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Effects of moxibustion on Treg cells in sarcoma microenvironment

Journal of Integrative Medicine 2021年第3期19卷 251-257页

作者： li-jun li Yu-chong Shi Min-xiang Luo Chang-lin Zhao Department of Acupuncture Guangdong Clifford HospitalGuangzhou 511495Guangdong ProvinceChina School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Health Science College Guangdong Pharmaceutical UniversityGuangzhou 510006Guangdong ProvinceChina

Objective:To investigate the therapeutic effect of moxibustion on sarcomas from mesenchymal tissues,which have a low response rate to chemotherapy and ***:S180 sarcoma cell line was inoculated in C57 BL/6 mice to form transplanted *** therapy was directly applied at the transplanted tumor sites,at a distance of 3.0 cm,10 min per session,till skin temperature reached 45°C,once a day,for 14 consecutive days of *** the mice were killed,serum was collected and used to detect concentrations of interleukin-10(IL-10),transforming growth factor-b1(TGF-b1),IL-4 and interferon-c(IFN-c)by Luminex liquid suspension *** numbers of Treg^(^(+) )T cells and CD4^(+) CD25^(+) Forkhead Box P3(Foxp3)^(+) T cells were detected by flow *** in situ hybridization was used to analyze the changes of CD4,CD8,Foxp3 and TGF-b1 in the tumor microenvironment(TME).Results:Weight of S180 transplanted tumor in the control group was(2.03±0.54)g,and that in the moxibustion group was(1.27±0.29)g,which was statistically different(P=0.023).The mean value of Foxp3^(+) T cells in the normal group was 2.01%,which increased to 3.63%after the formation of transplanted tumor,and decreased to 1.48%after moxibustion *** moxibustion group also had reduced numbers of CD4^(+) CD25^(+) Foxp3^(+) T cells in the spleen of mice with transplanted *** concentrations of IL-10,TGF-b1 and IL-4 decreased in the serum of mice with transplanted tumor,while the concentration of IFN-c *** was associated with downregulation in expression of Foxp3,IL-10 and TGF-b1 genes in the transplanted tumor,and increases in the gene expression of CD4^(+) T cells and CD8^(+) T cells in the ***:Moxibustion may have therapeutic effects on sarcomas by reducing the number of Treg cells in the blood and controlling the infiltration of Treg cells in the TME.

关键词： Sarcoma Moxibustion Treg cells Tumor microenvironment

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Research on inversion method for complex source-term distributions based on deep neural networks

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Nuclear Science and Techniques 2023年第12期34卷 159-176页

作者： Yi‑Sheng Hao Zhen Wu Yan‑Heng Pu Rui Qiu Hui Zhang jun‑li li Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging of Ministry of Education Beijing 100084China Nuctech Company limited Beijing 100084China

This study proposes a source distribution inversion convolutional neural network (SDICNN), which is deep neural network model for the inversion of complex source distributions, to solve inversion problems involving fixed-source distributions. A function is developed to obtain the distribution information of complex source terms from radiation parameters at individual sampling points in space. The SDICNN comprises two components:a fully connected network and a convolutional neural network. The fully connected network mainly extracts the parameter measurement information from the sampling points,whereas the convolutional neural network mainly completes the fine inversion of the source-term distribution. Finally, the SDICNN obtains a high-resolution source-term distribution image. In this study, the proposed source-term inversion method is evaluated based on typical geometric scenarios. The results show that, unlike the conventional fully connected neural network, the SDICNN model can extract the two-dimensional distribution features of the source terms, and its inversion results are better. In addition, the effects of the shielding mechanism and number of sampling points on the inversion process are examined. In summary, the result of this study can facilitate the accurate assessment of dose distributions in nuclear facilities.

关键词： Source term inversion Monte Carlo Artificial intelligence Neural network

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羊粪还田对青贮玉米产量、品质和土壤肥力的影响

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湖南农业科学 2024年第2期 42-46页

作者：韩秀秀张文珍王军民李俊丽刘建军荆门(中国农谷)农业科学研究院湖北荆门448000

为了实现标准化养殖场羊粪的资源化利用,构建种养结合循环模式,在荆门市开展了青贮玉米种植试验,设置5个处理(100%化肥、75%化肥+25%羊粪、50%化肥+50%羊粪、25%化肥+75%羊粪和100%羊粪)研究羊粪还田及替代化肥比例对青贮玉米产量、饲... 详细信息

