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The role of m^(6)A RNA methylation in autoimmune diseases: Novel therapeutic opportunities

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Genes & Diseases 2024年第1期11卷 252-267页

作者： Yunan Shan wei Chen Yanbin li The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinanShandong 250013China Department of Neurology The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qjanfoshan HospitalShandong Institute of NeuroimmunologyShandong Key Laboratory of Rheumatic Disease and Translational MedicineJinanShandong 250013China Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

N6-methyladenosine m^(6)A modifications,as one of the most common forms of in-ternal RNA chemical modifications in eukaryotic cells,have gained increasing attention in recent *** m^(6)A RNA modifications exert various crucial roles in various biological pro-cesses,such as embryonic development,neurogenesis,circadian rhythms,and *** advances have highlighted that m^(6)A RNA modification plays an important role in im-mune response,especially in the initiation and progression of autoimmune *** this re-view,we summarized the regulatory mechanisms of m^(6)A methylation and its biological functions in the immune system and mainly focused on recent progress in research on the po-tential role of m^(6)A RNA methylation in the pathogenesis of autoimmune diseases,thus providing possible biomarkers and potential targets for the prevention and treatment of auto-immunediseases.

关键词： Adaptive immunity Autoimmune diseases Innate immunity Immune response m^(6)A RNA methylation

Anomalies of Precipitation over China on Days with Tropical Cyclone Activity over the Bay of Bengal: Role of Moisture Transport

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Journal of Meteorological Research 2024年第2期38卷 368-382页

作者： Na wei Ying li Xiaoting FAN Nanjing Joint Institute for Atmospheric Sciences Nanjing 210041 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200433

Tropical cyclones over the Bay of Bengal(BoBTC)affect the precipitation over China,with distinct seasonal and daily *** study quantitatively examines the daily standardized precipitation anomalies(SPAs)over China on the days with BoBTC activities(storm-days)and related circulations,based on rainfall measurements at surface meteorological stations and ECMWF reanalysis data on a 0.25°×0.25°resolution during *** positive SPA is found over the stations in the two adjacent regions around BoB(Southwest China in May/November and southern Tibetan Plateau in October)and three distant regions(Southeast China and the northeastern boundary of the Qinghai-Tibet Plateau in May,and central North China in October).The SPA distributions are remarkably consistent with the integrated water vapor transport(IVT)*** IVT is found associated with the interaction between southwesterly(southerly)of the BoBTC circulation and low-level monsoonal flow in May(midlevel westerly in winter months).The probabilities of extreme precipitation(EP)occurrences over the above regions all increase on *** adjacent regions,EP is significantly correlated with the northward IVT anomalies to the east of BoBTC circulation,which strengthen the water vapor input through the southern *** IVT anomalies are stronger in May,benefited by the deep monsoonal southwesterlies than those in *** distant regions,EP is more closely related to the IVT anomaly extending back from *** moisture from BoB concentrates along a local low-level convergence line over Southeast China,being further facilitated by coexistence of the BoBTC depression and midlevel westerly trough in *** results highlight the interactions between BoBTCs and local weather systems that influence the general precipitation anomalies and occurrence of EP over China,especially over distant regions.

关键词： tropical cyclone Bay of Bengal precipitation anomaly moisture transport

Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： Shuping li Xin li Jiaqi Meng weier Bao Shuang Wang Peng Ye Xiao-Dong Gao wei wei Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

Trace formula of the integro-differential operator on a quantum graph

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 311-318页

作者： wei li-xiao YANG Chuan-fu School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China.

In this paper we study the eigenvalue problem for integro-differential operators on a lasso *** trace formula of the operator is established by applying the residual technique in complex analysis.

关键词： integro-differential operators eigenvalue trace formula

Effects of nitrogen deposition on the carbon budget and water stress in Central Asia under climate change

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Journal of Arid Land 2024年第8期16卷 1118-1129页

作者： HAN Qifei XU wei li Chaofan School of Geographical Sciences Nanjing University of Information Science&TechnologyNanjing 210044China

Atmospheric deposition of nitrogen(N)plays a significant role in shaping the structure and functioning of various terrestrial ecosystems ***,the magnitude of N deposition on grassland ecosystems in Central Asia still remains highly *** this study,a multi-data approach was adopted to analyze the distribution and amplitude of N deposition effects in Central Asia from 1979 to 2014 using a process-based denitrification decomposition(DNDC)*** showed that total vegetation carbon(C)in Central Asia was 0.35(±0.09)Pg C/a and the averaged water stress index(WSI)was 0.20(±0.02)for the whole *** N deposition led to an increase in the vegetation C of 65.56(±83.03)Tg C and slightly decreased water stress in Central *** of this study will expand both our understanding and predictive capacity of C characteristics under future increases in N deposition,and also serve as a valuable reference for decision-making regarding water resources management and climate change mitigation in arid and semi-arid areas globally.

