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Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility

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Asian Journal of Andrology 2023年第5期25卷 608-615页

作者： Yi-Ting Yang Bin Yan Yu-Hua li li-na guo Wei-Wei Wang li-Jie liu He-guo Yu Hua Diao NHC Key Laboratory of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies) School of Basic Medical SciencesFudan UniversityShanghai 200032China Reproductive Medicine Centre Zhongshan HospitalFudan UniversityShanghai 200032China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Urology Huashan HospitalFudan UniversityShanghai 200040China

Phosphodiesterase(PDE)inhibitors can improve sperm motility in patients with ***,the most commonly reported nonselective PDE inhibitor pentoxifylline and PDE5 inhibitor sildenafil have the disadvantages of requiring a high concentration and destroying sperm *** examined the PDE10A inhibitor PF-2545920 to compare its ability to promote sperm motility with that of pentoxifylline and *** seminal plasma was discarded,several semen samples were subjected to four treatments(control,PF-2545920,pentoxifylline,and sildenafil)to evaluate their ability to affect motility,viability,and spontaneous acrosome *** calcium and adenosine triphosphate(ATP),mitochondrial membrane potential,and penetration through viscous medium were assessed by flow cytometry,luciferase,and hyaluronic acid after treatment with *** analyses were performed using the analysis of variance statistical ***-2545920 elevated the percentage of motile spermatozoa compared to the control,pentoxifylline,and sildenafil groups at 10μmol l^(-1)(Plity(Plity.

关键词： pentoxifylline phosphodiesterase 10A sildenafil sperm motility spontaneous acrosome reaction

Solid-phase Decarburization Kinetics of High-carbon Ferromanganese Powders by Microwave Heating

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Journal of Iron and Steel Research International 2015年第4期22卷 311-316页

作者： li-na guo Jin CHEN Jing ZHAO Wan-ming liN Wen-li SHI Min liANG College of Materials Science and Engineering Taiyuan University of Technology

Solid-phase decarburization of high-carbon ferromanganese powders （HCFPs） was conducted using calcium carbonate powders （CCPs） as a decarburizer by microwave heating. Solid-phase decarburization kinelSics was investi- gated by isothermal method. The results show that the HCFPs show excellent microwave absorption at a higher av- erage heating rate of 80 ℃/min, while CCPs exhibit poor microwave absorption at a lower heating rate of 5--20 ℃/min; the heating characteristics are in-between when HCFPs and CCPs are mixed. The average heating rates of the mix- ture are 32.14, 31.25, 31.43, and 30.77 ℃/rain when the mixture is heated up to 900, 1000, 1100, and 1200 ℃, respectively. The good microwave absorption property of the mixed material lays the foundation for the solid-phase decarburization of HCFPs containing CCPs. Solid-phase decarburization of HCFPs containing CCPs is a first-order reaction by microwave heating. Apparent activation energy of solid-phase decarburization is 55.07 kJ/mol, which is far less than that of ordinary carbon gasification reaction and that of solid-phase decarburization under the same de- carburization condition by conventional heating. It indicates that microwave heating not only produces thermal effect, but also has non-thermal effect.

关键词： high-carbon ferromanganese powder solid-phase decarburization kinetics microwave heating calcium carbonate powder

Regioselective C-C bond cleavage/aminocarbonylation cascade under copper catalysis

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Science China Chemistry 2024年第11期67卷 3798-3806页

作者： Qi-Chao Shan Yan Zhao Yong Wu Hong-Fei liu Xin-Hua Duan li-na guo Department of Chemistry School of ChemistryEnergy Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000China

A regioselective C-C bond cleavage/aminocarbonylation cascade is presented. In recent years, tremendous progress has been made in the alkoxyl radical-mediated C-C bond cleavage of unstrained monocarbocycles. In contrast, the deconstruction and functionalization of bicyclic skeletons has been less developed and has mainly focused on the ring expansion process. Inspired by the aromatization-driven C-C bond cleavage, here we demonstrate a ring-opening/aminocarbonylation cascade under copper catalysis, in which the formation of a stable γ-lactam or succinimide skeleton reverses the selectivity of C-C cleavage. Remarkably, the photo and thermal assistance is not required when the succinimide skeleton is formed during the ring opening process. DFT calculations revealed that this unexpected ring-opening process is thermodynamically and kinetically favourable.

