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Self-assembled PEG-b-PDPA-b-PGEM copolymer nanoparticles as protein antigen delivery vehicles to dendritic cells:preparation,characterization and cellular uptake

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Regenerative Biomaterials 2017年第1期4卷 11-20页

作者： Pan li Junhui Zhou Pingsheng Huang Chuangnian Zhang Weiwei Wang Chen lia Deling Kong Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China School of Chemical Engineering and Technology Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin UniversityTianjin 300072China

Antigen uptake by dendritic cells(DCs)is a key step for initiating antigen-specific T cell *** the present study,novel synthetic polymeric nanoparticles were prepared as antigen delivery vehicles to improve the antigen uptake by ***-defined cationic and acid-responsive copolymers,monomethoxy poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate)-block-poly(2-(guanidyl)ethyl methacrylate)(mPEG-b-PDPA-b-PGEM,PEDG)were synthesized by reversible addition-fragmentation chain transfer polymerization of 2-(diisopropylamino)ethyl methacrylate and N-(tert-butoxycarbonyl)amino ethyl methacrylate monomers,followed by deprotection of tert-butyl protective groups and guanidinylation of obtained primary amines.1H NMR,13C NMR and GPC results indicated the successful synthesis of well-defined PEDG *** copolymers could self-assemble into nanoparticles in aqueous solution,which were of cationic surface charges and showed acid-triggered disassembly contributed by PGEM and PDPA moieties,***,PEDG nanoparticles could effectively condense with negatively charged model antigen ovalbumin(OVA)to form OVA/PEDG nanoparticle formulations with no influence on its secondary and tertiary structures demonstrating by far-UV circular dichroism and UV-vis *** vitro antigen cellular uptake by bone marrow DCs(BMDCs)indicated using PEDG nanoparticles as antigen delivery vehicles could significantly improve the antigen uptake efficiency of OVA compared with free OVA or the commercialized Alum ***,as the surface cationic charges of OVA/PEDG nanoparticle formulations reduced,the uptake efficiency decreased ***,our work suggests that guanidinylated,cationic and acid-responsive PEDG nanoparticles represent a new kind of promising antigen delivery vehicle to DCs and hold great potential to serve as immunoadjuvants in the development of vaccines.

关键词： guanidyl synthetic copolymer nanoparticles antigen delivery dendritic cells

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Development of Sn^(2+)-based oxyfluoride photocatalyst with visible light response of ca.650 nm via strengthened hybridization of Sn 5s and O 2p orbitals

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Journal of Energy Chemistry 2021年第12期30卷 385-390,I0009页

作者： Yanpei Luo Xin Zhou jiangwei Zhang Yu Qia Zheng lia Fuxiang Zhang Can li State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian National Laboratory for Clean EnergyThe Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)Dalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China College of Environment and Chemical Engineering Dalian UniversityDalian 116622LiaoningChina

The hybridization between the outmost s orbitals of metal(Bi^(3+),Sn^(2+),Pb^(2+),Ag^(+))and O 2 p orbitals has been widely employed to develop innovative semiconductors with upshift valence band as well as extended visible light response,but it is still challenging to obtain photocatalyst with absorption edge of above 550 *** we report a novel Sn^(2+)-based oxyfluoride Sn_(2)TiNbO_6 F(STNOF)photocatalyst with a pyrochlore structure to exhibit an extended absorption edge to 650 nm and dual functionalities of both water reduction and *** functional theory calculations suggest that the unprecedented broad-spectrum response of STNOF is mainly ascribed to the strengthened hybridization between O 2 p and Sn 5 s orbitals remarkably upshifting the valence band,which is caused by the distortion and compressive strain in the Sn06 F2 dodecahedron with second-order Jahn-Teller effect due to partial fluorine *** structural distortion and compressive strain are experimentally confirmed by the Fourier-transformed extended X-ray absorption fine *** probe tests of the photocatalytic functionalities,water reduction and oxidation half reactions were examined to see obvious H_(2)and O_(2)evolution under visible light *** work may provide an alternative strategy of developing extended visible light responsive semiconductors for promising solar energy conversion.