关键词： carbon dynamics climate change grassland ecosystems nitrogen deposition water stress index

Transient Monte Carlo simulation of phonon transport in silicon nanofilms with the local heat source

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Science China(Technological Sciences) 2024年第7期67卷 2087-2098页

作者： li JiaQi CAI JiuQing li Rui liU ZhiChun liU wei School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China Wuhan Second Ship Design and Research Institute Wuhan 430205China

Accurate prediction of junction temperature is crucial for the efficient thermal design of silicon nano-devices. In nano-scale semiconductor devices, significant ballistic effects occur due to the mean free path of phonons comparable to the heat source size and device scale. We employ a three-dimensional non-gray Monte Carlo simulation to investigate the transient heat conduction of silicon nanofilms with both single and multiple heat sources. The accuracy of the present method is first verified in the ballistic and diffusion limits. When a single local heat source is present, the width of the heat source has a significant impact on heat conduction in the domain. Notably, there is a substantial temperature jump at the boundary when the heat source width is 10 *** increasing heat source width, the boundary temperature jump weakens. Furthermore, we observe that the temperature excitation rate is independent of the heat source width, while the temperature influence range expands simultaneously with the increase in heat source width. Around 500 ps, the temperature and heat flux distribution in the domain stabilize. In the case of dual heat sources, the hot zone is broader than that of a single heat source, and the temperature of the hot spot decreases as the heat source spacing increases. However, the mean heat flux remains unaffected. Upon reaching a spacing of 200 nm between the heat sources, the peak temperature in the domain remains unchanged once a steady state is reached. These findings hold significant implications for the thermal design of silicon nano-devices with local heat sources.

关键词： phonon transport Monte Carlo simulation transient heat conduction silicon nanofilms local heat source

Spectroscopic factors of resonance states with the Gamow shell model

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 38-45页

作者： Mengran Xie Jianguo li Nicolas Michel Honghui li wei Zuo CAS Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

We provide an investigation of the spectroscopic factor of resonance states in A=5-8 nuclei,utilizing the Gamow shell model(GSM).Within the GSM,the configuration mixing is taken into account exactly with the shell model framework,and the continuum coupling is addressed via the complex-energy Berggren ensemble,which treats bound,resonance,and non-resonant continuum single-particle states on an equal *** a result,both the configuration mixing and continuum coupling are meticulously considered in the *** first calculate the low-lying states of helium isotopes and isotones with the GSM,and the results are compared with that of ab initio no-core shell model(NCSM)*** results indicate that GSM can reproduce the low-lying resonance states more accurately than the *** this,we delve into the spectroscopic factors of the resonance states as computed through both GSM and NCSM,concurrently conducting systematic calculations of overlap functions pertinent to these resonance ***,the calculated overlap function and spectroscopic factor of6He(01+)■νp3/2→^(7)He(3/2_(1)-)with GSM are compared with the results from ab initio NCSM,variational Monte Carlo,and Green’s function Monte Carlo calculations,as well as available experimental *** results assert that wave function asymptotes can only be reproduced in GSM,where resonance and continuum coupling are precisely addressed.

关键词： spectroscopic factor overlap function resonance states continuum coupling isospin symmetry breaking

Application of N-succinimidyl 4-[^18F](fluoromethyl) benzoate to protein labeling

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Nuclear Science and Techniques 2003年第1期14卷 69-71页

作者： li Jun-ling, WANG Yong-Xian, ZHANG xiu-li, ZHOU wei, TIAN Hai-Bin, YIN Duan-Zhi (Shanghai Institue of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) Shanghai Institute of Nuclear Research the Chinese Academy of Sciences 上海 201800

N-succinimidyl 4-[18F](fluoromethyl) benzoate for protein labeling was prepared (57%, EOB) in about 30min. Reaction conditions of S18FMB with IgG including pH of solutions, protein concentration, reaction temperature and time were studied. The optimal labeling conditions were: 0.2mg/mL IgG, pH = 7.8-8.5, 25℃, and reaction time *** these conditions the yield was about 80%. The 18F-labeled protein was purified by size exclusion chromatography.

关键词：氟18 放射性核素 S^18FMB IgG 标记色谱免疫球蛋白应用医学

Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng li Yuan Yang Hua Yue Shuang Wang Xiao Zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery