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mLife 2024年第1期3卷 143-155页

作者： Jing Zhang Qi-Yun liang Da-Shuai Mu Fengbai lian Ya Gong Mengqi ye Guan-Jun Chen Yuqi ye Zong-Jun Du State Key Laboratory of Microbial Techlogy Insttute of Micrbial TchnoogyShandong UniversityQingdaoChina Marine College Shandong UniverstyWeihaiChina Shandong University-Weihai Research Institute of Industrial Technology WeihaiChina

In the classical microbial isolation technique,the isolation process inevitably destroys all microbial interactions and thus makes it difficult to culture the many microorganisms that rely on these interactions for survival.In this study,we designed a simple coculture technique named the“sandwich agar plate method,”which maintains microbial interactions throughout the isolation and pure culture processes.The total yield of uncultured species in sandwich agar plates based on eight helper strains was almost 10-fold that of the control group.Many uncultured species displayed commensal lifestyles.Further study found that heme was the growth-promoting factor of some marine commensal bacteria.Subsequent genomic analysis revealed that heme auxotrophies were common in various biotopes and prevalent in many uncultured microbial taxa.Moreover,our study supported that the survival strategies of heme auxotrophy in different habitats varied considerably.These findings highlight that cocultivation based on the“sandwich agar plate method”could be developed and used to isolate more uncultured bacteria.

关键词： cultivation growth factors heme sandwich agar plate uncultured bacteria

Revisiting thermal comfort and thermal sensation

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Building Simulation 2024年第2期17卷 185-188页

作者： Zhiwei lian Department of Architecture Shanghai Jiao Tong UniversityShanghai200240China

The thermal environment is closely intertwined with comfort,health,efficiency,and building energy consumption.Thermal Comfort stands as a crucial concept for evaluating the thermal environment,yet the prevailing evaluation metric is Thermal Sensation.The correspondence between genuine Thermal Comfort and Thermal Sensation is influenced by a variety of environmental factors.

关键词： thermal Comfort prevailing

Exploring non-curative endoscopic submucosal dissection:Current treatment optimization and future indication expansion

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World Journal of Gastroenterology 2024年第9期30卷 1257-1260页

作者： Yi-Nong Zhu Xiang-Lei Yuan Wei Liu Yu-Hang Zhang Yi Mou Bing Hu lian-Song ye Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

The increasing popularity of endoscopic submucosal dissection(ESD)as a treatment for early gastric cancer has highlighted the importance of quality assessment in achieving curative resections.This article emphasizes the significance of evaluating ESD quality,not only for curative cases but also for non-curative ones.Postoperative assessment relies on the endoscopic curability(eCura)classification,but management strategies for eCuraC-1 tumour with a positive horizontal margin are unclear.Current research primarily focuses on comparing additional surgical procedures in high-risk patients,while studies specifically targeting eCuraC-1 patients are limited.Exploring management strategies and follow-up outcomes for such cases could provide valuable insights.Furthermore,the application of molecular imaging using near-infrared fluorescent tracers holds promise for precise tumour diagnosis and navigation,potentially impacting the management of early-stage gastric cancer patients.Advancing research in these areas is essential for improving the overall efficacy of endoscopic techniques and refining treatment indications.

关键词： Early gastric cancer Endoscopic submucosal dissection Quality control Noncurative endoscopic submucosal dissection Near-infrared fluorescent tracer

Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex,mesocortex,and cerebellum

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Genes & Diseases 2024年第1期11卷 53-56页

作者： ye Cheng Lei Zhang Xiaolong Wu Hiroaki Wakimoto Haoming Geng Yukui Wei Geng Xu Xinru Xiao Jie Bai Yaming Wang Zeliang Hu Leiming Wang Qingtang lian Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Brain Tumor Research Center Massachusetts General HospitalDepartment of NeurosurgeryHarvard Medical SchoolBostonMA02134USA Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Gliomas originating from anatomically and developmentally distinct brain regions have different clinical outcomes.However,the molecular landscape underlying this difference remains largelyunknown.We analyzed key molecular mutations via sequencing and correlated them with clinical characteristics in 180 adult patients with gliomas originating from the neocortex,mesocortex,and cerebellum.Cases of cerebellar origin had significantly longer survival than those of supratentorial origin,consistent with higher rates of mutation in key genes associated with supratentorial gliomas.

