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Acta Metallurgica Sinica(English Letters) 2015年第3期28卷 386-393页

作者： Ri-Ming Wu Wei li Cheng-lin wang Yi Xiao li wang Xue-Jun Jin School of Materials Science and Engineering Shanghai Jiao Tong University School of Materials Science and Engineering Shanghai University State Key Lab of Development and Application Technology of Automotive Steels Baosteel Research Institute

Intercritical annealing（IA） at various temperatures followed by quenching and partitioning（IAQP） treatments was conducted on a cold-rolled Fe-0.2C-1.42Si-l.87Mn（wt%） sheet *** microstructure and enhanced mechanical properties were achieved through appropriate adjustment of IA *** steel which was annealed at1,033 K for 600 s,then quenched to 573 K and partitioned at 693 K for 20 min,designated as 1033 QP steel,exhibits maximum 16.3 vol% retained austenite（RA） with good mechanical properties（ultimate tensile strength 886 MPa and total elongation 27%）.It was found that the thermal and mechanical stabilities of RA are mainly influenced by the combined effect of its average carbon content and amount of adjacent ***,the transformation-induced plasticity effect increased the peak n-values observed at the second stage of the work hardening of IAQP steels.

关键词： Intercritical annealing and quenching and partitioning treatment(IAQP) Retained austenite(RA) Average carbon content(ACC) Amount of adjacent martensite(AAM) Transformation-induced plasticity(TRIP)

A new approach to the synthesis of α-chlorocycloalkanones

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Chinese Chemical Letters 2007年第12期18卷 1476-1478页

作者： xing Hai li xin ling Yang Xiao Mei liang Zhen Peng Kai Yun ling Fu Heng Chen Dao Quan wang Department of Applied Chemistry China Agricultural University Beijing 100094 China

α-Chlorocycloalkanones （IV） were synthesized from cycloalkanones via potassium ot-oxocycloalkylsulfonates （Ⅱ）. A two-step mechanism was proposed to explain the formation of IV from Ⅱ.

关键词： α-Chlorocycloalkanones Synthesis Potassium α-oxocycloalkylsulfonates

Two new benzophenone glucosides from Cratoxylon cochinchinensis

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Chinese Chemical Letters 2009年第4期20卷 459-461页

作者： Hai Yang Yu San lin Jin Xue.Zhang Yuan liu Yang Fu Ou Nai li wang xin Sheng Yao College of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Shenzhen Key Laboratory for New Drugs Research of Traditional Chinese Medicines Research Institute of Tsinghua University Shenzhen 518057 China

Two new benzophenone glucosides were isolated from the 60% ethanol extract of the dried stems of Cratoxylum cochinchinense. The structures were elucidated as 3-O-β-D-glucopyranosyl-2＇,4,6＇-trihydroxy-benzophenone a... 详细信息

关键词： Cratoxylum cochinchinense Benzophenone glucosides

Kinematics Analysis and Optimization of the Fast Shearing-extrusion Joining Mechanism for Solid-state Metal

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Chinese Journal of Mechanical Engineering 2015年第6期28卷 1123-1131页

作者： ZHANG Shuangjie YAO Yunfeng li lingchong wang lijuan li Junxia li Qiang School of Materials Science and Engineering Hebei University of Science and Technology Key Laboratory of Material Near-net Forming Technology of Hebei Province School of Mechanical Engineering Yanshan University

Dynamical Joining of the solid-state metal is the key technology to realize endless hot rolling. The heating and laser welding method both require long joining time. Based on super deformation method, a 7-bar and 2-slider mechanism was developed in Japan, and the joining time is less than 0.5 s, however the length of each bar are not reported and this mechanism is complex. A relatively simple 6-bar and 1-slider mechanism is put forward, which can realize the shearing and extrusion motion of the top and bottom blades with a speed approximately equal to the speed of the metal plates. In order to study the kinematics property of the double blades, based on complex vector method, the multi-rigid-body model is built, and the displacement and speed functions of the double blades, the joining time and joining thickness are deduced, the kinematics analysis shows that the initial parameters can＇t satisfy the joining process. Hence, optimization of this mechanism is employed using genetic algorithm（GA） and the optimization parameters of this mechanism are obtained, the kinematics analysis show that the joining time is less than 0.1 s, the joining thickness is more than 80% of the thickness of the solid-state metal, and the horizontal speeds of the blades are improved. A new mechanism is provided for the joining of the solid-state metal and a foundation is laid for the design of the device.

