检索结果-南通市图书馆

Dry environment on the expression of lacrimal gland S100A9,Anxa1,and Clu in rats via proteomics

International Journal of Ophthalmology(English edition) 2024年第3期17卷 435-443页

作者： Yi-lin Sun A-Yuan Cui li-xin wang wang-wang Zhang Hong Shi College of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina Research on High Incidence of Diseases in xinjiang Region Key Laboratory of the Ministry of Education(Xinjiang Medical University)Urumqi 830011Xinjiang Uygur Autonomous RegionChina

●AIM:To investigate the underlying mechanism of dry environment(autumn dryness)affecting the lacrimal glands in rats.●METHODS:Twenty Sprague-Dawley rats were randomly divided into two *** rats were fed in specific pathogen free environment as the control group(n=10),and the rats fed in dry environment as the dryness group(n=10).After 24d,lacrimal glands were collected from the *** tissues morphology was observed by hematoxylineosin(HE)*** mass tags(TMT)quantitative proteomics analysis technology was used to screen the differential expressed proteins of lacrimal glands between the two groups,then bioinformatics analysis was ***,the immunohistochemical(IHC)method was used to verify the target proteins.●RESULTS:In dryness group,the lacrimal glands lobule atrophied,the glandular cavities enlarged,the sparse nuclear distribution and scattered inflammatory infiltration between the acinus were *** proteomics exhibited that a total of 195 up-regulated and 236 downregulated differential expressed proteins screened from the lacrimal glands of *** was indicated that the biological processes(BP)of differential expressed proteins mainly included cell processes and single *** cellular compositions of differential expressed proteins mainly located in cells,*** molecular functions of differential expressed proteins mainly included binding,catalytic ***,the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that the differential expressed proteins mainly involved lysosome,complement and coagulation cascade,and ribosome *** IHC result verified that the up-regulated expression proteins of Protein S100A9(S100A9),Annexin A1(Anxa1),and Clusterin(Clu)in lacrimal glands of rats in dryness group were higher than control group.●CONCLUSION:The up-regulated expression proteins of S100A9,Anxa1,and Clu may be the potential mechanisms of dry eye symptoms caused by dry *** study pr

关键词： dry eye lacrimal gland S100A9 Clu Anxa1 environment rats

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney,and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways

引用

World Journal of Diabetes 2024年第3期15卷 502-518页

作者： Zi-Ang Ma li-xin wang Hui Zhang Han-Zhou li li Dong Qing-Hai wang Yuan-Song wang Bao-ChaoPan Shu-Fang Zhang Huan-Tian Cui Shu-Quan Lv Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese MedicineCangzhou 061000Hebei ProvinceChina School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 300000China The First School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 065000Yunnan ProvinceChina Department of Endocrinology Hebei Cangzhou Hospital of Integrative MedicineCangzhou 061000Hebei ProvinceChina

BACKGROUND Jianpi Gushen Huayu Decoction(JPGS)has been used to clinically treat diabetic nephropathy(DN)for many ***,the protective mechanism of JPGS in treating DN remains *** To evaluate the therapeutic effects and the possible mechanism of JPGS on *** We first evaluated the therapeutic potential of JPGS on a DN mouse *** then investigated the effect of JPGS on the renal metabolite levels of DN mice using non-targeted ***,we examined the effects of JPGS on c-Jun N-terminal kinase(JNK)/P38-mediated apoptosis and the inflammatory responses mediated by toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/NOD-like receptor family pyrin domain containing 3(NLRP3).RESULTS The ameliorative effects of JPGS on DN mice included the alleviation of renal injury and the control of inflammation and oxidative *** metabolomic analysis revealed that JPGS altered the metabolites of the kidneys in DN mice.A total of 51 differential metabolites were *** analysis results indicated that nine pathways significantly changed between the control and model groups,while six pathways significantly altered between the model and JPGS *** related to cysteine and methionine metabolism;alanine,tryptophan metabolism;aspartate and glutamate metabolism;and riboflavin metabolism were identified as the key pathways through which JPGS affects *** experimental validation showed that JPGS treatment reduced the expression of TLR4/NF-κB/NLRP3 pathways and JNK/P38 pathway-mediated apoptosis related *** JPGS could markedly treat mice with streptozotocin(STZ)-induced DN,which is possibly related to the regulation of several metabolic pathways found in ***,JPGS could improve kidney inflammatory responses and ameliorate kidney injuries in DN mice via the TLR4/NF-κB/NLRP3 pathway and inhibit JNK/P38 pathwaymediated apoptosis in DN mice.