关键词： clinical cortex glioma

Review on biomass metallurgy:Pretreatment technology,metallurgical mechanism and process design

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International Journal of Minerals,Metallurgy and Materials 2022年第6期29卷 1133-1149页

作者： Jianliang Zhang Hongyuan Fu Yanxiang Liu Han Dang lian ye Alberto N.Conejio Runsheng Xu School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China MCC Capital Engineering&Research Incorporation Limited Beijing 100176China

The metallurgy industry consumes a considerable amount of coal and fossil fuels,and its carbon dioxide emissions are increasing every year.Replacing coal with renewable,carbon-neutral biomass for metallurgical production is of great significance in reducing global carbon consumption.This study describes the current state of research in biomass metallurgy in recent years and analyzes the concept and scientific principles of biomass metallurgy.The fundamentals of biomass pretreatment technology and biomass metallurgy technology were discussed,and the industrial application framework of biomass metallurgy was proposed.Furthermore,the economic and social advantages of biomass metallurgy were analyzed to serve as a reference for the advancement of fundamental theory and industrial application of biomass metallurgy.

关键词： biomass pretreatment technology blast furnace ironmaking direct reduction new process design benefit assessment

Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution:Prospective single-centre trial

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World Journal of Gastrointestinal Endoscopy 2024年第5期16卷 259-272页

作者： Yuan Gao lian-Song ye Xu Li Bin Yu Ke Liao Jia Xie Jiang Du Qiong-Ying Zhang Bing Hu Department of Gastroenterology and Hepatology Digestive Endoscopy Medical Engineering Research LaboratoryWest China HospitalMed-X Center for MaterialsSichuan UniversityChengdu 610041Sichuan ProvinceChina Design Measurement and Evaluation(CBDME)Department of Clinical Research ManagementWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Institute for Disaster Management and Reconstruction Sichuan University-The Hong Kong Polytechnic UniversityChengdu 610065Sichuan ProvinceChina West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610044Sichuan ProvinceChina Precision Medicine Research Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Esophageal chromoendoscopy with iodine solution is important for detecting early esophageal cancer.The effect of routine treatment for lesions lightly stained with Lugol’s iodine solution is limited,and the addition of natural substances to a regular diet is becoming increasingly common.Vinegar has antitumor effects as reported in previous studies.AIM To evaluate whether vinegar supplementation could improve the prognosis of patients with lightly stained esophageal lesions.METHODSThis prospective single-centre trial included consecutive patients with lightly stained lesions between June 2020 and April 2022.Patients in the experimental group received increased amounts of vinegar for 6 months.The primary outcome of the study was the clinical therapeutic effect.Complications related to vinegar ingestion and adverse events were also recorded in detail.RESULTS A total of 166 patients were included in the final analysis.There was no significant difference in the baseline data between the two groups.Intention-to-treat(ITT)analysis demonstrated that the rates at which endoscopic characteristics improved were 33.72%in the experimental group and 20.00%in the conventional group(P=0.007);and the rates at which biopsy pathology improved were 19.77%and 8.75%,respectively(P=0.011).Additional vinegar consumption had a statistically protective effect on the rate at which endoscopic characteristics improved[hazard ratio(HR)_(ITT)=2.183,95%CI:1.183-4.028;HR_(per-protocol(PP))=2.307,95%CI:1.202-4.426]and biopsy pathology improved(HR_(ITT)=2.931,95%CI:1.212-7.089;HR_(PP)=3.320,95%CI:1.295-8.507).No statistically significant effect of increased vinegar consumption on preventing high-grade intraepithelial neoplasia or early cancer was observed(HR_(ITT)=0.382,95%CI:0.079-1.846;HRPP=0.382,95%CI:0.079-1.846).The subgroup analyses indicated that the overall therapeutic improvement of endoscopic characteristics and biopsy pathology seemed more obvious in older(age>60)male patients with small lesions(lesion size≤0.5 cm).Three pati

关键词： Chromoendoscopy Esophageal squamous epithelium Vinegar Atypical hyperplasia Prognosis

Micro/nano flow chemistry by Beyond Limits Manufacturing

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Chinese Chemical Letters 2024年第5期35卷 3-12页

作者： Peiwen Liu Fang Zhao Jing Zhang Yunpeng Bai Jinxing ye Bo Bao Xinggui Zhou Li Zhang Changlu Zhou Xinhai Yu Peng Zuo Jianye Xia lian Cen Yangyang Yang Guoyue Shi Lin Xu Weiping Zhu Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for BiomanufacturingEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

In September 2018,we proposed the cutting-edge concept of“Beyond Limits Manufacturing”(BLM).BLM technology is based on the three-dimensional inner engraving or precise outer engraving of ultra-fast laser,to invent micro/nano scale flow chips or devices,which makes it possible for the microform,integration,economy,safety,high efficiency,green and intelligence of research,development and manufacturing process,so as to realize transformational manufacturing in the era of Industry 4.0.In this paper,we reviewed the representative results we made in the field of micro/nano flow chemistry during the implementation of the BLM major project(December 2019 to August 2023),and discussed its application prospects in micro/nano flow chemistry.

关键词： Beyond Limits Manufacturing Flow chemistry Pharmaceutical manufacturing Microreactor

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注意力机制下的多层次特征融合图像去雾算法

福州大学学报（自然科学版） 2024年第1期52卷 7-13页

作者：连文杰叶少珍福州大学计算机与大数据学院福建福州350108 福州大学智能制造仿真研究院福建福州350108

提出一种基于注意力机制的多层次特征融合的图像去雾算法.该算法通过残差密集网络和自校准卷积网络来提取不同尺度的特征,再利用双重注意单元和像素注意力将特征融合重建.同时采用一种由均方误差损失、边缘损失和鲁棒性损失函数相结合... 详细信息

提出一种基于注意力机制的多层次特征融合的图像去雾算法.该算法通过残差密集网络和自校准卷积网络来提取不同尺度的特征,再利用双重注意单元和像素注意力将特征融合重建.同时采用一种由均方误差损失、边缘损失和鲁棒性损失函数相结合的损失函数,可以更好地保留细节特征.实验表明,该算法与其他去雾算法相比在峰值信噪比和结构相似度指标上得到一定的提高,去雾图像在主观视觉上取得了较好表现.

关键词：图像去雾注意力机制多层次特征融合

Feasibility analysis of a single-sensor-based approach for source identification of hazardous chemical releases

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1642-1650页

作者： Zengqiang Chen lian ye Bo Dai Fang Wang College of Information Engineering Beijing Institute of Petrochemical TechnologyBeijing 102617China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Office of Academic Affairs Beijing Institute of Petrochemical TechnologyBeijing 102617China

Source identification is critical for emergency responses to hazardous chemical releases,especially sudden releases of toxic gases.The timely arrangement of multiple sensors at the scene of a sudden accident is difficult.To overcome this limitation,a two-step source identification method based on a single sensor was developed.In the first step,the measured concentration was transmitted to the computing platform.First,a preliminary estimation of the release source was calculated from recently detected concentrations.Then,the preliminary result was used to predict the concentrations and to assess whether more measurements were needed.This data processing was conducted by the computing platform.In the second step,a new objective monitoring point was transmitted to the detector for the measurement of additional concentrations.These two steps were conducted repeatedly until the estimation adequately represented the release source.The fixed and mobile single sensor results were analyzed,and a comparison to multi-sensor results was also conducted.The results show that single-sensor source identification is attainable with a sufficient number of observations,and the number of valid concentration observations is required to be no less than the number of unknown parameters.To best estimate the release source,the movement strategy of the single sensor was based on the possible release source and the hazard partition of the gas plume.It is highly recommended that the single-sensor source identification method be used in unexpected incidents due to its flexibility and timely response.

关键词： Safety analysis Emergency response Inverse problems Optimization Dispersion model

基于自适应上下文匹配网络的小样本知识图谱补全

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计算机科学 2024年第5期51卷 223-231页

作者：杨旭华张炼叶蕾浙江工业大学计算机科学与技术学院杭州310023

知识图谱在构建过程中需要面对繁杂的现实世界信息,无法建模所有知识,因此需要补全。真实的知识图谱中很多类型的关系通常只有少量的训练实体样本对。因此,如何进行小样本知识图谱补全是一个十分有价值的问题。目前基于嵌入的方法一般... 详细信息

知识图谱在构建过程中需要面对繁杂的现实世界信息,无法建模所有知识,因此需要补全。真实的知识图谱中很多类型的关系通常只有少量的训练实体样本对。因此,如何进行小样本知识图谱补全是一个十分有价值的问题。目前基于嵌入的方法一般通过注意力机制等方法聚合实体上下文信息,通过学习关系嵌入的方式来补全知识图谱,仅考虑关系层面的匹配程度,虽然能够预测未知关系,但往往准确度不高。针对小样本知识图谱补全问题,提出了一个自适应上下文匹配网络(Adaptive Context Matching Network,ACMN)。首先提出一个共性邻居感知编码器,聚合参考集实体上下文,即一跳邻居实体,获得共性邻居感知编码;接着提出一个任务相关实体编码器,挖掘任务实体上下文与共性上下文的相似度信息,区分一跳邻居对当前任务的贡献,增强实体表征;然后提出一个上下文关系编码器获得动态关系表征;最后通过加权求和综合考虑实体上下文和关系的匹配程度,完成补全。ACMN从实体上下文相似度和关系匹配程度两个方面综合评价查询三元组是否成立,能够在小样本的背景下有效提高预测准确性。在两个公共数据集上和其他8个广泛使用的算法进行比较,ACMN在不同规模的小样本情况下,取得了目前最好的补全结果。

关键词：知识图谱补全小样本学习实体上下文关系预测表示学习