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Iodine Mediated Efficient Formation of Ferrocenylcyanide in Aqueous Solution

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Chinese Chemical Letters 2006年第7期17卷 880-882页

作者： Zheng DUAN Zhong Xian li yang jie WU Chemistry Department Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities Zhengzhou University Zhengzhou 450052

Ferrocenecarboxyaldehyde reacted with iodine in commercial available ammonia water gave ferrocenylcyanide with high yield.

关键词： Ferrocenylcyanide iodine aqueous ammonia preparation.

Formation of Na_(1+x)V_3O_8 Nanoribbon Thin Film from V_2O_5 Xerogel on Sodium Silicate Glass Substrate

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Chemical Research in Chinese Universities 2007年第4期23卷 381-383页

作者： GUO Yi XU Jin-jie li Jun yang Wen-sheng College of Chemistry Jilin University Changchun 130012 P. R. China

Na1＋xV3O8 nanoribbon thin film was successfully fabricated by annealing the V2O5 xerogel film on sodium sili-cate glass substrate at 450℃. It has been identified that the amount of sodium ions diffused into the V2O5 xerogel film increases with the high temperature of annealing treatment. The sodium glass substrate serves as a limited sodium source to induce the transformation from V2O5 to Na1＋xV3O8.

关键词： Vanadium pentoxide Sodium silicate glass Nanoribbon Cathode materials

Hybrid Tungstocuprate [Cu(2,2′-bpy)_3]_2H_4[CuW_(12)O_(40)]·6H_2O Based on Keggin Polyoxoanion [CuW_(12)O_(40)]^(6-) with Cu~Ⅱas Heteroatom

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Chemical Research in Chinese Universities 2007年第3期23卷 263-267页

作者： WANG Jing-ping MA Peng-tao li jie NIU Jing-yang Institute of Molecular and Crystal Engineering School of Chemistry and Chemical Engineering Henan University Kaifeng 475001 P. R. China

A novel hybrid tungstocuprate （ Ⅱ ） [ Cu （2,2＇-bpy） 3 ] 2 H4 [ CuW12O40 ] · 6H2O （ 2,2＇-bpy = 2,2＇-bipyfidine） was synthesized via hydrothermal method and characterized using elemental analyses, IR, UV, XPS, TG-DSC, EPR, and X-ray single crystal diffraction. The structural analysis shows that the complex consists of an unusual Keggin-type polyoxoanion [ CuW12O40 ]^6- and a pair of chiral complex cations [ Cu（2,2＇-bpy） 3 ]^＋ together with four protons and six crystallization water molecules, and the Keggin polyoxoanion is connected with [ Cu （2,2＇-bpy）3 ]^＋v/a multiple C-H…O hydrogen bonds resulting in a dimer.

关键词： Hydrothermal synthesis Polyoxometalates Keggin Tungstocuprate

Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice

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Cellular & Molecular Immunology 2015年第6期12卷 729-742页

作者： yang Xiao Fang liu Jingyi yang Maohua Zhong Ejuan Zhang Yaoming li Dihan Zhou Yuan Cao Wei li jie Yu Yi yang Huimin Yan Mucosal immunity Research Group State Key Laboratory of Virology Wuhan institute of Virology Chinese Academy of Sciences Wuhan China

Flagellin is a potent activator of a broad range of cell types that are involved in innate and adaptive immunity. Therefore, it is a good adjuvant candidate for vaccines, and it might function as a biological protectant against both major acute radiation syndrome during cancer radiotherapy and a mitigator of radiation emergencies. However, accumulating evidence has implicated flagellin in the occurrence of some inflammatory diseases, such as acute lung inflammation, cardiovascular collapse and inflammatory bowel disease. The aim of this study was to elucidate whether only flagellin-TLR5 signaling activation plays a role in the pathophysiology of liver or whether some other flagellin activity also contributes to liver injury either via bacterial infections or during clinical applications. Recombinant flagellin proteins with or without TLR5-stimulating activity were used to evaluate the role of flagellin-TLR5 signaling in liver injury in wild-type and TLR5 KO mice. Gross lesions and large areas of hepatocellular necrosis were observed in liver tissue 12 h after the intraperitoneal administration of 100 or 200 pg flagellin （FliC） in a dose-and time-dependent manner in wild-type mice, but not in TLR5 KO mice. Deletion of the N-terminal or TLR5 binding domain of flagellin inhibited flagellin-induced inflammatory responses and the subsequent acute liver function abnormality and damage. These data confirmed that flagellin is an essential determinant of liver injury and demonstrated that the over-activation of TLR5 signaling by high-dose flagellin caused acute inflammatory responses, neutrophil accumulation and oxidative stress in the liver, which contributes to the progression and severity of flagellin-induced liver injury.

