检索结果-南通市图书馆

Gemcitabine plus concurrent irreversible electroporation vs gemcitabine alone for locally advanced pancreatic cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第22期8卷 5564-5575页

作者： Yang-Yang Ma Yin Leng Yan-li Xing Hong-Mei li Ji-Bing Chen li-zhi niu Central Laboratory Affiliated Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina Department of Oncology Affiliated Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina Department of Interventional Radiology Affiliated Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina

BACKGROUND Locally advanced pancreatic cancer(LAPC)is a common malignant digestive system tumor that ranks as the fourth leading cause of cancer-related death in the *** prognosis of LAPC is poor even after standard *** electroporation(IRE)is a novel ablative strategy for *** studies have confirmed the safety of *** date,no prospective studies have been performed to investigate the therapeutic efficacy of conventional gemcitabine(GEM)plus concurrent *** To compare the therapeutic efficacy between conventional GEM plus concurrent IRE and GEM alone for *** From February 2016 to September 2017,a total of 68 LAPC patients were treated with GEM plus concurrent IRE(n=33)or GEM alone(n=35).Overall survival(OS),progression free survival(PFS),and procedure-related complications were compared between the two *** analyses were performed to identify any prognostic *** There were no treatment-related *** technical success rate of IRE ablation was 100%.The GEM+IRE group had a significantly longer OS from the time of diagnosis of LAPC(19.8 mo vs 9.3 mo,P<0.0001)than the GEM alone *** GEM+IRE group had a significantly longer PFS(8.3 mo vs 4.7 mo,P<0.0001)than the GEM alone *** volume less than 37 cm3 and GEM plus concurrent IRE were identified as significant favorable factors for both the OS and *** Gemcitabine plus concurrent IRE is an effective treatment for patients with LAPC.

关键词： Irreversible electroporation Gemcitabine Locally advanced pancreatic cancer Overall survival Progression free survival Prognostic factors

Cryoablation for liver metastasis from solid pseudopapillary tumor of the pancreas: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第2期8卷 398-403页

作者： Yang-Yang Ma Ji-Bing Chen Juan-Juan Shi li-zhi niu Ke-Chen Xu Central Laboratory Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina Department of Oncology Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina

BACKGROUND Solid pseudopapillary tumor(SPT) of the pancreas is a rare pancreatic tumor and 10% to 15% of cases are associated with metastasis. Cryoablation is a new method that can induce tumor necrosis, and treatment of tumors by cryoablation can cause anti-tumor immune *** SUMMARY A 16-year-old woman with SPT of the pancreas developed liver metastases 5.3 years after complete resection of the primary pancreatic tumor. She was admitted with chief complaints of abdominal pain in the upper abdomen and a weight loss of approximately 5 kg over 4 mo. Carbohydrate antigen(CA) 125,carcinoembryonic antigen, and CA 199 were normal. An abdominal computed tomography scan found multiple nodules in the right lobe of the liver that measured approximately 13.5 cm × 10.8 cm × 21.4 cm. Immunohistochemical staining results showed that CD10 and CD56 were positive, and the patient was diagnosed with SPT of the pancreas with liver metastasis. The patient underwent percutaneous cryoablation and interventional embolization. During the 5-year follow-up, the patient remained disease-free after cryoablation, with relatively normal immune *** Herein, we for the first time report the treatment of liver metastasis from SPT of the pancreas using cryoablation plus interventional embolization, which could be a promising alternative therapy for pancreatic SPT liver metastasis.

