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Pudilan Xiaoyan oral liquid regulates tissue inflammation and apoptosis in mice with influenza virus pneumonia

Traditional Medicine Research 2024年第6期9卷 55-63页

作者： Shan Cao Shuang-Rong Gao Chen Ni Zi-Han Geng ying-li xu Bo Pang Meng-Ping Chen Yu Zhang Shan-Shan Guo Yu-Jing Shi li-Qi Ni Kun Wang Rong-Hua Zhao Xiao-Lan Cui Yan-Yan Bao Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Jumpcan Pharmaceutical Group Co. Ltd.Taizhou 225400China

Background:The influenza A virus is the primary cause of respiratory infections and poses a global health *** Xiaoyan oral liquid(PDL)exhibits anti-inflammatory and immunomodulatory *** is commonly employed in clinical practice to manage upper respiratory tract ***,there is still much to uncover regarding its potential therapeutic ***:Institute of cancer research mice were infected with influenza A virus via nasal *** general state of the mice,lung index,and lung index inhibition rate were used to evaluate the efficacy of ***-linked immunosorbent assay,western blotting,and immunohistochemistry were used to observe the presence of proteins and cytokines in the lung *** was evaluated using the TUNEL ***:PDL improved the mental state of influenza A virus-infected mice,reduced the lung index,and inhibited viral *** expression of interleukin-1βand tumor necrosis factor-αwere decreased,whereas the expression of interleukin-10 in the lung tissue was increased due to PDL *** addition,PDL treatment modulated Toll-like receptor 4 and MyD88 expressions in the lung *** significantly reduced apoptosis and decreased cleaved caspase-3 and PARP levels,whereas increased B-cell lymphoma-2 expression in the lung ***,the moderate-dose group of PDL exhibited a more pronounced *** findings indicate that PDL exerts a protective effect against pneumonia injury in influenza A virus-infected ***:PDL inhibited the inflammatory response and regulated apoptosis by regulating Toll-like receptor 4 and MyD88 protein expressions,thereby protecting the lung tissue from viral infection-induced lung tissue injury.

关键词： Pudilan Xiaoyan oral liquid influenza A virus immune response apoptosis Toll-like receptors

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a-Si/c-Si heterojunction solar cells on SiSiC ceramic substrates

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Rare Metals 2006年第z1期25卷 186-189页

作者： li xudong xu ying CHE Xiaoqi Beijing Solar Energy Research Institute Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China

Silicon thin-film solar cells are considered to be one of the most promising cells in the future for their potential advantages, such as low cost, high efficiency, great stability, simple processing, and none-pollution. In this paper, latest progress on poly-crystalline silicon solar cells on ceramic substrates achieved by our group was reported. Rapid thermal chemical vapor deposition (RTCVD) was used to deposited poly-crystalline silicon thin films, and the grains of as-grown film were enlarged by Zone-melting Recrystallization (ZMR). As a great change in cell′s structure, traditional diffused pn homojunction was replaced by a-Si/c-Si heterojunction, which lead is to distinct improvement in cell′s efficiency. A conversion efficiency of 3.42% has been achieved on 1 cm2 a-Si/c-Si heterojunction solar cell (Isc=16.93 mA, Voc=310.9 mV, FF=0.6493, AM=1.5 G, 24 ℃), while the cell with diffused homojunction only got an efficiency of 0.6%. It indicates that a-Si emitter formed at low temperature might be more suitable for thin film cell on ceramics.

关键词： a-Si/c-Si heterojunction thin film solar cell ceramic substrate

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Microstructure Characterization of Single-crystal ZnO Nanorods Synthesized by Solvothermal at Low Temperature

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Journal of Materials Science & Technology 2007年第5期23卷 583-586页

作者： Chunna YANG ying li Ge xu Xiuliang MA Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Single-crystalline ZnO nanorods have been synthesized by a simple solvothermal process at low temperature. Transmission electron microscopy （TEM） observations have confirmed that the as-synthesized products have rod-like morphologies with diameters ranging from several nanometers to 30 nm and lengths from 100 nm to 2 μm. Such hexagonal ZnO nanorods are structurally uniform and the growth direction is identified to be [0001]. Growth mechanism of the ZnO nanorods was proposed.

关键词： ZnO nanorod Transmission electron microscopy

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数字经济时代新财经人才培养的改革与实践

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当代教研论丛 2024年第5期10卷 89-92页

作者：康远志李迎旭韩山师范学院经济与管理学院广东潮州521000

数字经济对人类生产生活、商业业态带来巨大影响。新财经人才培养在数字经济时代有新内涵和新要求。文章阐释数字时代新财经人才培养的内涵变革与目标定位,提出坚持价值引领,开设创新班先行先试,推进校企协同育人,营造学生中心泛在学习... 详细信息

数字经济对人类生产生活、商业业态带来巨大影响。新财经人才培养在数字经济时代有新内涵和新要求。文章阐释数字时代新财经人才培养的内涵变革与目标定位,提出坚持价值引领,开设创新班先行先试,推进校企协同育人,营造学生中心泛在学习新场域等具体推进路径,形成“学生中心、文理融合、数智赋能、多元协同、先行先试”的财经人才培养新模式。

