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Ulinastatin suppresses endoplasmic reticulum stress and apoptosis in the hippocampus of rats with acute paraquat poisoning

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Neural Regeneration Research 2015年第3期10卷 467-472页

作者： Hai-feng li Shi-xing Zhao Bao-peng Xing ming-li sun Department of Emergency Medicine the First Hospital of Jilin University-the Eastern Division

Lung injury is the main manifestation of paraquat poisoning. Few studies have addressed brain damage after paraquat poisoning. Ulinastatin is a protease inhibitor that can effectively stabilize lysosomal membranes, prevent cell damage, and reduce the production of free radicals. This study assumed that ulinastatin would exert these effects on brain tissues that had been poisoned with paraquat. Rat models of paraquat poisoning were intraperitoneally injected with ulinastatin. Simultaneously, rats in the control group were administered normal saline. Hematoxylin-eosin staining showed that most hippocampal cells were contracted and nucleoli had disappeared in the paraquat group. Fewer cells in the hippocampus were concentrated and nucleoli had dis- appeared in the ulinastatin group. Western blot assay showed that expressions of GRP78 and cleaved-caspase-3 were significantly lower in the ulinastatin group than in the paraquat group. Immunohistochemical findings showed that CHOP immunoreactivity was significantly lower in the ulinastatin group than in the paraquat group. Terminal deoxynucleotidyl transferase-medi- ated dUTP nick end labeling staining showed that the number of apoptotic cells was reduced in the paraquat and ulinastatin groups. These data confirmed that endoplasmic reticular stress can be induced by acute paraqnat poisoning. Ulinastatin can effectively inhibit this stress as well as cell apoptosis, thereby exerting a neuroprotective effect.

关键词： nerve regeneration paraquat poisoning rats endoplasmic reticulum stress apoptosis ulinastatin CHOP GRP78 caspase-3 hippocampus reactive oxygen species neural regeneration

Fatigue crack growth behavior of 2624-T39 aluminum alloy with different grain sizes

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Rare Metals 2021年第9期40卷 2523-2529页

作者： Guan Huang Zhi-Hui li li-ming sun Xi-Wu li Kai Wen li-Zhen Yan Bai-Qing Xiong Yong-An Zhang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China Northeast light Alloy Co. Ltd.Harbin 150060China

The microstructure of 2624-T39 aluminum alloy was analyzed by means of metallographic(OM), scanning electron microscope(SEM) and transmission electron microscope(TEM). The effects of different microstructure characteristics on the tensile properties and fatigue crack growth rate of 2624-T39 aluminum alloy were *** showed that the grain size of the alloy was a typical fiber structure along the rolling direction, and the main second phase was the A_(l2)CuMg phase. The grain size of the alloy had an obvious influence on the fatigue crack growth rate, and the alloy showed a lower fatigue crack growth rate due to the larger grain size. The crack initiation zone on the fracture surface of alloys with lower fatigue crack growth rate was relatively rough, the crack propagation zone had obvious fatigue striations, and the transient fracture zone had a large number of smaller dimples.

关键词： 2624-T39 aluminum alloy Grain size Fatigue crack growth rate Fatigue fracture morphology

TBAB hydrate formation and growth in a microdevice under static and dynamic conditions

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Petroleum Science 2024年第2期21卷 1396-1404页

作者： Xingxun li ming liu Qingping li Weixin Pang Guangjin Chen Changyu sun State Key Laboratory of Heavy Oil Processing China University of Petroleum BeijingBeijing102249China State Key Laboratory of Natural Gas Hydrate CNOOC Research Institute Co.Ltd.Beijing100027China

