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Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1500-1513页

作者： jian-Rong Sun Dong-Mei Chen Rong Huang Rui-Tao Wang li-qun jia School of Clinical Medicine Beijing University of Chinese MedicineBeijing 100029China Integrated Chinese and Western Medicine Oncology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is one of the most common malignancies worldwide,and its development comprises a multistep process from intraepithelial neoplasia(IN)to carcinoma(CA).However,the critical regulators and underlying molecular mechanisms remain largely *** To explore the genes and infiltrating immune cells in the microenvironment that are associated with the multistage progression of ESCC to facilitate diagnosis and early *** A mouse model mimicking the multistage development of ESCC was established by providing warter containing 4-nitroquinoline 1-oxide(4NQO)to C57BL/6 ***,we established a control group without 4NQO treatment of ***,transcriptome sequencing was performed for esophageal tissues from patients with different pathological statuses,including low-grade IN(LGIN),high-grade IN(HGIN),and CA,and controlled normal tissue(NOR)*** expressed genes(DEGs)were identified in the LGIN,HGIN,and CA groups,and the biological functions of the DEGs were analyzed via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment *** CIBERSORT algorithm was used to detect the pattern of immune cell ***(IHC)was also conducted to validate our ***,the Luminex multiplex cytokine analysis was utilized to measure the serum cytokine levels in the *** Compared with those in the NOR group,a total of 681541,and 840 DEGs were obtained in the LGIN,HGIN,and CA groups,*** the intersection of the three sets of DEGs,we identified 86 genes as key genes involved in the development of *** analysis revealed that these genes were enriched mainly in the keratinization,epidermal cell differentiation,and interleukin(IL)-17 signaling *** analysis revealed that,compared with those in the NOR group,M0 and M1 macrophages in the 4NQO group showed stronger infiltration,which was validated by *** cytok

关键词： Esophageal squamous cell carcinoma Intraepithelial neoplasia Tumorigenesis Transcriptome sequencing Biomarkers Immune cell infiltration 4-nitroquinoline 1-oxid

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Propagation form of internal cracks induced by continuous casting soft reduction and control strategy for internal quality

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Journal of Iron and Steel Research(International) 2024年第3期31卷 622-633页

作者： Pu Wang liang Chen qun-wei Tang Wei-tao li Shao-xiang li jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Weifang Special Steel Group Co..Ltd. Weifang 262400ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The propagation form of internal cracks induced by continuous casting soft reduction and the control strategy for enhancing the internal quality of 45 steel through industrial trials and a three-dimensional flow-heat transfer-solidification coupling model were *** results showed that the internal cracks induced by soft reduction exhibited a characteristic of being"coarse in the middle and fine at both ends",and displayed an elliptical arc distribution on the loose side of the strand cross *** cracks originated within the brittle temperature range and propagated inward to the liquid impenetrable temperature and outward to the zero ductility temperature or *** control strategy for enhancing the internal quality of the 45 steel strand through soft reduction is to adjust the casting speed or the reduction zone appropriately,ensuring that the central solid fraction of the reduction zone falls within the range of *** this point,a reasonable reduction amount is allocated to eliminate the center shrinkage cavities and center segregation,even if it results in minor reduction-induced cracks.

关键词： Continuous casting Soft reduction Crack propagation Internal quality Control strategy

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Meta label associated loss for fine-grained visual recognition

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Science China(Information Sciences) 2024年第6期67卷 230-247页

作者： Yanchao li Fu XIAO Hao li qun li Shui YU School of Computer Science Nanjing University of Posts and Telecommunications School of Network Engineering Zhoukou Normal University School of Computer Science University of Technology Sydney

Recently, intensive attempts have been made to design robust models for fine-grained visual recognition, most notably are the impressive gains for training with noisy labels by incorporating a reweighting strategy into a meta-learning framework. However, it is limited to up or downweighting the contribution of an instance for label reweighting approaches in the learning process. To solve this issue, a novel noise-tolerant method with auxiliary web data is proposed. Specifically, first, the associations made from embeddings of well-labeled data with those of web data and back at the same class are measured. Next, its association probability is employed as a weighting fusion strategy into angular margin-based loss, which makes the trained model robust to noisy datasets. To reduce the influence of the gap between the well-labeled and noisy web data, a bridge schema is proposed via the corresponding loss that encourages the learned embeddings to be coherent. Lastly, the formulation is encapsulated into the meta-learning framework, which can reduce the overfitting of models and learn the network parameters to be noise-tolerant. Extensive experiments are performed on benchmark datasets, and the results clearly show the superiority of the proposed method over existing state-of-the-art approaches.

