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PLG-g-mPEG Mediated Multifunctional Nanoparticles for Photoacoustic Imaging Guided Combined Chemo/Photothermal Antitumor Therapy

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Chinese Journal of Polymer Science 2023年第4期41卷 538-546,I0007页

作者： Chong liu ling li Zhao-Pei Guo lin lin Yan-Hui li hua-Yu Tian School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun130022China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen361005China School of Materials Science and Engineering Xiamen University of TechnologyXiamen361024China

Under laser irradiation,photothermal therapy(PTT)effectively ablates tumors above 50℃.However,hyperthermia can cause additional damage due to the inevitable heat spread to surrounding healthy ***,nanoparticles named as GI@P NPs were designed for enhanced PTT with heat shock protein 90(HSP90)inhibition at temperatures below 50℃to achieve optimal cancer therapy and avoid surrounding ***@P NPs were done by co-loading Garcinia cambogia acid(GA)and photosensitizer IR783 in polymer PLG-g-mPEG to form a nanomedicine,where IR783 with excellent photoacoustic(PA)signal acted as an excellent photothermal therapeutic agent that converted the laser energy into heat to kill tumor cells,GA was used as antitumor drug for chemotherapy and an inhibitor of HSP90 to overcome the heat resistance of tumors for efficient cryo-photothermal therapy,and PLG-g-mPEG can encapsulate IR783 and GA to increase biocompatibility and accumulate effectively in the *** GI@P NPs were injected into the mice,we could observe that the PA signals gradually increased in the tumor region and showed the strongest PA signals at 12 *** laser irradiation,the tumor temperature of the mice could raise to about 43.5℃,and the tumor was significantly inhibited after long-term monitoring by PA *** a result,gentle PTT produced by GI@P NPs exhibited good antitumor effects at relatively low temperature and minimized nonspecific thermal damage to normal *** GI@P NPs as nanomedicine enriched our understanding of various applications of polymeric carriers,especially in the biomedical field.

关键词： Mild-temperature photothermal therapy Photoacoustic imaging Polymer carrier Combination therapy Co-loading

Negative effect on molecular planarity to achieve organic ternary memory: triphenylamine as the spacer

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Science China Chemistry 2016年第6期59卷 692-698页

作者： Shugang Xia Jinghui He hua li Qingfeng Xu Najun li Dongyun Chen Jianmei Lu College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University

Adjusting the spacers between the electron-acceptor and the elector-donor is important to design organic ternary memory material but rarely reported. In this paper, two small molecules, ZIPGA and ZIPCAD with benzene ring or triphenylamine as the spacers, were designed and synthesized to fabricate memory devices. The A1/ZIPGA/indium-tin oxide （ITO） device showed ternary characteristics, whereas A1/ZIPCAD/ITO had no obvious memory characteristics. Density functional theory calculation, X-ray diffraction （XRD） and atomic force microscopy （AFM） were employed to interpret the different memory properties. ZIPGA thin film has the closer intermolecular packing and flatter surface morphology than ZIPCAD film, which was favorable to the electron migration. This work demonstrates the importance of spacers and reveals that triphenylamine may be not a good spacer in design of new memory material.

关键词： small molecules different spacers ternary memory device molecular stacking

Improved formation density measurement using controllable D-D neutron source and its lithological correction for porosity prediction

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Nuclear Science and Techniques 2022年第1期33卷 24-34页

作者： li Zhang hua-Wei Yu Yang li Wen-Bao Jia Xiao Han Xue-Sen Geng College of Resources Shandong University of Science and TechnologyTai’an 271019China School of Geosciences China University of PetroleumQingdao 266580China College of Mechanical and Electronic Engineering Shandong Agricultural UniversityTai’an 271018China Department of Nuclear Science and Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Controllable D-D neutron sources have a long service life,low cost,and *** are favorable prospects for its application in geophysical well logging,since traditional chemical radioactive sources used for well logging pose potential threats to the safety of the human body and *** paper presents an improved method to measure formation density that employs a D-D neutron *** addition,the lithological effect on the measured density was removed to better estimate the formation ***,we investigated the spatial distribution of capture gamma rays through Monte Carlo simulations as well as the relationship between the ratio of capture gamma ray counts and formation density to establish theoretical support for the design of density logging tools and their corresponding data processing ***,we obtained the far to near detector counts of captured gamma rays for an optimized tool structure and then established its correlation with the density and porosity of three typical formations with pure quartz,calcite,and dolomite ***,we determined the values for correcting the densities of sandstone and dolomite with the same porosity using limestone data as the reference and established the equations for calculating the correction values,which lays a solid foundation for accurately calculating formation *** observed that the capture gamma ray counts first increased then decreased and varied in different formations;this was especially observed in high-porosity *** the same lithologic conditions(rock matrix),as the porosity increases,the peak value of gamma ray counts moves toward the neutron *** different detector-source distances,the ratio of the capture gamma ray counts was well correlated with the formation *** equation of the formation density conversion was established based on the ratio of capture gamma ray counts at the detector-source distances of 30 cm and 65 cm,and the calculate

