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Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao Zhang Jun-Zheng Wang li-Tao Yang Qian yue Ke-Jun Kang yuan-Jing li Hai-Peng An C.Greeshma Jian-Ping Chang yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-yuan Guo li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin li Jian-Min li Jin li Qian-yun li Ren-Ming-Jie li Xue-Qian li yu-Lan li Yi-Fan liang Bin liao Fong-Kay lin Shin-Ted lin Jia-Xuan liu Shu-Kui liu Yan-Dong liu yu liu yuan-yuan liu Zhong-Zhi liu Hao Ma yu-Cai Mao Qi-yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang li Wang Qing Wang yu-Feng Wang yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu yu-Cheng Wu Hao-Yang Xing Rui Xu Yin Xu Tao Xue yu-Lu Yan Nan Yi Chun-Xu yu Hai-Jun yu Jian-Feng yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-yu Zhang Kang-Kang zhao Ming-Gang zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-yun zhao Shao-lin Xiong Xiang-Yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-yuan liao Yan-Qiu Zhang yue Huang Lu li Xing Wen Fei Zhang Jing Duan Chen-Wei Wang Dong-li Shi Peng Zhang Qi-Bin Yi Chao-Yang li Yan-Bing Xu Xiao-Hua liang Ya-Qing liu Da-li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-yu Wang Sheng Yang Xiao-Jing liu Min Gao Mao-Shun li Jin-Zhou Wang Xing Zhou Yi zhao Wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo li Ping Wang Xin-Ying Song li-Ming Song Shi-Jie Zheng Bing li Hong-Mei Zhang yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-yu Wang Zong-yuan Yang Zhi-Long Wen Zhi Chang yuan-yuan Du Rui Gao Xiao-Fei Lan Yan-Guo li Gang li Xu-Fang li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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舒洛地特失活YAP减轻大鼠动静脉瘘新生内膜增生

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陆军军医大学学报 2024年第12期46卷 1403-1409页

作者：李雅馨李冰玉林鑫刘烜代承麟赵渝傅麒宁王韵重庆医科大学附属第一医院血管外科重庆400016 陆军军医大学(第三军医大学)基础医学院细胞生物学教研室重庆400038

目的研究舒洛地特(sulodexide,SDX)对慢性肾脏疾病(chronic kidney disease,CKD)大鼠动静脉瘘(arteriovenous fistula,AVF)新生内膜增生的作用及调节机制。方法选取体质量(300±50)g雄性大鼠18只,随机分为3组(n=6):AVF组,对正常大鼠进行AVF手术;慢性肾病组(CKD+AVF),大鼠经诱导慢性肾病后进行AVF手术+生理盐水灌胃2月;舒洛地特组(CKD+AVF+SDX),大鼠经诱导慢性肾病后进行AVF手术+8 mg/(kg·d)SDX灌胃2月。HE染色检测血管内膜增生程度,免疫荧光检测Hippo信号通路相关分子YAP、pYAP、YAP下游靶蛋白间充质细胞标志分子(connective tissue growth factor,CTGF)表达情况。以不同浓度SDX(0、2.5、5、10、20、40μg/mL)处理人脐静脉细胞融合细胞(EAHy926),并以2.5μg/mL SDX分别处理细胞24、48、72 h,用CCK-8法检测细胞存活率。进一步利用CKD大鼠血清处理细胞,并在此基础上用SDX及YAP阻断剂维替泊芬处理,通过Western blot实验检测YAP、pYAP、CTGF及内皮细胞标志分子CD31表达。结果HE染色及免疫荧光结果表明,与AVF组大鼠相比,慢性肾病组大鼠瘘口处内膜严重增生(P<0.05),pYAP表达微弱而CTGF表达增强,舒洛地特组经SDX灌胃处理后内膜增生减轻,pYAP表达增强,CTGF表达水平降低(P<0.05)。CCK-8结果表明,随SDX浓度及处理时间的增加,细胞存活率降低(P<0.05)。Western blot结果发现,SDX促进EAHy926细胞pYAP及CD31的表达,抑制了CTGF的表达(P<0.05),与维替泊芬处理效果一致。结论舒洛地特通过阻止CKD引起的YAP激活,减轻了AVF血管内膜增生。

关键词：动静脉瘘新生内膜增生舒洛地特 YAP 内皮间质化

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青少年主动健康行为量表的编制及信效度检验

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现代预防医学 2024年第19期51卷 3529-3534页

作者：樊可馨路致远李素云于连龙胡添刘琳周云平青岛大学护理学院山东省疾病预防控制中心

目的编制青少年主动健康行为量表并评价其信效度，为研究青少年主动健康行为及相关因素提供工具。方法根据量表编制流程，结合已有的青少年健康生活方式量表，采用文献回顾、半结构式访谈及德尔菲专家函询等方法形成初始版量表。选取3... 详细信息