关键词： Diabetic nephropathy Jianpi Gushen Huayu Decoction Oxidative stress Inflammation Untargeted metabolomics Toll-like receptor 4/nuclear factor-kappa B/NOD-like receptor family pyrin domain containing 3 pathway c-Jun N-terminal kinase/P38-mediated apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantum self-attention neural networks for text classification

引用

Science China(Information Sciences) 2024年第4期67卷 301-313页

作者： Guangxi li Xuanqiang ZHAO xin wang Institute for Quantum Computing Baidu Research Centre for Quantum Software and Information University of Technology Sydney QICI Quantum Information and Computation Initiative Department of Computer ScienceThe University of Hong Kong Thrust of Artificial Intelligence Information HubHong Kong University of Science and Technology(Guangzhou)

An emerging direction of quantum computing is to establish meaningful quantum applications in various fields of artificial intelligence, including natural language processing(NLP). Although some efforts based on syntactic analysis have opened the door to research in quantum NLP(QNLP), limitations such as heavy syntactic preprocessing and syntax-dependent network architecture make them impracticable on larger and real-world data sets. In this paper, we propose a new simple network architecture, called the quantum selfattention neural network(QSANN), which can compensate for these limitations. Specifically, we introduce the self-attention mechanism into quantum neural networks and then utilize a Gaussian projected quantum self-attention serving as a sensible quantum version of self-attention. As a result, QSANN is effective and scalable on larger data sets and has the desirable property of being implementable on near-term quantum devices. In particular, our QSANN outperforms the best existing QNLP model based on syntactic analysis as well as a simple classical self-attention neural network in numerical experiments of text classification tasks on public data sets. We further show that our method exhibits robustness to low-level quantum noises and showcases resilience to quantum neural network architectures.

关键词： quantum neural networks self-attention natural language processing text classification parameterized quantum circuits

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stability of the Stratification of Water Bodies in the North Passage of the Yangtze River Estuary Based on the EFDC Model

引用

Journal of Ocean University of China 2024年第1期23卷 23-32页

作者： WU De’an li xin wang Yigang College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China Tianjin Research Institute For Water Transport Engineering Tianjin 300456China

To study the stratified stability of a water column in the North Passage of the Yangtze River Estuary,a numerical model of the hydrodynamics of this estuary is established using the EFDC *** the basis of EFDC results,this paper derives and pro-vides the discriminative index of water body stability caused by salinity and analyzes the along-range variation in water body strati-fication stability in the North Passage of the Yangtze River Estuary and the periodic variation at a key location(bend area)based on the simulation results of the numerical *** work shows that the water body in the bend area varies between mixed and strati-fied types,and the vertical average flow velocity has a good negative correlation with the differential velocity between the surface and bottom layers of the water *** model simulation results validate the formulae for the stratified stability discriminant during spring tides.