关键词： Density measurement D-D neutron source lithological correction Porosity prediction

温控相转移催化新体系中α,β-不饱和酮的常压加氢反应

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应用化学 2024年第9期41卷 1350-1356页

作者：刘炳芹王艳华大连理工大学化学学院大连116024

构建了一种由水、1-己醇和Ru纳米(Ru_(nano))催化剂组成的温控相转移(TPT)催化新体系,并将上述催化体系应用于查耳酮常压下的选择性加氢反应中。在优化后的反应条件下,查耳酮的转化率以及查耳酮中C==C双键加氢产物二氢查耳酮的选择性均... 详细信息

构建了一种由水、1-己醇和Ru纳米(Ru_(nano))催化剂组成的温控相转移(TPT)催化新体系,并将上述催化体系应用于查耳酮常压下的选择性加氢反应中。在优化后的反应条件下,查耳酮的转化率以及查耳酮中C==C双键加氢产物二氢查耳酮的选择性均高于99%,Ru_(nano)催化剂可重复使用6次,查耳酮的转化率和二氢查耳酮的选择性均保持不变。反应的转化频率(TOF)高于迄今所报道的常压H2下Ru_(nano)催化剂的最高值,且Ru的流失也得以进一步减少。此外,上述TPT催化新体系在其它α,β-不饱和酮的常压加氢反应中亦获得了高于99%的转化率和选择性。

关键词：水/1-己醇两相体系 Ru纳米催化剂选择性加氢 α,β-不饱和酮常压氢气

脑源性神经营养因子在牦牛与黄牛端脑不同区域的表达与分布

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解剖学报 2024年第1期55卷 10-16页

作者：郑丽平刘霞杜晓华吴亚娟刘珊珊甘肃农业大学生命科学技术学院兰州730070 甘肃农业大学动物医学院兰州730070

目的探讨高原牦牛与平原黄牛端脑中脑源性神经营养因子(BDNF)表达与分布,探讨BDNF功能发挥与高原低氧适应性之间的关联。方法选取牦牛和黄牛各5只,应用Real-time PCR、Western blotting及免疫组织化学技术对BDNF在牦牛和黄牛端脑的额叶... 详细信息

目的探讨高原牦牛与平原黄牛端脑中脑源性神经营养因子(BDNF)表达与分布,探讨BDNF功能发挥与高原低氧适应性之间的关联。方法选取牦牛和黄牛各5只,应用Real-time PCR、Western blotting及免疫组织化学技术对BDNF在牦牛和黄牛端脑的额叶、颞叶、顶叶、枕叶、大脑白质以及海马中的含量与分布进行了定量与定性分析。结果Real-time PCR结果表明,在牦牛与黄牛端脑中,BDNF mRNA均在颞叶皮质中的表达量最高,海马次之,其后依序为顶叶皮质,枕叶皮质和额叶皮质,在大脑白质中的表达量最低。Western blotting结果表明,BDNF蛋白在牦牛颞叶皮质中含量最高,海马次之,其他组织含量由高到低依次为顶叶皮质、额叶皮质、大脑白质,枕叶皮质中含量最低。BDNF蛋白在黄牛端脑颞叶皮质中含量最高,海马次之,其余组织含量由高及低依次为顶叶皮质、枕叶皮质、额叶皮质,大脑白质中蛋白含量最低。免疫组织化学结果表明,BDNF蛋白在牦牛和黄牛端脑中的阳性表达情况基本相似,主要分布在额叶皮质、颞叶皮质、顶叶皮质、枕叶皮质的颗粒细胞和神经胶质细胞,大脑白质的神经胶质细胞以及海马的锥体细胞层和多形细胞层,在端脑皮质区的马丁诺提细胞和海马的分子细胞层中有少量分布。结论BDNF mRNA和蛋白在牦牛和黄牛端脑不同区域中均有表达,但表达量存在差异,推测与端脑不同分区的特定功能密切相关。牦牛端脑中的表达水平除枕叶皮质外,均高于黄牛,推测与其生存的高原低氧环境有关,BDNF在动物机体适应低氧环境过程中可能发挥着增强低氧耐受性和保护机体内环境稳态等重要功能。

