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Hepa.ic a.giotensin-converting enzyme 2 expression in meta.olic dysfunction-a.socia.ed stea.otic liver disea.e a.d in pa.ients with fa.a. COVID-19

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World j.urna. of Ga.troenterology 2024年第31期30卷 3705-3716页

作者： a.gus K j.0}obs Steven D Morley Ka. Sa.uel Ka.ie morgan Lyndsey Boswell Timothy j.Kenda.l Da.id a.Dorwa.d j.na.ha. a.Fa.lowfield Peter C Ha.es j.hn N Plevris Hepa.ology La.ora.ory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish Na.iona. Blood Tra.sfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regenera.ion a.d Repa.r University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pa.hology University of EdinburghEdinburgh EH164SBUnited Kingdom

Ba.KGROUND Meta.olic dysfunction-a.socia.ed stea.otic liver disea.e(Ma.LD),cha.a.terised by hepa.ic lipid a.cumula.ion,ca.ses infla.ma.ion a.d oxida.ive stress a.compa.ied by cell da.a.e a.d *** inj.ry(LI)is a.so frequently reported in pa.ients hospita.ised with corona.irus disea.e 2019(COVID-19),while preexisting Ma.LD increa.es the risk of LI a.d the development of COVID-19-a.socia.ed *** of inj.ry a. the cellula. level rema.n unclea.,but it ma. be significa.t tha. severe a.ute respira.ory syndrome corona.irus 2(Sa.S-CoV-2)which ca.ses COVID-19,uses a.giotensin-converting expression enzyme 2(a.E2),a.key regula.or of the‘a.ti-infla.ma.ory’a.m of the renin-a.giotensin system,for vira. a.ta.hment a.d host cell *** To determine if hepa.ic a.E2 levels a.e a.tered during progression of Ma.LD a.d in pa.ients who died with severe *** a.E2 protein levels a.d loca.isa.ion,a.d histologica. fibrosis a.d lipid droplet a.cumula.ion a. ma.kers of Ma.LD were determined in forma.in-fixed liver tissue sections a.ross the Ma.LD pa.hologica. spectrum(isola.ed hepa.ocellula. stea.osis,meta.olic dysfunction-a.socia.ed stea.ohepa.itis(Ma.H)+/-fibrosis,end-sta.e cirrhosis)a.d in post-mortem tissues from pa.ients who ha. died with severe COVID-19,using a.E2 immunohistochemistry a.d ha.ma.oxylin a.d eosin a.d picrosirius red sta.ning of tota. colla.en a.d lipid droplet a.ea.,followed by qua.tifica.ion using ma.hine lea.ning-ba.ed ima.e pixel *** a.E2 sta.ning is prima.ily intra.ellula. a.d concentra.ed in the cytopla.m of centrilobula. hepa.ocytes a.d a.ica. membra.es of bile duct ***,a.E2 protein levels a.e eleva.ed in non-fibrotic Ma.H compa.ed to hea.thy controls but not in the progression to Ma.H with fibrosis a.d in ***2 protein levels a.d histologica. fibrosis a.e not a.socia.ed,but a.E2 a.d liver lipid droplet content a.e significa.tly correla.ed a.ross the Ma.LD *** A

关键词： Meta.olic dysfunction-a.socia.ed stea.otic liver disea.e a.giotensin-converting enzyme 2 Immunohistochemistry COVID-19 COVID-19-a.socia.ed chola.giopa.hy

Outcomes of critica.ly ill children with pre-existing menta. hea.th conditions

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Pedia.ric Investiga.ion 2024年第2期8卷 108-116页

作者： Conra. Kra.iec morgan Ca.h Ga.y Ceneviva.Zizhong Tia. Shouha. Zhou Nea. j.Thoma. Depa.tment of Pedia.rics Pediatric Critical Care MedicinePenn State Hershey Children's HospitalPennsylvaniaUSA Depa.tment of Public Hea.th Sciences Division of Biostatistics and BioinformaticsPennsylvania State University College of MedicinePennsylvaniaUSA Depa.tment of Public Hea.th_Sciences Pennsylvania State University College of MedicinePennsylvaniaUSA

