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Staged Revascularization for Chronic Total Occlusion in the Non-IRA in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention:An Updated Systematic Review and Meta-analysis

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Cardiovascular Innovations and Applications 2022年第2期6卷 209-218页

作者： Yu Geng Yintang Wang lianfeng liu Guobin Miao Ou Zhang Yajun Xue Ping Zhang Department of Cardiology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijingChina

Objectives:Meta-analysis was performed to evaluate the effect of staged revascularization with concomitant chronic total occlusion(CTO)in the non-infarct-associated artery(non-IRA)in patients with ST-segment elevation myocardial infarction(STEMI)treated with primary percutaneous coronary intervention(p-PCI).Methods:Various electronic databases were searched for studies published from inception to June,2021.The primary endpoint was all-cause death,and the secondary endpoint was a composite of major adverse cardiac events(MACEs).Odds ratios(ORs)were pooled with 95%conﬁdence intervals(CIs)for dichotomous data.Results:Seven studies involving 1540 participants were included in theﬁnal analysis.Pooled analyses revealed that patients with successful staged revascularization for CTO in non-IRA with STEMI treated with p-PCI had overall lower all-cause death compared with the occluded CTO group(OR,0.46;95%CI,0.23–0.95),cardiac death(OR,0.43;95%CI,0.20–0.91),MACEs(OR,0.47;95%CI,0.32–0.69)and heart failure(OR,0.57;95%CI,0.37–0.89)com-pared with the occluded CTO group.No signiﬁcant differences were observed between groups regarding myocardial infarction and repeated revascularization.Conclusions:Successful revascularization of CTO in the non-IRA was associated with better outcomes in patients with STEMI treated with p-PCI.

关键词： ST segment elevation myocardial infarction chronic total occlusion primary percutaneous coronary intervention

兰尼碱受体2基因突变与多种类型遗传性心律失常相关

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中国医学前沿杂志（电子版） 2024年第2期16卷 13-18页

作者：吕婷婷孟令丙李思源刘连丰张萍北京清华长庚医院心脏内科清华大学临床医学院北京102218

兰尼碱受体2(ryanodine receptor 2,RyR2)是心肌细胞肌质网上重要的钙离子释放通道,在介导心肌收缩和舒张中发挥关键作用。近年来,越来越多的研究报道,编码RyR2蛋白的RYR2基因突变可引发儿茶酚胺敏感性多形性室性心动过速、长QT综合征... 详细信息

兰尼碱受体2(ryanodine receptor 2,RyR2)是心肌细胞肌质网上重要的钙离子释放通道,在介导心肌收缩和舒张中发挥关键作用。近年来,越来越多的研究报道,编码RyR2蛋白的RYR2基因突变可引发儿茶酚胺敏感性多形性室性心动过速、长QT综合征、特发性心室颤动和心房颤动等多种类型遗传性心律失常。本文旨在综述RYR2基因突变导致的RyR2离子通道功能异常与多种类型遗传性心律失常的发生相关。全面认识RyR2相关的多种遗传性心律失常,将为临床诊疗遗传性心脏疾病开拓思路。

关键词：兰尼碱受体2 心律失常钙离子释放

先天性肺囊性腺瘤样畸形的影像特征及误诊分析

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临床误诊误治 2024年第8期37卷 10-14,19页

作者：焦振华刘连锋郭文文秦琛琛李天云咸阳市中心医院影像中心陕西咸阳712000 咸阳市中心医院病理科陕西咸阳712000 空军军医大学西京医院放射科西安710032

目的探讨先天性肺囊性腺瘤样畸形(CCAM)的影像特征,并分析误诊原因,总结防范误诊措施。方法回顾性分析2020年5月—2023年11月收治经手术和病理检查证实的CCAM 9例的临床资料。结果本组5例主要表现为间断性咳嗽、咳痰、痰中带血、发热及... 详细信息