关键词：脑源性神经营养因子端脑实时定量聚合酶链反应免疫印迹法免疫组织化学牦牛黄牛

一例肺部感染诱发噬血细胞综合征导致死亡的病例报告

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中华医院感染学杂志 2024年第10期34卷 1487-1491页

作者：李彦华田淬韦妍妍郭新红解放军总医院第六医学中心心血管病医学部北京100853

目的通过分析总结一例肺部感染合并心包积液患者临床特点、诊断及治疗转归,提高对噬血细胞综合征危重症的认识。方法对象为近期在解放军总医院就诊的一例肺部感染合并心包积液的患者,通过对患者的病史、疾病演变过程、化验检查及治疗反... 详细信息

目的通过分析总结一例肺部感染合并心包积液患者临床特点、诊断及治疗转归,提高对噬血细胞综合征危重症的认识。方法对象为近期在解放军总医院就诊的一例肺部感染合并心包积液的患者,通过对患者的病史、疾病演变过程、化验检查及治疗反应进行总结,探讨在疾病诊治过程中出现不能解释的病情变化时的处置策略,为救治赢得时间。结果患者以肺部感染合并心包积液起病,病程中出现心脏压塞症状,抗感染及心包穿刺引流一度有效,后病情反复,炎症指标升高、血清铁蛋白升高、贫血、血小板减低、肝功能异常、甘油三酯升高,自然杀伤(NK)细胞活性下降(12.34%),sCD25升高(32843 pg/ml),骨髓涂片见噬血细胞,符合2004年噬血细胞综合征的诊断标准。结论感染可诱发炎症的过度表达,尤其存在基础风湿免疫系统疾病或血液系统疾病的患者,诊治过程中出现检查结果与临床病情分离的现象,及时完善NK细胞计数、CD4^(+)/CD8^(+)、sCD25、甘油三酯和纤维蛋白原等相对特异性指标,必要时尽快行骨髓穿刺及涂片,查找噬血细胞,有利于明确诊断,及时调整治疗方向,尽最大努力改善患者预后。

关键词：肺部感染心包积液噬血细胞综合征自身免疫性疾病诊断

醛糖还原酶AKR1B1调控甲型流感病毒复制机制的初步研究

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中国预防兽医学报 2024年第8期46卷 775-782页

作者：王一晗王波王雨琴李奇兵王一涵李梦雅姜丽陈化兰李呈军中国农业科学院哈尔滨兽医研究所动物疫病防控全国重点实验室/农业农村部动物流感重点开发实验室黑龙江哈尔滨150069

醛糖还原酶AKR1B1属于醛酮还原酶家族,是一种NADPH依赖性酶,可催化还原亲水性和疏水性醛。本实验室前期实验发现AKR1B1可以抑制流感病毒复制。为了探究醛糖还原酶AKR1B1调控流感病毒复制的具体机制,本研究通过siRNA干扰下调A549细胞中AK... 详细信息