关键词： label associated loss weighting noisy samples fine-grained visual recognition noise-tolerant learning meta-learning

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Data-driven active vibration control for helicopter with trailing-edge flaps using adaptive dynamic programming

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Chinese Journal of Aeronautics 2024年第6期37卷 151-166页

作者： Yu CHEN qun ZONG Xiuyun ZHANG Jinna li School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China School of Information and Control Engineering Liaoning Petrochemical UniversityFushun 113001China

The helicopter Trailing-Edge Flaps(TEFs)technology is one of the recent hot topics in morphing wing *** employing controlled deflection,TEFs can effectively reduce the vibration level of ***,designing specific vibration reduction control methods for the helicopters equipped with trailing-edge flaps is of significant practical *** paper studies the optimal control problem for helicopter-vibration systems with TEFs under the framework of adaptive dynamic programming combined with Reinforcement Learning(RL).Time-delay and disturbances,caused by complexity of helicopter dynamics,inevitably deteriorate the control performance of vibration *** solve this problem,a zero-sum game formulation with a linear quadratic form for reducing vibration of helicopter systems is presented with a virtual *** this context,an off-policy reinforcement learning algorithm is developed to determine the optimal control *** algorithm utilizes only vertical vibration load data to achieve a policy that reduces vibration,attains Nash equilibrium,and addresses disturbances while compensating for time-delay without knowledge of the dynamics of the helicopter *** effectiveness of the proposed method is demonstrated in a virtual platform.

关键词： Active control Adaptive dynamic program-ming Helicopter rotor Vibration control Zero-sum game

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Two-dimensional ballistic transistors for advanced-node integrated circuits

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National Science Review 2024年第3期11卷 9-10页

作者： jia li Xidong Duan Hunan Provincial Key Laboratory of Two-Dimensional Materials State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University

As the feature size of metal-oxide-semiconductor-field-effect-transistors(MOSFETs) in integrated circuits(ICs)is reduced to sub-10-nm, the traditional channel materials are plagued by enhanced scattering and short-cha... 详细信息

关键词： CONTACT

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Torque limit-based Inertial Control Method Based on Delayed Support for Primary Frequency Control of Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 561-570页

作者： Wei Gu Zaiyu Chen qun li Minghui Yin Qiang li Yun Zou School of Automation Nanjing University of Science and TechnologyNanjing 210094China State Grid jiangsu Electric Power Co. Ltd.Research InstituteNanjing 211103China

To avoid the secondary frequency dip caused by the steep drop of the electrical power of wind turbines(WTs)at the end of frequency support stage,the torque limit-based iner-tial control(TliC)method sets the power reference as a linear function of rotor speed,rather than the step form for the step-wise inertial ***,the compensation effect on the frequency nadir(FN)caused by the load surge is weakened as the TliC power is no longer in the step ***,the maximum point of the frequency response component(FRC)contributed by TliC occurs earlier than the minimum point of FRC corresponding to the load surge,so that the FN cannot be adequately ***,this paper first investigates the relation between the peak and nadir times of FRCs stimulated by the TliC and load *** this basis,with the compensation principle of matching the peak and nadir times of FRCs,the improved TliC method based on delayed support is ***,the effectiveness of the proposed method is validated via the experiments on the test bench of wind-integrated power system.