关键词： Photocatalyst Visible light Water splitting DFT Structural characterizations

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A FUNCTIONAL CONJUGATED HYPERBRANCHED POLYMER DERIVED FROM TETRAPHENYLETHENE AND OXADIAZOLE MOIETIES:SYNTHESIS BY ONE-POT “A_4+B_2+C_2” POLYMERIZATION AND APPliCAION AS EXPLOSIVE CHEMOSENSOR AND PLED

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Chinese Journal of Polymer Science 2013年第10期31卷 1432-1442页

作者： Wen-bo Wu Shang-hui Ye li-jin Huang Gui Yu Yun-qi liu Jin-gui Qin Zhen lia Department of Chemistry Hubei Key Lab on Organic and Polymeric Opto-Electronic MaterialsWuhan University Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences

A new conjugated hyperbranched polymer （hb-TFO） containing tetraphenylethylene （TPE） units, a famous aggregation-induced emission （AIE） active group, as the core, was synthesized successfully with modest yield via one-pot Suzuki polymerization reaction. Thanks to the introduction of TPE moieties, hb-TFO exhibited aggregation-enhanced emission （AEE） property, and could work as explosive chemosensor with high sensitivity. The polymeric light-emitting diode （PLED） device was fabricated to investigate its electroluminescent property, and hb-TFO demonstrated a maximum luminance efficiency of 0.22 cd/A and a maximum brightness of 545 cd/m2 at 15.9 V.

关键词： Hyperbranched polymer AEE TPE Explosive chemosensor PLED.

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Hard carbon derived from coconut shells,walnut shells,and corn silk biomass waste exhibiting high capacity for Na-ion batteries

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Journal of Energy Chemistry 2021年第7期30卷 207-218页

作者： Cristina Nita Biao Zhang Joseph Dentzer Camélia Matei Ghimbeu Universitéde Haute-Alsace Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde Strasbourg F-67081 StrasbourgFrance Center for Advanced Laser Technologies(CETAL) National Institute for LasersPlasma and Radiation PhysicsAtomistilor 409 bisRO-77125 MagureleRomania Department of Applied Physics The Hong Kong Polytechnic UniversityKowloonHong KongChina Réseau sur le Stockage Electrochimique de l’Energie(RS2E) CNRS FR345933 Rue Saint Leu80039 Amiens CedexFrance

In recent years,hard carbon materials have gained significant interest as anode materials for Na-ion *** waste is considered one of the most interesting,renewable,available,and cost-effective precursor to obtain hard carbon(HC);however,HC properties must be finely tuned to achieve performance comparable to those provided by li-ion *** this work,three biomass wastes(coconut shells,walnut shells,and corn silk) were evaluated as potential precursors for HC preparation involving a pyrolysis process and subsequent acid washing to remove the inorganic *** obtained materials exhibited low and similar specific surface areas(lized graphitized *** HCs delivered high initial reversible capacities between 293 and 315 mAh g^(-1) at 50 mA g^(-1) current rate,which remained rather stable during long-term *** best capacity(293 mAh g^(-1) after 100 charge/discharge cycles) and highest capacity retention(93%) was achieved in walnut HCs in half-cells,which could be associated with its higher sp2 C content,better organized structure,and fewer *** "adsorption-insertion" Na storage mechanism is suggested based on several *** walnut HCs exhibited an attractive energy density of 279 Wh/kg when tested in full cells.

关键词： Biomass Pyrolysis Hard carbon Anode Na-ion batteries Energy storage

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Insights into the nucleation,grain growth and phase transformation behaviours of sputtered metastableβ-W films

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Journal of Materials Science & Technology 2021年第31期90卷 66-75页

作者： Shuqun Chen Jinshu Wang Ronghai Wu Zheng Wang Yangzhong li Yiwen Lu Wenyuan Zhou Peng Hua Hongyi lia Key Laboratory of Advanced Functional Materials Education Ministry of ChinaFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an 710129China High Performance Computing Department National Supercomputing Center in ShenzhenShenzhen 518055China China Ship Development and Design Center Wuhan 430074China

Metastable phase in tungsten film is of great interests in recent years due to its giant spin Hall effects,however,little information has been known on its nucleation,growth and phase *** this paper,a 900 nm-thick tungsten film with double-layer structure(α-W underlayer andβ-W above it)was produced on SiO_(2)/Si substrate by high vacuum magnetron sputtering at room *** structural properties ofβ-W were systemically investigated by X-ray diffraction,transmission electron microscopy,thermodynamic calculation,first-principle and phase-field *** is found that theβ-W nucleation is energetically favoured on the SiO_(2)surface compared to theα-W *** the film thickening proceeds,β-W[211]turns to be preferred direction of growth owing to the elastic strain energy minimization,which is verified by phase-field ***,theβ→αphase transformation takes place near the film-substrate interface while the rest of the film keeps theβ-W phase,leading to a doublelayer *** localized phase transition is induced by lower Gibbs free energy ofα-W phase at larger grain sizes,which can be confirmed by thermodynamic *** in-situ heating TEM analysis of the as-deposited film reveals that theβ→αphase transformation is fulfilled byα/βinterface propagation rather than local atomic *** findings offer valuable insights into the intrinsic properties of metastable phase in tungsten.