为了实现标准化养殖场羊粪的资源化利用,构建种养结合循环模式,在荆门市开展了青贮玉米种植试验,设置5个处理(100%化肥、75%化肥+25%羊粪、50%化肥+50%羊粪、25%化肥+75%羊粪和100%羊粪)研究羊粪还田及替代化肥比例对青贮玉米产量、饲用价值和土壤肥力的影响。结果表明:(1)随着羊粪替代化肥比例的增加,土壤中有机质、全氮、碱解氮、有效钾和有效磷等指标的含量均增加,100%羊粪组较100%化肥组分别增加了8.35%、5.68%、7.46%、7.51%和10.53%(P <0.05),土壤容重呈减小趋势,100%羊粪组较100%化肥组下降5.56%(P <0.05);(2)随着羊粪替代化肥比例的增加,青贮玉米产量先增加后减少,其中施用75%化肥+25%羊粪组的产量最高,较100%化肥组增加5.58%(P <0.05),较100%羊粪组增加20.89%(P <0.05);(3)随着羊粪替代比例的增加,青贮玉米的粗蛋白、粗脂肪含量和相对饲用价值都呈先增加后减小的趋势,其中施用75%化肥+25%羊粪组的最高,粗蛋白较100%化肥组增加7.81%(P <0.05)、较100%羊粪组增加15.53%(P <0.05);粗脂肪与100%化肥组差异性不显著,较100%羊粪组增加16.13%(P <0.05);相对饲用价值(RFV)与100%化肥组差异性不显著,较100%羊粪组增加18.82%(P <0.05)。综合来说,25%的羊粪代替化肥还田不仅能改善土壤肥力,还能提高青贮玉米产量和饲用品质。

关键词：羊粪青贮玉米土壤肥力产量营养品质

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丙烯酰胺类聚合物稠化剂的分子结构及应用性能

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应用化工 2024年第5期53卷 1224-1227页

作者：李俊莉沈燕宾曹晨茜王鹏程张颖路建萍陕西化工研究院有限公司陕西西安710054 陕西省石油精细化学品重点实验室陕西西安710054 中国石油天然气股份有限公司长庆油田分公司第九采油厂陕西西安710000

综述了四类丙烯酰胺类聚合物稠化剂:阴离子聚合物、阳离子聚合物、两性离子聚合物和非离子聚合物的分子结构及应用性能,并对耐高温酸液稠化剂的开发提出建议,可望为我国深层高温、低渗透特低渗非常规油气田的开发利用提供参考。

关键词：稠化剂丙烯酰胺共聚物分子结构应用性能

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Effects of mid-passage gap with a variable surface angle on a turbine vane endwall’s aerothermal and film cooling performances

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Chinese Journal of Aeronautics 2024年第6期37卷 20-37页

作者： Zhiyu li Kaiyuan ZHANG Zhigang li jun li Institute of Turbomachinery Xi’an Jiaotong UniversityXi’an 710049China

The mid-passage gap is an inevitable structure in a vane passage due to turbine vanes being manufactured *** coolant from this gap is able to prevent hot mainstream ingression and provide cooling protection for the endwall.A novel idea of enlarging the endwall’s coverage area and reducing the endwall’s thermal load by applying the mid-passage gap with variable surface angles is carried out in this *** endwall’s aerothermal and film cooling performances under four mid-passage gap modes at three typical mass flow ratio conditions are numerically *** indicate that under the traditional mid-passage mode,the coolant flows into the mainstream with a perpendicular incidence angle and can’t stick to the ***,cooling failure occurs,and the endwall’s thermal load is badly *** film cooling level at the suction-side endwall is improved when applying the mid-passage gap of a 45surface angle due to the secondary vortex being *** addition,when applying the mid-passage gap of a 135surface angle,the horseshoe vortex is pushed away,and the coverage area at the pressure-side endwall is enlarged *** best film cooling performance is achieved when the upstream surface angle is 135and the downstream surface angle is 45due to the adiabatic film cooling effectiveness being increased at both the pressure-and suction-side *** the mass flow ratio is 1.5%,the coverage area is enlarged by 43%,and the area-averaged adiabatic film cooling effectiveness is increased by 37%,when compared with those under the traditional mid-passage mode.

关键词： Film cooling Heat transfer Surface angle Mid-passagegap Turbinevane endwall

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Metabolic Regulation of Mammary Gland Epithelial Cells of Dairy Cow by Galactopoietic Compound Isolated from Vaccariae segetalis

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Agricultural Sciences in China 2011年第7期10卷 1106-1116页

作者： TONG Hui-li GAO Xue-jun li Qing-zhang liU Jie li Nan WAN Zhong-ying Key Laboratory of Dairy Science Ministry of Education/Life College Northeast Agricultural University Harbin 150030 P.R.China