关键词： Solid pseudopapillary tumor Pancreas liver metastasis Cryoablation Interventional embolization Case report

Irreversible electroporation for liver metastasis from pancreatic cancer: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第2期8卷 390-397页

作者： Yang-Yang Ma Juan-Juan Shi Ji-Bing Chen Ke-Chen Xu li-zhi niu Central Laboratory Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina Department of Oncology Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina

BACKGROUND Pancreatic cancer has a poor prognosis;40%–50% of patients have liver metastases at the time of initial diagnosis and only 15%–20% undergo surgical resection. Irreversible electroporation(IRE) is a new, non-thermal local ablation method for solid tumors, which can induce cell membrane permeabilization,resulting in unrecoverable nanoscale perforation and apoptotic cell death without damaging the structural components of *** SUMMARY We report the case of a 66-year-old female patient with liver metastasis from pancreatic cancer with a pathological diagnosis of poorly differentiated adenocarcinoma. Carbohydrate antigen 19-9 was elevated to 420.3 U/m *** tomography showed a pancreas mass of 2.7 cm × 2.5 cm and single liver metastasis of 1.4 cm × 1.1 cm in the S6 area. The patient underwent IRE and arterial infusion chemotherapy and received tegafur. The therapeutic effect of the combination treatment has been evaluated as complete response. To date, the patient has survived for > 12 mo and is receiving tegafur as maintenance therapy(at the time this case report was written).CONCLUSION IRE plus arterial infusion chemotherapy and tegafur may be synergistic,providing a reference for treating liver metastasis from pancreatic cancer.

关键词： Irreversible electroporation liver metastasis from pancreatic cancer Chemotherapy Complete response Case report

Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第22期19卷 3473-3480页

作者： li-zhi niu Jia-liang li Jian-Ying Zeng Feng Mu Meng-Tian liao Fei Yao li li Chun-Yan liu Ji-Bing Chen Jian-Sheng Zuo Ke-Cheng Xu Surgical Department Fuda Cancer Hospital Jinan University School of Medicine Surgical Department Fuda Institute of Cryosurgery for Cancer Surgical Department Fuda Hospital Guangzhou Institutes of Biomedicine and Health Chinese Academy of Science

AIM: To retrospectively assess the effect of comprehensive cryosurgery (ablation of intraand extra-hepatic tumors) plus dendritic cell-cytokine-induced killer cell immunotherapy in metastatic hepatocellular cancer. METHODS: We divided 45 patients into cryo-immunotherapy (21 patients), cryotherapy (n = 12), immunotherapy (n = 5) and untreated (n = 7) groups. Overall survival (OS) after diagnosis of metastatic hepatocellular cancer was assessed after an 8-year follow-up. RESULTS: Median OS was higher following cryo-immu-notherapy (32 mo) or cryotherapy (17.5 mo; P < 0.05) than in the untreated group (3 mo) and was higher in the cryo-immunotherapy group than in the cryotherapy group (P < 0.05). In the cryo-immunotherapy group, median OS was higher after multiple treatments (36.5 mo) than after a single treatment (21 mo; P < 0.05). CONCLUSION: Cryotherapy and, especially, cryoimmunotherapy significantly increased OS in metastatic hepatocellular cancer patients. Multiple cryo-immunotherapy was associated with a better prognosis than single cryo-immunotherapy.

关键词： Cryoablation Dendritic cell-cytokine-induced killer cell Immunotherapy Metastatic hepatocellular cancer Survival time

Advances in cryoablation for pancreatic cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第2期22卷 790-800页

作者： Xiao-Mei Luo li-zhi niu Ji-Bing Chen Ke-Cheng Xu Medical College Jinan University Guangzhou Fuda Cancer Hospital School of Medicine Jinan University

Pancreatic carcinoma is a common cancer of the digestive system with a poor prognosis. It is characterized by insidious onset, rapid progression, a high degree of malignancy and early metastasis. Atpresent, radical surgery is considered the only curative option for treatment, however, the majority of patients with pancreatic cancer are diagnosed too late to undergo surgery. The sensitivity of pancreatic cancer to chemotherapy or radiotherapy is also poor. As a result, there is no standard treatment for patients with advanced pancreatic cancer. Cryoablation is generally considered to be an effective palliative treatment for pancreatic cancer. It has the advantages of minimal invasion and improved targeting, and is potentially safe with less pain to the patients. It is especially suitable in patients with unresectable pancreatic cancer. However, our initial findings suggest that cryotherapy combined with 125-iodine seed implantation, immunotherapy or various other treatments for advanced pancreatic cancer can improve survival in patients with unresectable or metastatic pancreatic cancer. Although these findings require further in-depth study, the initial results are encouraging. This paper reviews the safety and efficacy of cryoablation, including combined approaches, in the treatment of pancreatic cancer.