目的编制青少年主动健康行为量表并评价其信效度，为研究青少年主动健康行为及相关因素提供工具。方法根据量表编制流程，结合已有的青少年健康生活方式量表，采用文献回顾、半结构式访谈及德尔菲专家函询等方法形成初始版量表。选取38例青少年进行预调查，根据学生反馈进一步修订量表。采用分层整群抽样法，对青少年进行两轮正式调查并检验量表信效度。结果两轮调查分别选取1 096和1 636例12～18岁青少年，最终形成的青少年主动健康行为量表包括24个条目，探索性因子分析提取5个公因子(健康责任、体育活动、营养膳食、精神心理及节制自律)，累积方差贡献率为67.157%。验证性因子分析提示模型拟合良好(Tli=0.894,CFI=0.907,GFI=0.873,NFI=0.898,IFI=0.907,RMSEA=0.076)。条目水平的内容效度指数为0.833～1.000，量表水平的内容效度指数为0.986，总量表Cronbach α系数为0.946，折半信度为0.847。结论青少年主动健康行为量表包括健康责任、体育活动、营养膳食、精神心理和节制自律维度，信效度良好，可用来测量我国青少年人群的主动健康行为。

关键词：青少年主动健康行为量表信度效度

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STUDIES ON THE PRENYLFLAVONOIDS PART Ⅳ^([1]). SYNTHESIS OF(±)LESPEDEZAFLAVANONEE

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Chinese Chemical Letters 1993年第5期4卷 393-394页

作者： Fang Jie ZHANG lian yun zhao yu lin li State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhon 730000

(±)Lespedezaflavanone E, 6, 8, 3'-tri (γ,γ-dimethylallyl)-5, 7, 2', 4'-tetrahydroxy-flavanone, has been synthesized by the condensation of 3, 5-di (γ,γ-dimethylallyl)-4, 6-dimethoxymethoxy-2-hydroxyacetophenone a... 详细信息

关键词： ppm OH LESPEDEZAFLAVANONEE STUDIES ON THE PRENYLFLAVONOIDS PART SYNTHESIS OF

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内侧杏仁核的神经调节素1信号通路调控青春期社会隔离导致的自闭样行为

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Science Bulletin 2024年第10期69卷 1375-1379页

作者：林连虹吴倩云曾恺陈梓瑜王梓萍李伟民张斌高天明刘吉红 Department of Psychiatry Institute of Brain DiseaseNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Southern Medical UniversityGuangzhou 510515China

Autistic spectrum disorder(ASD),characterized by impairments in social interaction and repetitive behaviors,is a complex neurodevelopmental brain disorder that is reportedly increasing in prevalence globally[1].It is ... 详细信息

关键词：社会隔离 impairment prevalence

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Modification effect of Yb and Na_3PO_4 on microstructure of Mg_2Si/Mg-4Si alloy and mechanism

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China Foundry 2015年第6期12卷 440-445页

作者： Xiao-lin Wei Zheng lian Huai-zhi zhao Lu li Wen-bin yu Faculty of Materials and Energy Southwest University

The modification effects of ytterbium(Yb), Na_3PO_4 and Yb + Na_3PO_4 on primary Mg_2Si phase in Mg-4Si alloys were investigated by means of X-ray diffraction(XRD), optical microscopy(OM), scanning electron microscopy(SEM) and energy dispersive spectroscopy(EDS) analysis in this work. The results indicate that the morphology of the primary Mg_2Si phase apparently changes from coarse dendrites to fine dispersive polygonal particles and the mean size decreases from 276.6 μm to 7.1 μm, with combined modification of 0.8wt.% Yb and 2.64 wt.% Na_3PO_4. Such a morphological evolution results in improvement in the ultimate tensile strength and elongation of the alloys as compared to the base alloy. This may be attributed to the formation of the YbP particles that acted as the heterogeneous nucleation substrates for the primary Mg_2Si particles, resulting in a refined distribution of these precipitates. The results of XRD examination show that there was no reaction between Si and Yb or Na_3PO_4. Solo addition of Yb or Na_3PO_4 into the melt has no real modification effect on the microstructure, but the primary Mg_2Si particles and α-Mg phases become coarser than that in the unmodified alloy.

关键词： Mg alloy Yb Na3PO4 modification Mg2Si particles

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MgCO_(3)分子的解离产物合成MgAl_(2)O_(4)分子

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原子与分子物理学报 2024年第5期41卷 22-28页

作者：崔金玉任海林赵帅程佥千蒋倩云王丽王飞营口理工学院基础教研部营口115014 大连工业大学大连116034

本研究碳酸镁MgCO_(3)分子的解离过程及其解离产物与三氧化二铝Al_(2) O_(3)合成MgAl_(2)O_(4)的微观过程.利用Gaussian 09软件采用CCSD(T)6-311++G(d,p)和M06-2x/6-311++G(d,p)方法分别计算反应物碳酸镁MgCO_(3)分子单点能和频率,并计算反应物受热分解的过程,寻找解离的过渡态.并通过高温烧结法,在实验室用MgCO_(3)和Al_(2) O_(3)粉末为原料,1450℃合成铝酸镁MgAl_(2)O_(4),通过X-ray diffraction即XRD测试表征实验产物与理论计算是一致的.