In previous experiment, we isolated a compound dibutyl phthalate （DBP） from Vaccaria segetalis which had galactopoietic function on mammary gland epithelial cells of dairy cow （DCMECs）. In this experiment, we ascertained the metabolic regulation function of DBP on DCMECs. Many genes related to lactation including Stat5, AMPK, b-casein, Glut1, SREBP-1, PEPCK, and ACC were detected by real-time PCR. Furthermore, Stat5 and AMPK were detected by Western blot and immunofluorescence co-localization, respectively. The results showed that DBP stimulates the expression of Stat5 and p-Stat5, thus activates Stat5 cell signal transduction pathway and stimulates b-casein synthesis. DBP also raises the activities of Glut1 and AMPK to stimulate glucose uptake and glycometabolism and activates the expression of AMPK downstream target genes PEPCK and ACC and expression of SREBP-1 to stimulate milk fat synthesis. In addition, the activities of HK, G-6-PDH, ICDH, ATPase, and energy charges were stimulated by DBP to increase the energy metabolism level of DCMECs. The results showed DBP stimulates energy metabolism related to galactopoietic function in DCMECs.

关键词： Vaccaria segetalis DBP dairy cow mammary gland epithelial cell metabolic regulation

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Seismic Analysis of Shear-Wall Structures with Vertically Installed Dampers

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Journal of China University of Geosciences 2005年第4期16卷 349-353页

作者： Yang jun li li Fan Aiwu School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074 China

Shear-wall structures are quite common in seismic areas because of their successful seismic behavior during severe earthquakes. But shear walls are prone to brittle failure. This study proposes a new method of vertically installed dampers （VID） to reduce the vibration in shear-wall structures. The motion characteristic of a vertical damping system is that every mass has horizontal and rotational displacements simultaneously, The establishment of dynamic equations should take into account the equilibrium conditions of both horizontal and rotational vibrations. Dynamic equilibrium equations of VID systems are derived from a model of a structure with VID. An example shear-wall structure, with and with- out VID, is studied. There are some changes in the characteristics of the maximum horizontal displacement response. Without dampers, the relative displacements between different floors in the shear wall increase with height. With dampers, the relative displacements are more uniformly distributed, and lateral displacements at the top and at the bottom are closer. When the damping coefficient is 1 000 kN · s/ m, the numerical results reveal that the maximum horizontal displacement and the maximum rotational displacement of the top floor have reduced by 59.3 % and 54.8 % respectively.

关键词： shear wall damper dynamic equilibrium equation seismic response.

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Oxidative stress related enzymes in response to chromium(VI) toxicity in Oxya chinensis (Orthoptera: Acridoidae)

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Journal of Environmental Sciences 2005年第5期17卷 823-826页

作者： li li-jun ZHANG Feng liU Xue-mei GUO Ya-ping MA En-bo College of life Science and Technology Shanxi University Taiyuan 030006 China Institution of Soil Science and Fertilizer Shanxi Academy of Agriculture Science Taiyuan 030031 China

The toxic effects of Cr（Vl） on antioxidant enzymes of Oxya chinensis（Orthoptera： Acridoidae） were determined. Changes in the activities of the antioxidant enzymes superoxide dismutase（SOD）, catalase（CAT）, and guaiacol peroxidase（GPx） were measured in O. chinensis insects injected with Cr（VI）. Fifth-nymphs of O. chinensis insects were injected with Cr（VI） with different concentrations （0, 75, 150, 225, 300, 375, 450 mg/kg of body weight）. The results showed that Cr（VI） led to the change of SOD, CAT, and GPx activities at different concentrations, which revealed that：（1） The oxidative stress of SOD increased with the increase of Cr （VI） concentration. （2） With the increase of Cr （VI） concentrations, CAT activities for females increased at lower concentrations, but decreased at higher concentration range, which indicated that antioxidant system of O. chinensis was not influenced by the presence of Cr （VI）. A very similar response to Cr（VI） effect for males indicated that Cr（VI） concentrations were not high enough to damage O. chinensis in terms of CAT. （3） The GPx activity for females increased in all treatments, which revealed that the damage power of Cr（VI） was increased with the increase of Cr（Vi） concentrations in terms of GPx, but the effect was not so remarkable. There was not a consistent trend of GPx activities for males in all treatments of Cr（VI）. Cr（VI）-induced changes in antioxidant enzymes were different for SOD, CAT and GPx, of which the tendency was that activities generally changed with increase of concentrations of Cr（VI） suggesting SOD, CAT, and GPx could serve as indices of oxidative stress to some extent.

