Increased MCL-1 expression predicts poor prognosis and disease recurrence in acute myeloid leukemia
作者单位：Department of HematologyAffiliated People's Hospital of Jiangsu University The Key Lab of Precision Diagnosis and Treatment of Zhenjiang City School of MedicineJiangsu University Laboratory CenterAffiliated People's Hospital of Jiangsu University Department of HematologyThe Third People's Hospital of KunShan City
会议名称：《2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛》
会议日期：2017年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：BACKGROUND: Altered expression of the BCL-2 family member MCL-1 has been linked to the progression and outcome of various malignancies. However, MCL-1 expression pattern in acute myeloid leukemia(AML) and its impact on prognosis remain poorly defined. METHODS: Real-time quantitative PCR was carried out to detect the pattern of MCL-1 expression in AML patients. RESULTS: MCL-1 expression was significantly up-regulated in AML compared with controls(P=0.042). High MCL-1 expressed patients had a higher incidence of NPM1 mutation(P=0.030). Moreover, MCL-1 overexpression correlated with lower complete remission(CR) rate and shorter overall survival(OS) time. Meanwhile, Cox regression analyses revealed that overexpression of MCL-1 acted as an independent risk factor not only in non-APL patients but also in CN-AML patients(P=0.011 and P=0.045, respectively). Furthermore, gene expression profiling(GEP) data also confirmed the adverse prognostic impact of MCL-1 high-expression in CN-AML patients. In follow-up patients, MCL-1 expression level decreased after CR compared with newly diagnosis time(P=0.020) and increased after relapse(P=0.004). CONCLUSION: Our findings suggest that MCL-1 overexpression predicts poor prognosis and can be used for disease monitoring.