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Glucose detection in a highly scattering medium with diffuse photon-pair density wave

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Journal of Innovative Optical Health Sciences 2017年第1期10卷 53-58页

作者： li-ping yu Jheng-Syong Wu Sheng-Yi Chang Chien Chou Biomedical Engineering Research Center Chang Gung University Taoyuan 333Taiwan Graduate Institute of Electro-Optical Engineering Chang Gung University Taoyuan 333Taiwan Institute of Chemistry A cademic SinicaNankangTaipei 115Taiwan Ph.D Program of Biomedical Engineering Chang Gung University Taoyuan 333Taiwan Department of Mechanics Ming Chi University of Technology New Taipei 243Taiwan

We propose a novel optical method for glucose measurement based on difuse photon-pair density wave(DPPDW)in a multiple scattering medium(MSM)where the light scattering of photon-pair is induced by refractive index mismatch between scatters and phantom ***-mentally,the DPPDW propagates in MSM via a two frequency laser(TFL)beam wherein highly correlated pairs of linear polarized photons are *** reduced scattering coefficientμ2s and absorption coefficientμ2a of DPPDW are measured simultaneously in terms of the amplitude and phase measurements of the detected heterodyne signal under arrangement at different dis-tances between the source and detection fibers in *** results show that the sensitivity of glucose detection via glucose-induced change of reduced scattering coefficient(δμ′2)is 0.049%mM^(-1)in a 1%intralipid *** addition,the linear range ofδμ′2s vs glucose concentration implies that this DPPDW method can be used to monitor glucose concentration continuously and noninvasively subcutaneously.

关键词： Difuse photon-pair density wave glucose multiple scattering polarization gating spatial coherence gating.

New type flooding systems in enhanced oil recovery

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Chinese Chemical Letters 2009年第10期20卷 1251-1254页

作者： Xin ping li li yu Yong Qiang Ji Bo Wu Gan Zuo li li Qiang Zheng Key Laboratory of Colloid and Interfacial Chemistry of Ministry of Education in Shandong University Jinan Shandong 250100 China

Wormlike micelles, obtained in anionic surfactam sodium oleate （NaOA） solutions in the presence of sodium phosphate （Na3PO4）, were studied using the steady and dynamic rheological methods. The laboratory simulation flooding experiments were used to investigate the effects of flooding for the wormlike micelles system. The results show that the oil recovery is 32.7%. This flooding system is a new type and has high activity with a low cost.

关键词： Wormlike miceUes Rheology Oil recovery

Analysis of Essential Oils from Flower-buds, Leaves and Stems of Filipendula palmata(Pall.) Maxim.

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Chemical Research in Chinese Universities 2005年第6期21卷 658-662页

作者： WU Yin MENG Xiang-ying liU Xiao-hua BAO Yong-li WANG Shu-ping li yu-xin Institute of Genetics and Cytology Northeast Normal University Changchun 130024 P. R. China

The essential oils of the flower-buds, leaves and stems of Filipendula palmata（ Pall. ） Maxim. were analyzed by GC and GC-MS. Thirty-three, forty-seven and forty-seven compounds in the flower-buds, leaves and stems were identified, respectively. Methyl salicylate exists in a great amount which is up to 70. 10% in the flower-buds. Its amount is also high in other two parts. The data obtained show that it may be one of the main natural mosquito-expelling and pain-alleviating components in the three parts. The flower-buds are the main active part with the mosquito-expelling function.

关键词： Filipendula palmata( Pall. ) Maxim. Essential oil GC-MS

In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease

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World Journal of Gastroenterology 2023年第1期29卷 171-189页

作者： li-ping yu Yan-Juan li Tao Wang yu-Xuan Tao Mei Zhang Wen Gu Jie yu Xing-Xin Yang College of Pharmaceutical Science Yunnan University of Chinese MedicineKunming 650500Yunnan ProvinceChina College of Pharmaceutical Science Yunnan Key Laboratory of Southern Medicine UtilizationKunming 650500Yunnan ProvinceChina

BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human *** multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic ingredients for mitigating MAFLD remain *** To research the active ingredients of PM adjusting mitochondria to relieve highfat diet(HFD)-induced MAFLD in *** Fat emulsion-induced L02 adipocyte model and HFD-induced MAFLD rat model were used to investigate the anti-MAFLD ability of PM and explore their action *** adipocyte model was also applied to evaluate the activities of PM-derived constituents in liver mitochondria from HFD-fed rats(mitochondrial pharmacology).PM-derived constituents in liver mitochondria were confirmed by ultra-high-performance liquid chromatography/mass spectrometry(mitochondrial pharmacochemistry).The abilities of PM-derived monomer and monomer groups were evaluated by the adipocyte model and MAFLD mouse model,*** PM repaired mitochondrial ultrastructure and prevented oxidative stress and energy production disorder of liver mitochondria to mitigate fat emulsion-induced cellular steatosis and HFD-induced ***-derived constituents that entered the liver mitochondria inhibited oxidative stress damage and improved energy production against cellular *** chemicals were found in the liver mitochondria of PM-administrated *** anti-steatosis ability of one monomer and the anti-MAFLD activity of the monomer group were *** PM restored mitochondrial structure and function and alleviated MAFLD,which may be associated with the remedy of oxidative stress and energy *** identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent ***,PM provides a new approach to prevent MAFLD-related mitochondrial *** pharmacology and pharmacochemistry further showed efficient strategies for de