关键词： Cr( VI ) Oxya chinensis oxidative stress superoxide dismutase(SOD) catalase (CAT) guaiacol peroxidase(GPx)

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Elevated plasma lipoprotein-associated phospholipase A2 activity is associated with plaque rupture in patients with coronary artery disease

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Chinese Medical Journal 2011年第16期124卷 2469-2473页

作者： liU Chuan-fen QIN li REN Jing-yi CHEN Hong WANG Wei-min liU Jian SONG jun-xian li li-jun Department of Cardiology Peking University People's Hospital Beijing 100044China Department of Laboratory Medicine Peking University People's Hospital Beijing 100044China

Background lipoprotein-associated phospholipase A2 （Lp-PLA2） has recently been shown to be positively related to coronary events in patients with coronary artery disease （CAD）. However, direct evidence about the relationship between circulation Lp-PLA2 activity and vulnerable plaque in patients with CAD remains lacking. Methods Plasma Lp-PLA2 activity was determined in 146 consecutive patients with CAD who underwent clinically-indicated coronary angiography and preinterventional intravascular ultrasound （IVUS）. Results Eighty-three patients were included in the final analysis after the initial screening. Sixty （72.3%） were acute coronary syndrome （ACS） patients and 23 （27.7%） were stable angina pectoris （SAP） patients. Plaque rupture occurred in 39 （47.0%） patients, and 34 （87.2%） were from ACS patients and 5 （12.8%） from SAP patients. There were no significant differences in clinical and angiographic characteristics between patients with plaque rupture and those without plaque rupture, except for smoking, high-sensitive C-reactive protein （hs-CRP） level and Lp-PLA2 activity （all P 〈0.05）. IVUS measurement uncovered that patients with plaque rupture had more frequent positive remodeling （74.4% vs. 43.2%, P=0.004）, soft plaques （64.1% vs. 36.4%, P=-0.012） and higher remodeling index （1.13~0.16 vs. 0.99＋_0.11, P=0.041） as compared with those without plaque rupture. Multivariate Logistic regression analysis showed that plasma Lp-PLA2 activity was independently associated with plaque rupture after adjusting for smoking, positive remodeling and soft plaque （Model 1： odds ratio （OR） 1.13, 95% confidence interval （CO ： 1.06-1.20） or adjusting for smoking, hs-CRP level, positive remodeling and soft plaque （Model 2： OR 1.11,95%C1： 1.04-1.19）. Conclusions Plasma Lp-PLA2 activity is associated with plaque rupture in patients with CAD, independently of traditional CAD risk factors, hs-CRP level and IVUS parameters. Lp-PLA2 may be a risk marker for vulnerable plaques.

关键词： lipoprotein-associated phospholipase A2 plaque intravascular ultrasound inflammation coronary artery disease

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Value of T cell receptor gamma alternate reading frame protein and keratin 5 in endometrial carcinoma

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Chinese Medical Journal 2013年第22期126卷 4260-4264页

作者： ZHAO li-jun li Xiao-ping QI Wen-juan WANG Jian-liu WEI li-hui Department of Obstetrics & Gynecology Peking University People's Hospital Beijing 100044 China

Background Tumors with different gene expression develop and progress in different ways. To deepen our understanding of the progression in endometrial cancer, and provide a useful tool for accurate diagnosis and prognosis assessment, we identified the new molecular prognostic markers in endometrial carcinoma and analyzed the relationship of them with clinical and pathological features of endometrial carcinoma. Methods Ninety-four cases of endometrial endometrioid adenocarcinoma with complete data from the Peking University People＇s Hospital from 2000 to 2008 and 40 cases of normal endometrium were enrolled. Among these, 30 endometrial endometrioid adenocarcinoma samples of different International Federation of Gynecology and Obstetrics （FIGO） stage were selected for further Agilent genome-wide microarray analysis. Significance analysis of microarrays （SAM） was used to identify genes that are significantly associated with tumor progress. Immunohistochemistry was utilized to identify the genes of interest in endometrial carcinoma and normal endometrium. The relationship between the genes and the age, clinical stage, histological grade, myometrium invaded depth, lymph node metastasis status, and the expression of ER, PR, P53, and PTEN were analyzed by X2 test. Results Analysis between FIGO 1988 stage I and stage III identified a 362-gene ＂progress signature＂; 171 downregulated and 191 up-regulated genes. Among the alterative genes, TARP （T cell receptor gamma alternate reading frame protein） and KRT5 （keratin 5） decreased 3.57 fold and 5.8 fold in FIGO stage III patients. The expression of TARP in endometrial carcinoma increased compared to normal endometrium, while that of KRT5 decreased （P〈0.05）. The expression of TARP and KRT5 decreased when stage, histological grading, myometrium invaded depth increased （P〈0.05）. In the cases with lymph node metastasis, the expression of TARP decreased, while the expression of KRT5 did not differ （both P〈0.05） both. The expression

关键词： endometrial cancer T cell receptor gamma alternate reading frame protein keratin 5

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