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Effects of antiviral agents and HBV genotypes on intrahepaticcovalently closed circular DNA in HBeAg-positive chronichepatitis B patients

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World Journal of Gastroenterology 2008年第8期14卷 1268-1273页

作者： Hai-Ying Lu li-wei zhuang Yan-Yan Yu Chong-Wen Si Jun li Jian-Jun Zhang Zheng Zeng Xin-Yue Chen Zhong-Hou Han Yong Chen Departnlent of Infectious Diseases Peking University First Hospital Beijing 100034 China Beijing Zhongfuyouxin Beijing 100085 China Beijing You'an Hospital Beijing 100054 China Qinhuangdao Third Hospital Qinhuangdao 066000 Hebei Province China Huai'an Infectious Disease Hospital Huai'an 223300 Jiangsu Province China

AIM： To evaluate the effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA （ccc DNA） in HBeAg-positive chronic hepatitis B patients.METHODS： Seventy-one patients received lamivudine （n = 35）, or sequential therapy with lamivudine- interferon alpha 2b （IFN-α 2b, n = 24） for 48 wk, or IFN-α 2b （n = 12） for 24 wk. All subjects were followed up for 24 wk. Intrahepatic ccc DNA was measured quantitatively by PCR. HBV genotypes were analyzed by PCR-RFLP.RESULTS： Sequential lamivudine- INF-α therapy, lamivudine and INF-α monotherapy reduced ccc DNA of 1.7 log, 1.4 log and 0.8 log, respectively （P 〈 0.05）. Seventeen out of the 71 patieots developed HBeAg seroconversion, the reduction of ccc DNA in the HBeAg seroconversion patients was more significant than that in the HBeAg positive patients （3.0 log vs 1.6 log, P = 0.0407）. Twenty-four weeks after antiviral therapy withdrawal, 16 patients had a sustained virological response, the baseline intrahepatic ccc DNA in the patients with a sustained virological response was significantly lower than that in the patients with virological rebound （4.6 log vs 5.4 log, P = 0.0472）. HBV genotype C accounted for 85.9% （n = 61）, and genotype B for 14.1% （n = 10）, respectively, in the 71 patients. There was no significant difference in the change of ccc DNA level between HBV genotypes C and B （2.1 log vs 1.9 log）.CONCLUSION： Forty-eight week sequential lamivudine- INF-α therapy and lamivudine monotherapy reduce ccc DNA more significantly than 24-wk INF-α monotherapy. Low baseline intrahepatic ccc DNA level may predict the long-term efficacy of antiviral treatment. HBV genotypes C and B have no obvious influence on ccc DNA load.

关键词： Covalently closed circular DNA, Hepatitis Bvirus Sequential therapy Lamivudine Interferon

Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients

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World Journal of Gastroenterology 2007年第20期13卷 2878-2882页

作者： Hai-Ying Lu li-wei zhuang Yan-Yan Yu Hadad Ivan Chong-Wen Si Zheng Zeng Jun li Dong-Ming Hou Xin-Yue Chen Zhong-Hou Han Yong Chen Department of Infectious Diseases Peking University First Hospital Beijing 100034 China Indiana University School of Medicine Indianapolis IN 46202 United States Beijing You'an Hospital Beijing 100054 China Qinhuangdao Third Hospital Qinhuangdao 066000 Hebei Province China Huai'an Infectious Disease Hospital Huai'an 223300 Jiangsu Province China

AIM： To evaluate the effect of antiviral agents on intrahepatic HBV DNA in HBeAg-positive chronic hepatitis B patients. METHODS： Seventy-one patients received treatment with lamivudine, interferon alpha （IFN-α2b） or sequential therapy with lamivudine-IFN-α2b for 48 wk. All subjects were followed up for 24 wk. Serum and intrahepatic HBV DNA were measured quantitatively by PCR. HBV genotypes were analyzed by PCR-RFLP. RESULTS： At the end of treatment, the intrahepatic HBV DNA level in 71 patients decreased from a mean of （6.1 ± 1.0） Iog10 to （4.9± 1.4） Iog10. Further, a larger decrease was seen in the intrahepatic HBV DNA level in patients with HBeAg seroconversion. Intrahepatic HBV DNA level （before and after treatment） was not significantly affected by the patients＇ HBV genotype, or by the probability of virological flare after treatment. CONCLUSION： Intrahepatic HBV DNA can be effectively lowered by antiviral agents and is a significant marker for monitoring antivirus treatment. Low intrahepatic HBV DNA level may achieve better efficacy of antivirus treatment.

