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Rare Metals 2018年第8期37卷 690-698页

作者： Dong-Qing li li-xian zhou Kuan-Jun Zhu Jian Gu Shu-Hui Zheng Department of Transmission and Transformation Engineering Mechanics China Electric Power Research Institute

B2 FeA1 intermetallic compounds modified with reactive elements （REs） including Sc and Y were fabricated by vacuum arc-melting, and the isothermal oxidation behavior of the RE-doped alloys at 1373 K was investigated. Both Sc and Y single-doping significantly decrease the alumina film growth rate of the alloys. The alumina film growth rate of Sc＋ Y co-doped alloy even further reduces compared to that of the Sc and Y single-doped alloys. The synergistic effect produced by Sc＋ Y codoping on the growth behavior of alumina was discussed. It could be anticipated that the combined additions of Sc and Y which have matched chemical properties might decrease the alumina film growth rate more effectively and provide FeA1 alloys with enhanced oxidation resistance.

关键词： Ferritic aluminides Reactive elements Codoping Isothermal oxidation Segregation

Enhanced alumina film adhesion of Hf/Y-doped iron-aluminum alloys during high-temperature oxidation:a new observation

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Rare Metals 2019年第9期38卷 877-884页

作者： Dong-Qing li li-xian zhou Jun Zhan Jing-Chao Wang Jian Gu Jia-Jun Si Department of Transmission and Transformation Engineering Mechanics China Electric Power Research Institute

The cyclic oxidation behavior of Hf/Y-doped B2 FeAl intermetallics at 1373 K was *** an undoped FeAl alloy,premature spallation of the alumina film occurs due to the formation of numerous voids at the film/alloy interface and apparent shrinkage in the *** contrast to this,doping with either Hf or Y significantly improves the interfacial adhesion between the alumina film and the alloy substrate,particularly with *** observation in combination with Anger electron spectroscopic analysis suggests that in addition to prohibiting interfacial void formation and alleviating film shrinkage,the addition of Hf in the FeAl alloy could consolidate the film/alloy interface by directly participating in chemical bonding across the interface as a Hf *** causes the spallation of alumina film from the equiaxed grains/columnar grains interface rather than the bottom of the film.

关键词： Intermetallics Reactive elements Thermal cycling Alumina film Interfacial adhesion Segregation

Five new nervogenic acid derivatives from liparis nervosa

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Chinese Chemical Letters 2013年第8期24卷 734-736页

作者： Shuai Huang Ming-Feng Pan xian-li zhou Zi-li zhou Cui-Juan Wang lian-Hai Shan Jie Weng School of life Science and Engineering Southwest Jiaotong University Key Laboratory of Advanced Technology of Materials Ministry of EducationSouthwest Jiaotong University

Five new nervogenic acid derivatives（1-5） have been isolated from liparis nervosa（*** ***） *** structures were elucidated on the basis of extensive spectroscopic analysis,including 1D NMR,2D NMR,and HR-ESI-MS.

关键词： Orchidaceae liparis nervosa Benzamide derivatives Nervogenic acid derivatives

Value of Intrauterine Autologous Platelet-Rich Plasma Therapy on Endometrial Receptivity:A literature Review

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Current Medical Science 2023年第6期43卷 1075-1083页

作者： Chu-jun li Ya-dou ZHAN xian-li zhou Jie YANG ling DENG Xue-lan li Xin CHEN Reproductive Medicine Center Shunde Hospital of Southern Medical University(The First People’s Hospital of Shunde)Shunde528300China

Endometrial receptivity is an important factor that influences embryo ***,it is important to identify an applicable approach to improve endometrial receptivity in women undergoing assisted reproductive ***,growing evidence has indicated that intrauterine platelet-rich plasma(PRP)infusion is an effective method to obtain a satisfactory reproductive outcome by increasing endometrial thickness and improving endometrial ***,the present review aims to outline the possible mechanisms of PRP on endometrial receptivity and summarize the present literature on the effects of PRP therapy in improving endometrial receptivity.

关键词： platelet-rich plasma intrauterine perfusion endometrial thickness endometrial receptivity

New alkylamides from pericarps of Zanthoxylum bungeanum

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Chinese Chemical Letters 2012年第11期23卷 1247-1250页

作者： Shuai Huang Lei Zhao xian li zhou Mei Ying Cui Juan Wang Jie Weng School of life Science and Engineering Southwest Jiaotong UniversityChengdu 610031SichuanChina Food and Agriculture Standardization Institute China National Institute of StandardizationBeijing 100088China

Two new unsaturated alkylamides （2E,7E,9E）-N-（2-hydroxy-2-methylpropyl）-6,11-dioxo-2,7,9-dodecatrienamide （1） and （2E,6E,8E）-N-（2-hydroxy-2-methylpropyl）-10-oxo-2,6,8-decatrienamide （2） together with six known compounds （3-8） have been isolated from the pericarps of Zanthoxylum bungeanum. Their structures were elucidated on the basis of extensive spectroscopic analysis, including MS, IR, 1D and 2D NMR experiments.

