Acupuncture combined with Buyang Huanwu decoction in the treatment of sequelae of cerebrovascular accident:a systematic review and meta-analysis

作     者：Shao-Fu Yu Yun-Yun Wang Qi-Yuan He Lei Zhang Ying-Hui Jin Bo-Xuan Liu Jian-Ping Gong Li-Ming Tan 

作者机构：Department of Clinical Pharmacythe Second People’s Hospital of HuaihuaHuaihua 418000China Center for Evidence-Based and Translational MedicineZhongnan Hospital of Wuhan UniversityWuhan 430071China Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical ChemistryNational Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of ChinaCollege of Life SciencesShaanxi Normal UniversityXi’an 710119China Precision Medicine Centerthe Second People’s Hospital of HuaihuaHuaihua 418000China The Second People’s Hospital of HuaihuaHuaihua 418000China 

出 版 物：《TMR Non-Drug Therapy》 (TMR非药物治疗)

年 卷 期：2020年第3卷第3期

页      面：101-124页

学科分类：1006[医学-中西医结合] 1005[医学-中医学] 100502[医学-中医临床基础] 100602[医学-中西医结合临床] 10[医学] 

基　　金：This study was supported by Fundamental Research Funds for the Central University(No.GK202003050,GK202003048) the Innovation Training Program for University Student(No.cx2019013,s201910718084) 

主　　题：Acupuncture Buyang Huanwu decoction Sequelae of cerebrovascular accident Randomized controlled trials Clinical efficacy Nerve function 

摘      要：Background:Cerebrovascular accident has high morbidity,high disability,and high mortality,possibly causing several serious sequelae and bringing a heavy burden to the patient,the family,and the *** Huanwu decoction,a classic ancient prescription of traditional Chinese medicine,and acupuncture are often used in combination to treat the sequelae of cerebrovascular *** the present study,we systematically evaluated the clinical efficacy and safety of acupuncture combined with Buyang Huanwu decoction in treating the sequelae of cerebrovascular ***:Relevant randomized controlled trials of acupuncture combined with Buyang Huanwu decoction in treating the sequelae of cerebrovascular accident were comprehensively retrieved from electronic databases from inception to May 8,2020,including PubMed,Embase,The Cochrane Library,China National Knowledge Infrastructure,WanFang Data,and China Science and Technology Journal *** main outcomes of clinical efficacy,degree of nerve function impairment,daily self-care capacity,Fugl-Meyer locomotor function score,life quality score,and occurrence of adverse reactions were subjected to ***:The 28 randomized controlled trials included 2,341 patients with the sequelae of cerebrovascular *** review and meta-analysis indicated that compared with acupuncture alone,its combined treatment with Buyang Huanwu decoction significantly increased clinical efficacy(RR=1.19,95%CI(1.14,1.23),P0.001),improved nerve function impairment(WMD=−4.89,95%CI(−8.25,−1.53),P=0.004),promoted daily self-care capacity(WMD=15.87,95%CI(11.22,20.51),P0.001),strengthened Fugl-Meyer locomotor function(WMD=20.89,95%CI(13.79,27.98),P0.001),enhanced physical functioning(WMD=16.99,95%CI(6.01,27.96),P0.001)and mental health(WMD=16.91,95%CI(9.14,24.69),P0.001)in terms of life quality score(SF-36 scale)of patients with sequelae of cerebrovascular accident,with few adverse ***:Compared wit