关键词： Wind turbine frequency response component torque limit inertial control delayed support

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Re-evaluating the nano-sized inorganic protective layer on Cu current collector for anode free lithium metal batteries

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Chinese Chemical Letters 2024年第7期35卷 452-455页

作者： Shuo Zhang Haitao liao Zhi-qun liu Chong Yan jia-Qi Huang School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Wuxi Yiwen Microelectronics Technology Co. Ltd.Wuxi 214000China Shanxi Research Institute for Clean Energy Tsinghua UniversityTaiyuan 030032China

Anode free lithium metal batteries(AF-LMBs)have conspicuous advantages both in energy density and the compatibility of battery manufacturing ***,the limited cycle life of AF-LMBs is a crucial factor hindering its practical *** or nitride artificial inorganic solid electrolyte interphase(SEI)has been found as an effective method to prolong the lifespan of ***,by investigating the impact of nano-sized inorganic gradient layers(liF or li3N)on initial li deposition behavior,we notice that the li^(+) diffusion barrier and the deposition morphology are highly depended on the thickness of inorganic *** protective layers cause larger overpotential as well as more aggregated li^(+) *** study reveals that the ideal SEI should be synthesized thin and uniformly enough and uncontrollable artificial SEI can cause damage to the lifespan of AF-LMBs.

关键词： Anode free lithium metal battery Solid electrolyte interphase Nano-sized protective layer lithium fluoride li deposition behavior

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Structural engineered living materials

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Nano Research 2024年第2期17卷 715-733页

作者： Yang Geng Zian jia ling li 635 Prices Fork Road Department of Mechanical EngineeringVirginia Polytechnic Institute and State UniversityBlacksburg VA24061USA

Biological structural materials not only exhibit remarkable mechanical properties but also often embody dynamic characteristics such as environmental responsiveness,autonomy,and self-healing,which are difficult to achieve in conventional engineering *** merging materials science,synthetic biology,and other disciplines,engineered living materials(ELMs)provide a promising solution to combine living organisms with abiotic components,thus facilitating the construction of functional“living”*** natural materials,ELMs possess vitality and hold immense application potential in areas such as medicine,electronics,and construction,captivating increasing research attention *** an emerging branch of ELMs,structural ELMs aim to mimic living biological structural materials by achieving desired mechanical performance while maintaining important“living”*** we summarize the recent progress and provide our perspectives for this emerging research *** first summarize the superiority of structural ELMs by reviewing biological structural materials and biomimetic material design ***,we provide a systematic discussion on the definition and classifications of structural ELMs,their mechanical performance,and physiological ***,we summarize some critical challenges faced by structural ELMs and highlight directions of future *** hope this review article can provide a timely summary of the state of the art and relevant perspectives for future development of structural ELMs.

关键词： structural materials engineered living materials(ELMs) structural ELMs composites mechanical properties

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Effect of pravastatin on endothelial dysfunction in children with medium to giant coronary aneurysms due to Kawasaki disease

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World Journal of Pediatrics 2014年第3期10卷 232-237页

作者： Chao Duan Zhong-Dong Du Yu Wang li-qun jia Department of Hematology/Oncology Beijing Children's HospitalCapital Medical UniversityBeijing 100045China Department of Cardiology Beijing Children's HospitalCapital Medical UniversityBeijing 100045China Department of Ultrasonography Beijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background:Ongoing low-grade inflammation and endothelial dysfunction persist in children with coronary lesions diagnosed with Kawasaki disease(KD).Statins,frequently used in the management of high cholesterol,have also shown to improve surrogate markers of infl ammation and endothelial *** study was undertaken to investigate the effi cacy and safety of pravastatin in children with coronary artery aneurysms due to ***:The study enrolled 14 healthy children and 13 male children,aged 2-10 years,with medium-to-giant coronary aneurysms for at least 12 months after the onset of *** was given orally to the KD group at a dose of 5 mg/day for children under 5 and 10 mg/day for children older than 5 *** determine the effects of pravastatin on endothelial function,high-frequency ultrasound was performed before the start of the study and 6 months after pravastatin *** parameters measured were brachial artery flow-mediated dilation(FMD),non-flow mediated dilation(NMD),and carotid artery stiffness index(SI).High sensitive C-reactive protein(hs-CRP)levels,the circulating endothelial progenitor cells(EPCs)number,and serum lipid profiles were also determined at baseline and after 6 months of pravastatin ***:Before treatment,the KD group had significantly decreased FMD(Pline KD group(3.16±6.49 to 10.05±7.74,Pline and that following pra

关键词： coronary aneurysm endothelial function endothelial progenitor cells Kawasaki disease statins

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Protective Effects of Phellodendron Species on Bone Health: A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis

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Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN li TAN Guo-yao ZHANG Qiang ZHANG qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

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