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Advances in the role of circulating tumor cell heterogeneity in metastatic small cell lung cancer

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Cancer Innovation 2024年第2期3卷 1-10页

作者： Qunxia Wang li-ming tan Department of Laboratory Medicine Jiangxi Province's Key Laboratory of Laboratory MedicineThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina

Small cell lung cancer(SCLC),a highly aggressive malignancy,is rapidly at an extensive stage once diagnosed and is one of the leading causes of death from *** the past decade,the treatment of SCLC has largely remained unchanged,and chemotherapy remains the cornerstone of SCLC *** therapeutic value of adding immune checkpoint inhibitors to chemotherapy for SCLC is low,and only a few SCLC patients have shown a response to immune checkpoint *** tumor cells(CTCs)are tumor cells shed from solid tumor masses into the peripheral circulation and are key to tumor ***-cell sequencing has revealed that the genetic profiles of individual CTCs are highly heterogeneous and contribute to the poor outcome and prognosis of SCLC ***,phenotypic analysis of CTCs may be able to predict the diagnostic significance of new potential targets for metastatic *** this paper,we will discuss in depth the heterogeneity of CTCs in SCLC and the value of CTCs for the diagnosis and prognosis of SCLC and as relevant tumor markers in metastatic SCLC.

关键词： circulating tumor cell heterogeneity immunotherapy small cell lung cancer tumor micro-environment

Constructing highly safe and long-life calcium ion batteries based on hydratedvanadium oxide cathodes featuring a pillar structure

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Rare Metals 2024年第6期43卷 2597-2612页

作者： Chun-Fang Wang Shi-Wei Zhang Lan Huang Yuan-Min Zhu Feng liu Jian-Chuan Wang li-ming tan Chun-Yi Zhi Cui-Ping Han Powder Metallurgy Research Institute Central South UniversityChangsha410083China Songshan Lake Materials Laboratory Dongguan 523808China Research Institute of Interdisciplinary Science and School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Calcium-ion batteries(CIBs)have generated intense interest due to the growing demand for safer,cheaper,and large-scale energy storage ***,their development is still in its infancy,owing to the lack of suitable cathodes for sustaining reversiblc Ca^(2+)intercalation/***,layered H_(2)V_(3)O_(8)(HVO)with Zn^(2+)pre-insertion(ZHVO)is reported as a high-rate and highly durable cathode material for *** existence of Zn^(2+)and H_(2)O pillars could expand the interlayer spacing up to 1.8 nm,which is favorable for the diffusion of bulky Ca^(2+).The formation of Zn-O bonds facilitates electron transfer and enhances electrical ***,the ZHVO cathode achieves superior capacity performance(213.9 mAh·g^(-1)at 0.2 A·g^(-1))and long lifespan(78.3%for 1,000 cycles at 5 A·g^(-1))compared to pristine *** functional theory(DFT)calculations revealed that Zn^(2+)moved during Ca^(2+)intercalation,thereby reducing the diffusion energy barrier and facilitating Ca^(2+)***,a safe aqueous calcium ion cell was successfully assembled.

关键词： Multivalent batteries Calcium-ion batteries Layered structure Vanadium oxide Cathode materials

Anticonvulsants Delaying the Diagnosis of Cushing＇s Syndrome in a Patient Who Presents with Schizophrenia

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Chinese Medical Journal 2015年第5期128卷 700-701页

作者： Xin Zhao Harrison X Bai li-ming tan li Yang Department of Neurology The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of Radiology Hospital of the University of Pennsylvania Philadelphia PA 19104 USA

To the Editor：In August 2013,a 22-year-old female was referred to a psychiatric hospital with 6 months history of insomnia,suicidal thought,social withdrawal,irritability and persecutory *** was given the diagnosis o...