目的探讨先天性肺囊性腺瘤样畸形(CCAM)的影像特征,并分析误诊原因,总结防范误诊措施。方法回顾性分析2020年5月—2023年11月收治经手术和病理检查证实的CCAM 9例的临床资料。结果本组5例主要表现为间断性咳嗽、咳痰、痰中带血、发热及气短等,3例为住院期间常规查体发现肺部异常,1例为常规体检发现肺部异常。术前首诊确诊2例,误诊7例。误诊为支气管源性肺囊肿3例,肺脓肿、囊性支气管扩张伴感染、肺隔离征和先天性大叶性肺气肿各1例。误诊时间8 d~2周。9例CT检查4例为大囊型,CT表现为占据胸腔的较大含气体或液体的囊腔,囊内见弯曲细线样分隔或气液平面;5例为小囊型,CT表现为局限于一侧肺叶多发薄壁小囊,部分呈蜂窝状改变,部分见短小气液平面。9例皆行单操作孔电视胸腔镜肺叶或肺段切除术,病理检查示4例大囊型为StockerⅠ型,5例小囊型为StockerⅡ型。9例出院后随访0.5~1.0年,均预后良好。结论CCAM因病理分型不同而影像学特征各异,虽易误诊,但仍具有一定影像学特征,确诊需病理学检查。

关键词：囊性腺瘤样畸形肺先天性体层摄影术,螺旋计算机病理检查误诊囊肿肺脓肿

Early Imaging Features and Differential Diagnosis of Novel Coronavirus Pneumonia

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Journal of Clinical and Nursing Research 2020年第5期4卷 35-38页

作者： Xiaofeng Jiang Xuyang Ma Tao Zhang Yanliang Kong Lei Cai Lin Lv Yanli Shao Jiangtao Bai lianfeng liu Department of Medical Imaging Xianyang Hospital of Yan'an UniversityXianyangChina Department of Medical Imaging Tongchuan People's HospitalTongchuanChina

Objective:To discuss the early imaging features of novel coronary pneumonia(NCP)and its differential diagnosis with common pneumonia for the clinical Provide relatively correct imaging diagnosis.Methods:A review of 10 cases of novel coronavirus pneumonia diagnosed in our hospital and surrounding counties was collected,and our hospital's 2019-2020 Common pneumonia such as influenza A and B virus pneumonia,lobar pneumonia and adenovirus confirmed by laboratory tests and abnormal chest radiographs Ten patients each with pneumonia,a total of 40 patients,were collected and their imaging features were analyzed.Results:In 10 patients with neo-coronary pneumonia,there were 30 lesions on chest CT,with typical characteristic lesions containing bronchograms within their Angiographic thickening;located in the subpleura,with grinding glass-like or combined solid changes,referred to as"extratubular halo",with multifocal and multifocal distribution.Morphology or unilobular large lamellar foci without lymph node enlargement and pleural effusion;10 cases of influenza A and B virus pneumonia in chest CT performance In nine patients,the lesions were distributed in the subpleural or along the perimeter of the bronchial vessels in the form of an analogous circular ground-glass shadow,some of which was a small piece of solid shadow,1 The case involved a single lobe of the lung and showed a large mixed ground glass image,and the CT in 10 cases of lobar pneumonia showed that they all had a single large solid lobe The variegated shadow or patchy cloud with blurred margins was triangularly altered with the tip pointing to the lung portal,and there were five cases of air-containing bronchograms.Adenoviral pneumonia is more common in infants and young children,and CT showed single or multiple grinded glass images in both lungs with patchy solid variegated shadows and lobar distribution.Conclusion:NCP and common pneumonia have certain imaging features that,in combination with laboratory tests and epidemiologic history,allow a preliminary dia

关键词： NCP Pneumonia Differential diagnosis Laboratory examination,CT features

卵巢癌患者DCE-MRI联合高b值DWI检查的表现分析

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国际医药卫生导报 2024年第10期30卷 1703-1707页

作者：唐敏丽张涛蔡雷刘连锋白江涛任召杨宁丽马旭阳唐海利延安大学咸阳医院CT/MRI室咸阳712000 中国人民解放军空军军医大学第二附属医院普通外科西安710038

目的分析卵巢癌患者磁共振动态增强(DCE-MRI)联合高b值弥散加权成像(DWI)检查的表现。方法回顾性分析延安大学咸阳医院在2020年6月至2023年6月收治的50例确诊为卵巢癌患者的临床资料,作为观察组,并选取同期体检健康者50例为对照组。对... 详细信息