关键词： Fatty liver Mitochondria Pharmacodynamic ingredients Polygonum multiflorum

Plasticity performance of Al_(0.5)CoCrCuFeNi high-entropy alloys under nanoindentation

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Journal of Iron and Steel Research International 2017年第4期24卷 390-396页

作者： li-ping yu Shu-ying Chen Jing-li Ren Yang Ren Fu-qian Yang Karin A.Dahmen Peter K.liaw School of Mathematics and Statistics Zhengzhou University Department of Materials Science and Engineering The University of Tennessee State Key Laboratory of Nonlinear Mechanics Institute of MechanicsCAS X-ray Science Division Argonne National Laboratory Department of Chemical and Materials Engineering University of Kentucky Department of Physics University of Illinois at Urbana-Champaign

The statistical and dynamic behaviors of the displacement-load curves of a high-entropy alloy,Al_（0.5）CoCrCuFeNi,were analyzed for the nanoindentation performed at two *** behavior of serrations at room temperature and chaotic flows at 200°C were *** results are attributed to the interaction among a large number of slip *** the nanoindentation at room temperature,recurrent partial events between slip bands introduce a hierarchy of length scales,leading to a critical *** the nanoindentation at 200°C,there is no spatial interference between two slip bands,which is corresponding to the evolution of separated trajectory of chaotic behavior.

关键词： High-entropy alloys Nanoindentation Critical behavior Chaotic behavior

Development and validation of a risk assessment model for prediabetes in China national diabetes survey

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World Journal of Clinical Cases 2022年第32期10卷 11789-11803页

作者： li-ping yu Fen Dong Yong-Ze li Wen-Ying Yang Si-Nan Wu Zhong-Yan Shan Wei-ping Teng Bo Zhang Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China Institute of Clinical Medical Sciences China-Japan Friendship HospitalBeijing 100029China Department of Endocrinology and Metabolism First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Prediabetes risk assessment models derived from large sample sizes are *** To establish a robust assessment model for prediabetes and to validate the model in different *** The China National Diabetes and Metabolic Disorders Study(CNDMDS)collected information from 47325 participants aged at least 20 years across China from 2007 to *** Thyroid Disorders,Iodine Status and Diabetes Epidemiological Survey(TIDE)study collected data from 66108 participants aged at least 18 years across China from 2015 to 2017.A logistic model with stepwise selection was performed to identify significant risk factors for prediabetes and was internally validated by bootstrapping in the *** validations were performed in diverse populations,including populations of Hispanic(Mexican American,other Hispanic)and non-Hispanic(White,Black and Asian)participants in the National Health and Nutrition Examination Survey(NHANES)in the United States and 66108 participants in the TIDE study in China.C statistics and calibration plots were adopted to evaluate the model’s discrimination and calibration *** A set of easily measured indicators(age,education,family history of diabetes,waist circumference,body mass index,and systolic blood pressure)were selected as significant risk factors.A risk assessment model was established for prediabetes with a C statistic of 0.6998(95%CI:0.6933 to 0.7063)and a calibration slope of *** externally validated in the NHANES and TIDE studies,the model showed increased C statistics in Mexican American,other Hispanic,Non-Hispanic Black,Asian and Chinese populations but a slightly decreased C statistic in non-Hispanic White *** the risk assessment model to the TIDE population,we obtained a C statistic of 0.7308(95%CI:0.7260 to 0.7357)and a calibration slope of 1.1137.A risk score was derived to assess *** with scores≥7 points were at high risk of prediabetes,with a se

关键词： Hyperglycemia Prediabetes Risk assessment model Risk scores

Postprandial glucagon-like peptide 1 secretion is associated with urinary albumin excretion in newly diagnosed type 2 diabetes patients

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World Journal of Diabetes 2023年第3期14卷 279-289页

