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无机化学学报 2006年第12期22卷 2242-2246页

作者：糜裕宏张孝彬周胜名王杏花贺狄龙王俊莲浙江大学硅材料国家重点实验室杭州310027 浙江大学材料科学与工程系杭州310027

0引言纳米晶体合成时的形态可控仍然是现代材料化学的一个重要目标。与纳米颗粒相比．一维纳米材料（纳米棒或纳米线）由于其独特的性能及其在纳米器件上广泛的应用更为人们关注．由一维纳米材料组装的复杂纳米结构及其性能的研究已成... 详细信息

0引言纳米晶体合成时的形态可控仍然是现代材料化学的一个重要目标。与纳米颗粒相比．一维纳米材料（纳米棒或纳米线）由于其独特的性能及其在纳米器件上广泛的应用更为人们关注．由一维纳米材料组装的复杂纳米结构及其性能的研究已成为当前纳米材料研究的趋势。例如，分枝状MnS、CdSe、ZnO、CdTe、Au、CdS等纳米棒组成的复杂纳米结构的合成．不但为利用离散的一维纳米材料独特的光学和电学性能提供了可能，而且还发现了这种三维结构引起的新的现象。

关键词：羟基氧化锰多枝状物水热法单晶

土壤改良剂对灌溉咸水冬小麦光合和蒸腾的影响

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中国生态农业学报 2012年第5期20卷 542-549页

作者：张余良王正祥王艳廉晓娟贺宏达天津市农业科学院资源与环境研究所天津300192

在天津滨海地区高水位、黏重土壤利用田间小区试验研究调盐土壤改良对微咸水灌溉的冬小麦光合速率、蒸腾速率、气孔导度、叶绿素含量指数等生理指标的影响。结果表明,冬小麦播种前采用适当土壤改良能够提高冬小麦抽穗期、灌浆期的光合... 详细信息

在天津滨海地区高水位、黏重土壤利用田间小区试验研究调盐土壤改良对微咸水灌溉的冬小麦光合速率、蒸腾速率、气孔导度、叶绿素含量指数等生理指标的影响。结果表明,冬小麦播种前采用适当土壤改良能够提高冬小麦抽穗期、灌浆期的光合速率、叶绿素含量指数,降低气孔导度、蒸腾速率。冬前施用75kg.100m 2改良剂Ⅱ(风化褐煤40%+磷石膏40%+脱硫石膏20%)有利于提高冬小麦灌浆期的光合速率,有降低抽穗期、灌浆期小麦蒸腾速率的效果;小麦冬前施用45 kg.100m 2改良剂I(风化褐煤20%+磷石膏40%+脱硫石膏20%+沸石粉20%)对提高冬小麦抽穗期光合速率有利,同时也提高抽穗期小麦的蒸腾速率;土壤改良对咸水灌溉冬小麦的气孔导度有明显降低效应,冬前施用30 kg.100m 2改良剂Ⅲ(磷石膏40%+脱硫石膏20%+沸石粉40%)冬小麦气孔导度与不采用改良措施相比,抽穗期降低52.28%,灌浆期降低39.51%;冬前施用45kg.100m 2改良剂Ⅱ混合30 kg.100m 2改良剂Ⅲ或75 kg.100m 2改良剂Ⅱ均能够显著提高抽穗、灌浆期冬小麦的叶绿素含量指数;冬前施用45 kg.100m 2改良剂I混合30 kg.100m 2改良剂Ⅲ,即使较高土壤含盐量也能使冬小麦光合速率保持在较高水平,使冬小麦蒸腾速率受土壤含盐量影响较小。

关键词：滨海盐碱地冬小麦咸水灌溉土壤改良剂光合速率蒸腾速率气孔导度土壤含盐量

聚亚苯基乙烯衍生物中溶剂诱导的共轭聚合物高分子线团与可逆超分子凝胶

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高分子学报 2019年第12期50卷 1280-1289页

作者：张冬莲何矩新周学宏郑楠刘琳琳解增旗马於光发光材料与器件国家重点实验室华南理工大学材料科学与工程学院

通过引入与聚(2-(4-(3’,7’-二甲基辛氧基苯)-1,4-亚苯基乙烯)(P-PPV)主链亚苯基乙烯结构类似的R-limonene作为辅助溶剂,有效地实现聚合物链段的充分溶解和解缠结,并在此基础上成功制备了P-PPV的共轭高分子线团和可逆超分子凝胶.通过P-... 详细信息