Importa.ce:Critica.ly ill children with pre-existing menta. hea.th conditions ma. ha.e a. increa.ed risk of poor hea.th ***:We a.med to eva.ua.e if pre-existing menta. hea.th conditions in critica.ly ill pedia.ric pa.ients would be a.socia.ed with worse clinica. outcomes,compa.ed to children with no documented menta. hea.th ***:This retrospective observa.iona. cohort study utilized the TriNetX electronic hea.th record da.a.a.e of critica.ly ill subj.cts a.ed 12-18 *** were a.a.yzed for demogra.hics,pre-existing conditions,dia.nostic,medica.ion,procedura. codes,a.d ***:From a.da.a.et of 102027 critica.ly ill children,we a.a.yzed 1999 subj.cts(284[14.2%]with a.pre-existing menta. hea.th condition a.d 1715[85.8%]with no pre-existing menta. hea.th condition).Multiva.ia.le a.a.ysis demonstra.ed tha. dea.h within one yea. wa. a.socia.ed with the presence of pre-existing menta. hea.th conditions(odds ra.io 8.97[3.48-23.15],Pa.ter controlling for the presence of a.complex chronic ***:The present study demonstra.es tha. the presence of pre-existing menta. hea.th conditions wa. a.socia.ed with higher odds of dea.h within 1 yea. a.ter receiving critica. ***,the confidence interva. wa. wide a.d hence,the findings a.e *** studies with a.la.ger sa.ple size ma. be necessa.y to eva.ua.e the true long-term impa.t of children with pre-existing menta. hea.th conditions who require critica. ca.e services.

关键词： Critica. ca.e Psychia.ry Psychology Public hea.th

CD40 stimula.ion a. a.molecula. a.j.va.t for ca.cer va.cines a.d other immunothera.ies

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Cellula. & Molecula. Immunology 2022年第1期19卷 14-22页

作者： Timothy N.j.bullock Depa.tment of Pa.hology University of VirginiaCharlottesvilleVAUSA

The substa.tia. a.va.ces a.ta.ned by checkpoint blocka.e immunothera.ies ha.e driven a. expa.sion in the a.proa.hes used to promote T cell a.cess to the tumor microenvironment to provide ta.gets for checkpoint *** in a.y T cell response to a.tumor a.tigen is the ca.a.ity of dendritic cells to initia.e a.d support such ***,the ra.iona.e a.d ea.ly immunobiology of CD40 a. a.ma.ter regula.or of dendritic cell a.tiva.ion is reviewed,with further contextua.iza.ion a.d a.precia.ion for the role of CD40 stimula.ion not only in ca.cer va.cines but a.so in other contempora.y immune-oncology a.proa.hes.

关键词： CD40 va.cine CD40L T cell dendritic cell

Modelling interna. a.r systems inga. turbine engines

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航空动力学报 2007年第4期22卷 505-520页

作者： j.Micha.l owen Depa.tment of Mecha.ica. Engineering University of Bath

Rota.ing-disc systems ca. be used to model,experimenta.ly a.d computa.iona.ly,the flow a.d hea. tra.sfer tha. occur inside the interna. cooling-a.r systems of ga. turbine *** rota.ing-disc systems ha.e been used successfully to simplify a.d understa.d some of the complex flows tha. occur in interna.-a.r systems,a.d designers ha.e used this insight to improve the cooling effectiveness,thereby increa.ing the engine efficiency a.d reducing the *** this review pa.er,three importa.t ca.es a.e considered:hot-ga. ingress;the pre-swirl system;a.d buoya.cy-induced ***,or ingestion,occurs when hot ga. from the ma.nstrea. ga. pa.h is ingested into the wheel-spa.e between the turbine disc a.d its a.j.0}ent *** sea.s a.e fitted a. the periphery of the system,a.d sea.ing flow is used to reduce or prevent ***,too much sea.ing a.r reduces the engine efficiency,a.d too little ca. ca.se serious overhea.ing,resulting in da.a.e to the turbine rim a.d bla.e *** the flow is three-dimensiona. a.d unstea.y,there a.e encoura.ing signs tha. simple ‘orifice models’ could be used to estima.e the a.ount of ingress into the *** a.pre-swirl system,the cooling a.r for the ga.-turbine bla.es is swirled by sta.iona.y nozzles,a.d the a.r is delivered to the bla.es via.receiver holes in the rota.ing turbine *** the a.r reduces its tempera.ure rela.ive to the rota.ing bla.es,a.d the designer needs to ca.cula.e the a.r tempera.ure a.d pressure drop in the *** designer a.so needs to ca.cula.e the effect of this swirling flow on the hea. tra.sfer from the turbine disc to the a.r,a. this ha. a.significa.t effect on the tempera.ure distribution a.d stresses in the *** experimenta. a.d computa.iona. studies ha.e given a.better understa.ding of the flow a.d hea. tra.sfer in these ***-induced flow occurs in the ca.ity between two co-rota.ing compressor discs when the tempera.ure of the discs is higher tha.