醛糖还原酶AKR1B1属于醛酮还原酶家族,是一种NADPH依赖性酶,可催化还原亲水性和疏水性醛。本实验室前期实验发现AKR1B1可以抑制流感病毒复制。为了探究醛糖还原酶AKR1B1调控流感病毒复制的具体机制,本研究通过siRNA干扰下调A549细胞中AKR1B1基因的表达后,经荧光定量RT-PCR(RT-qPCR)检测细胞内AKR1B1 m RNA的转录水平;通过western blot检测siRNA干扰后细胞内AKR1B1蛋白的表达水平;采用噬斑滴定法检测过表达及干扰AKR1B1后对流感病毒滴度的影响;通过western blot检测干扰AKR1B1表达后对细胞内病毒蛋白表达量的影响及甲型流感病毒A/WSN/33(H1N1)(简写为WSN)感染过程中对内源AKR1B1蛋白表达量的影响;采用激光共聚焦试验检测干扰AKR1B1表达对流感病毒NP蛋白核转运的影响;利用双荧光素酶报告系统检测过表达AKR1B1对流感病毒聚合酶活性的影响。RT-qPCR检测结果显示si_AKR1B1_671和si_AKR1B1_721均能极显著下调A549细胞中AKR1B1基因mRNA的转录水平,与对照组相比分别下降95.62%和85.10%(P<0.001),且不影响细胞活力;western blot检测结果显示si_AKR1B1_671能极显著降低细胞中AKR1B1蛋白的表达量(P<0.001),干扰AKR1B1能够增加细胞内病毒蛋白HA、PB2、NP、M1和NS1的表达量;噬斑滴定结果显示,与对照组相比,干扰AKR1B1表达能显著增加流感病毒WSN的病毒滴度,于感染后24 h和48 h病毒滴度分别上升了4.39倍(P<0.01)和5.53倍(P<0.001);与对照组相比,过表达AKR1B1后,流感病毒滴度于感染后24 h和48 h分别下降了62.59%(P<0.01)和82.78%(P<0.001);激光共聚焦试验结果显示,干扰AKR1B1表达不影响流感病毒的入核和出核阶段;Western blot检测结果显示,在流感病毒WSN感染过程中,细胞内源AKR1B1蛋白的表达量较为稳定,不受病毒感染的影响;双荧光素酶报告试验结果显示,与对照组相比,过表达AKR1B1后流感病毒的聚合酶活性下降了26.24%(P<0.001)。上述结果首次表明,醛糖还原酶AKR1B1通过抑制流感病毒聚合酶活性抑制流感病毒复制,干扰AKR1B1蛋白表达对流感病毒NP蛋白的入核和出核均无影响,并且流感病毒感染不影响细胞内源性AKR1B1的表达。本研究初步探究了宿主因子AKR1B1参与流感病毒复制的分子机制,为进一步了解流感病毒的复制调控提供了实验数据。

关键词：流感病毒醛糖还原酶 AKR1B1 流感病毒聚合酶

Effects of binder components and PVA modifier on bonding performance of phosphate binder for sand core-making

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China Foundry 2023年第2期20卷 134-138页

作者： Wei-hua liu Xin Jia Lai Song Ying-min li School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

A type of heat-curing phosphate binder was proposed,and orthogonal experiments based on the tensile strength of sand samples determined that the optimal composition of the binder was phosphoric acid:water:aluminum hydroxide:magnesium oxide:boric acid=300:70:60:9:*** 10%polyvinyl alcohol(PVA)solution during the sand mixture process can significantly improve the 24 h tensile strength of sand *** adding 30 g phosphate binder and 8 g 10%PVA solution,the initial tensile strength of the sample is 0.76 MPa,the room temperature tensile strength is 2.29 MPa,and the 24 h tensile strength is 1.73 *** heat-curing modified phosphate sand mold has high tensile strength and low gas generation,which can meet general casting production requirements.

关键词： phosphate binder heat curing modifier tensile strength

EFFECTS OF NH_4Cl ON THE INTERACTION BETWEEN POLY(ETHYLENE OXIDE) AND IONIC SURFACTANTS IN AQUEOUS SOLUTIONS

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Chinese Journal of Polymer Science 2008年第1期26卷 31-37页

作者： li, Jing li, hua-zhen Yang, Hai-yang Zhu, Ping-ping He, Ping-sheng Univ Sci & Technol China Dept Polymer Sci & Engn Hefei 230026 Peoples R China

The interaction of poly(ethylene oxide)(PEO)with the ionic surfactants,sodium dodecylsulfate(SDS)and cetyltrimethylammonium chloride(CTAC)respectively,in aqueous solutions containing a certain concentration of NH_4Cl, is studied by the viscosity *** has been found that the ion-dipole interaction between PEO and ionic surfactants is changed considerably by the organic *** anionic suffactant of SDS,the addition of NH_4Cl into solution strengthens the interaction between PEO and the headgroup o...

关键词： Viscosity Ion-dipole interaction Non-ionic polymer Ionic surfactant NH_4Cl