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Stroke-like Migraine Attacks after Radiation Therapy Syndrome

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Chinese Medical Journal 2015年第15期128卷 2097-2101页

作者： Qian Zheng li Yang li-ming tan li-Xia Qin Chun-Yu Wang Hai-Nan Zhang Department of Neurology Second Xiangya Hospital Central South University Changsha Hunan 410011 China

Objective：To summarize the clinical presentation,pathogenesis,neuroimaging,treatment,and outcome of stroke-like migraine attacks after radiation therapy （SMART） syndrome,and to propose diagnostic criteria for this *** Sources：We searched the PubMed database for articles in English published from 1995 to 2015 using the terms of ＂stroke-like AND migraine AND radiation.＂ Reference lists of the identified articles and reviews were used to retrieve additional *** Selection：Data and articles related to late-onset effects of cerebral radiation were selected and ***：SMART is a rare condition that involves complex migraines with focal neurologic deficits following cranial irradiation for central nervous system *** recovery,which ranges from hours to days to weeks,can be partial or *** propose the following diagnostic criteria for SMART：（1） Remote history of therapeutic external beam cranial irradiation for malignancy;（2） prolonged,reversible clinical manifestations mostly years after irradiation,which may include migraine,seizures,hemiparesis,hemisensory deficits,visuospatial defect,aphasia,confusion and so on;（3） reversible,transient,unilateral cortical gadolinium enhancement correlative abnormal T2 and fluid-attenuated inversion recovery signal of the affected cerebral region;（4） eventual complete or partial recovery,the length of duration of recovery ranging from hours to days to weeks;（5） no evidence of residual or recurrent tumor;（6） not attributable to another *** date,no specific treatment has been identified for this ***：SMART is an extremely rare delayed complication of brain ***,improvements in cancer survival rates have resulted in a rise in its ***,awareness and recognition of the syndrome is important to make a rapid diagnosis and avoid aggressive interventions such as brain biopsy and cerebral angiography.

关键词： Cranial Irradiation Epilepsy Migraine Stroke-like Migraine Attacks after Radiation Therapy

Endovascular treatment of pseudo-aneurysm occurring after embolization of traumatic carotid cavernous fistula with detachable balloons

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Chinese Medical Journal 2008年第15期121卷 1487-1491页

作者： FANG Chun li ming-hua tan Hua-qiao ZHANG Pei-lei ZHOU Bin Department of Radiology Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 China

Traumatic carotid-cavemous fistula （CCF） is an abnormal passageway between the intracavemous carotid artery and the cavernous sinus after a head injury. Most CCFs have direct high flow. Clinical presentations primarily depend on the pressure inside the cavernous sinus and on the direction of the venous drainage. The ideal goal for the treatment of direct CCF is the obliteration of the fistula while preserving the internal carotid artery （ICA）. Transarterial embolization of direct CCF with detachable balloons has been proven to be the best option for an initial treatment, although transarterial embolization by detachable balloons is frequently associated with pseudo-aneurysm formation. Many treatment options such as coiling, stent-assisted coiling, and covered stent have been proposed to treat pseudo-aneurysm. However, the best management for a pseudo-aneurysm occurring after an embolization of a CCF with detachable balloons remains unknown. In this article, we will report our successful attempt in treating the said pseudo-aneurysm. We initially dealt with a pseudo-aneurysm occurring after an embolization of a CCF with stent-assisted coiling; then, the pseudoaneurysm recanalized, and eventually a covered stent was placed for the recanalized pseudoaneurysm.

关键词： carotid-cavernousfistula pseudo-aneurysm covered stent endovascular treatment

Effect of porosity on mechanical properties of porous tantalum scaffolds produced by electron beam powder bed fusion

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Transactions of Nonferrous Metals Society of China 2022年第9期32卷 2922-2934页

作者： Yu GUO Chao CHEN Qiang-bing WANG Min liU Yuan-kui CAO Yan-ming PAN li-ming tan State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Guangzhou Sailong Additive Manufacturing Co. Ltd.Guangzhou 510700China State Key Laboratory of Porous Metal Materials Northwest Institute for Nonferrous Metal ResearchXi’an 710016China

The effect of porosity on compressive,bending,and tensile properties of the porous tantalum scaffolds fabricated by electron beam powder bed fusion(EB-PBF)was *** porous tantalum scaffolds with porosity from 69%to 77.8%were obtained by varying the designed porosity and adjusting the processing *** is found that the pores and unfused powder decrease with the increase of deposited energy *** decrease of porosity leads to an improvement in mechanical *** relevancy between compressive/bending/tensile yield strength and relative density can be described appropriately by exponential model,while the relationship between elastic modulus and relative density is in good agreement with the Gibson-Ashby *** the porous tantalum scaffolds exhibit good ductility in compressive,bending and tensile *** fragmentation of struts is observed during the compression process,but cracks are formed on the strut surface after 90°bending,mainly due to the high sensibility to defects caused by the oxide.

关键词： porous tantalum scaffold electron beam powder bed fusion porosity mechanical properties Gibson−Ashby model

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美国、欧盟和日本生物技术产业政策研究

生产力研究 2006年第10期 173-174页

作者：王明明李静潭北京化工大学经济管理学院北京100029

文章分析研究了美国、欧盟和日本的生物技术产业发展进程、所取得的成就,特别是三国为鼓励和推动其生物技术产业发展所制定和实施的产业政策。其研究可为我国政府制定相关产业发展政策提供借鉴和参考依据。

关键词：生物技术产业政策

Asialoglycoprotein receptor 1 gene expression in peripheral blood monocytes associates with serum total cholesterol and low-density lipoprotein cholesterol levels

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Chinese Medical Journal 2020年第12期133卷 1505-1506页

作者： Xiang Zhao Bin tang Zhi-Hua Shi Zi-Wei Deng Ye Deng li-ming tan Shi-Long Jiang Yuan-Lu Shu Cheng-Feng Qiu Department of General Practice The First People’s Hospital of HuaihuaUniversity of South ChinaHuaihuaHunan 418000China Department of Evidence-based Medicine and Clinical Center The First People’s Hospital of HuaihuaUniversity of South ChinaHuaihuaHunan 418000China Department of Pharmacology The First People’s Hospital of HuaihuaUniversity of South ChinaHuaihuaHunan 418000China Department of Pharmacology The Second People’s Hospital of Huaihua CityHuaihuaHunan 418000China Department of Clinical Pharmacology Xiangya Hospital Central South UniversityChangshaHunan 410008China

To the Editor:Asialoglycoprotein receptor 1(ASGR1)is the major subunit of ASGR,it is predominantly expressed by liver parenchymal cells and relatively lower expression was found in peripheral blood monocytes.[1]A genetic study recently revealed that ASGR1 haploinsufficiency resulted from loss-of-function(LOF)variants was strongly associated with the pronounced reductions in serum total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)levels,[2,3]suggesting that ASGR1 may play a key role in cholesterol ***,the function of ASGR1 remains largely *** study was focused on the association of ASGR1 gene expression in monocytes and plasma cholesterol level.

关键词： cholesterol lipoprotein monocytes

Acupuncture combined with Buyang Huanwu decoction in the treatment of sequelae of cerebrovascular accident:a systematic review and meta-analysis

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TMR Non-Drug Therapy 2020年第3期3卷 101-124页

作者： Shao-Fu Yu Yun-Yun Wang Qi-Yuan He Lei Zhang Ying-Hui Jin Bo-Xuan liu Jian-Ping Gong li-ming tan Department of Clinical Pharmacy the Second People’s Hospital of HuaihuaHuaihua 418000China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of ChinaCollege of Life SciencesShaanxi Normal UniversityXi’an 710119China Precision Medicine Center the Second People’s Hospital of HuaihuaHuaihua 418000China The Second People’s Hospital of Huaihua Huaihua 418000China

Background:Cerebrovascular accident has high morbidity,high disability,and high mortality,possibly causing several serious sequelae and bringing a heavy burden to the patient,the family,and the *** Huanwu decoction,a classic ancient prescription of traditional Chinese medicine,and acupuncture are often used in combination to treat the sequelae of cerebrovascular *** the present study,we systematically evaluated the clinical efficacy and safety of acupuncture combined with Buyang Huanwu decoction in treating the sequelae of cerebrovascular ***:Relevant randomized controlled trials of acupuncture combined with Buyang Huanwu decoction in treating the sequelae of cerebrovascular accident were comprehensively retrieved from electronic databases from inception to May 8,2020,including PubMed,Embase,The Cochrane library,China National Knowledge Infrastructure,WanFang Data,and China Science and Technology Journal *** main outcomes of clinical efficacy,degree of nerve function impairment,daily self-care capacity,Fugl-Meyer locomotor function score,life quality score,and occurrence of adverse reactions were subjected to ***:The 28 randomized controlled trials included 2,341 patients with the sequelae of cerebrovascular *** review and meta-analysis indicated that compared with acupuncture alone,its combined treatment with Buyang Huanwu decoction significantly increased clinical efficacy(RR=1.19,95%CI(1.14,1.23),Plife quality score(SF-36 scale)of patients with sequelae of cerebrovascular accident,with few adverse ***:Compared wit

关键词： Acupuncture Buyang Huanwu decoction Sequelae of cerebrovascular accident Randomized controlled trials Clinical efficacy Nerve function