关键词： Hua Jiao Zanthoxylum bungeanum Unsaturated alkylamides

Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists

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Chinese Chemical Letters 2016年第1期27卷 159-162页

作者： Jing Huang Bin Guo Wen-Jing Chu Xin Xie Yu-She Yang xian-li zhou School of life Science and Engineering Southwest Jiao Tong University State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences CAS Key Laboratory of Receptor Research The National Center for Drug Screening Shanghai Institute of Materia Medica Chinese Academy of Sciences

GPR40 has emerged as an attractive drug target for the treatment of type 2 diabetes due to its role in the enhancement of insulin secretion with glucose dependency. With the aim to improve the metabolic and safety profiles, a series of novel phenylpropionic acid derivatives were synthesized. Extensive structural optimization led to identification of compounds 22 g and 23 e as potent GPR40 agonists with moderate liver microsomal stability. All the discovery supported further exploration surrounding this scaffold.

关键词： GPR40 Anti-diabetic Agonist Phenylpropionic acid derivative

Three new pyrrolizidine alkaloids derivatives from liparis nervosa

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Chinese Chemical Letters 2016年第5期27卷 757-760页

作者： Shuai Huang De-Xin Zhong lian-Hai Shan Ye-Zi Zheng Zhi-Kuan Zhang Ya-Heng Bu Hong-Wen Ma xian-li zhou School of life Science and Engineering Southwest Jiaotong University

Three new pyrrolizidine alkaloids, nervosineⅦ（1）, nervosine Ⅷ（2） and nervosine IX （3） were isolated from the whole plant extract of liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses （including 1 D, 2D NMR, and HR-ESI-MS） and chemical methods. Compounds 1-3 were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.

关键词： Orchidaceae liparis nervosa Pyrrolizidine alkaloids Nervogenic acid derivatives

Implementation of two-dimensional shear wave elastography and acoustic radiation force impulse induced strain elastography in combination with B-mode ultrasound:a method avoids unnecessary biopsies of breast lesions

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Implementation of two-dimensional shear wave elastography an...

中国超声医学工程学会第五届全国介入超声医学学术交流大会

作者： Jia-Wei Sun xian-li zhou In-Patient Ultrasound Department Second Affiliated Hospital of Harbin Medical University

Purpose:To investigate the diagnostic performance of two-dimensional shear wave elastography and acoustic radiation force impulse induced strain elastography in diff erentiation benign and malignant breast *** to explore the performance in avoiding unnecessary biopsies when they combine with B(mode ***:One hundred fifty nine benign breast lesions and one hundred eleven malignant breast lesions were retrospectively *** ultrasound(CUS) features and virtual touch imaging(VTI) and virtual touch tissue imaging and quantification(VTIQ) parameters of all the lesions were *** shear wave speed(SWS) and VTI score were *** area under the receiver operating characteristic(AUCROC) curve analysis was performed to evaluate the best cut(off value of SWS and VTI *** decreased the BI-RADS grade of the lesion form 4 a to 3 when either one of the VTIQ or VTI were *** reference standard was histopathological and/or core-needle biopsy(CNB) ***:The SWS and the VTI score of malignant lesions were significantly higher than those of benign lesions(P <0.05).Among VTIQ parameters,the maximum of SWS-SWS(max) achieved the highest diagnostic performance with a cut-off value of 4.46 m/*** cut-off value of VTI score was *** to the SWS-max and VTI scores,there were 84.4%(27/32) BI-RADS 4 a lesions on B-mode ultrasound degraded to 3 which avoided unnecessary ***:Combination of VTIQ and VTI is a strong complement to B-mode ultrasound,which is a promising method in the differential diagnosis of the breast lesions as well as reduce unnecessary biopsies.

关键词： Virtual touch tissue imaging and quantification Breast lesions Virtual touch imaging Biopsy

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铝合金一体化压铸技术浅析

铸造 2023年第4期72卷 462-465页

作者：李先洲广汽乘用车有限公司广东广州511434

新能源车企为了降本、减重和提高生产效率,新能源车身已开始采用铝合金一体化压铸技术,特斯拉、蔚来、小鹏等新能源车企已布局一体化压铸领域,压铸机将取代焊接机器人成为新能源造车的核心装备。一体化压铸技术在生产效率、降本、减重... 详细信息

新能源车企为了降本、减重和提高生产效率,新能源车身已开始采用铝合金一体化压铸技术,特斯拉、蔚来、小鹏等新能源车企已布局一体化压铸领域,压铸机将取代焊接机器人成为新能源造车的核心装备。一体化压铸技术在生产效率、降本、减重等方面优势明显。一体化压铸技术核心在于大型压铸机的性能、免热处理材料配方、压铸模设计和压铸工艺参数优化,铝合金一体化压铸将是新能源车企的标配技术。

关键词：铝合金一体化压铸降本新能源汽车

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Pyrrolizidine Alkaloids from liparis nervosa with Antitumor Activity by Modulation of Autophagy and Apoptosis

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Pyrrolizidine Alkaloids from Liparis nervosa with Antitumor ...