关键词： Pancreatic cancer Cryoablation Combinationtherapy Cryoimmunotherapy

Percutaneous cryosurgery for the treatment of hepatic colorectal metastases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第9期14卷 1430-1436页

作者： Ke-Cheng Xu li-zhi niu Wei-Bing He Yi-Zi Hu Jian-Sheng Zuo Cryosurgery Center for Cancer Fuda Cancer Hospital Guangzhou Guangzhou 510300 Guangdong Province China

AIM:To determine the safety and efficacy of efficacy of percutaneous cryosurgery for treatment of patients with hepatic colorectal metastases. METHODS: Three hundred and twenty-six patients with non-resectable hepatic colorectal metastases underwent percutaneous cryosurgery under the guidance of ultrasound or CT. Follow-up was 1 mo after cryosurgery and then every 4 mo thereafter by assessment of tumor markers, liver ultrasonography, and abdominal CT. For lesions suspicious of recurrence, a liver biopsy was performed and subsequent repeat cryosurgery was given if histology was positive for cancer. RESULTS: All patients underwent a total of 526 procedures of cryosurgery. There were 151 patients who underwent repeat procedures of cryosurgery for recurrent tumors in the liver and extrahepatic places. At 3 mo after cryosurgery, carcinoembryonic antigen (CEA) levels in 197 (77.5%) patients who had elevated markers before cryosurgery decreased to normal range. Among 280 patients who received CT following-up, cryotreated lesions showed complete response (CR) in 41 patients (14.6%), partial response (PR) in 115 patients (41.1%), stable disease (SD) in 68 patients (24.3%) and progressive disease (PD) in 56 patients (20%). The recurrence rate was 47.2% during a median follow-up of 32 mo (range, 7-61). Sixty one percent of the recurrences were seen in liver only and 13.9% in liver and extrahepatic areas. The recurrence rate at cryotreated site was only 6.4% for all cases. During a median follow-up of 36 mo (7-62 mo), the median survival of all patient was 29 mo (range 3-62 mo). Overall survival was 78%, 62%, 41%, 34% and 23% at 1, 2, 3, 4 and 5 years, respectively, after the treatment. Patients with tumor size less than 3 cm, tumor in right lobe of liver, lower CEA levels (< 100 ng/dL) and post- cryosurgery TACE had higher survival rate. There wasno significant difference in terms of survival based on the number of tumors, pre-cryosurgery chemotherapy and the timing of the dev

关键词： Hepatic colorectal metastases Hepatic cryosurgery Percutaneous cryosurgery Colorectal cancer

General displacement arch-cantilever element method for stress analysis of arch dam

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Water Science and Engineering 2009年第1期2卷 32-42页

作者： Hao REN Tong-chun li zhi-wei niu Lan-hao ZHAO College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China

Based on the general displacement method and the basic hypothesis of the trial load method, a new advanced trial load method, the general displacement arch-cantilever element method, was proposed to derive the transformation relation of displacements and loads between the surface nodes and middle plane nodes. This method considers the nodes on upstream and downstream surfaces of the arch dam to be exit nodes （master nodes）, and the middle plane nodes to be slave nodes. According to the derived displacement and load transformation matrices, the equilibrium equation treating the displacement of middle plane nodes as a basic unknown variable is transformed into one that treats the displacement of upstream and downstream nodes as a basic unknown variable. Because the surface nodes have only three degrees of freedom （DOF）, this method can be directly coupled with the finite element method （FEM）, which is used for foundation simulation to analyze the stress of the arch dam with consideration of dam-foundation interaction. Moreover, using the FEM, the nodal load of the arch dam can be easily obtained. Case studies of a typical cylindrical arch dam and the Wudongde arch dam demonstrate the robustness and feasibility of the proposed method.