The natural gas hydrate has become one of the most promising future green energy sources on the *** natural gas hydrates mostly exist in the sediments with porous structure, so a solid understanding of the hydrate formation and growth processes in the porous medium is of significance for the exploitation of natural gas hydrate. The micro-packed bed device is one of the efficient microfluidic devices in the engineering field, but it has been rarely used for the hydrate-based research. In this study, a transparent micro-packed bed device filled with glass beads was developed to mimic the porous condition of sediments, and used to in-situ visualize the hydrate formation and growth habits in the pore spaces under both static and dynamic conditions. For the static experiment, two types of hydrate growth patterns in porous medium were observed and identified in the micro-packed bed device, which were the graincoating growth and pore-filling growth. For the dynamic condition, the hydrate formation, growth,distribution habits and hydrate blockage phenomena in the pore spaces were in-situ visually *** impacts of flowrate and subcooling on the pressure variation of the micro-packed bed and the duration of the hydrate growth under dynamic flow condition in pores were in-situ monitored and analyzed. The higher flowrate could result in the faster hydrate growth and more severe blockage in pores, but the effect of subcooling condition might be less significant at the high flowrate.

关键词： Hydrate formation Hydrate growth Microdevice In-situ measurement

A study of novel real-time power balance strategy with virtual asynchronous machine control for regional integrated electric-thermal energy systems

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Science China(Technological Sciences) 2024年第7期67卷 2074-2086页

作者： WANG Rui li ming-Jia WANG YiBo sun QiuYe ZHANG PinJia College of Information Science and Engineering Northeastern UniversityShenyang 110819China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China

The development of regional integrated electric-thermal energy systems(RIETES) is considered a promising direction for modern energy supply systems. These systems provide a significant potential to enhance the comprehensive utilization and efficient management of energy resources. Therein, the real-time power balance between supply and demand has emerged as one pressing concern for system stability operation. However, current methods focus more on minute-level and hour-level power optimal scheduling methods applied in RIETES. To achieve real-time power balance, this paper proposes one virtual asynchronous machine(VAM) control using heat with large inertia and electricity with fast response speed. First, the coupling timescale model is developed that considers the dynamic response time scales of both electric and thermal energy systems. Second, a real-time power balance strategy based on VAM control can be adopted to the load power variation and enhance the dynamic frequency response. Then, an adaptive inertia control method based on temperature variation is proposed, and the unified expression is further established. In addition, the small-signal stability of the proposed control strategy is validated. Finally, the effectiveness of this control strategy is confirmed through MATLAB/Simulink and HIL(Hardware-in-the-Loop) experiments.

关键词： regional integrated electric-thermal energy systems real-time power balance virtual asynchronous machine adaptive inertia small-signal stability

Quantitative analysis and prediction of the sound field convergence zone in mesoscale eddy environment based on data mining methods

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Acta Oceanologica Sinica 2024年第5期43卷 110-120页

作者： ming li Yuhang liu Yiyuan sun Kefeng liu College of Advanced Interdisciplinary Studies National University of Defense TechnologyNanjing 211101China Jiangsu Ocean University Lianyungang 222061China College of Horticulture Forestry Sciences Huazhong Agricultural UniversityWuhan 430070China

The mesoscale eddy(ME)has a significant influence on the convergence effect in deep-sea acoustic *** paper use statistical approaches to express quantitative relationships between the ME conditions and convergence zone(CZ)*** on the Gaussian vortex model,we construct various sound propagation scenarios under different eddy conditions,and carry out sound propagation experiments to obtain simulation *** a large number of samples,we first adopt the unified regression to set up analytic relationships between eddy conditions and CZ *** sensitivity of eddy indicators to the CZ is quantitatively ***,we adopt the machine learning(ML)algorithms to establish prediction models of CZ parameters by exploring the nonlinear relationships between multiple ME indicators and CZ *** the research,we can express the influence of ME on the CZ quantitatively,and achieve the rapid prediction of CZ parameters in ocean *** prediction accuracy(R)of the CZ distance(mean R:0.9815)is obviously better than that of the CZ width(mean R:0.8728).Among the three ML algorithms,Gradient Boosting Decision Tree has the best prediction ability(root mean square error(RMSE):0.136),followed by Random Forest(RMSE:0.441)and Extreme Learning Machine(RMSE:0.518).

关键词： convergence zone mesoscale eddy statistic analysis quantitative prediction machine learning

Novel adaptive Hatch filter to mitigate the effects of ionosphere and multipath on LAAS

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Journal of Systems Engineering and Electronics 2010年第6期21卷 1046-1053页

作者： lin Zhao, liang li, ming sun, and Xiaoxu Wang College of Automation, Harbin Engineering University, Harbin 150001, P. R. China College of Automation Harbin Engineering University Harbin 150001 P. R. China

It has been proven that carrier smoothing and differential global positioning system （DGPS） are effective to improve the accuracy of pseudorange by reducing the noise in it and eliminating almost all the common mode errors between the ground station and user. However, another issue coming with local area augmentation system （LAAS） is how to find an adaptive smoothing window width to minimize the error on account of ionosphere delay and multipath. Based on the errors analysis in carrier smoothing process, a novel algorithm is formulated to design adaptive Hatch filter whose smoothing window width flexibly varies with the characteristic of ionosphere delay and multipath in the differential carrier smoothing process. By conducting the simulation in LAAS and after compared with traditional Hatch filers, it reveals that not only the accuracy of differential correction, but also the accuracy and the robustness of positioning results are significantly improved by using the designed adaptive Hatch filter.

关键词： Hatch filter adaptive ionosphere delay multipath differential correction local area augmentation system.

Analysis of application range of simplified models for field to thermo-field to thermionic emission processes from the cathode

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Plasma Science and Technology 2024年第9期26卷 51-60页

作者： li sun Zhuo DAI ming XU Wei WANG Zengyao li Applied Physics Department Xi’an University of TechnologyXi’an 710048People’s Republic of China Key Laboratory of Thermo-Fluid Science and Engineering Ministry of EducationSchool of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Electron emission plays a dominant role in plasma-cathode interactions and is a key factor in many plasma phenomena and industrial *** is necessary to illustrate the various electron emission mechanisms and the corresponding applicable description models to evaluate their impacts on discharge *** this study,detailed expressions of the simplified formulas valid for field emission to thermo-field emission to thermionic emission typically used in the numerical simulation are proposed,and the corresponding application ranges are determined in the framework of the Murphy-Good theory,which is commonly regarded as the general model and to be accurate in the full range of conditions of the validity of the *** parameterization was used to evaluate the emission current density of the Murphy-Good formula,and a deviation factor was defined to obtain the application ranges for different work functions(2.5‒5 eV),cathode temperatures(300‒6000 K),and emitted electric fields(10^(5) to 10^(10) V·m^(-1)).The deviation factor was shown to be a nonmonotonic function of the three parameters.A comparative study of particle number densities in atmospheric gas discharge with a tungsten cathode was performed based on the one-dimensional implicit particle-in-cell(PIC)with the Monte Carlo collision(MCC)method according to the aforementioned application *** was found that small differences in emission current density can lead to variations in the distributions of particle number density due to changes in the collisional *** study provides a theoretical basis for selecting emission models for subsequent numerical simulations.

关键词： electron emission processes application range Murphy-Good theory implicit particlein-cell Monte Carlo collision method

Uncovering the prominent role of satellite cells in paravertebral muscle development and aging by single-nucleus RNA sequencing

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Genes & Diseases 2023年第6期10卷 2597-2613页

作者： Xin Qiu Hao-Yu Wang Zhen-Yu Yang li-ming sun Shu-Nan liu Chui-Qin Fan Feng Zhu Department of Spinal Surgery The University of Hong Kong-Shenzhen HospitalShenzhenGuangdong 518000China Department of Orthopedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China College of life Sciences University of Chinese Academy of SciencesBeijing 100000China Lars Bolund Institute of Regenerative Medicine Qingdao-Europe Advanced Institute for Life SciencesBGI-QingdaoQingdaoShandong 266000China China Medical University ShenyangLiaoning 110000China Department of Plastic and Reconstructive Surgery Xijing HospitalForth Military Medical UniversityXi'anShaanxi 710000China

