物营养与资源环境研究所北京100097 东北农业大学资源与环境学院黑龙江哈尔滨150038

溶解性有机质(DOM)和微生物群落间具有紧密联系,DOM为微生物提供营养,微生物代谢可转化DOM,两者间相互作用共同影响着生态系统的物质循环与能量流动。采集北方寒区天然湿地(河流湿地,hl;湖泊湿地,HP)和人工湿地(水田,ST;鱼塘,YT)表层(0~... 详细信息

溶解性有机质(DOM)和微生物群落间具有紧密联系,DOM为微生物提供营养,微生物代谢可转化DOM,两者间相互作用共同影响着生态系统的物质循环与能量流动。采集北方寒区天然湿地(河流湿地,hl;湖泊湿地,HP)和人工湿地(水田,ST;鱼塘,YT)表层(0~15 cm)底泥样品,采用三维荧光光谱法和高通量测序技术,揭示不同类型湿地表层底泥DOM荧光光谱及真菌群落特征,并进一步分析其相关性。结果表明:表层底泥DOM荧光光谱共识别出4种荧光组分,包括类富里酸(C1)、类胡敏酸(C2)和类蛋白质(类色氨酸C3和类酪氨酸C4)。C1和C2成显著正相关,而与类蛋白质间相关性不显著。C1的相对浓度高于C2,C3和C4的相对浓度接近。YT中DOM浓度相对高于其余样品,hl和HP中C2和类蛋白质相对浓度具有显著差异,ST和YT中C1、C2和C3的相对浓度均具有显著差异。湿地表层底泥真菌群落优势门(除未分类类群)为子囊菌门(Ascomycota)、担子菌门(Basidiomycota)、罗兹菌门(Rozellomycota)。YT中真菌群落Chao1丰富度指数、Shannon多样性指数显著较低,而Simpson优势度指数显著较高,HP中Shannon多样性指数显著高于其余样品。C1、C2与真菌群落多样性显著相关,C2与真菌群落组成显著相关,而类蛋白质与真菌群落无显著相关性。C1、C2与子囊菌门均成显著正相关,C1与壶菌门(Chytridiomycota)和单毛壶菌门(Monoblepharomycota)成显著负相关,C2与担子菌门、罗兹菌门、壶菌门、单毛壶菌门均成显著负相关。因此,真菌群落对DOM相对大分子量荧光组分的相对浓度具有显著影响。针对北方寒区典型湿地表层底泥DOM荧光光谱特征及与真菌群落相关性进行分析,为湿地环境监测与评价提供基础数据,并为湿地合理利用提供理论参考。

关键词：三维荧光光谱溶解性有机质荧光组分真菌

The tri-band high spectral resolution spectrometer with gratings in tandem for the charge-exchange recombination spectroscopy diagnostic system on hl-2A tokamak

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Plasma Science and Technology 2024年第6期26卷 103-110页

作者：刘亮余德良马倩何小斐 Maarten DE BOCK Manfred von HELLERMANN Michael WALSH 陈文锦何小雪魏彦玲张能李栋魏会领 the hl-2A Team Southwestern Institute of Physics Chengdu 610041People’s Republic of China College of Physics and Optoelectronic Technology Baoji University of Arts and SciencesBaoji 721000People’s Republic of China ITER Organization Route de Vinon-sur-VerdonCS 90046St.Paul Lez Durance Cedex 13067France Fusion Spectroscopy Markgraf-Albrecht Str.14Berlin 10711Germany

Charge-exchange(CX) recombination spectroscopy is a powerful tool monitoring ion temperature and plasma rotation with good temporal and spatial resolutions. A compact, new design for a high-throughput, tri-band high spectral resolution spectrometer has been developed for the charge-exchange recombination spectroscopy measurement on the hl-2A tokamak. The simultaneous measurements of He II(468.57 nm), C VI(529.1 nm), and Dα(656.1 nm accompanied by beam emission spectra) with an acquisition frequency up to 400 Hz are achieved by vertically binning the spectrum from each fiber in experiments. Initial results indicate that the system can provide radial profiles of not only ion temperature and rotation velocity,but also concentration of carbon. For the case of helium, the measurements for the ion temperature and rotation velocity are straightforward but the apparent concentration associated with the observed CX intensity is obviously too high. Modeling of the active He II CX feature including plume contributions needs to be carried out to extract the true helium *** spectrometer could become a prototype for the ITER charge-exchange recombination spectroscopy diagnostic and the pilot experiments, as presented here, demonstrate the possibility of impurity concentrations measurements based on the combined measurement of local beam emission and charge-exchange recombination spectroscopy spectra.

关键词： CXRS ion temperature plasma rotation impurity concentration

Multi-scale interaction between tearing modes and micro-turbulence in the hl-2A plasmas

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Plasma Science and Technology 2020年第8期22卷 1-7页

作者： Min JIANG Yuhong XU Zhongbing SHI Wulyu ZHONG Wei CHEN Rui KE Jiquan LI Xuantong DING Jun CHENG Xiaoquan JI Zengchen YANG Peiwan SHI Jie WEN Kairui FANG Na WU Xiaoxue HE Anshu liang Yi LIU Qingwei YANG Min XU hl-2A Team Southwestern Institute of Physics Chengdu 610041People's Republic of China Institute of Fusion Science School of Physical Science and TechnologySouthwest Jiaotong UniversityChengdu 610031People's Republic of China School of Physics Dalian University of TechnologyDalian 116024People's Republic of China

The influence of m/n=2/1(m and n are poloidal and toroidal mode numbers)tearing modes on plasma perpendicular flows and micro-fluctuations has been investigated in hl-2A neutral beam injection heated L-mode *** is found that the local perpendicular rotation velocity and turbulence energy are modulated by the alternation between the island X-point and O-point of the naturally rotating tearing ***-correlation analysis indicates that the modulation of density fluctuations by the tearing mode is not only limited to the island region,but also occurs in the edge region near the last closed flux *** turbulence exhibits distinct spectral characteristics inside and outside the island *** addition,it is observed that the particle flux near the strike point is also significantly impacted by the tearing *** experimental evidence reveals that there are strong core-edge interactions between the core tearing modes and the edge transport.

关键词： tearing modes turbulence particle flux modulation core-edge interaction

Two-parameter estimation in a matter-wave Sagnac interferometer

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Communications in Theoretical Physics 2020年第9期72卷 39-48页

作者： Xu Yu Hong-Bin liang Xiao-Guang Wang Zhejiang Institute of Modem Physics Department of PhysicsZhejiang UniversityHangzhou 310027China Graduate School of China Academy of Engineering Physics Beijing 100193China

We explore the general characteristics of a matter-wave Sagnac interferometer in a two-parameter estimation scheme. We find that the measurement precisions of both parameters cannot reach the Heisenberg limit(hl) simultaneously when the input state is maximally entangled. Only one of the parameters' uncertainties can approach the hl while the other is scaled by the standard quantum *** provide the conditions with which the measurement precision of the specific parameter can reach the hl. We also discuss and figure out the concrete expressions of the constraint conditions for saturating the quantum Cramér–Rao bound. To satisfy these constraint conditions, the evolution time has to be a series of discrete values. Additionally, we calculate the variances of the parameters through some examples under these constraint conditions. The results provided in our work show some intrinsic features of the matter-wave Sagnac interferometer for the two-parameter estimation, which can be valuable in actual experiments.

关键词： multi-parameter estimation matter wave Sagnac interferometer Heisenberg limit