目的分析卵巢癌患者磁共振动态增强(DCE-MRI)联合高b值弥散加权成像(DWI)检查的表现。方法回顾性分析延安大学咸阳医院在2020年6月至2023年6月收治的50例确诊为卵巢癌患者的临床资料,作为观察组,并选取同期体检健康者50例为对照组。对照组年龄(33.58±5.47)岁;观察组年龄(33.37±5.53)岁,国际妇产科联盟(FIGO)分期Ⅰ期8例、Ⅱ期25例、Ⅲ期12例、Ⅳ期5例。两组受试者均接受DCE-MRI及高b值DWI检查,比较两组受试者的DCE-MRI定量参数,包括容量转移常数(Ktrans)、速率常数(Kep)、血管外细胞外容积分数(Ve);观察并比较两组DWI表观弥散系数(ADC)情况;绘制受试者操作特征曲线(ROC),计算曲线下面积(AUC)评估DCE-MRI联合高b值DWI检查对卵巢癌患者的诊断效能。采用F检验。结果观察组Ktrans、Kep、Ve分别为(0.43±0.05)min、(0.85±0.13)min、(0.75±0.25),均高于对照组的(0.07±0.06)min、(0.27±0.12)min、(0.26±0.16),观察组ADC值为(0.93±0.13)×10^(-3) mm^(2)/s,低于对照组的(1.53±0.23)×10^(-3) mm^(2)/s,差异均有统计学意义(均P<0.05);Ⅳ期患者Ktrans、Kep、Ve高于Ⅲ期,Ⅲ期高于Ⅱ期,Ⅱ期高于Ⅰ期,Ⅳ期患者ADC值低于Ⅲ期,Ⅲ期低于Ⅱ期,Ⅱ期低于Ⅰ期,差异均有统计学意义(均P<0.05)。经ROC分析,DCE-MRI对卵巢癌不同分期的诊断灵敏度为85.35%,特异度为90.14%,高b值DWI对卵巢癌不同分期的诊断灵敏度为82.45%,特异度为87.14%,DCE-MRI联合高b值DWI对卵巢癌不同分期的诊断灵敏度为94.14%,特异度为95.85%。结论DCE-MRI联合高b值DWI检查应用于卵巢癌患者具有更高效能,显著优于单项检测;当b值为1600 s•mm^(-2)时,结合DCE-MRI对卵巢癌的临床分期诊断具有更高的灵敏度和特异度;作为临床无创诊断辅助手段,两种检查方式可互为补充,避免卵巢癌的误诊,对患者治疗和预后具有重要临床价值。

关键词：磁共振动态增强高b值弥散加权成像卵巢癌速率常数

Dietary sodium acetate and sodium butyrate attenuate intestinal damage and improve lipid metabolism in juvenile largemouth bass(Micropterus salmoides) fed a high carbohydrate diet by reducing endoplasmic reticulum stress

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Animal Nutrition 2024年第1期16卷 443-456页

作者： liulan Zhao Liangshun Cheng Yifang Hu Xiaohui Li Yihui Yang Jin Mu lianfeng Shen Guojun Hu Kuo He Haoxiao Yan Qiao liu Song Yang College of Animal Science and Technology Sichuan Agricultural University

High-carbohydrate(HC) diets decrease the intestinal levels of sodium acetate(SA) and sodium butyrate(SB) and impair the gut health of largemouth bass; however, SA and SB have been shown to enhance immunity and improve intestinal health in farmed animals. Thus, the present study was to investigate the effects of dietary SA and SB on HC diet-induced intestinal injury and the potential mechanisms in juvenile largemouth bass. The experiment set five isonitrogenous and isolipidic diets, including a lowcarbohydrate diet(9% starch)(LC), a high carbohydrate diet(18% starch)(HC), and the HC diet supplemented with 2 g/kg SA(HCSA), 2 g/kg SB(HCSB) or a combination of 1 g/kg SA and 1 g/kg SB(HCSASB).The feeding experiment was conducted for 8 weeks. A total of 525 juvenile largemouth bass with an initial body weight of 7.00 ± 0.20 g were used. The results showed that dietary SA and SB improved the weight gain rate and specific growth rate (P<0.05) and ameliorated serum parameters(alkaline phosphatase, acid phosphatase, glutamate transaminase, and glutamic oxaloacetic transaminase)(P<0.05). And, importantly, dietary SA and SB repaired the intestinal barrier by increasing the expression levels of zonula occludens-1, occludin, and claudin-7(P<0.05), reduced HC-induced intestinal damage, and alleviated intestinal inflammation and cell apoptosis by attenuating HC-induced intestinal endoplasmic reticulum stress(P<0.05). Further results revealed that dietary SA and SB reduced HC-induced intestinal fat deposition by inhibiting adipogenesis and promoting lipolysis(P<0.05). In summary, this study demonstrated that dietary SA and SB attenuated HC-induced intestinal damage and reduced excessive intestinal fat deposition in largemouth bass.