作者： Lu-Lu Song Na Wang Jin-ping Zhang li-ping yu Xiao-ping Chen Bo Zhang Wen-Ying Yang Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Microalbuminuria is an early and informative marker of diabetic *** study found that microalbuminuria developed in patients with newly diagnosed type 2 diabetes mellitus(T2DM).AIM To investigate the association between glucagon-like peptide 1(GLP-1)and microalbuminuria in newly diagnosed T2DM *** In total,760 patients were recruited for this cross-sectional *** GLP-1 levels during a standard meal test and urinary albumin-creatinine ratio(UACR)were *** Patients with microalbuminuria exhibited lower GLP-1 levels at 30 min and 120 min during a standard meal test than patients with normal albuminuria(30 min GLP-1,16.7±13.3 pmol vs 19.9±15.6 pmol,P=0.007;120 min GLP-1,16.0±14.1 pmol vs 18.4±13.8 pmol,P=0.037).The corresponding area under the curve for active GLP-1(AUCGLP-1)was also lower in microalbuminuria patients(2257,1585 to 3506 vs 2896,1763 to 4726,pmol×min,P=0.003).Postprandial GLP-1 levels at 30 min and 120 min and AUCGLP-1 were negatively correlated with the UACR(r=0.159,r=0.132,r=0.206,respectively,Plic blood pressure,estimated glomerular filtration rate,homeostasis model assessment of insulin resistance,AUC_(glucose)and AUC_(glucagon)patients in quartile 4 of the AUCGLP-1 presented a lower risk of microalbuminuria compared with the patients in quartile 1(odds ratio=0.547,95%confidence interval:0.325-0.920,P=0.01).A consistent association was also found between 30 min GLP-1 or 120 min GLP-1 and *** Postprandial GLP-1 levels were independently associated with microalbuminuria in newly diagnosed Chinese T2DM patients.

关键词： Microalbuminuria Glucagon-like peptide 1 Type 2 diabetes Nephropathy

Thermal state of soils in the active layer and underlain permafrost at the kilometer post 304 site along the China-Russia Crude Oil Pipeline

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Journal of Mountain Science 2016年第11期13卷 1984-1994页

作者： WANG Yong-ping li Guo-yu JIN Hui-jun LU Lan-zhi HE Rui-xia ZHANG Peng State Key Laboratory of Frozen Soils Engineering Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of SciencesLanzhou 730000China Beifang University of Nationalities Yinchuan 750000China Nanjing Tech University Nanjing 210009China

On-site monitoring is very important for understanding formation mechanisms of frost hazards frequently occurring in pipeline foundation soils and for designing and deploying according mitigative measures in permafrost *** thaw subsidence of ground surfaces along the ChinaRussia Crude Oil Pipeline(CRCOP) from Mo'he to Daqing,Heilongjiang Province,Northeast China have been observed at some segments underlain by ice-rich warm(>1.0°C) permafrost since the official operation in January *** monitoring results of the thermal states of foundation soils at the kilometer post(KP) 304 site along the CRCOP are presented in this *** results indicate that during the period from 2012 to 2014,shallow soils(at the depths from0.8 to 4.0 m from ground surface) has warmed by approximately 1.0°C in the lateral range of 1.2 to 2.1 maway from the pipeline axis,and deeper permafrost(such as at the depth of 15 m,or the depth of zero annual amplitude of ground temperatures) by 0.08°C per year 4 m away from the pipe axis,and 0.07°C per year 5 m away from the pipeline *** results indicate an all-season talik has developed around and along the *** thaw bulb,with a faster lateral expansion(compared with the vertical growth),enlarges in summer and shrinks in *** research will provide important references and bases for evaluating thermal influences of warm pipeline on permafrost and for design,construction,operation and maintenance of pipelines in permafrost regions.

关键词： China-Russia Crude Oil Pipeline Permafrost Thermal regime Talik formation Thaw subsidence

POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY USING A MODIFIED BALANCE DETECTOR

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Journal of Innovative Optical Health Sciences 2012年第4期5卷 18-23页

作者： li-ping yu JIAN-CHEN GUO li-DEK CHOU TE-LUN MA JHENG-SYONG WU JIANN-DER LEE CHIEN CHOU Center for Biomedical Engineering Chang Gung University Taoyuan 333 Taiwan Department of Biomedical Imaging and Radiological Science National Yang Ming University Taipei 112 Taiwan Graduate Institute of Electro-Optical Engineering Chang Gung University Taoyuan 333 Taiwan Department of Optics and Photonics National Central University Jhongli 320 Taiwan Department of Electrical Engineering Chang Gung University Taoyuan 333 Taiwan Graduate Institute of Electro-Optical Engineering and Center for Biomedical Engineering Chang Gung University Taoyuan 333 Taiwan

In conventional polarization sensitive optical coherence tomography(PS-OCT),phase retar-dation is obtained by the amplitude of P and S polarization only,and the fast axis angle is obtained by the phase difference in P and S polarizations via Hilbert *** this paper,we proposed a modifed PS OCT setup in which the phase retardation and fast axis angle are simply expressed as the function of the amplitude ofP and S polarization and their differential *** to the common-path feature between the two channels ofP and S polarization,the fuctuation in the measurement of phase retardation and fast axis angle caused by excess noise and phase noise from the laser source can be reduced by the differential signal of P and S polarization via a modified balance ***,the signal of phase retardation and fast angle axis in the deep layer of a porcine sample can be improved.

关键词： PS OCT modifed balanced detector Hilbert transformation