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Journal of Hydrodynamics 2018年第5期30卷 872-881页

作者： li-na cao Xiao-ping li Ji-qiang Zhang Cheng Luo Xiao-hua Tan China ZhenHua Oil Co. Ltd. Beijing 100031 China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University Chengdu 610500 China CNOOC Zhanjiang Co. Ltd. Zhanjiang 524057 China Geological Exploration and Development Research Institute of CNPC Chuanqing Drilling Engineering Ltd. Chengdu 610056 China

Most researches of the threshold pressure gradient in tight gas reservoirs are experimental and mainly focus on the transient pressure response, without paying much attention to the transient rate decline. This paper establishes a dual-porosity rate transient decline model for the horizontal well with consideration of the threshold pressure gradient, which represents the non-Darcy flow in a fracture system. The solution is obtained by employing the Laplace transform and the orthogonal transform. The bi-logarithmic type curves of the dimensionless production rate and derivative are plotted by the Stehfest numerical inversion method. Seven different flow regimes are identified and the effects of the influence factors such as the threshold pressure gradient, the elastic storativity ratio, and the cross flow coefficient are discussed. The presented research could interpret the production behavior more accurately and effectively for tight gas reservoirs.

关键词： Rate transient analysis horizontal well dual-porosity threshold pressure gradient tight gas reservoirs

白颖苔草对不同浓度naCl胁迫的响应及其耐盐阈值

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草业科学 2017年第3期34卷 479-487页

作者：张昆李明娜曹世豪孙彦中国农业大学动物科技学院草业科学系草业科学北京重点实验室北京100093

以白颖苔草(Carex rigescens)为研究材料,采用盆栽试验研究了不同浓度naCl(0,100,200,300,400,500mmol·L^(-1))处理下白颖苔草地上部生长和生理等指标的变化趋势,分析了不同浓度盐处理对白颖苔草生长的影响,并计算确定了其耐盐性的阈... 详细信息

以白颖苔草(Carex rigescens)为研究材料,采用盆栽试验研究了不同浓度naCl(0,100,200,300,400,500mmol·L^(-1))处理下白颖苔草地上部生长和生理等指标的变化趋势,分析了不同浓度盐处理对白颖苔草生长的影响,并计算确定了其耐盐性的阈值。结果表明,盐处理对白颖苔草的生长产生了抑制作用。随naCl处理浓度增加,白颖苔草的株高、叶长和叶宽均呈下降趋势,同时枯叶率显著升高(PnaCl浓度的增加呈下降趋势,而叶片的质膜透性则呈升高趋势。但两指标在低浓度盐(naCl为100和200mmol·L^(-1))处理下较无胁迫对照无显著差异(P>0.05),当naCl浓度超过300mmol·L^(-1)时,两指标发生显著变化(PnaCl浓度的增加呈先升高后降低的趋势,在300mmol·L^(-1)处理下均达到最大值,说明在naCl浓度300mmol·L^(-1)左右可能存在白颖苔草耐盐的临界浓度。不同浓度naCl处理对白颖苔草叶片叶绿素a,叶绿素b和叶绿素a+b均产生了不同程度的影响。随盐浓度的增加,叶绿素a和叶绿素a+b含量呈先升高后降低趋把势,叶绿素b含量呈降低趋势,而叶绿素a/b值无显著变化(P>0.05)。以白颖苔草生物量下降50%时的盐浓度来评价其耐盐性,建立回归方程确定其耐盐阈值为263mmol·L^(-1)。上述结果表明,白颖苔草对盐胁迫有较高的耐受性,在一定范围的盐胁迫环境中能正常生长,该结果可为后续白颖苔草耐盐机制的研究提供理论依据。

关键词：白颖苔草盐胁迫耐盐性生长特性抗氧化酶叶绿素含量阈值

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牧草与草坪草耐盐基因工程研究进展

中国草地学报 2017年第2期39卷 96-104页

作者：张昆李明娜曹世豪孙彦中国农业大学动物科技学院草业科学系/草业科学北京重点实验室北京100193

土壤盐渍化是制约全球农业生产的重要原因,而植物耐盐的分子机理非常复杂,涉及到大量的诱导基因及多条信号转导途径,因此掌握牧草与草坪草耐盐的分子机理对提高其抗盐性和培育耐盐新品种具有重要意义。近些年随着生物技术的发展,有关牧... 详细信息

土壤盐渍化是制约全球农业生产的重要原因,而植物耐盐的分子机理非常复杂,涉及到大量的诱导基因及多条信号转导途径,因此掌握牧草与草坪草耐盐的分子机理对提高其抗盐性和培育耐盐新品种具有重要意义。近些年随着生物技术的发展,有关牧草与草坪草耐盐机理的分子生物学解析已取得了很大的进展。本文总结了前人的研究,从牧草与草坪草盐诱导相关基因的鉴定和功能分析、表达与调控以及盐胁迫早期信号的传导过程等多个方面,对近年来耐盐基因工程方面的研究做了综述。同时我们还对现阶段存在的问题进行了分析,对未来的研究方向进行了展望。

关键词：牧草与草坪草盐胁迫耐盐性耐盐基因

Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing li Xiaoge Wang Xiaofan cao Zhiqun He Chunjun liang Mingxing Chen Jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing national Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Post-growth mechanism Heterogeneous structure Single-particle spectroscopy Laser irradiation

Modification strategies on nickel-based electrocatalysts for energyefficient anodic reactions

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nano Research 2025年第1期18卷 50-75页

作者： Jingwen Yu Yunliang liu naiyun liu Yaxi li Yuanyuan Cheng Peng cao Yixian liu Xinya Yuan Xinyue Zhang Haitao li Institute for Energy Research School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China

Electrocatalytic chemical oxidation(ECO)is an energy-efficient anodic reaction alternative to the oxygen evolution reaction(OER).ECO lowers the reaction potential and yields higher-value fine chemicals at the *** catalyst material plays a crucial role in influencing and determining ECO *** catalyst performance encompasses aspects such as activity,stability,selectivity and *** electrocatalysts have garnered significant attention for their exceptional performance and widespread use in ECO *** modifying nickel-based electrocatalysts,the formation of NiOOH active centers can be *** such as adjusting size and morphology,doping,introducing defects and constructing heterojunctions are advantageous for enhancing *** the rapid advancements in related research fields,it is imperative to comprehend the mechanisms of nickel-based electrocatalysts in ECO and develop innovative *** article provides an overview of the modification strategies of nickel-based electrocatalysts,as well as their applications and mechanisms in ECO.

关键词： anodic reactions electrocatalytic chemical oxidation nickel-based electrocatalysts NiOOH modification strategies

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei liu Dai li Xiaoqi Pang Fanglian Chen Hailong cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong cao Chengjun li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina national Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the Rna level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated Rna immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

从网络角度研究元胡止痛胶囊治疗头痛与痛经的分子作用机制

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中国新药杂志 2016年第20期25卷 2323-2330页

作者：张新庄柯志鹏李娜曹亮王振中萧伟徐筱杰江苏康缘药业股份有限公司中药制药新技术国家重点实验室连云港222001 北京大学化学与分子工程学院北京100871

目的:研究元胡止痛胶囊治疗头痛和痛经的药效物质和分子作用机制。方法:采用分子对接、分子-靶蛋白网络特征分析以及靶蛋白-生物通路信息挖掘的方法研究元胡止痛胶囊中分子与靶蛋白的相互作用。结果:分子对接与网络分析发现元胡止痛胶... 详细信息

目的:研究元胡止痛胶囊治疗头痛和痛经的药效物质和分子作用机制。方法:采用分子对接、分子-靶蛋白网络特征分析以及靶蛋白-生物通路信息挖掘的方法研究元胡止痛胶囊中分子与靶蛋白的相互作用。结果:分子对接与网络分析发现元胡止痛胶囊中有63个活性成分,且大部分具有良好的生物利用度和血脑屏障通透性,其中Coptisine,Protopine,Berberine等17个为其主要活性成分,可通过与Glu A2,i NOS,AKR1C2,ROCK1等28个靶蛋白相互作用,一方面降低疼痛信号的感知和传递,另一方面调控血管/子宫平滑肌的舒张与收缩,进而达到缓解疼痛的治疗作用。结论:通过数据分析确定了元胡止痛胶囊止痛的分子作用机制和主要活性成分,有助于减少后续药效物质基础和分子作用机制实验研究的盲目性。

关键词：疼痛分子描述符中药白芷网络药理学

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芦根中脂溶性成分的分离与鉴定

沈阳药科大学学报 2009年第6期26卷 441-443页

作者：骆昉李娜曹桂东遇璐宋少江沈阳药科大学中药学院辽宁沈阳110016

目的研究芦根中的脂溶性成分。方法采用硅胶、Sephadex LH-20柱色谱以及制备液相色谱分离纯化,利用理化常数和核磁共振谱学方法鉴定结构。结果共分离得到8个化合物,分别鉴定为对羟基苯甲醛(p-hydroxybenzaldehyde,1)、5-羟甲基糠醛(5-hy... 详细信息

目的研究芦根中的脂溶性成分。方法采用硅胶、Sephadex LH-20柱色谱以及制备液相色谱分离纯化,利用理化常数和核磁共振谱学方法鉴定结构。结果共分离得到8个化合物,分别鉴定为对羟基苯甲醛(p-hydroxybenzaldehyde,1)、5-羟甲基糠醛(5-hydroxymethylfurfural,2)、大黄素甲醚(physcion,3)、胡萝卜苷(daucosterol,4)、β-谷甾醇(β-sitosterol,5)、香草醛(vanillin,6)、西米杜鹃醇(simiarenol,7)和3α-O-β-D-吡喃葡萄糖基南烛木树脂酚(3α-O-(β-D-glucopyranosyl)-lyoni-resinol,8)。结论化合物2、3、7、8为首次从芦苇属植物中分离得到。

关键词：芦根化学成分结构鉴定