通过引入与聚(2-(4-(3’,7’-二甲基辛氧基苯)-1,4-亚苯基乙烯)(P-PPV)主链亚苯基乙烯结构类似的R-limonene作为辅助溶剂,有效地实现聚合物链段的充分溶解和解缠结,并在此基础上成功制备了P-PPV的共轭高分子线团和可逆超分子凝胶.通过P-PPV的稀溶液旋涂薄膜的AFM图像,可以清晰地观察到纳米纤维形成的高分子线团及线团内部的精细结构. P-PPV在R-limonene的作用下,分子链从相互纠缠的状态发生解缠结作用,形成相互孤立的卷曲团,增强PLQY与荧光寿命.通过不同溶剂条件,得到了不同曲率的聚集体,对共轭高分子柔顺性有了进一步的认识.浓溶液下,P-PPV形成可逆的超分子凝胶,并具有良好的温度响应特性,凝胶生成区间在55~35℃.凝胶化的P-PPV是一种均匀的物理交联网络,使P-PPV的结构更为稳定,可以有效提升器件的稳定性、亮度和寿命.

关键词：凝胶共轭聚合物聚合物发光二极管链缠结

DD proton spectrum for diagnosing the areal density of imploded capsules on Shenguang Ⅲ prototype laser facility

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Chinese Physics B 2014年第7期23卷 536-540页

作者：滕建张天奎伍波蒲昱东洪伟单连强朱斌何卫华卢峰温贤伦周维民曹磊峰江少恩谷渝秋 Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterChina Academy of Engineering Physics

The primary DD proton spectrum is used for diagnosing the fuel-shell areal density pR of imploded capsules on Shenguang Ⅲ （SG-Ⅲ） prototype laser facility for the first time. A charged particle spectrometer （CPS） with a CR39 nuclear track detector is used to measure the DD proton spectrum. The proton spectrum is determined from both the proton track and its size. A typical proton energy peak shift from 3.02 MeV to 2.6 MeV is observed in our experiment, which yields a maximum pR larger than 6 mg/cm2.

关键词： DD proton spectrum charged particle spectrometer areal density implosion

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SDN中基于时延优化的多控制器部署方案

计算机工程与设计 2015年第5期36卷 1121-1125页

作者：张联镇黄传河曾毓珑张海贾永宏武汉大学计算机学院湖北武汉430072 华为技术有限公司广东深圳518129

针对SDN在广域网中部署时,单一集中式的控制器无法满足整个网络性能需求这一问题,提出一种多控制器部署方案。评估给定网络拓扑所需部署的控制器个数,使用聚类方法将控制器初步部署到网络中,向网络中输入动态数据流,根据蜂群算法思想,... 详细信息

针对SDN在广域网中部署时,单一集中式的控制器无法满足整个网络性能需求这一问题,提出一种多控制器部署方案。评估给定网络拓扑所需部署的控制器个数,使用聚类方法将控制器初步部署到网络中,向网络中输入动态数据流,根据蜂群算法思想,以最小化流表建立时间和控制器之间的同步时延开销为目标进一步优化控制器的部署。仿真结果表明,该方案在优化流表建立时间的同时,能够获得较小的控制器间同步时延开销。

关键词：软件定义网络广域网多控制器控制器部署蜂群算法

Observation effect of clinical ursodeoxycholic acid combined with holmium laser by laparoscopic choledochoscopy in the treatment of intrahepatic and intrahepatic bile duct stones

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Journal of Hainan Medical University 2020年第5期26卷 25-29页

作者： Yan-liang Wang lian-Chen Wang Sheng Chen hong-Wei Xiao Li-Ping Li yu Wang Zhan-Huan Cai Yan-Zhong zhang Danzhou people's Hospital General surgery 571700 The third people's Hospital of Hainan Province General surgery 572000

Objective: To investigate the effect of clinical ursodeoxycholic acid combined with holmium laser by laparoscopic choledochoscopy in the treatment of intrahepatic and intrahepatic bile duct stones. Methods: Patients with intrahepatic and intrahepatic bile duct stones treated by surgery in our hospital from October 2017 to December 2018 were randomly divided into control group and observation *** in the control group were treated with laparoscopic choledochoscopy combined with holmium laser lithotripsy, and patients of the observation group were treated with ursodeoxycholic acid on the basis of the control group. The clinical efficacy, total bile acid (TBA), phospholipid (PLIP), cholesterol (CHO) levels and the incidence of complications of liver function and bile related indicators were compared between the two groups after 3 and 6 months treatment. Results: After 3 months treatment, there were 22 cases of cured patients, 11 cases of markedly effective and 5 cases of effective patients in the observation group of, which he clinical curative effect was significantly better than that of control group (Phe liver function of patientsin the observation group was obviously better than that in the control group with the statistical significance difference (Phe symptoms such as the right upper quadrant pain, jaundice, chills, fever in the observation group was significantly improvedthan that of the control group. The incidence of complications including nausea and vomiting, fatiguewas 4.76%, significantly lower than that 19.05% in the control group (Phe control group. The difference was statistically significant (Phecl