关键词： Metastable phases Tungsten Nucleation and growth Phase field modelling Phase transformation

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Instant formation of nanopores on flexible polymer membranes using intense pulsed light and nanoparticle templates

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International Journal of Smart and Nano Materials 2023年第4期14卷 391-405页

作者： Miaoning Ren Tianyu li Wenxing Huo Yu Guo Zhiqiang Xia Ya lia Jing Niua M.Serdar Onses Xian Huang Department of Biomedical Engineering Tianjin UniversityTianjinChina ERNAM-Nanotechnology Research and Application Center Department of Materials Science and EngineeringErciyes UniversityKayseriTurkey

The development of simple and high-throughput approaches to yield solid-state nanopores on large surface membranes may facilitate the prevalence of nanopore analysis technology and in-vitro diagnosis using portable ***,solidstate nanopores are typically realized by complex and highend nanofabrication ***,we present a method to achieve nanopores on polymer membranes using,silver nanoparticles(AgNPs)as templates and intense pulsed light(IPL)as a heating *** density and size of nanopores are controllable by adjusting the spin coating rate,the concentration of nanoparticle suspension,and the size of nanoparticles(NPs).The temperature of the AgNPs can rapidly reach 1132 K under instant heating of photothermal effect through light irradiation in 2 ms,resulting in localized melting and decomposition of an underneath polycarbonate(PC)membrane to yield nanopores with sizes ranging from 10 to 270 *** removing the nanoparticle residues,the flexible membrane with nanopores can be integrated into a flow cell to achieve a nanopore sensor that has been used to measure the translocation behaviors of bovine serum albumin(BSA).The results have demonstrated the capability of the sensor in protein denaturation *** low-cost and highthroughput technique to fabricate solid-state nanopores on flexible polymeric membranes may facilitate the development of more nanopore-based flexible sensors that can be integrated with other flexible components for wearable diagnosis.

关键词： Solid-state nanopore intense pulsed light polymer AgNPs flexible membrane

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Research Progress of Qiweibaizhu Powder in Treating Digestive System Diseases

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World Journal of Traditional Chinese Medicine 2021年第4期7卷 391-396页

作者： Shi-Qi liu Ji li College of Basic Medical Sciences Heilongjiang University of Chinese MedicineHarbinChina

Diarrhea is a common clinical problem that can lead to health complications,including *** is the second-most common cause of death in *** World Health Organization introduced a program to encourage the development and use of traditional herbal medicines in the treatment of *** Powder(QWBZP)is a well-known pediatric prescription in China that is commonly used to treat digestive system diseases,such as diarrhea,which is also a type of syndrome in traditional Chinese *** studies have examined the clinical effects and mechanisms of QWBZP,and innovative and improved formulations have been *** studies on the effects of QWBZP on diarrhea caused by human rotavirus,antibiotic-associated diarrhea,and mesenteric lymphadenitis in experimental models and clinical trials with diarrhea patients have been *** conducted a literature search of several databases,including PubMed,China National Knowledge Infrastructure,Chongqing VIP Information Co.,Ltd.,and Wanfang.A short background of the QWBZP is also *** collective findings highlight the curative effects of QWBZP on diarrhea caused by viral infection,antibiotic use,and mesenteric ***,QWBZP can regulate the balance of the gastrointestinal microbiota and protect and repair the intestinal mucosal *** review will provide a reference for further studies on QWBZP.

关键词： Antibiotic-associated diarrhea intestinal microbiota mesenteric lymphadenitis spleen deficiency viral diarrhea

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Interleukin-10-1082G/A polymorphism and acute liver graft rejection:A meta-analysis

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World Journal of Gastroenterology 2012年第8期18卷 847-854页

作者： Fei liu Bo li Wen-Tao Wang Yong-Gang Wei Lv-Nan Yan Tian-Fu Wen Ming-Qing Xu lia-Yin Yang Department of liver and Vascular Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM: To investigate the association between interleukin (IL)-10-1082 (G/A) promoter polymorphism and acute rejection (AR) in liver transplant (LT) recipients. METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases. Summary odds ratios (ORs) and 95% CIs for IL-10-1082 G/A polymorphism and AR were calculated in a fixed and a random-effects model as appropriate. RESULTS: This meta-analysis included seven casecontrol studies, which comprised 652 cases of LT recipients in which 241 cases developed AR and 411 cases did not develop AR. Overall, the variant A allele was not associated with AR risk when compared with the wild-type G allele (OR = 0.94, 95% CI: 0.64-1.39). Moreover, similar results were observed when the AA genotype was compared with the AG/GG genotype (OR = 1.05, 95% CI: 0.55-2.02). When stratifying for eth-nicity, no significant association was observed among either Caucasians or Asians. Because only one study was performed in Asian patients, the result of subgroup analysis by ethnicity would not be reliable for Asians. limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust. No publication bias was found in the present study. CONCLUSION: This meta-analysis suggests that IL-10-1082 G/A polymorphism may be not associated with AR risk in LT recipients among Caucasians.

