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反射式共聚焦显微镜联合光学相干断层扫描在黄褐斑组织学改变观察及疗效评估中的应用分析

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中华皮肤科杂志 2024年第7期57卷 623-631页

作者：姜倩王玥田黎明夏萍陈柳青华中科技大学同济医学院附属武汉中西医结合医院皮肤科武汉430022

目的应用反射式共聚焦显微镜(RCM)联合光学相干断层扫描(OCT)观察黄褐斑治疗过程中在体微观组织学改变,同时探讨其在疗效评估中的应用价值。方法收集2023年1-10月在华中科技大学同济医学院附属武汉中西医结合医院皮肤科30例黄褐斑患者... 详细信息

目的应用反射式共聚焦显微镜(RCM)联合光学相干断层扫描(OCT)观察黄褐斑治疗过程中在体微观组织学改变,同时探讨其在疗效评估中的应用价值。方法收集2023年1-10月在华中科技大学同济医学院附属武汉中西医结合医院皮肤科30例黄褐斑患者的临床资料,回顾性分析治疗前及治疗后第4、8、12、16周临床照片,采用黄褐斑面积和严重指数(MASI)评分评价疗效。同时,回顾性分析RCM下黄褐斑患者皮损处色素分布、黑色素细胞形态和空间分布、真皮浅层炎症浸润等各影像学指标的变化情况。为清晰阐述概念及后续定量分析,根据RCM下观察的结果及以往文献报道,将治疗前黄褐斑皮损处各特征性微观组织学改变进行模式分类。此外,通过OCT采集的光学相干信号,得到治疗前后皮损处血管的特性参数。最后,采用Spearman相关法分析各微观组织学改变与临床疗效的相关性。结果随治疗时间延长,RCM下色素分布模式Ⅱ、Ⅲ占比逐渐减少,接近正常模式Ⅰ的比例明显增加;黑色素细胞4种异形形态模式占比均降低,其中模式Ⅱ形态黑色素细胞在观察结束时仍在皮损中灶性分布;同时,空间分布模式Ⅱ、Ⅲ占比减少,逐渐恢复为正常的模式Ⅰ;真皮浅层噬黑色素细胞及炎症细胞浸润减轻,其中模式Ⅲ在第4周即有明显减少,但是持续时间较长;色素分布模式Ⅱ、Ⅲ(r值分别为0.82、0.97,均P<0.05),黑色素细胞形态模式Ⅰ、Ⅲ、Ⅳ(r值分别为0.84、0.83、0.83,均P<0.05),炎症浸润模式Ⅰ、Ⅲ(r值分别为0.85、0.81,均P<0.05)占比均减少,黑色素细胞空间分布模式Ⅰ(r=0.89,P<0.05)占比增加,上述指标变化率与MASI评分下降率相关性较高,为敏感性较高的临床疗效评价指标。此外,治疗后OCT测得的皮损处血管平均直径及密度均减小,且下降率与MASI评分的下降率具有相关性(r值分别为0.76、0.78,均P<0.05);平均血管丛深度与治疗前相比无明显改变。结论在黄褐斑治疗过程中,RCM联合OCT可以为黄褐斑疗效评价提供无创、客观、有力的参考依据。

关键词：黄褐斑显微镜检查共焦光学相干断层扫描组织学疗效评估

江西甘坊洞上稀有金属花岗岩中铷矿化特征及成因机制

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地质通报 2024年第1期43卷 86-100页

作者：姜军胜郭欣然徐净田立明熊光强王力圆陈素余黄维坤中国地质调查局武汉地质调查中心(中南地质科技创新中心) 湖北武汉430205 中国地质调查局花岗岩成岩成矿地质研究中心湖北武汉430205 广东省地质科普教育馆广东广州510000 福州大学紫金地质与矿业学院福建福州350108 江西省地质矿产勘查开发局物化探大队江西南昌330000 福建冶地恒元建设有限公司福建福州350108

江西省宜丰县甘坊地区是一个重要的稀有金属成矿区,目前在甘坊岩体内发现了一系列锂铷稀有多金属矿床(点),但其成矿机制尚不明确。选择甘坊岩体内洞上花岗岩作为研究对象,采用电子探针技术对多种花岗岩中的长石和云母类矿物进行了精细... 详细信息

江西省宜丰县甘坊地区是一个重要的稀有金属成矿区,目前在甘坊岩体内发现了一系列锂铷稀有多金属矿床(点),但其成矿机制尚不明确。选择甘坊岩体内洞上花岗岩作为研究对象,采用电子探针技术对多种花岗岩中的长石和云母类矿物进行了精细的结构和成分分析。结果表明,云母类矿物是铷的主要载体(Rb_(2)O<1.07%),长石类矿物中Rb含量低(Rb_(2)O<0.11%),尤其是在钠长石中Rb的含量几乎为0。含铷云母主要是白云母花岗岩、伟晶岩和细晶岩中的多硅白云母-铁锂云母类,其中铷可能主要通过与钠双置换云母结构中的层间钾离子存在。矿物结构特征显示,洞上花岗岩经历了明显的岩浆结晶分异和流体交代作用。结晶分异作用可能是洞上花岗岩Rb富集成矿的关键机制,而后期流体交代蚀变过程对铷的聚集作用有限。结合前人研究成果,笔者认为甘坊地区具有较好的锂、铷等稀有金属成矿潜力,后续的找矿勘查应注重与早白垩世—晚侏罗世(140~150Ma)高分异花岗岩相关的锂、铷等稀有金属矿床的找矿工作。