关键词：碳酸镁MgCO_(3) 三氧化二铝Al_(2)O_(3) 铝酸镁MgAl_(2)O_(4) 解离过渡态

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基于止血药效的地榆炒炭工艺及质量标志物研究

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中国中药杂志 2024年第10期49卷 2710-2721页

作者：程旭希周子云胡庆莲吴洪丹戚树扬李欣欣宋金云赵宏宇王裔惟童黄锦曹晖毛春芹陆兔林顾薇南京中医药大学药学院江苏南京210023 南京中医药大学江苏省中医外用药开发与应用工程研究中心江苏南京210023 南京中医药大学附属南京医院(南京市第二医院)临床科研中心江苏南京210023 南京中医药大学附属中西医结合医院药学部江苏南京210009 暨南大学药学院江苏南京210028 江苏省中药炮制重点实验室广东广州510632

地榆经炒炭后止血活性显著增强被广泛报道与应用,而药典中规定的指标性成分鞣质与没食子酸经炒炭后含量下降,这与止血效应增强相矛盾。由此,该研究根据止血药效优化地榆炒炭工艺,并全面解析地榆及其不同程度炮制品的成分,由此探寻止血... 详细信息

地榆经炒炭后止血活性显著增强被广泛报道与应用,而药典中规定的指标性成分鞣质与没食子酸经炒炭后含量下降,这与止血效应增强相矛盾。由此,该研究根据止血药效优化地榆炒炭工艺,并全面解析地榆及其不同程度炮制品的成分,由此探寻止血物质基础。结果表明,250℃炒制14 min的炮制品符合药典对炭药的性状描述,该炮制品展现出显著优于生地榆的快速凝血与血液吸附能力(P<0.05)。在大鼠断尾、肝脏出血、肌肉创伤模型中都能显著缩短出血时间,显著优于生品、炒炭过度品及氨甲环酸(P<0.05)。鞣花鞣质、鞣花酸、没食子酸甲酯、焦没食子酸、原儿茶酸、镁(Mg)、钙(Ca)、锰(Mn)、铜(Cu)、锌(Zn)等物质的含量与止血效应呈强或极强正相关,或为地榆炭止血的物质基础,其中鞣花鞣质、鞣花酸、Mg、Ca含量高,在14 min地榆炭中分别达(106.73±14.87)、(34.86±4.43)、(2.81±0.23)、(1.21±0.23) mg·g^(-1)。最后,地榆炮制品与生地榆的粉末色差值(ΔE^(*)ab)与上述止血物质的含量呈强或极强正相关。综上,根据止血药效优化地榆炒炭工艺:250℃炒制14 min止血效果最佳;提出增设鞣花酸和/或饮片粉末色度值为地榆炭炮制工艺指标与质量控制指标。

关键词：地榆地榆炭止血药效物质炮制工艺质量标志物

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Regulation of IL12B Expression in Human Macrophages by TALEN-mediated Epigenome Editing

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Current Medical Science 2020年第5期40卷 900-909页

作者： Meng CHEN Hua ZHU yu-juan MAO Nan CAO Ya-li yu lian-yun li Qiu zhao Min WU Mei YE Deparment of Gastroenterology Zhongnan HospitalWuhan UniversityWuhan 430071China Hubei Clinical Center and Key Lab of Intestinal and Colorectal Diseases Wuhan 430071China College of life Sciences Wuhan UniversityWuhan 430072China

Although the exact etiology of inflammatory bowel disease(IBD)remains unclear,exaggerated immune response in genetically predisposed individuals has been ***1 and Th17 cells mediate IBD *** produce IL-12 and IL-23 that share p40 subunit encoded by IL12B gene as heteromer partner to drive Th1 and Th17 *** available animal and human data strongly support the pathogenic role of IL-12/IL-23 in IBD development and suggest that blocking p40 might be the potential strategy for IBD ***,aberrant alteration of some cytokines expression via epigenetic mechanisms is involved in pathogenesis o f *** this study,we analyzed core promoter region of IL12B gene and investigated whether IL12B expression could be regulated through targeted epigenetic modification with gene editing *** activator-like effectors(TALEs)are widely used in the field of genome editing and can specifically target DNA sequence in the host *** synthesized the TALE DNA-binding domains that target the promoter of human IL12B gene and fused it with the functional catalytic domains of epigenetic *** expression of these engineered enzymes demonstrated that the TALE-DNMT3A targeted the selected IL12B promoter region,induced loci-specific DNA methylation,and down-regulated IL-12B expression in various human cell ***,our data suggested that epigenetic editing of IL12B through methylating DNA on its promoter might be developed as a potential therapeutic strategy for IBD treatment.

关键词： transcription activator-like effectors epigenome editing DNA methylation cytokine IL12B inflammatory bowel disease

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