关键词：数字经济人才培养新财经文理融合

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西藏南木林地区达那古火山机构中花岗岩大地构造意义

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岩石矿物学杂志 2024年第4期43卷 803-820页

作者：韩飞宋元宝李峥黄永高代克刚张伟李应栩贾小川杨学俊四川省综合地质调查研究所稀有稀土战略资源评价与利用四川省重点实验室四川成都610081 西藏地质矿产勘查开发局第五地质大队西藏拉萨850000 中国地质调查局成都地质调查中心四川成都610081

新发现的西藏南木林地区达那古火山机构为探讨陆相火山机构岩相组成及其大地构造意义提供了窗口。本项研究对达那古火山机构开展了地质剖面测量、岩相学研究,并对期后侵入的斑状二长花岗岩进行了锆石U-Pb年代学和全岩地球化学分析。结... 详细信息

新发现的西藏南木林地区达那古火山机构为探讨陆相火山机构岩相组成及其大地构造意义提供了窗口。本项研究对达那古火山机构开展了地质剖面测量、岩相学研究,并对期后侵入的斑状二长花岗岩进行了锆石U-Pb年代学和全岩地球化学分析。结果表明,斑状二长花岗岩锆石U-Pb年龄为54.0±1.4 Ma,具有高硅(SiO_(2)=71.03%~75.88%)、高钾低钠(K_(2)O/Na_(2)O=1.45~1.79)、富碱(ALK=8.97%~9.67%)、低钛(TiO_(2)=0.17%~0.37%)等特征,铝饱和指数(A/CNK)介于0.95~1.00之间,里特曼指数(σ)介于2.45~3.38之间,属于准铝质、钙碱性岩石系列;轻稀土元素富集而重稀土元素相对亏损(LREE/HREE=7.60~9.78),且分异特征明显,(La/Sm)_(N)=2.85~4.21;Rb、Th、U等大离子亲石元素(liLE)和不相容元素相对富集,Nb、Ta、P、Ti等高场强元素(HFSE)相对亏损,表现出具有典型的俯冲带弧型或者壳源岩浆岩的地球化学属性。综合上述地质信息表明,达那古火山机构形成于54 Ma之前,斑状二长花岗岩形成于印度-欧亚大陆碰撞期的活动大陆边缘构造背景,在幔源岩浆底侵作用下,中下地壳发生熔融,之后岩浆分异上升侵位于火山通道结晶而成。

关键词：达那古火山机构二长花岗岩地球化学构造背景西藏

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Female Fertility： Is it Safe to Freeze.

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Chinese Medical Journal 2015年第3期128卷 390-397页

作者： Lu Zhang li-ying Yan xu Zhi Jie Yah Jie Qiao Department of Obstetrics and Gynecology Center for Reproductive Medicine Peking University Third Hospital Key Laboratory of Assisted Reproduction Ministry of Education Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction Beijing 100191 China

Objective： To evaluate the safety and risk of cryopreservation in female fertility preservation. Data sources： The data analyzed in this review were the English articles from 1980 to 2013 from journal databases, primarily PubMed and Google scholar. The criteria used in the literature search show as tbllowing：（ 1 ） human; embryo; cryopreservation/freezing/vitrification, （2） human; oocyte/immature oocyte; cryopreservation/freezing/vitrification, （3） human; ovarian tissue transplantation; cryopreservation/ freezing/vitrification, （4） human; aneuploidy/DNA damage/epigenetic; cryopreservation/freezing/vitrification, and （5） human; fertility preservation; maternal age. Study selection： The risk ratios based on survival rate, maturation rate, fertilization rate, cleavage rate, implantation rate. pregnancy rate. and clinical risk rate were acquired from relevant meta-analysis studies. These studies included randomized controlled trials or studies with one of tile primary outcome measures covering cryopreservation of human mature oocytes, embryos, and ovarian tissues within the last 7 years （from 2006 to 2013. since the pregnancy rates of oocyte vitrification were significantly increased due to the improved techniques）. The data involving immature oocyte cryopreservation obtained from individual studies was also reviewed by the at, thors. Results： Vitrifications of mature oocytes and embryos obtained better clinical outcomes and did not increase the risks of DNA damage, spindle configuration, embryonic aneuploidy, and genomic imprinting as compared with fresh and slow-freezing procedures, respectively. Conclusions： Both embryo and oocyte vitrifications are safe applications in female fertility preservation.