关键词： Yangtze Estuary North Passage EFDC model stratification stability salinity distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Interface Form on Creep Failure and life of Dissimilar Metal Welds Involving Nickel-Based Weld Metal and Ferritic Base Metal

引用

Chinese Journal of Mechanical Engineering 2024年第1期37卷 265-285页

作者： Xiaogang li Junfeng Nie xin wang Kejian li Haiquan Zhang Institute of Nuclear and New Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China

For dissimilar metal welds(DMWs)involving nickel-based weld metal(WM)and ferritic heat resistant steel base metal(BM)in power plants,there must be an interface between WM and BM,and this interface suffers mechanical and microstructure mismatches and is often the rupture location of premature *** this study,a new form of WM/BM interface form,namely double Y-type interface was designed for the *** behaviors and life of DMWs containing double Y-type interface and conventional I-type interface were compared by finite element analysis and creep tests,and creep failure mechanisms were investigated by stress-strain analysis and microstructure *** applying double Y-type interface instead of conventional I-type interface,failure location of DMW could be shifted from the WM/ferritic heat-affected zone(HAZ)interface into the ferritic HAZ or even the ferritic BM,and the failure mode change improved the creep life of *** interface premature failure of I-type interface DMW was related to the coupling effect of microstructure degradation,stress and strain concentrations,and oxide notch on the WM/HAZ *** creep failure of double Y-type interface DMW was the result of Type IV fracture due to the creep voids and micro-cracks on fine-grain boundaries in HAZ,which was a result of the matrix softening of HAZ and lack of precipitate pinning at fine-grain *** double Y-type interface form separated the stress and strain concentrations in DMW from the WM/HAZ interface,preventing the trigger effect of oxide notch on interface failure and inhibiting the interfacial microstructure *** is a novel scheme to prolong creep life and enhance reliability of DMW,by means of optimizing the interface form,decoupling the damage factors from WM/HAZ interface,and then changing the failure mechanism and shifting the failure location.

关键词： Dissimilar metal weld Nickel-based weld metal Ferritic heat resistant steel Interface Creep strain Microstructure Failure mechanism Creep life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Joint fuzzy background and adaptive foreground model for moving target detection

引用

Frontiers of Computer Science 2024年第2期18卷 93-106页

作者： Dawei ZHANG Peng wang Yongfeng DONG linhao li xin li School of Artificial Intelligence Hebei University of TechnologyTianjin 300401China Lane Department of Computer Science and Electrical Engineering West Virginia UniversityMorgantownWV 26506-6109USA

Moving target detection is one of the most basic tasks in computer *** conventional wisdom,the problem is solved by iterative optimization under either Matrix Decomposition(MD)or Matrix Factorization(MF)*** utilizes foreground information to facilitate background *** uses noise-based weights to fine-tune the *** both noise and foreground information contribute to the recovery of the *** jointly exploit their advantages,inspired by two framework complementary characteristics,we propose to simultaneously exploit the advantages of these two optimizing approaches in a unified framework called Joint Matrix Decomposition and Factorization(JMDF).To improve background extraction,a fuzzy factorization is *** fuzzy membership of the background/foreground association is calculated during the factorization process to distinguish their contributions of both to background *** describe the spatio-temporal continuity of foreground more accurately,we propose to incorporate the first order temporal difference into the group sparsity constraint *** temporal constraint is adjusted *** foreground and the background are jointly estimated through an effective alternate optimization process,and the noise can be modeled with the specific probability *** experimental results of vast real videos illustrate the effectiveness of our *** with the current state-of-the-art technology,our method can usually form the clearer background and extract the more accurate ***-noise experiments show the noise robustness of our method.

关键词： matrixdecomposition matrix factorization generalized sparsity noise modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of tailpipe carbonyls and volatile organic compounds emissions from in-use gasoline/CNG bi-fuel vehicles

引用

Journal of Environmental Sciences 2024年第1期135卷 619-629页

作者： Jiachen li Yunshan Ge xin wang Mengzhu Zhang Haohao wang School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China

Ground-level ozone contamination has been globally an urban air quality issue,particularly for China,which has recently made significant progress in purifying its *** exhaust emissions from motor vehicles,predominantly carbonyls and volatile organic compounds(VOCs),are among the leading contributors to ozone *** this chassislevel study,the unregulated emissions from five China-5 certified gasoline/CNG bi-fuel taxis,along with their ozone forming potential(OFP),were *** is found that carbonyls and VOCs were mainly emitted during the starting phase no matter the engine was cold or *** to gasoline,CNG fueling reduced VOCs emissions on a large scale,especially in the starting phase,but had elevated *** a fleet average,CNG fueling derived 15%and 46%less OFP than gasoline in cold-and hot-start tests,*** contributed to over 90%of the total OFP of the *** terms of alleviating ground-level ozone contamination,CNG is a feasible alternative to gasoline on light-duty vehicles.

关键词： CNG Gasoline Carbonyls VOCs OFP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Morphological features and endovascular repair for type B multichanneled aortic dissection: A case report

引用

World Journal of Clinical Cases 2023年第18期11卷 4313-4317页

作者： Wei-Feng Lu Gang Chen li-xin wang Department of Vascular Surgery Zhongshan Hospital(Xiamen)Fudan UniversityXiamen 361015Fujian ProvinceChina

BACKGROUND Among the various types of aortic dissection,multichanneled aortic dissection(MCAD)differs from classic double-channeled aortic dissection and involves the formation of an additional false lumen in the aortic wall or the *** is considered a relatively rare condition with high perioperative mortality and ***,the morphological characteristic and the optimal therapeutic strategy for MCAD has not been fully *** SUMMARY A 64-year-old man presented to our hospital with severe epigastric abdominal pain radiating to the back that was associated with nausea without emesis.A computed tomography angiogram was performed that revealed a type B aortic dissection with multiple channels extending from the level of the left subclavian artery to the bilateral femoral *** used a medical three-dimensional modeling(3D)modeling system to identify the location and extension of multiple lumens from different *** also precisely located the two primary entries leading to the false lumens,which helped us to exclude the two false lumens with one *** By applying medical 3D modeling system,we discover the fragility of aortic wall and the collapse of true lumen caused by the multiple false lumens are the two morphological features of MCAD.

关键词： Aortic dissection Endovascular repair Three-dimensional modeling Multichanneled Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Threshold Selection and Resource Allocation for Quantized Identification

引用

Journal of Systems Science & Complexity 2024年第1期37卷 204-229页

作者： wang Ying li xin ZHAO Yanlong ZHANG Ji-Feng Key Laboratory of Systems and Control Institute of Systems ScienceAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

This paper is concerned with the optimal threshold selection and resource allocation problems of quantized identification, whose aims are improving identification efficiency under limited resources. Firstly, the first-order asymptotically optimal quantized identification theory is extended to the weak persistent excitation condition. Secondly, the characteristics of time and space complexities are established based on the Cramér-Rao lower bound of quantized systems. On these basis, the optimal selection methods of fixed thresholds and adaptive thresholds are established under aperiodic signals, which answer how to achieve the best efficiency of quantized identification under the same time and space complexity. In addition, based on the principle of maximizing the identification efficiency under a given resource, the optimal resource allocation methods of quantized identification are given for the cases of fixed thresholds and adaptive thresholds, respectively, which show how to balance time and space complexity to realize the best identification efficiency of quantized identification.

关键词： Quantized output resource allocation system identification threshold selection.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Traction force with extracellular matrix mediated by cytoskeleton influences metastasis through SLC8A1 induced Wnt-b-catenin pathway in endometrial cancer

引用

Genes & Diseases 2024年第5期11卷 98-101页

作者： xingchen li xin Xu Jianliu wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Department of Obstetrics and Gynecology Beijing ChaoYang HospitalCapital Medical UniversityBeijing 100020China

Endometrial cancer(EC)is one of the most prominent malignancies in ***,despite these advancements in understanding EC pathogenesis,mortality rates have not *** force(TF)refers to endogenous mechanical forces exerted by cells.1 These forces act on the extracellular matrix and the extracellular tumor microenvironment through focal adhesions,thereby regulating cell proliferation and ***,the TF characteristics of endometrial cancer cells and their heterogeneity remain unclear.

关键词： endometrial metastasis endogenous

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：