To uncover the role of satellite cells(SCs)in paravertebral muscle development and aging,we constructed a single-nucleus transcriptomic atlas of mouse paravertebral muscle across seven timepoints spanning the embryo(day 16.5)to old(month 24)*** cell types,including SCs,fast muscle cells,and slow muscle cells,were *** energy metabolism-related gene set,TCA CYCLE IN SENESCENCE,was enriched in ***-two skeletal muscle disease-related genes were highly expressed in SCs and exhibited similar expression *** them,Pdha1 was the core gene in the TCA CYCLE IN SENESCENCE;Pgam2,Sod1,and Suclg1 are transcription factors closely associated with skeletal muscle energy *** factor enrichment analysis of the 42 genes revealed that Myod1 and Mef2a were also highly expressed in SCs,which regulated Pdha1 expression and were associated with skeletal muscle *** findings hint that energy metabolism may be pivotal in SCs development and *** ligand-receptor pairs of extracellular matrix(ECM)-receptor interactions,Lamc1-Dag1,Lama2-Dag1,and Hspg2-Dag1,may play a vital role in SCs interactions with slow/fast muscle cells and SCs ***,we built the first database of a skeletal muscle single-cell transcriptome,the Musculoskeletal Cell Atlas(http://***),which lists 630,040 skeletal muscle cells and provides interactive visualization,a useful resource for revealing skeletal muscle cellular heterogeneity during development and *** study could provide new targets and ideas for developing drugs to inhibit skeletal muscle aging and treat skeletal muscle diseases.

关键词： Niche Paraspinal muscle Satellite cells Senescence Single-nucleus RNA sequencing

Synergy enhancement of Co single atoms and asymmetric subnanoclusters for Fenton-like activation

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Nano Research 2024年第9期17卷 7935-7944页

作者： ming Ma Zhiyi sun Ziwei Deng Xiang li Fang Zhang Wenxing Chen School of Materials Key Laboratory of Cluster Science Ministry of EducationBeijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsAdvanced Technologies Research Institute(Jinan)Advanced Research Institute of Multidisciplinary ScienceSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Energy and Catalysis Center School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Analysis and Testing Center Beijing Institute of TechnologyBeijing Institute of TechnologyBeijing 100081China

As a new water treatment technology,Fenton-like reaction has great *** this study,we successfully prepared an excellent Fenton-like catalyst,which is composed of cobalt monoatoms and asymmetric subnanoclusters(labeled CoSA/Clu-C_(2)N),and exhibits excellent peroxymonosulfate(PMS)activation *** directly comparing the catalytic properties of CoSA-C_(2)N and CoSA/Clu-C_(2)N,the synergistic effects of coasymmetric Co subclusters and Co atoms on the activation of PMS and degradation of organic micropollutants were *** results showed that CoSA/Clu-C_(2)N had higher degradation rates of carbamazepine(CBZ),antipyrine(AT)and chlorobenzoic acid(CA)when combined with active oxidant *** cyclic frequency of CBZ was 5.4 min^(-1),which was twice as high as the catalytic constant of CoSA-C_(2)N(2.4 min^(-1)).The results show that CoSA/Clu-C_(2)N cobalt subnanoclusters and cobalt single atom can synergistically improve the catalytic performance of activated PMS oxidation of micropollutants in *** addition,electron paramagnetic resonance(EPR)technology has proved that the introduction of Co subnano clusters in CoSA/Clu-C_(2)N is conducive to the production of singlet oxygen(1O_(2)),thereby improving the efficiency of pollutant *** work lays a solid foundation for the future design of advanced multifunctional catalysts by carefully regulating and combining monmetallic atoms and metal subnanoclusters.

关键词： carbamazepine Fenton-like reaction Co single atoms asymmetrical sub-nanoclusters peroxymonosulfate synergy enhancement