关键词： Embryo Cryopreservation Oocyte Cryopreservation: Ovarian Tissue Cryopreservation

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Study of Thermal Treatment on Properties of Polycrystalline Silicon

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Journal of Rare Earths 2006年第z1期24卷 237-240页

作者： Ren Bingyan Gou Xianfang Ma lifen li xudong xu ying Wang Wenjing Institute of Information Function Materials Hebei University of Technology Tianjin 300130 China Institute of Information Function Materials Hebei University of Technology Tianjin 300130 China Institute of Information Function Materials Hebei University of Technology Tianjin 300130 China Beijing Solar Energy Research Institute Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China Beijing Solar Energy Research Institute Beijing 100083 China

The effects of thermal annealing on oxygen behavior and carrier lifetimes of mc-Si wafers were investigated by means of FTIR and QSSPCD during single step and two step heat treatments in N2 and O2 ambient. It reveals that interstitial oxygen concentration of mc-Si and CZ-Si has a slighter decrease in N2 and O2 ambient during single-step annealing, which means oxygen precipitates are not generated. But oxygen concentration greatly decreases and generates a number of oxygen precipitates during two-step annealing. Bulk lifetime of mc-Si increases in N2 ambient at 850, 950, 1150 ℃ respectively, and annealing in O2 shows better results than that in N2 and annealing in two-step reflected better consequence than annealing in single-step. But lifetime of CZ-Si annealed in N2 or O2 decreases rapidly. The reason of lifetime increase is probably considered due to the fact that interstitial Si atoms of Si/SiO2 interface fill vacancies or some recombination centers at high temperature annealing. Moreover, a number of impurities in mc-Si probably diffuse to grain boundaries so that greatly reduce recombination centers result to lifetime rising.

关键词： polycrystalline silicon oxygen lifetime

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Multicomponent Domino [4＋1＋1] Carbocyclization Providing an Efficient and Regioselective Strategy to Fluoren-9-ones

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Chinese Journal of Chemistry 2013年第6期31卷 737-744页

作者： ying li Haiwei xu liping Fu Qingqing Shi Bo Jiang Shujiang Tu School of Chemistry and Chemical Engineering Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University Xuzhou Jiangsu 221116 China

Concise and efficient three-component domino [4＋ 1 ＋ 1] carbocyclization to highly substituted fluoren-9-one derivatives promoted by K2CO3 has been developed under microwave irradiation conditions. The direct bis-cyanation and aryl amination residing in fluoren-9-one framework were achieved in a one-pot operation. The reaction proceeds at fast rates and can be finished within 30 min, which makes workup convenient to give good to excellent chemical yields.

关键词： fluoren-9-one synthesis multicomponent reactions carbocyclization regioselectivity microwaveheating

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Monitoring models for base flow effect and daily variation of dam seepage elements considering time lag effect

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Water Science and Engineering 2018年第4期11卷 344-354页

作者： Shao-wei Wang ying-li xu Chong-shi Gu Teng-fei Bao School of Environmental and Safety Engineering Changzhou University State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University

Affected by external environmental factors and evolution of dam performance, dam seepage behavior shows nonlinear time-varying characteristics. In this study, to predict and evaluate the long-term development trend and short-term fluctuation of the dam seepage behavior, two monitoring models were developed, one for the base flow effect and one for daily variation of dam seepage elements. In the first model, to avoid the influence of the time lag effect on the evaluation of seepage variation with the time effect component of seepage elements, the base values of the seepage element and the reservoir water level were extracted using the wavelet multi-resolution analysis method, and the time effect component was separated by the established base flow effect monitoring model. For the development of the daily variation monitoring model for dam seepage elements, all the previous factors, of which the measured time series prior to the dam seepage element monitoring time may have certain influence on the monitored results, were considered. Those factors that were positively correlated with the analyzed seepage element were initially considered to be the support vector machine(SVM) model input factors, and then the SVM kernel function-based sensitivity analysis was performed to optimize the input factor set and establish the optimized daily variation SVM model. The efficiency and rationality of the two models were verified by case studies of the water level of two piezometric tubes buried under the slope of a concrete gravity *** analysis of the optimized SVM model shows that the influences of the daily variation of the upstream reservoir water level and rainfall on the daily variation of piezometric tube water level are processes subject to normal distribution.

关键词： Dam seepage monitoring model Time lag effect Support vector machine(SVM) Sensitivity analysis Base flow Daily variation Piezometric tube water level

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New treatment for gastroesophageal reflux disease:Traditional Chinese medicine Xiaochaihu decoction

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World Journal of Gastroenterology 2022年第11期28卷 1184-1186页

作者： li-ying xu Bin-Yan Yu Lu-Sha Cen Department of Emergency Medicine The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Acupuncture and Moxibustion The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

Gastroesophageal reflux disease(GERD)has a high prevalence *** et al performed a well-designed study on the efficacy of modified Xiaochaihu decoction(MXD)for GERD,which showed that MXD is an optional therapy for GERD beyond proton pump inhibitors(PPIs).The herbal granule administration mode minimized the bias from traditional herbal formula in clinical *** limitation of that study was that it lacked records of side effects and rescue *** a chronic disease with recurrent symptoms,GERD rehabilitation requires prolonged observation of the clinical course with MXD therapy.

关键词： Gastroesophageal reflux disease Xiaochaihu decoction New treatment Traditional Chinese medicine Modified Xiaochaihu decoction Chronic disease

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