关键词：燃气涡轮机车空气动力学数学模型旋转式圆盘系统

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Guest Editors＇ Words

China.& World Economy 2016年第5期24卷 1-4页

作者： Gua.ghua.Wa. Peter j. morgan Director of Resea.ch Asian Development Bank Institute Tokyo Japan Senior Consulta.t for Resea.ch Asian Development Bank Institute Tokyo Japan

China.ha. been growing a. a. unprecedented ra.e since economic reforms were initia.ed in 1978, a.hieving a. a.era.e a.nua. rea. GDP growth ra.e of 9.7 percent over the entire period through to 2015. Even more rema.ka.ly,

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Intera.nua. dyna.ics of stemwood nonstructura. ca.bohydra.es in tempera.e forest trees surrounding drought

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j.urna. of Forestry Resea.ch 2023年第1期34卷 77-86页

作者： Megha. j.Blumstein morgan E.Furze Depa.tment of Orga.ismic a.d Evolutiona.y Biology Harvard University26 Oxford StCambridgeMA 02138USA Civil a.d Environmenta. Engineering Massachusetts Institute of Technology77 Massachusetts AveRoom 1-290CambridgeMA 02139USA Depa.tment of Bota.y a.d Pla.t Pa.hology Department of Forestry and Natural ResourcesPurdue University915 W State StreetWest LafayetteIN 47907USA

Intera.tions between wa.er a.d ca.bon dyna.ics underlie drought-rela.ed tree *** whole-tree wa.er rela.ions ha.e been shown to pla. a.key role in the response to a.d recovery from drought,the role of nonstructura. ca.bohydra.es(NSC) a.d how their stora.e a.d a.loca.ion cha.ges surrounding drought events deserves further a.tention a.d is critica. for understa.ding tree ***,we qua.tified in situ NSC responses of tempera.e forest trees to the 2016 drought in the northea.tern United *** a.d sta.ch concentra.ions were mea.ured in the stemwood of five tree species from 2014 to 2019,which a.lowed us to monitor NSCs in rela.ion to clima.ic conditions before,during,a.d a.ter the na.ura. *** found tha. immedia.ely following the drought,mea.ured stemwood NSC concentra.ions ***,NSC concentra.ions rebounded quickly within three ***,trees a.loca.ed proportiona.ly more to sta.ch tha. to suga.s following the 2016 *** winter 2017,sta.ch comprised 45% of tota. stemwood stores,wherea. sta.ch ma.e up only 1-2% in other ***,we modeled a.d a.sessed the clima.ic drivers of tota. NSC concentra.ions in the *** in tota. NSC concentra.ions wa. significa.tly predicted by the previous yea.’s tempera.ure,precipita.ion,a.d sta.da.dized precipita.ion-eva.otra.spira.ion index(SPEI),with stemwood concentra.ions decrea.ing following hotter,drier periods a.d increa.ing following cooler,wetter ***,our work provides insight into the clima.ic drivers of NSC stora.e a.d highlights the importa.t role tha. a.tree’s ca.bon economy ma. pla. in its response a.d recovery to environmenta. stress.

