检索结果-南通市图书馆

Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe Ma Bin qi qingqiang Min Ming li Huabing Chen Hengte Ke xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

关键词：

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi li Weiwei lin Zhihua Han Beijie qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

在线全文

学校读者我要写书评

暂无评论

高校军事课教学质量评估体系的构建

湖南人文科技学院学报 2007年第6期24卷 119-122页

作者：李星奇刘光连中南大学湖南长沙410083

我国高校军事课教学缺乏科学有效的教学质量评估体系,对军事课教学任务的完成与教学质量的提高无法实施有效的监督和激励。因此,进行高校军事课教学质量评估研究,构建科学的教学质量评估体系,切实提高我国高校军事课的教学质量,已成为... 详细信息

我国高校军事课教学缺乏科学有效的教学质量评估体系,对军事课教学任务的完成与教学质量的提高无法实施有效的监督和激励。因此,进行高校军事课教学质量评估研究,构建科学的教学质量评估体系,切实提高我国高校军事课的教学质量,已成为当务之急。

关键词：军事课质量评估体系构建

在线全文

学校读者我要写书评

暂无评论

论军事训练与大学生德性养成

湖南人文科技学院学报 2008年第6期25卷 130-132页

作者：刘光辉李星奇湖南人文科技学院武装部湖南娄底417001

军事训练的育人功能是其他任何教育形式都不能替代的,军事训练为大学生德育工作提供了一种有效的方法,因此开展对军事训练与大学生德性养成的探讨,具有深远的现实意义。

关键词：军事训练德性养成大学生

在线全文

学校读者我要写书评

暂无评论

鲜山药片干制过程中的无硫护色剂配方优化

食品工业科技 2014年第12期35卷 324-329页

作者：黄艳斌李星琪张洵熊伟成陈厚荣西南大学食品科学学院重庆400715 农业部农产品贮藏保鲜质量安全风险评估实验室(重庆) 重庆400716 重庆市农产品加工技术重点实验室重庆400716 西南大学国家食品科学与工程实验教学中心重庆400715

研究了鲜山药片在干制过程中的无硫护色剂配方。以重庆新鲜怀山药为原料,在单因素实验的基础上,对所选护色剂进行筛选,得出适合山药干燥的护色剂种类和添加量,以色差值、L值为评价指标,通过正交实验优化了护色效果的护色剂配方。结果表... 详细信息

研究了鲜山药片在干制过程中的无硫护色剂配方。以重庆新鲜怀山药为原料,在单因素实验的基础上,对所选护色剂进行筛选,得出适合山药干燥的护色剂种类和添加量,以色差值、L值为评价指标,通过正交实验优化了护色效果的护色剂配方。结果表明:柠檬酸、植酸、氯化钠的护色效果好,VC、EDTA效果不佳。响应面优化结果为1.99g/100mL氯化钠+0.84g/100mL柠檬酸+0.06g/100mL植酸复配效果最佳,色差值及L值的预测值分为17.1791、86.8254,验证值分别为17.8451、86.3742,与之接近,优化结果可靠。

关键词：山药干燥护色配方优化

Successful emergency surgical intervention in acute non-STsegment elevation myocardial infarction with rupture:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： xing-Po li Zi-Shan Wang Hong-Xia Yu Shan-Shan Wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

High-selectivity electroreduction of low-concentration CO2 with large concentration fluctuation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Mengyu qi Yanbin Ma Chao Zhang Bingwei li Xueqing Yang Zhaolin Shi Simeng liu Changhua An Jiqing Jiao Tongbu Lu MOE International Joint Laboratory of Materials Microstructure Analysis and Testing CenterInstitute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringSchool of Chemistry and Chemical EngineeringTianjin University of Technology Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

Electrochemical CO2reduction reaction（CO2RR） has been regarded as one of the most promising solutions to achieving “zero carbon emission”. In most of the CO2RR-related studies, high-purity CO2has been employed as the feed gas; however, in practice, CO2is generally emitted in low concentrations, so it is of great significance to realize high-selectivity electroreduction of low-concentration CO2with large concentration fluctuation. In this work, we constructed a dual-active-site catalyst and successfully achieved CO2local enrichment and conversion for low-concentration CO2. Operando experiments reveal that the catalyst has one type of site for activating CO2and one type of site for binding the reaction intermediates. The dual-active-site catalyst displays a selectivity for formic acid consistently above 97% over a broad potential window（from-0.9 to-1.6 V ***）. Even when fed with a low-concentration CO2stream（volume ratio from 50% down to 10%）, the dual-active-site catalyst could display high activity and selectivity（>91%）. In particular, the selectivity is still above 85% when the CO2volume ratio is as low as 5%. This work offers a feasible route for converting low-concentration CO2via a synergistic effect for dual-active-site catalysts.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

浅谈测听室的改建

中国听力语言康复科学杂志 2009年第5期38卷 32-35页

作者：邹建华（综述）李兴启（审校）广东省残疾人康复中心广州510055 解放军总医院耳鼻咽喉科研究所北京100853

随着我国社会经济的发展，对0～6岁儿童的听力检测及干预已作为政府行为逐渐在全国范围内推广和普及。由于听力损失程度需要量化，因此．对听力检测的环境（包括背景噪声和电干扰）必须有严格的要求，并符合国家标准．但又必须考虑自身... 详细信息

随着我国社会经济的发展，对0～6岁儿童的听力检测及干预已作为政府行为逐渐在全国范围内推广和普及。由于听力损失程度需要量化，因此．对听力检测的环境（包括背景噪声和电干扰）必须有严格的要求，并符合国家标准．但又必须考虑自身的条件．做到经济实用。2006年广东省残疾人康复中心改建测听室。

关键词：测听室改建听力损失程度听力检测政府行为背景噪声经济实用国家标准

Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na li Yue-Yue Ren Ying Tang qi Yang Tian-Tian Meng Song li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

矿井提升系统常见故障类型分析与诊断技术研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

煤矿现代化 2025年第1期34卷 148-152页

作者：邢琪晋能控股煤业集团同忻煤矿山西有限公司山西大同037000

针对矿井提升系统故障形式复杂、故障类型多样、传统故障诊断结果不准确等问题,本文对矿井提升系统常见故障类型和特征进行分析,指出了矿井提升机常见电动机故障、齿轮箱故障和减速机故障的原因和故障主要特征,确定了不同故障异常特征... 详细信息

针对矿井提升系统故障形式复杂、故障类型多样、传统故障诊断结果不准确等问题,本文对矿井提升系统常见故障类型和特征进行分析,指出了矿井提升机常见电动机故障、齿轮箱故障和减速机故障的原因和故障主要特征,确定了不同故障异常特征检测点的位置。建立了矿井提升机多维数据融合故障智能诊断系统,以现场实际应用的立式缠绕式双滚筒提升系统进行案例分析,在对应的部位安装传感器采集异常特征,对异常进行可视化分析,不同的故障类型得到振动曲线不同,通过对异常振动曲线可以判断提升系统故障类型。现场试验表明采集到的异常分析过程仅用时1.43 s,异常识别准确率高达98.4%,取得了满意的试验结果.

关键词：矿井提升系统可视化故障诊断远程运维