关键词：稀有金属花岗岩铷洞上花岗岩甘坊岩体江西矿产勘查工程

Slow Recovery in the Dyestuff Sector

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China Chemical Reporter 2009年第29期20卷 22-23页

作者： tian liming

In the first half of 2009, as the physicaleconomy continued to suffer from the globalfinancial crisis, China issued a series of macropolicies to cope with the situation. The declinein the growth of the dyestuff sector... 详细信息

关键词： sector continued suffer issued checked revenue dow

Big Challenges for Dyestuffs and Pigments Makers

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China Chemical Reporter 2010年第7期21卷 20-21页

作者： tian liming China Dyestuffs Industry Association

China Dyestuffs Industry Association (CDIA) recently issued a report that recovery signals arose for China’s dyestuffs industry. The industry achieved combined sales revenue of RMB35.65 billion in 2009, a drop of 6.8% year on year. The total output of dyestuffs was 719 000 tons, a growth of 6%. (The National Bureau of Statistics reported that the total output of dyestuffs was 1.424 million tons in 2009.) Of that, the output of disperse dyes amounted to 348 000 tons, that of reactive dyes was 196 000 tons, sulfur dyes being 97 000 tons and other dyes 78 000 tons. The total output of organic pigments was 182 000 tons, down 1.6%.

关键词： revenue pigments disperse Bureau issued sulfur tho

Dyestuffs and Organic Pigment Face Challenge

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China Chemical Reporter 2007年第25期18卷 18-19页

作者： tian liming

Raoid growth of outputAccording to statistics from theChina Dyestuff Industry Associa-tion(CDIA), the product sales rev-enue realized in 2006 was RMB31.092 billion(including dyestuffs andorganic pigments), an increase of6.7% over 2005. The profit wasRMB2.062 billion(including dye-stuffs and organic pigments), anincrease of 3.2% over 2005. Export-oriented companies improved re-markably in economic performance.

关键词： Challenge pigments companies profit thousand Expor

Price Increase Helped Dyestuff Firms

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China Chemical Reporter 2008年第29期19卷 20-21页

作者： tian liming

In the first half of 2008 China’s dyestuff and organic pigment sector came across the im-pacts from the reduced export rebates,ap-preciated RMB value against US dollar,in-creased labor cost,price rise of raw materials,plunged demand from downstream,pressure of energy conservation and pollutant reduc-tion and tight transportation,which

关键词： downstream creased sector tight dollar reduc pigme

Dyestuff and Organic Pigment Develop Steadily in 2007

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China Chemical Reporter 2008年第10期19卷 19-22页

作者： tian liming

1 Production growth slow down 1.1 Slight growth slowdown of output According to the statistics made by China Dyestuff Industry Association (CDIA) to its member enterprises,the industrial output value in 2007 was 10.8 percentage points higher than 2006 and the product sales revenue was 14.0 per-centage points higher.2007 was the year with the relatively rapid growth in re-cent *** with 2006,the output of dyestuffs and organic pigments in 2007 increased,but the output growth was slowed *** growth was down by 1.3 percentage points for

关键词： centage revenue slowed pigments slowdown Hangzhou

An arch-shape wood evaporator decorated by metal-organic framework for solar interface evaporation

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Nano Research 2024年第7期17卷 6661-6672页

作者： tiantian Wu liming Zhao Yaning Xu Ziwei Cui Lixing Kang Yahui Cai Zupeng Chen Dan tian Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China

To achieve sustainable desalination and water purification,solar interface evaporation technology is an effective means due to its high energy *** photothermal conversion materials and surface design are crucial for the interfacial solar evaporation *** to design water transport routes and thermal insulating layers simultaneously is one of the major challenges to solar interface evaporation technology ***,this work reports an arch-shaped wood evaporator(pine@carbon black(CB)-metal-organic framework-801(MOF-801)-36%)for efficient,fast and continuous interfacial solar evaporation,which is composed of an arch-shaped wood substrate,MOF-801,and CB as a light absorption *** archshaped structure has a double-sided evaporation effect,which has a synergistic effect on augmenting solar evaporation *** addition,the in-situ growth of MOF-801 in pretreated wood microchannels renders the wood evaporator a significant function of reducing the equivalent enthalpy of evaporation due to the reduction of the hydrogen bonding density of water molecules as they pass through the wood *** best evaporation rate of the arch-shaped wood evaporator can reach 2.535 kg·m^(−2)·h^(−1),and the efficiency reaches 93.7%under the irradiation of 1 sun ***,it could be used for desalination and wastewater treatment to collect fresh water that meets drinking requirements set by the World Health Organization(WHO).This integrated evaporator provides an efficient way for commercial portable photothermal conversion and new ideas for advanced solar-driven water treatment technology.

关键词： arch-shaped solar evaporation wood metal-organic frameworks(MOFs) double-sided evaporation

Review and Prospects of Dyestuffs and Organic Pigments Sector

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China Chemical Reporter 2009年第9期20卷 17-19页

作者： tian liming,China Dyestuffs Industry Association

1. Output decreasedfor the first timeAccording to statistics of the China DyestuffsIndustry Association (CDIA) forits member enterprises, the industrial productionvalue in 2008 was 1.1% higherthan 2007 and the product... 详细信息

关键词： turmoil tianjin downstream Shandong venture Jiangs