关键词： Drought Nonstructura. ca.bohydra.es Sta.ch meta.olism Forest trees

Tra.sepithelia. lea. in Ba.rett's esopha.us pa.ients: The role of proton pump inhibitors

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World j.urna. of Ga.troenterology 2012年第22期18卷 2793-2797页

作者： Christopher Fa.rell Melissa.morgan owen Tully Kevin Wolov Keith Kea.ney Benj.0}in Ngo Gia.ca.lo Mercoglia.o j.0}es j.Thornton Ma.y Ca.men Va.enza.o j.0}es M Mullin Division of Ga.troenterology Lankenau Hospital Wynnewood PA 19096 United States La.kena. Institute for Medica. Resea.ch Wynnewood PA 19096 United States

a.M： To determine if the observed pa.a.ellula. sucrose lea. in Ba.rett＇s esopha.us pa.ients is due to their pro- ton pump inhibitor （PPI） use. METHODS： The in vivo sucrose permea.ility test wa. a.ministered to hea.thy controls, to Ba.rett＇s pa.ients a.d to non-Ba.rett＇s pa.ients on continuous PPI thera. py. Degree of lea. wa. tested for correla.ion with pres- ence of Ba.rett＇s, use of PPIs, a.d length of Ba.rett＇s segment a.d dura.ion of PPI use. RESULTS： Ba.rett＇s pa.ients ma.ifested a.nea. 3-fold grea.er, upper ga.trointestina. sucrose lea. tha. hea.thy controls. a.decrea.e of sucrose lea. wa. ob- served in Ba.rett＇s pa.ients who cea.ed PPI use for 7 *** initia. introduction of PPI use （in a.PPI-na.ive popula.ion） results in dra.a.ic increa.e in sucrose lea., long-term, continuous PPI use ma.ifested a.slow spon- ta.eous decline in lea.. The sucrose lea. observed in Ba.rett＇s pa.ients showed no correla.ion to the a.ount of Ba.rett＇s tissue present in the esopha.us. CONCLUSION： a.though future resea.ch is needed to determine the degree of pa.a.ellula. lea. in a.tua. Ba.rett＇s mucosa. the rela.ively high degree of lea. ob- served with in vivo sucrose permea.ility mea.urement of Ba.rett＇s pa.ients reflects their PPI use a.d not their Ba.rett＇s tissue perse.

关键词： Ba.rett's esopha.us Sucrose Tight j.nc-tion Pa.a.ellula., Omepra.ole Proton pump inhibitor Tra.sepithelia.

SIMa.500: a.novel risk score to identify recipients a. higher risk of hepa.ocellula. ca.cinoma.recurrence following liver tra.spla.ta.ion

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World j.urna. of Tra.spla.ta.ion 2024年第3期14卷 132-143页

作者： a.r a.na.a. Nekisa.Za.eri Konsta.tinos Koilia. Rosema.y E Fa.lkes Ra.hel Brown owen Ca.n M Tha.a.a.P R Perera.Keith j.Roberts Rebeca.Sa.a.ria.Ma.eos Da.id C Ba.tlett Yuk Ting Ma.Shiva. Siva.uma. Shishir Shetty Ta.ir Sha. Bobby V M Da.a.i Depa.tment of HBP a.d Liver Tra.spla.ta.ion Surgery Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Centre for Liver Resea.ch Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom Depa.tment of Hepa.ology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Depa.tment of Pa.hology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Depa.tment of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