关键词： flagellin liver injury pathological effect TLR5

Bioinformatics Analysis and Identification of Potential Genes Associated with Pathogenesis and Prognosis of Gastric Cancer

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Current Medical Science 2022年第2期42卷 357-372页

作者： Dan-wen WANG Fei SU li-jie yang li-wen SHI Tie-cheng yang Hua-qiao WANG Xuan-fei li Mao-hui FENG Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan443071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan Wuhan443071China Clinical Cancer Study Center of Hubei Provence Wuhan443071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan443071China Department of Oncology the First Hospital of Lanzhou UniversityLanzhou730000China

Objective Gastric cancer(GC)is a deadly cancer and a challenging public health problem *** study aimed to analyze potential genes associated with pathogenesis and prognosis of gastric *** This work selected the overlapping differentially expressed genes(DEGs)in GC from four datasets,the GSE29272,GSE29998,GSE54129 and GSE118916 Gene Expression Omnibus *** DEGs were used to carry out comprehensive bioinformatic analysis to analyze the related functions and pathways enriched,the relative expression levels and immune infiltrates,the prognostic characteristics and the interaction *** In total,55 DEGs increased while 98 decreased in their expression *** those DEGs with increased expression,they were mostly concentrated on“focal adhesion”and“ECM-receptor interaction”,whereas DEGs with decreased expression were mostly associated with“gastric acid secretion”and“drug metabolism cytochrome P450”.MCODE and ClueGO results were then integrated to screen 10 hub genes,which were FN1,COL1A1,COL3A1,BGN,TIMP1,COL1A2,LUM,VCAN,COL5A2 and *** analysis revealed that higher expression of the ten hub genes significantly predicted lower overall survival of GC ***1 was most significantly related to neutrophils,CD8+T cells,as well as dendritic cells,while LUM was most significantly related to *** Immunohistochemistry results and functional testing showed that the expression of COL5A2 was elevated in GC and that it might be a key gene in GC tumorigenesis.

关键词： gastric cancer differentially expressed genes bioinformatics analysis prognosis immune infiltrate

Atrial fibrillation after surgery for esophageal carcinoma:Clinical and prognostic significance

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World Journal of Gastroenterology 2006年第3期12卷 449-452页

作者： Jian-yang Ma Yun Wang Yong-Fan Zhao Zhu Wu Lun-Xu liu Ying-li Kou Jun-jie yang Department of Thoracic and Cardiovascular Surgery West China Hospital Sichuan UniversityChengdu 610041 Sichuan Province China

AIM： To retrospectively evaluate the clinical relevance, perioperative risk factors, outcome of different pharmacological prophylaxis, and short-term prognostic value of atrial fibrillation （AF） after surgery for esophageal carcinoma. METHODS： We retrospectively studied 63 patients with AF after surgery for esophageal carcinoma in comparison with 126 patients without AF after esophagectomy during the same time. Postoperative AF incidence was related to different clinical factors possibly involved in its occurrence and short-term survival. RESULTS： A strong relationship was observed between AF and postoperative hypoxia, history of chronic obstructive pulmonary disease （COPD）, postoperative thoracic-gastric dilatation, age older than 65 years, male sex and history of cardiac disease. No difference was observed between the two groups with regard to shortterm mortality and length of hospital stay. CONCLUSIONS： AF occurs more frequently after esophagectomy in aged and male patients. Other factors contributing to postoperative AF are history of COPD and cardiac disease, postoperative hypoxia and thoracicgastric dilatation.