关键词： Sodium acetate Sodium butyrate High carbohydrate diet Endoplasmic reticulum stress Intestine health Lipid metabolism

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颗粒聚合体碰撞破损的细观力学仿真研究

力学进展 2006年第4期36卷 599-610页

作者：刘连峰中国地质大学工程技术学院北京100083

粉末和颗粒材料常常以聚合体(agglomerate,还可译成结块,聚团等)的形式存在．无论是自然环境中还是工业处理过程中,微小颗粒聚合体碰撞破损是一常见物理现象．近十几年来,对颗粒聚合体碰撞研究在试验和数值模拟方面均取得了很大的进展... 详细信息

粉末和颗粒材料常常以聚合体(agglomerate,还可译成结块,聚团等)的形式存在．无论是自然环境中还是工业处理过程中,微小颗粒聚合体碰撞破损是一常见物理现象．近十几年来,对颗粒聚合体碰撞研究在试验和数值模拟方面均取得了很大的进展．特别是利用颗粒离散元方法,结合经典接触力学理论,对微米颗粒聚合体碰撞破损的细观力学机理进行的研究,取得了很多重要成果．基本形成了较为完善的模拟分析方法,提出了许多新概念,形成了目前适于分析研究的专用分析程序．本文介绍了目前国际上颗粒聚合体碰撞破损模拟研究的一般方法和理论,总结了现有的主要研究内容及成果,并提出一些研究展望．

关键词：颗粒聚合体离散元法碰撞破损散体细观力学

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食品企业生产过程的智能化追溯技术实践

质量与认证 2022年第7期 68-70页

作者：周庆刘联峰钱青中检集团溯源技术服务有限公司

食品安全历来是关系民生的大事,食品生产安全又是食品安全保障的第一道关卡,如何帮助企业主体建立安全便捷的质量管理手段,如何帮助监管者及时掌握真实有效的一手信息,成为亟待解决的难题。本文从食品生产企业和监管者两者结合的需求点... 详细信息

食品安全历来是关系民生的大事,食品生产安全又是食品安全保障的第一道关卡,如何帮助企业主体建立安全便捷的质量管理手段,如何帮助监管者及时掌握真实有效的一手信息,成为亟待解决的难题。本文从食品生产企业和监管者两者结合的需求点出发,阐述如何通过信息化手段建立食品安全智能化追溯体系,形成覆盖生产全过程的追溯信息数据链,客观、有效、真实地记录和保存食品质量安全信息,实现食品质量安全顺向可追踪、逆向可溯源、风险可管控,发生质量安全问题时产品可召回、原因可查清、责任可追究,切实落实食品安全主体责任,保障食品安全;帮助市场监管部门丰富监管手段、延伸监管链条、加强事中监管、支撑数据分析。

关键词：生产企业生产过程智能化追溯技术

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技术创新能力成长研究进展、问题和未来展望

创新科技 2023年第5期23卷 18-24页

作者：刘连峰刘凤朝王元地大连理工大学科技质量管理办辽宁大连116024 大连理工大学经济管理学院辽宁大连116024 中国科学技术大学公共事务学院安徽合肥230026

当前,我国正处于从“制造大国”迈向“制造强国”的关键时期,技术创新能力是推动“制造强国”建设、实现经济高质量发展的最有力保障。为此,技术创新能力理论和实践受到了学者们的广泛关注,并成为未来研究的热点议题。采用文献分析法,... 详细信息

当前,我国正处于从“制造大国”迈向“制造强国”的关键时期,技术创新能力是推动“制造强国”建设、实现经济高质量发展的最有力保障。为此,技术创新能力理论和实践受到了学者们的广泛关注,并成为未来研究的热点议题。采用文献分析法,通过关键词检索在中国知网、Web of Science等数据库中获得国内外相关文献,进一步人工筛查出研究类的高质量学术论文,从企业、区域和国家3个层面对此进行回顾,梳理技术创新能力成长研究的进展,分析技术创新能力成长研究所面临的主要问题以及未来研究的方向。

关键词：技术创新能力成长研究问题展望