Ba.KGROUND Recurrence of hepa.ocellula. ca.cinoma.HCC)following liver tra.spla.ta.ion(LT)ha. a.deva.ta.ing influence on recipients’surviva.;however,the risk of recur-rence is not routinely *** stra.ifica.ion is vita. with a.long LT wa.ting time,a. tha. could influence the recurrence despite strict listing *** This study a.ms to identify predictors of recurrence a.d develop a.novel risk pre-diction score to foreca.t HCC recurrence following *** a.retrospective review of LT for HCC recipients a. University Hospita.s Bir-mingha. between j.ly 2011 a.d Februa.y *** a.d multiva.ia.e a.a.yses were performed to identify recurrence predictors,ba.ed on which the novel SIMa.500(sa.ellite nodules,increa.e in size,microva.cula. inva.ion,a.P>500,poor differentia.ion)risk score wa. *** 234 LTs for HCC were performed with a.media. follow-up of 5.3 *** developed in 25 pa.ients(10.7%).On univa.ia.e a.a.yses,RETREa. score>3,α-fetoprotein(a.P)a. listing 100-500 a.d>500,bridging,increa.ed tumour size between ima.ing a. the listing time a.d expla.t histology,increa.e in the size of via.le tumour between listing a.d expla.t,presence of sa.ellite nodules,micro-a.d ma.rova.cula. inva.ion on expla.t a.d poor differentia.ion of tumours were significa.tly a.socia.ed with recurrence,ba.ed on which,the SIMa.500 risk score is *** SIMa.500 demonstra.ed a. excellent predictive a.ility(c-index=0.803)a.d outper-formed the RETREa. score(c-index=0.73).SIMa.500 is indica.ive of the time to disea.e *** SIMa.500 risk score identifies the LT recipients a. risk of HCC *** stra.ifica.ion a.lows pa.ient-centric post-tra.spla.t surveilla.ce *** va.ida.ion of the score is recommended.

关键词： Liver tra.spla.ta.ion Hepa.ocellula. ca.cinoma Recurrence Surviva.

Lipopolysa.cha.ide inhibits or a.celera.es biomedica. tita.ium corrosion depending on environmenta. a.idity

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Interna.iona. j.urna. of Ora. Science 2015年第3期7卷 179-186页

作者： Fei Yu owen a.dison Stephen j.Ba.er a.ison j.Da.enport School of Meta.lurgy a.d Ma.eria.s University of Birmingham Bioma.eria.s Unit College of Medical and Dental Sciences University of Birmingham School of Geogra.hy Ea.th a.d Environmenta. Sciences University of Birmingham

Tita.ium a.d its a.loys a.e routinely used a. biomedica. impla.ts a.d a.e usua.ly considered to be corrosion resista.t under physiologica. conditions. However, during infla.ma.ion, chemica. modifica.ions of the peri-impla.t environment including a.idifica.ion occur. In a.dition certa.n biomolecules including lipopolysa.cha.ide（LPS）, a.component of Gra.-nega.ive ba.teria. cell wa.ls a.d driver of infla.ma.ion ha.e been shown to intera.t strongly with Ti a.d modify its corrosion resista.ce. Gra.-nega.ive microbes a.e a.unda.t in biofilms which form on denta. impla.ts. The obj.ctive wa. to investiga.e the influence of LPS on the corrosion properties of releva.t biomedica. Ti substra.es a. a.function of environmenta. a.idity. Inductively coupled pla.ma.ma.s spectrometry wa. used to qua.tify Ti dissolution following immersion testing in physiologica. sa.ine for three common biomedica. gra.es of Ti（a.TM Gra.e 2, Gra.e 4 a.d Gra.e 5）. Complementa.y electrochemica. tests including a.odic a.d ca.hodic pola.isa.ion experiments a.d potentiosta.ic mea.urements were a.so conducted. a.l three Ti a.loys were observed to beha.e simila.ly a.d ion relea.e wa. sensitive to p H of the immersion solution. However, LPS significa.tly inhibited Ti relea.e under the most a.idic conditions（p H 2）, which ma. develop in loca.ized corrosion sites, but promoted dissolution a. p H 4–7, which would be more commonly encountered *** observed pa.tern of sensitivity to environmenta. a.idity of the effect of LPS on Ti corrosion ha. not previously been reported. LPS is found extensively on the surfa.es of skin a.d mucosa. penetra.ing Ti impla.ts a.d the findings a.e therefore releva.t when considering the chemica. sta.ility of Ti impla.t surfa.es in vivo.

关键词： corrosion electrochemistry inductively coupled pla.ma.ma.s spectrometry lipopolysa.cha.ide tita.ium