关键词： Ursodeoxycholicacid Choledochoscope Holmiumlaser Bile duct stones Clinical observation

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1845-1855页

作者： Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng zhang Jian-Qi lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di zhang Mingru zhang Xiu-Xuan Sun Likun Ding Kui zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe zhang Zhao-Wei Gao hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen yu-Meng Zhu Li-Juan Wang Qian he Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue liang Fei Huo Zhe Wang Yang zhang Xu Yang Ye zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'anChina Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi'anChina Center for Infectious Diseases Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Nuclear Medicine Xijing HospitalFourth Military Medical UniversityXi'anChina department of Clinical Diagnosis Tangdu HospitalFourth Military Medical UniversityXKanChina College of Military Preventive Medicine Fourth Military Medical UniversityXi'anChina Department of Pharmaceutics Tangdu HospitalFourth Military Medical UniversityXi'anChina Department of Pathology Fourth Military Medical UniversityXi'anChina Jiangsu Pacific Meinuoke Biopharmaceutical Co.Ltd ChangzhouChina Department of Foreign Languages Fourth Military Medical UniversityXi'anChina

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 *** is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)***,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 *** phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was *** serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic *** obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each *** biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to *** the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent *** meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control *** results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.

关键词： patients dosage phase

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活性碳纤维吸附法脱蜡降浊点的研究

应用化工 2018年第12期47卷 2692-2695,2700页

作者：单晓宇张连红蒋林时何宇轩邱辉辽宁石油化工大学化学化工与环境学部辽宁抚顺113001 抚顺石化公司洗涤剂化工厂辽宁抚顺113001

探讨了活性碳纤维对润滑油基础油脱蜡降浊点的工艺,考察两种不同比表面积的活性碳纤维在不同温度和不同空速条件下对浊点降低效果的影响和穿透量。结果表明,空速1 h-1,温度50℃,比表面积1 800 m2/g的活性碳纤维浊点降低效果最好,下降的... 详细信息

探讨了活性碳纤维对润滑油基础油脱蜡降浊点的工艺,考察两种不同比表面积的活性碳纤维在不同温度和不同空速条件下对浊点降低效果的影响和穿透量。结果表明,空速1 h-1,温度50℃,比表面积1 800 m2/g的活性碳纤维浊点降低效果最好,下降的总温度可达10℃。当吸附的基础油体积达到脱蜡塔体积的23倍时,活性碳纤维被穿透。SEM、BET等分析结果表明,比表面积1 800 m2/g的活性碳纤维的孔容、孔径比1 000 m2/g的活性碳纤维大,其表面具有更多的活性位点,更有利于蜡烃组分的吸附。通过尿素络合法分析吸附前后基础油的烃类组成情况,正构烷烃的质量分数由20%下降至10%。气相色谱仪分析吸附前后正十二烷与异构十六烷含量的变化证明,活性碳纤维对正构烷烃具有选择性吸附。

关键词：活性碳纤维浊点吸附润滑油

不同乌天麻炮制品中天麻素、天麻苷元和天麻多糖的含量分析

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中国药学杂志 2017年第23期52卷 2062-2065页

作者：祝洪艳蒋然何忠梅赵岩郜玉钢包海鹰张连学吉林农业大学中药材学院长春130118 吉林省人参工程技术创新中心长春130118

目的评价乌天麻蒸制品、蒺藜制品、酒制品和姜制品等几种不同乌天麻炮制品的质量,优选乌天麻最佳炮制方法。方法采用高效液相色谱法同时检测天麻素和天麻苷元的含量,并采用苯酚-硫酸法检测天麻多糖的含量。结果乌天麻蒺藜制品中天麻素... 详细信息

目的评价乌天麻蒸制品、蒺藜制品、酒制品和姜制品等几种不同乌天麻炮制品的质量,优选乌天麻最佳炮制方法。方法采用高效液相色谱法同时检测天麻素和天麻苷元的含量,并采用苯酚-硫酸法检测天麻多糖的含量。结果乌天麻蒺藜制品中天麻素和天麻多糖含量最高,分别为1.90和3.25 mg·g^(-1);姜制品中天麻苷元含量最高为0.80 mg·g^(-1);两种酒制品中天麻素含量明显较其他炮制品低,且乌天麻酒浸三日炮制品中天麻多糖含量也明显低于其他。结论传统的蒺藜子制天麻炮制法优于现代蒸制法,该研究可为天麻的古法炮制机理提供科学依据。

关键词：乌天麻蒺藜子天麻素天麻苷元天麻多糖含量分析