关键词： Esophageal carcinoma Atrial fibrillation Surgery

Identification of Prognostic Genes for Colon Cancer through Gene Coexpression Network Analysis

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Current Medical Science 2021年第5期41卷 1012-1022页

作者： Dan-wen WANG Zhang-shuo yang Jian XU li-jie yang Tie-cheng yang Hua-qiao WANG Mao-hui FENG Fei SU Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Key Laboratory of Tumor Biological Behavior of Hubei Province Wuhan 430071China Centerfor Clinical Medicine of Peritoneal Cancer of Wuhan Wuhan 430071China Clinical Cancer Study Center of Hubei Province Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Oncology the First Hospital of Lanzhou UniversityLanzhou 730000Chin

Objective:The present study was aimed to identify novel key genes,prognostic biomarkers and molecular pathways implicated in tumorigenesis of colon ***:The microarray data GSE41328 containing 10 colon cancer samples and 10 adjacent normal tissues was analyzed to identify 4763 differentially expressed ***,another microarray data GSE17536 was performed for weighted gene co-expression network analysis(WGCNA).Results:In present study,12 co-expressed gene modules associated with tumor progression were identified for further *** red module showed the highest association with pathological stage by Pearson's correlation *** enrichment analysis revealed that genes in red module focused on cell division,cell proliferation,cell cycle and metabolic related ***,a total of 26 key hub genes were identified,and GEPIA database was subsequently selected for *** junction-recognizing protein(HJURP)and cell division cycle 25 homolog C(CDC25C)were identified as effective prognosis biomarkers,which were all detrimental to *** set enrichment analyses(GSEA)found the two hub genes were enriched in“oocyte meiosis”,“oocyte maturation that are progesterone-mediated”,“p53 signaling pathway”,and“cell cycle”.Furthermore,the immunohistochemistry and western blotting showed that HJURP was highly expressed in colon cancer ***:HJURP was identified as a key gene associated with colon cancer progression and prognosis by WGCNA,which might influence the prognosis by regulating cell cycle pathways.

关键词： colon cancer biomarkers weighted gene co-expression network analysis prognosis pathological stage

Overexpression of eRF3a Promotes Cell Proliferation and Migration in liver Cancer

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Current Medical Science 2022年第1期42卷 100-107页

作者： Yi-qing XI li-hua XU li-jie yang Hua-qiao WANG Tie-cheng yang Zhi li Wei XIE Jing-wei ZHANG Xuan-fei li Mao-hui FENG Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan 430071 China Clinical Cancer Study Center of Hubei Province Wuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China

Objective:The eukaryotic release factor 3a(eRF3a),a member of the eukaryotic peptide chain release factor family,is overexpressed in several types of *** study aims to investigate the biological role and mechanism of ... 详细信息

关键词： eukaryotic release factor 3a liver cancer migration invasion

DJ-1 Alters Epirubicin-induced Apoptosis via Modulating Epirubicin-activated Autophagy in Human Gastric Cancer Cells

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Current Medical Science 2018年第6期38卷 1018-1024页

作者： Xue-kai PAN Fei SU li-hua XU Zhang-shuo yang Dan-wen WANG li-jie yang Fan-zheng KONG Wei XIE Mao-hui FENG Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Oncology the First Hospital oJ'Lanzhou UniversityLanzhou 730000China

Epirubicin,which is a conventional chemotherapeutic drug for gastric cancer,has innate and adaptive *** studies revealed that epirubicin could induce autophagy as a defensive mechanism in drug resistance of mammary *** study implied that D J-1 may be a chemoresistance-related *** the association between D J-1 and drug resistance of epirubicin in gastric cancer is still *** the present report,we explored whether and how D J-1 conduced to epirubicin-induced apoptosis in gastric *** dose-dependently increased the expression of DJ-1 and induced *** of DJ-1 notably enhanced epirubicin-induced cell apoptosis,whereas overexpression of DJ-1 attenuated epirubicin-induced cell *** studies revealed that down-regulation of DJ-1 modulated epirubicin-activated autophagy which augmented epirubicin-induced *** conclusion,our results validated that DJ-1 reduced epirubicin-induced apoptosis in gastric cancer cells via modulating epirubicin-activated autophagy.

关键词： epirubicin gastric cancer DJ-1 apoptosis autophagy