关键词： Intrahepatic HBV DNA Histology Antivira therapy HBV genotype

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang li Shan Guo zhuang Tong Xiaotao Zhou Xu li Zhaohui Hou Shuquan liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode

汕尾电厂临时倾倒区对所在海域及其周边环境的影响

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广东海洋大学学报 2010年第6期30卷 45-49页

作者：李壮伟国家海洋局汕尾海洋环境监测中心站广东汕尾516600

分析汕尾电厂临时倾倒区2006年倾倒的疏浚泥对所在海域水质、沉积物、生物群落及生物质量等的影响。结果表明,在倾倒过程中,海水中悬浮物、石油类的含量增加,属第三类海水水质;倾倒活动改变了生物群落的水环境,使群落种数减少,多样性、... 详细信息

分析汕尾电厂临时倾倒区2006年倾倒的疏浚泥对所在海域水质、沉积物、生物群落及生物质量等的影响。结果表明,在倾倒过程中,海水中悬浮物、石油类的含量增加,属第三类海水水质;倾倒活动改变了生物群落的水环境,使群落种数减少,多样性、均匀度和丰度降低。倾倒活动结束1个月后,除海水中悬浮物的含量仍属第三类海水水质外,其他污染物含量均符合第二类海水水质标准,底栖生物恢复较缓慢。疏浚泥倾倒对海区沉积物质量和海洋生物质量的影响较小。

关键词：倾倒区疏浚泥水质沉积物生物群落生物质量

参与草菇子实体分化的VvHox1基因的鉴定及表达分析(英文)

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菌物学报 2018年第3期37卷 352-360页

作者：孟丽王威李壮王丽朱孟娟李玉谢宝贵山东农业大学植物保护学院山东省农业微生物重点实验室山东泰安271018 吉林农业大学食药用菌教育部工程研究中心吉林长春130118 福建农林大学生命科学学院菌物研究中心福建福州350002

通过草菇基因组注释,得到一含有同源框(homeobox)保守结构域的转录因子VvHox1,根据其在草菇不同生长发育阶段的基因表达量变化,推测其可能与草菇的子实体分化相关。利用转录组数据分析该基因结构,发现VvHox1由2 856个碱基组成,包含4个... 详细信息

通过草菇基因组注释,得到一含有同源框(homeobox)保守结构域的转录因子VvHox1,根据其在草菇不同生长发育阶段的基因表达量变化,推测其可能与草菇的子实体分化相关。利用转录组数据分析该基因结构,发现VvHox1由2 856个碱基组成,包含4个外显子和3个内含子。荧光定量PCR和数字基因表达谱结果显示VvHox1在草菇的异核菌丝体、原基期和蛋形期的表达量不断升高,并且在蛋形期表达量达到最高,但是,在伸长期的表达量却显著下降。因此,我们推测转录因子VvHox1可能调控子实体发育过程中的相关基因,从而影响草菇子实体的形态发生。

关键词：草菇形态发生转录因子

Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang Chenyang Zhang linlin Wu wei Sun Hongliang Zhang Jianhua Chen Yong Pei Songjiang li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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移植骨髓间充质干细胞治疗胰腺炎的最佳途径

世界华人消化杂志 2016年第14期24卷 2152-2160页

作者：李霞庄丽维朱承雁薄挽澜米丽娜哈尔滨医科大学附属第四医院消化内科黑龙江省哈尔滨市150000

目的:探讨不同途径移植Pkh26标记的大鼠骨髓间充质干细胞(bone mesenchymal stem cell,BMSCs)治疗胰腺炎的最佳移植途径.方法:取3周龄健康SD♀小鼠的股骨及胫骨骨髓,进行分离纯化BMSCs.取体质量250-300 g♀SD大鼠160只,分模型组及治疗组... 详细信息