关键词： arch dam arch-cantilever element method general displacement method finite element method (FEM) couoled analysis stress analysis Wudongde arch dam

Cryoablation for intrapulmonary bronchial cyst:A case report

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Radiology 2024年第10期16卷 616-620页

作者： Zhong-Hai li Yang-Yang Ma li-zhi niu Ke-Cheng Xu Department of Radiology Guangzhou Fuda Cancer HospitalGuangzhou 510665Guangdong ProvinceChina Central Laboratory Guangzhou Fuda Cancer HospitalGuangzhou 510665Guangdong ProvinceChina Department of Oncology Guangzhou Fuda Cancer HospitalGuangzhou 510665Guangdong ProvinceChina

BACKGROUND Bronchial cysts are congenital malformations usually located in the mediastinum,and intrapulmonary localization is very *** is a novel therapeutic approach that promotes tumor necrosis and stimulates anti-tumor immune *** SUMMARY This article reports a case of a 68-year-old male patient who was diagnosed with an intrapulmonary bronchogenic cyst by computed tomography examination and pathology,and the patient subsequently underwent cryoablation therapy and achieved complete response with after 3 months of *** Intrapulmonary bronchogenic cysts are very rare,cryoablation therapy is feasible,safe,and effective for intrapulmonary bronchial cysts.

关键词： Intrapulmonary bronchial cyst Cryoablation Complete response Case report

A pilot study on combination of cryosurgery and ^(125)iodine seed implantation for treatment of locally advanced pancreatic cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第10期14卷 1603-1611页

作者： Ke-Cheng Xu li-zhi niu Yi-Ze Hu Wei-Bing He Yi-Song He Ying-Fei li Jian-Sheng Zuo Cryosurgery Center for Cancer Fuda Cancer Hospital Guangzhou Guangzhou 510300 Guangdong ProvinceChina Department of Hepato-biliary Surgery Second affiliated Hospital Guangzhou Medical College Guangzhou 510260 Guangdong Province China Department of Gastroenterology Nanfang Hospital Nanfang Medical university Guangzhou 510515 Guangdong Province China

AIM: To study the therapeutic value of combination o cryosurgery and 125iodine seed implantation for locally advanced pancreatic cancer. METHODS: Forty-nine patients with locally advanced pancreatic cancer (males 36, females 13), with a median age of 59 years, were enrolled in the study. Twelve patients had liver metastases. In all cases the tumors were considered unresectable after a comprehensive evaluation. Patients were treated with cryosurgery, which was performed intraoperatively or percutaneously unde guidance of ultrasound and/or computed tomography (CT), and 125iodine seed implantation, which was performed during cryosurgery or post-cryosurgery under guidance of ultrasound and/or CT. A few patients received regional celiac artery chemotherapy. RESULTS: Thirteen patients received intraoperative cryosurgery and 36 received percutaneous cryosurgery Some patients underwent repeat cryosurgery. 125Iodine seed implantation was performed during freezing procedure in 35 patients and 3-9 d after cryosurgery in 14 cases. Twenty patients, 10 of whom had hepaticmetastases received regional chemotherapy. At 3 mo after therapy, CT was repeated to estimate tumor response to therapy. Most patients showed varying degrees of tumor necrosis. Complete response (CR) of tumor was seen in 20.4% patients, partial response (PR), in 38.8%, stable disease (SD), in 30.6%, and progressive disease (PD), in 10.2%. Adverse effects associated with cryosurgery included upper abdomen pain and increased serum amylase. Acute pancreatitis was seen in 6 patients one of whom developed severe pancreatitis. All adverse effects were controlled by medical management with no poor outcome. There was no therapy-related mortality. During a median follow-up of 18 mo (range of 5-40), the median survival was 16.2 mo, with 26 patients (53.1%) surviving for 12 mo or more. Overall, the 6-, 12-, 24- and 36-mo survival rates were 94.9%, 63.1%, 22.8% and 9.5%, respectively. Eight patients had survival of 24 mo or

关键词： Pancreatic cancer Cryosurgery Cryoablation ^125Iodine seed implantation