关键词： endless rolling solid-state metal dynamical joining mechanism kinematic optimization genetic algorithm

THE MULTIPliCITY AND CONCENTRATION OF POSITIVE SOLUTIONS FOR THE KIRCHHOFF-CHOQUARD EQUATION WITH MAGNETIC FIELDS

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Acta Mathematica Scientia 2022年第4期42卷 1453-1484页

作者： li wang Kun CHENG Jixiu wang College of Science East China Jiaotong UniversityNanchang 330013China Department of Information Engineering Jingdezhen Ceramic InstituteJingdezhen333403China School of Mathematics and Statistics Hubei University of Arts and ScienceXiangyang441053China

In this paper,we study the multiplicity and concentration of positive solutions for the following fractional Kirchhoff-Choquard equation with magnetic fields:(aε^(2s)+bε^(4 s-3)[u]_(ε)^(2),A/ε)(-Δ)_(A/ε)^(s)u+V(x)u=ε^(-α)(Iα*F(|u|^(2)))f(|u|^(2))u in R^(3).Hereε>0 is a small parameter,a,b>0 are constants,s E(0,1),(-Δ)As is the fractional magnetic Laplacian,A:R^(3)→R^(3) is a smooth magnetic potential,Iα=Γ(3-α/2)/2απ3/2Γ(α/2)·1/|x|^(α) is the Riesz potential,the potential V is a positive continuous function having a local minimum,and f:R→R is a C^(1) subcritical *** some proper assumptions regarding V and f,we show the multiplicity and concentration of positive solutions with the topology of the set M:={x∈R^(3):V(x)=inf V}by applying the penalization method and LjusternikSchnirelmann theory for the above equation.

关键词： Fractional Kirchhoff-Choquard problem penalization method Ljusternik-Schnirelmann theory variational methods

Thioxanthene-9-thione Mediated MMA Polymerization

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Chinese Journal of Polymer Science 2018年第7期36卷 805-810页

作者： Xu Yan Guan wang li-Hua Zhang li wang Xiao-Fei liu Wan-Tai Yang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical and Technology Beijing Laboratory of Biomedical Materials Polymer Materials Beijing University of Chemical and Technology

In the ＂cycloketyl radical mediated living polymerization＂（CMP） process, a cycloketyl compound, [9,9＇]bixanthenyl-9,9＇ diol （BIXAN） was ultilized as initiator and mediator. The cycloketyl （CK） radical was used as the dormant radical to achieve the increase of molecular weight. Herein, a series of cycloketyl thioketones were synthesised by Lawesson＇s reagent by one step reaction with high yeild, and we found that, when a special cyeloketyl thioketone compound, thioxanthene-9-thione （TXT）, was added to a routine radical polymerization system, TXT could capture chain radical, and simultaneously formed an radical analogous to CK radical in structure, which could trigger the growth of polymer chains. This simple system was efficient to initiate the polymerization of methyl methacrylate （MMA） and in all cases the molecular weights increased with the increase of conversions. By the end-group analysis with 1H-NMR and MALDI-TOF MS, it was confirmed that the P-STXT radical was used to control the polymerization. The re-initiating reactions were achieved when PMMA was used as the macro-initiator.