目的:探讨不同途径移植Pkh26标记的大鼠骨髓间充质干细胞(bone mesenchymal stem cell,BMSCs)治疗胰腺炎的最佳移植途径.方法:取3周龄健康SD♀小鼠的股骨及胫骨骨髓,进行分离纯化BMSCs.取体质量250-300 g♀SD大鼠160只,分模型组及治疗组,并在不同时间测大鼠的血清淀粉酶及血脂肪酶.将治疗组分为尾静脉组、胰腺局部注射组、肠系膜上静脉组,各实验组均移植红色荧光染料Pkh26标记的BMSCs.细胞移植术后12、24、48、72 h、1 wk测血清淀粉酶、血脂肪酶,3 wk观察Pkh26标记的BMSCs的定位及HE染色观察胰腺组织病理学变化.结果:细胞移植术后12、24、48、72 h、1 wk尾静脉注射组血清淀粉酶和血脂肪酶水平与模型组比较差异有统计学意义(P<0.05),肠系膜上静脉组、胰腺局部注射组与相应的模型组比较显著下降(P<0.05),胰腺局部注射组与肠系膜上静脉组比较显著下降(P<0.05),但是仍高于对照组.尾静脉组各时间点胰腺内可见极少量Pkh26标记的BMSCs,肠系膜上静脉组2 wk时胰腺内可见散在亮红色荧光的细胞,数量少,3 wk时数量稍多,胰腺局部注射组2 wk及3 wk胰腺内均可见较多红色荧光的细胞,对照组各时间点均未见Pkh26标记细胞.结论:BMSCs经尾静脉、肠系膜上静脉、胰腺局部注射移植于胰腺炎大鼠模型体内,明显改善了受损胰腺的功能,对胰腺炎损伤具有修复作用,胰腺局部注射移植途径优于其他移植途径.

关键词：胰腺炎骨髓间充质干细胞移植途径

The Predictive Value of On-treatment Virological Response for Sustained Virological Response in Patients with Chronic Hepatitis C Receiving a Personalized Treatment Program

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国际感染病学（电子版） 2013年第2期2卷 60-70页

作者： Ming-hui li Yao Xie Yao Lu Guo-hua Qiu Lu Zhang Ge Shen li-wei zhuang Ju-long Hu Jian-ping Dong Cai-qin Mu Lei-ping Hu li-jun Chen Xing-hong li Min Yang Yun-zhong Wu Hui Zhao Shu-jing Song Jun Cheng Dao-zhen Xu liver Diseases Center Beijing Ditan HospitalCapital Medical University Department of Infectious Diseases Beijing Haidian Hospital Medical Record library Beijing Ditan HospitalCapital Medical University Clinical Test Center Beijing Ditan HospitalCapital Medical University

To investigate the effects of individualised treatment with peginterferon alpha-2a(40 kD)plus ribavirin in Chinese patients with *** Total of 297 consecutive Chinese patients were enrolled,including 250 nave cases and 47 cases who were previously *** duration was determined according to viral genotypes,prior treatment history and viral responses at week 4,12 and *** Totally,235 patients(79.1%)completed treatment and 186(87.3%)achieved *** 219 out of 289(75.8%)patients achieved HCV RNA negative at week 4(RVR)and 259 of 276(93.8%)at week *** the 164 patients with RVR who completed follow-up,158(96.3%)achieved *** with RVR had lower baseline viral loads than patients without RVR(P=0.034).The positive predictive value(PPV)of RVR for SVR was 90.7%(OR 2.10 ***-RVR,95%CI:0.50-8.7).Similar outcomes were observed among patients with HCV undetectable at week *** Viral suppression by week 4 is associated with a high rate of treatment success in treatment nave and experienced patients receiving individualized CHC therapy.

关键词： Chronic hepatitis C Early viral kinetics Pegylated interferon Ribavirin Sustained virological response Tailored regimen

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao wei Panpan Zhao Yongchun Wang Mingxi li li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs