The Predictive Value of On-treatment Virological Response for Sustained Virological Response in Patients with Chronic Hepatitis C Receiving a Personalized Treatment Program

作     者：Ming-hui Li Yao Xie Yao Lu Guo-hua Qiu Lu Zhang Ge Shen Li-wei Zhuang Ju-long Hu Jian-ping Dong Cai-qin Mu Lei-ping Hu Li-jun Chen Xing-hong Li Min Yang Yun-zhong Wu Hui Zhao Shu-jing Song Jun Cheng Dao-zhen Xu 

作者机构：Liver Diseases CenterBeijing Ditan HospitalCapital Medical University Department of Infectious DiseasesBeijing Haidian Hospital Medical Record LibraryBeijing Ditan HospitalCapital Medical University Clinical Test CenterBeijing Ditan HospitalCapital Medical University 

出 版 物：《国际感染病学（电子版）》 (Infection International(Electronic Edition))

年 卷 期：2013年第2卷第2期

页      面：60-70页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：funded by Shanghai Roche Pharmaceuticals Ltd 

主　　题：Chronic hepatitis C Early viral kinetics Pegylated interferon Ribavirin Sustained virological response Tailored regimen 

摘      要：To investigate the effects of individualised treatment with peginterferon alpha-2a(40 kD)plus ribavirin in Chinese patients with *** Total of 297 consecutive Chinese patients were enrolled,including 250 nave cases and 47 cases who were previously *** duration was determined according to viral genotypes,prior treatment history and viral responses at week 4,12 and *** Totally,235 patients(79.1%)completed treatment and 186(87.3%)achieved *** 219 out of 289(75.8%)patients achieved HCV RNA negative at week 4(RVR)and 259 of 276(93.8%)at week *** the 164 patients with RVR who completed follow-up,158(96.3%)achieved *** with RVR had lower baseline viral loads than patients without RVR(P=0.034).The positive predictive value(PPV)of RVR for SVR was 90.7%(OR 2.10 ***-RVR,95%CI:0.50-8.7).Similar outcomes were observed among patients with HCV undetectable at week *** Viral suppression by week 4 is associated with a high rate of treatment success in treatment nave and experienced patients receiving individualized CHC therapy.