关键词： Thioxanthene-9-thione Lawesson's reagent Methyl methacrylate Radical polymerization

Evaluating the efficacy and cardiotoxicity of EGFR-TKI AC0010 with a novel multifunctional biosensor

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Microsystems & Nanoengineering 2023年第3期9卷 259-271页

作者： Deming Jiang xinwei Wei Yuxuan Zhu Yong Qiu xin liu liubing Kong Fengheng li Jingwen liu liujing Zhuang Hao Wan Kejing Ying Ping wang Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education MinistryDepartment of Biomedical EngineeringZhejiang UniversityHangzhouZhejiang 310027China Innovation Center for Smart Medical Technologies&Devices Binjiang Institute of Zhejiang UniversityZhejiang 310053China Cancer Center Zhejiang UniversityHangzhouZhejiang 310058China College of Pharmaceutical Sciences Zhejiang UniversityHangzhouZhejiang 310058China Department of Gastroenterology Zhejiang University School of Medicine Second Affiliated HospitalHangzhouZhejiang 310009China Department of Respiratory and Critical Medicine Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina State Key Laboratory for Sensor Technology Chinese Academy of SciencesShanghai 200050China

Non-small cell lung cancer(NSCLC)is a leading cause of cancer mortality *** epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)have dramatically improved the life expectancy of patients with NSCLC,concerns about TKI-induced cardiotoxicities have ***0010,a novel third-generation TKI,was developed to overcome drug resistance induced by EGFR-T790M ***,the cardiotoxicity of AC0010 remains *** evaluate the efficacy and cardiotoxicity of AC0010,we designed a novel multifunctional biosensor by integrating microelectrodes(MEs)and interdigital electrodes(IDEs)to comprehensively evaluate cell viability,electrophysiological activity,and morphological changes(beating of cardiomyocytes).The multifunctional biosensor can monitor AC0010-induced NSCLC inhibition and cardiotoxicity in a quantitative,label-free,noninvasive,and real-time ***0010 was found to significantly inhibit NCI-H1975(EGFR-L858R/T790M mutation),while weak inhibition was found for A549(wild-type EGFR).Negligible inhibition was found in the viabilities of HFF-1(normal fibroblasts)and *** the multifunctional biosensor,we found that 10μM AC0010 significantly affected the extracellular field potential(EFP)and mechanical beating of *** amplitude of EFP continuously decreased after AC0010 treatment,while the interval decreased first and then *** analyzed the change in the systole time(ST)and diastole time(DT)within a beating interval and found that the DT and DT/beating interval rate decreased within 1 h after AC0010 *** result probably indicated that the relaxation of cardiomyocytes was insufficient,which may further aggravate the ***,we found that AC0010 significantly inhibited EGFR-mutant NSCLC cells and impaired cardiomyocyte function at low concentrations(10μM).This is the first study in which the risk of AC0010-induced cardiotoxicity was *** addition,novel multifunctional bi

关键词： cardio TKI impaired

SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease

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Neural Regeneration Research 2022年第10期17卷 2293-2299页

作者： Meng-Yu Lai Jie li Xi-Xi Zhang Wei Wu Zhi-Ping li Zhi-xin Sun Meng-Yang Zhao Dong-Ming Yang Dong-Dong wang Wen li De-Ming Zhao Xiang-Mei Zhou li-Feng Yang National Animal Transmissible Spongiform Encephalopathy Laboratory College of Veterinary MedicineChina Agricultural UniversityBeijingChina

Prion disease represents a group of fatal neurogenerative diseases in humans and animals that are associated with energy loss,axonal degeneration,and mitochondrial *** degeneration is an early hallmark of neurodegeneration and is triggered by *** found that depletion or dysfunctional mutation of SARM1 protected against NAD+loss,axonal degeneration,and mitochondrial functional disorder induced by the neurotoxic peptide ***+supplementation rescued prion-triggered axonal degeneration and mitochondrial dysfunction and SARM1 overexpression suppressed this protective ***+supplementation in PrP106-126-incubated N2a cells,SARM1 depletion,and SARM1 dysfunctional mutation each blocked neuronal apoptosis and increased cell *** results indicate that the axonal degeneration and mitochondrial dysfunction triggered by PrP^(106-126) are partially dependent on SARM1 NADase *** pathway has potential as a therapeutic target in the early stages of prion disease.

关键词： axonal degeneration mitochondrial dysfunction NAD+metabolism NADase neurodegenerative disease prion disease SARM1 sterile alpha and TIR motif-containing 1

Carbon Nitride Quantum Dots:A Novel Fluorescent Probe for Non-Enzymatic Hydrogen Peroxide and Mercury Detection

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Journal of Ocean University of China 2023年第6期22卷 1572-1582页

作者： CHEN Lei li Quan wang xing wang Wentai wang lisha Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationCollege of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China

The mercury species in the ocean(MeHg,Hg^(2+))will be enriched in marine organisms and threaten human health through the food *** the excessive H_(2)O_(2)in the metabolic process will produce hydroxyl radicals and accelerate the aging of human cells,causing a series of ***,the cost-effective and rapid detection of mercury and H_(2)O_(2)is of urgent requirement and ***,we synthesized emerging graphitic carbon nitride quantum dots(g-CNQDs)with high fluorescence quantum yield(FLQY)of 42.69%via a bottom-up strategy by a facile one-step hydrothermal *** g-CNQDs can detect the H_(2)O_(2)and Hg^(2+)through the fluorescence quenching effect between g-CNQDs and detected *** the presence of KI,g-CNQDs show concentration-dependent fluorescence toward H_(2)O_(2),with a wide detection range of 1–1000μmolL^(-1)and a low detection limit of 0.23μmolL^(-1).The g-CNQDs also show sensitivity toward Hg^(2+)with a detection range of 0–0.1μmolL^(-1)and a detection limit of 0.038μmolL^(-1).This dual-function detection of g-CNQDs has better practical application capability compared to other quantum dot *** study may provide a new strategy for g-CNQDs preparation and construct a fluorescence probe that can be used in various systems involving H_(2)O_(2)and Hg^(2+),providing better support for future bifunctional or multifunction studies.

关键词： carbon nitride quantum dots hydrogen peroxide Hg2+ fluorescence probe

GIL:a tightly coupled GNSS PPP/INS/liDAR method for precise vehicle navigation

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Satellite Navigation 2021年第1期2卷 368-384页

作者： xingxing li Huidan wang Shengyu li Shaoquan Feng Xuanbin wang Jianchi liao School of Geodesy and Geomatics Wuhan University129 Luoyu RoadWuhan 430079China

Accurate positioning and navigation play a vital role in vehicle-related applications,such as autonomous driving and precision *** the rapid development of Global Navigation Satellite Systems(GNSS),Precise Point Positioning(PPP)technique,as a global positioning solution,has been widely applied due to its convenient ***,the performance of PPP is severely affected by signal interference,especially in GNSS-challenged *** Navigation System(INS)aided GNSS can significantly improve the continuity and accuracy of navigation in harsh environments,but suffers from degradation during GNSS ***(Laser Imaging,Detection,and Ranging)-Inertial Odometry(liO),which has performed well in local navigation,can restrain the divergence of Inertial Measurement Units(IMU).However,in long-range navigation,error accumulation is inevitable if no external aids are *** improve vehicle navigation performance,we proposed a tightly coupled GNSS PPP/INS/liDAR(GIL)integration method,which tightly integrates the raw measurements from multi-GNSS PPP,Micro-Electro-Mechanical System(MEMS)-IMU,and liDAR to achieve high-accuracy and reliable navigation in urban *** experiments were conducted to evaluate this *** results indicate that in comparison with the multi-GNSS PPP/INS tightly coupled solution the positioning Root-Mean-Square Errors(RMSEs)of the proposed GIL method have the improvements of 63.0%,51.3%,and 62.2%in east,north,and vertical components,*** GIL method can achieve decimeter-level positioning accuracy in GNSS partly-blocked environment(i.e.,the environment with GNSS signals partly-blocked)and meter-level positioning accuracy in GNSS difficult environment(i.e.,the environment with GNSS hardly used).Besides,the accuracy of velocity and attitude estimation can also be enhanced with the GIL method.

关键词： Multi-GNSS PPP MEMS-IMU liDAR Tightly coupled method GNSS-challenged environment Vehicle navigation