关键词： liver transplantation Acute rejection In-terleukin-10 Gene polymorphism Meta-analysis

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Lane departure warning systems and lane line detection methods based on image processing and semantic segmentation:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 748-774页

作者： Weiwei Chen Weixing Wang Kevin Wang Zhaoying li Huan li Sheng liu School of Information Engineering Chang’an UniversityXi'an 710064China Xi’an Aeronautical Polytechnic Institute Xi'an 710089China Royal Institute of Technology Stockholm 10044Sweden Audible Inc. NewarkNJ 07102USA School of Computer Science and Engineering Xi’an University of TechnologyXi'an 710048China

Recently,the development and application of lane line departure warning systems have been in the *** any of the systems,the key part of lane line tracking,lane line identification,or lane line departure warning is whether it can accurately and quickly detect lane *** 1990 s,they have been studied and implemented for the situations defined by the good viewing conditions and the clear lane markings on *** then,the accuracy for particular situations,the robustness for a wide range of scenarios,time efficiency and integration into higher-order tasks define visual lane line detection and tracking as a continuing research *** present,these kinds of lane marking line detection methods based on machine vision and image processing can be divided into two categories:the traditional image processing and semantic segmentation(includes deep learning)*** former mainly involves feature-based and model-based steps,and which can be classified into similarity-and discontinuity-based ones;and the model-based step includes different parametric straight line,curve or pattern *** semantic segmentation includes different machine learning,neural network and deep learning methods,which is the new trend for the research and application of lane line departure warning *** paper describes and analyzes the lane line departure warning systems,image processing algorithms and semantic segmentation methods for lane line detection.

关键词： Traffic engineering Lane departure warning Lane line detection Image processing Image analysis Semantic segmentation

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关节镜下前交叉韧带重建术后早期疼痛管理的研究进展

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中国修复重建外科杂志 2024年第2期38卷 218-225页

作者：余鸿施政良熊波涵李雅娟秦艺华董开颜李彦林李黎昆明医科大学第一附属医院运动医学科昆明650032

目的总结前交叉韧带重建(anterior cruciate ligament reconstruction,ACLR)术后早期疼痛管理方式,为促进ACLR术后功能康复选择合理且有效的疼痛管理方案。方法广泛查阅近年国内外关于ACLR术后早期疼痛管理方案相关文献,并从改善术后疼... 详细信息

目的总结前交叉韧带重建(anterior cruciate ligament reconstruction,ACLR)术后早期疼痛管理方式,为促进ACLR术后功能康复选择合理且有效的疼痛管理方案。方法广泛查阅近年国内外关于ACLR术后早期疼痛管理方案相关文献,并从改善术后疼痛效果方面进行综述。结果目前物理治疗和口服药物有经济、简便等优势,但改善术后疼痛效果并不佳,常需要联合静脉注射或静脉泵等方式,也是目前缓解疼痛的常用方式;但为了满足患者镇痛需求,镇痛药物使用量往往较大,增加了各种不良反应发生风险。局部浸润镇痛(local infiltration analgesia,lia)包括关节周围或关节内注射药物,可显著改善ACLR术后早期疼痛,达到与神经阻滞相似的术后疗效;lia可作为代替神经阻滞的一种镇痛技术,并避免神经阻滞带来的相应支配肌肉无力,从而增加术后跌倒风险。其中关节周围注射镇痛效果更优,可避免关节内注射对软骨损伤的风险。但lia的术后镇痛效果和时效性仍有待提升,可考虑将多模式混合药物lia(联合关节内和关节周围)联合其他疼痛干预方式,发挥协同作用,以避免单一药物或单途径给药带来的副作用和风险,有望成为缓解ACLR术后早期疼痛常用方法之一。结论关节镜下ACLR术后仍会出现早期疼痛影响患者进一步功能活动,各种镇痛方式均可获得一定疗效,但目前尚未制定统一标准,各类镇痛方式优劣有待进一步研究。

关键词：前交叉韧带重建早期疼痛局部浸润镇痛神经阻滞功能康复

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