关键词： C-C bond cleavage controllable regioselectivity aminocarbonylation bicyclic alkoxy radical

Nickel-catalyzed carbonylative four-component 1,4-dicarbofunctionalization of 1,3-enynes

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Science China Chemistry 2024年第6期67卷 2029-2038页

作者： Yan Zhao Qi-Chao Shan Hong Xin Pin Gao Xu Yang Xin-Hua Duan li-na guo Department of Chemistry School of ChemistryXi’an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy StorageMaterials and DevicesMinistry of EducationXi’an Jiaotong UniversityXi’an710049China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an710049China

An efficient Ni-catalyzed four-component 1,4-carbocarbonylation of 1,3-enynes with activated alkyl halides and arylboronic acids under atmospheric pressure of CO is *** tuning the electronic and steric effects of alkyl radicals,both electronrich and electron-deficient 1,3-enynes were compatible with this *** protocol features mild conditions,broad substrate scope,excellent functional group compatibility and facile gram-scale synthesis,providing a practical approach to the quaternary carbon center-containing allenyl *** study revealed that the acyl-NiIIspecies plays an important role in both the coupling and the alkyl radical generation processes.

关键词： Ni catalysis four-component 1 4-carbocarbonylation 1 3-enynes

Scriptaid is a prospective agent for improving human asthenozoospermic sample quality and fertilization rate in vitro

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Asian Journal of Andrology 2024年第5期26卷 490-499页

作者： Yi-Ting Yang Bin Yan li-na guo Miao liu Yu-Hua li Zhi-Yu Shao Hua Diao Su-Ying liu He-guo Yu NHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drug and DevicesShanghai-MOST Key Laboratory of Health and Disease GenomicsShanghai Institute for Biomedical and Pharmaceutical TechnologiesShanghai 200237China School of life Sciences and Technology Tongji UniversityShanghai 200092China Reproductive Medicine Center Zhongshan HospitalFudan UniversityShanghai 200032China College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China

Male infertility is a global issue caused by poor sperm quality,particularly *** of the sperm quality may improve the fertilization rate in assisted reproductive technology(ART)***,with a novel human sperm motility-stimulating activity,has been investigated as a prospective agent for improving sperm quality and fertilization rate in *** evaluated the effects of Scriptaid on asthenozoospermic(AZS)semen,including its impact on motility stimulation and protective effects on cryopreservation and duration of motility,by computer-aided sperm analysis(CASA).Sperm quality improvement by Scriptaid was characterized by increased hyaluronan-binding activity,tyrosine phosphorylation,adenosine triphosphate(ATP)concentration,mitochondrial membrane potential,and an ameliorated AZS fertilization rate in clinical intracytoplasmic sperm injection(ICSI)***,our identification of active Scriptaid analogs and different metabolites induced by Scriptaid in spermatozoa lays a solid foundation for the future biomechanical exploration of sperm *** summary,Scriptaid is a potential candidate for the treatment of male infertility in vitro as it improves sperm quality,prolongs sperm viability,and increases the fertilization rate.

关键词： asthenozoospermia HDAC6 ICSI Scriptaid sperm motility

Atomic Electronic Contract ProtocolBased on Convertible Signature

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Wuhan University Journal of natural Sciences 2005年第1期10卷 227-230页

作者： liUYi-chun WANGli-na ZHANGHuan-guo SchoolofComputer WuhanUniversityWuhan430072HubeiChina

A new class of atomicity, namely contract atomicity is presented. A newtechnical strategy based on convertible signature and two-phase commitment is proposed forimplementing atomicity of electronic contract protocol. A new atomic contract signing protocol isgiven out by using ElGam-al-like convertible undeniable signature and commitment of conversion key,and another new atomic contract signing protocol is brought forward by using RSA-based convertibleundeniable signature scheme and commitment ofconversion key. These two new protocols are proved tobe of atomicity, fairness, prnacy- non-repudiation.

关键词： electronic contract atomicity convertible signature

Photoinduced copper-catalyzed alkoxyl radical-triggered ring-expansion/aminocarbonylation cascade

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Chinese Chemical Letters 2024年第6期35卷 331-336页

作者： Jing-Qi Tao Shuai liu Tian-Yu Zhang Hong Xin Xu Yang Xin-Hua Duan li-na guo Department of Chemistry School of ChemistryXi’an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Jiaotong UniversityXi’an 710049China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000China

A photoinduced copper-catalyzed alkoxyl triggered C-C bond cleavage/aminocarbonylation cascade is *** adjusting the structure of alkoxyl radical precursors,functionalized lactones and ketoamides were synthesized with good yields and excellent functional group tolerance under redox-neutral ***,this protocol enables the integration of lactone fragments with many amine drugs and drug fragments.

关键词： Copper catalysis Ring-expansion Aminocarbonylatioin Macrolactones Keto-amides

Effect of Carbon on DA718 Alloy with P Addition

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Journal of Materials Science & Technology 2003年第6期19卷 616-618页

作者： na li, Shouren guo, Dezhong LU, Wenru SUN, Yan XU and Zhuangqi HUInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

Lower content of carbon can further improve the stress rupture life of p-modified DA 718 alloy up to more than 270%. Meanwhile, the ductility of the alloy decreased a little. More boron atoms dissociate due to decreasing carbon content and interact with phosphorus which brings the longer stress rupture life of the alloy. Less carbon may induce more phosphorus segregating in the grain boundary and result in brittleness.

关键词： DA 718 alloy Carbon Phosphorus

SEVEN CASES OF EPITHEliAL OVARIAN CARCINOMA WITH BRAIN METASTASIS

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Chinese Medical Sciences Journal 2008年第1期23卷 19-22页

作者： Jia-xin Yang Keng Shen Ying Shan li-na guo Hui-fang Huang Jing-he Lang Ming Wu ling-ya Pan Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To summarize the clinical characteristics, treatment, and prognosis of brain metastasis in patients with epithelial ovarian carcinoma. Metbods Retrospective analysis was conducted in 7 cases of brain metastases of epithelial ovarian carcinoma from January 1986 to March 2007 in Peking Union Medical College Hospital for summarizing therapy results and prognosisaffecting factors. Results Incidence of brain metastases of epithelial ovarian carcinoma was about 0. 66% （7/1 055 ）. Serous adenocarcinoma was the predominant pathological type in 4 cases and the subsequent was adenocarcinoma in 3 cases. All the patients were diagnosed at late stage, 6 cases with the International Federation of Gynecology and Obstetrics （HGO） stage Ⅲc and 1 with FIGO stage IV. The mean duration from diagnosis of ovarian carcinoma to brain metastasis was 32.7 ± 20. 0 months （range, 23-73 months）. Single metastasis focus occurred in 43% of cases and multiple metastases in 57% of cases. Fifty-seven percent of patients presented extracranial metastasis. Serum CA125 played a role in monitoring reoccur- rence and brain metastases. The average survival time was about 12 months. Better treatment with prolonged survival could be achieved by combination of operation and chemotherapy or combination of radiotherapy with chemotherapy. Concltusions As a rare condition, brain metastasis of epithelial ovarian carcinoma is rising in incidence with improved treatment of ovarian carcinoma and prolonged survival. However, brain metastasis indicates bad prognosis which can be improved by combined therapy.

关键词： ovarian carcinoma brain metastasis cytoreductive therapy chemotherapy