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Intraplantar Injection of Monosodium Iodoacetate Produces Hyperalgesia in Rats and the Mechanism Underlying the Effect

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Journal of Biosciences and Medicines 2024年第6期12卷 244-254页

作者： Sha-Sha li Tian-Yun Yao Dan Wu li-ting nan Shuang-Quan Yu Graduate School Youjiang Medical University for Nationalities Baise China Department of Physiology School of Basic Medical Sciences Youjiang Medical University for Nationalities Baise China

Objective: To observe the effect of intraplantar injection of monosodium iodoacetate (MIA) on pain perception in rats and to investigate the role of transient receptor potential vanilloid type 1 (TRPV1) in the effect. Methods: Adult male Wistar rats were used in the experiment. 1) MIA was injected subcutaneously into the right hindpaw of rats, the low, medium, and high doses of MIA were 0.11, 0.33, and 1 mg, respectively, then the changes of paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing within 4 hours after MIA injection were measured. 2) Capsazepine (TRPV1 antagonist, 30 μg) was injected subcutaneously into the right hindpaw of rats at 2 hours after intraplantar injection of MIA (1 mg), then the changes of paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing within 1 hour after capsazepine injection were measured. Results: 1) The paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing decreased after intraplantar injection of MIA in rats and the effect lasted for at least 4 hours. 2) The MIA-induced reduction in paw withdrawal thermal latency, paw withdrawal mechanical threshold, and dynamic weight bearing were significantly alleviated after intraplantar injection of capsazepine in rats. Conclusion: Intraplantar injection of MIA can produce thermal pain, mechanical pain, and spontaneous pain for more than 4 hours, which may be due to the TRPV1 activation caused by MIA.

关键词： TRPV1 Monosodium Iodoacetate Capsazepine Hyperalgesia

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Data-Driven Direct Adaptive Risk-Sensitive Control of Stochastic Systems

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Journal of Systems Science & Complexity 2024年第4期37卷 1446-1469页

作者： QIAO nan li Tao School of Mathematical Sciences East China Normal UniversityShanghai 200241China Shanghai Key Laboratory of Pure Mathematics and Mathematical Practice School of Mathematical SciencesEast China Normal UniversityShanghai 200241China

The authors propose a data-driven direct adaptive control law based on the adaptive dynamic programming(ADP) algorithm for continuous-time stochastic linear systems with partially unknown system dynamics and infinite horizon quadratic risk-sensitive *** authors use online data of the system to iteratively solve the generalized algebraic Riccati equation(GARE) and to learn the optimal control law *** the case with measurable system noises,the authors show that the adaptive control law approximates the optimal control law as time goes *** the case with unmeasurable system noises,the authors use the least-square solution calculated only from the measurable data instead of the real solution of the regression equation to iteratively solve the *** authors also study the influences of the intensity of the system noises,the intensity of the exploration noises,the initial iterative matrix,and the sampling period on the convergence of the ADP ***,the authors present two numerical simulation examples to demonstrate the effectiveness of the proposed algorithms.

关键词： Adaptive dynamic programming direct adaptive control generalized algebraic Riccati equation risk-sensitive control

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BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

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Current Medical Science 2024年第2期44卷 333-345页

作者： Jun-li ZHAO lin ZHAO Qiu-nan ZHAN Miao liU ting ZHANG Wen-wen CHU Department of Nephrology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghai 201318China Orthopedic Department Guangming Traditional Chinese Medicine Hospital of Pudong New AreaShanghai 201399China

Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to ***:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6J mice were infused with 4.25%glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5%PDF group,2.5%PDF group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of *** and Masson staining were performed to evaluate the extent of *** therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function ***-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25%*** were divided into control group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 ***:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to *** RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD *** found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD *** with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious f

关键词： peritoneal fibrosis bone marrow mesenchymal stem cell-derived exosomes miR-27a-3p TP53 epithelialmesenchymal transition

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Aspirin suppresses hepatocellular carcinoma progression by inhibiting platelet activity

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2742-2756页

作者： li-Jun Zhao Zhi-Yin Wang Wei-ting liu li-li Yu Hao-nan Qi Jie Ren Chen-Guang Zhang Hematology Laboratory The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina Xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy School of Medical TechnologyXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiang 453003Henan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common malignant liver disease in the ***(PLTs)are known to play a key role in the maintenance of liver homeostasis and the pathophysiological processes of a variety of liver *** is the most classic antiplatelet ***,the molecular mechanism of platelet action and whether aspirin can affect HCC progression by inhibiting platelet activity need further *** To explore the impact of the antiplatelet effect of aspirin on the development of *** Platelet-rich plasma,platelet plasma,pure platelet,and platelet lysate were prepared,and a coculture model of PLTs and HCC cells was ***-8 analysis,apoptosis analysis,Transwell analysis,and real-time polymerase chain reaction(RT-PCR)were used to analyze the effects of PLTs on the growth,metastasis,and inflammatory microenvironment of ***-PCR and Western blot were used to detect the effects of platelet activation on tumor-related signaling *** was used to block the activation and aggregation of PLTs both in vitro and in vivo,and the effect of PLTs on the progression of HCC RESULTS PLTs significantly promoted the growth,invasion,epithelial-mesenchymal transition,and formation of an inflammatory microenvironment in HCC *** PLTs promoted HCC progression by activating the mitogenactivated protein kinase/protein kinase B/signal transducer and activator of transcription three(MAPK/AKT/STAT3)signaling ***,aspirin inhibited HCC progression in vitro and in vivo by inhibiting platelet *** PLTs play an important role in the pathogenesis of HCC,and aspirin can affect HCC progression by inhibiting platelet *** results suggest that antiplatelet therapy has promising application prospects in the treatment and combined treatment of HCC.

关键词： Platelets Antiplatelet therapy Hepatocellular carcinoma Aspirin Antitumor

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light-emitting devices based on atomically thin MoSe_(2)

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Journal of Semiconductors 2024年第4期45卷 19-35页

作者： Xinyu Zhang Xuewen Zhang Hanwei Hu Vanessa li Zhang Weidong Xiao Guangchao Shi Jingyuan Qiao nan Huang ting Yu Jingzhi Shang Institute of Flexible Electronics Northwestern Polytechnical UniversityXi'an 710129China School of Physics and Technology Wuhan UniversityWuhan 430072China Wuhan Institute of Quantum Technology Wuhan 430206China

Atomically thin MoSe_(2) layers,as a core member of the transition metal dichalcogenides(TMDs)family,benefit from their appealing properties,including tunable band gaps,high exciton binding energies,and giant oscillator strengths,thus pro-viding an intriguing platform for optoelectronic applications of light-emitting diodes(LEDs),field-effect transistors(FETs),sin-gle-photon emitters(SPEs),and coherent light sources(CLSs).Moreover,these MoSe_(2) layers can realize strong excitonic emis-sion in the near-infrared wavelengths,which can be combined with the silicon-based integration technologies and further encourage the development of the new generation technologies of on-chip optical interconnection,quantum computing,and quantum information ***,we overview the state-of-the-art applications of light-emitting devices based on two-dimensional MoSe_(2) ***,we introduce recent developments in excitonic emission features from atomically thin MoSe_(2) and their dependences on typical physical ***,we focus on the exciton-polaritons and plasmon-exciton polaritons in MoSe_(2) coupled to the diverse forms of optical ***,we highlight the promising applications of LEDs,SPEs,and CLSs based on MoSe_(2) and their ***,we summarize the challenges and opportunities for high-quality emis-sion of MoSe_(2) and high-performance light-emitting devices.

关键词： MoSe_(2) light-matter interaction exciton polariton light-emitting device

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Growth and development of children in China:achievements,problems and prospects

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World Journal of Pediatrics 2024年第2期20卷 97-104页

作者： Xin-nan Zong Hui li Department of Growth and Development Capital Institute of PediatricsBeijing 100020China

Growth reflects the general condition of society,and is a measure of the nutritional and hygienic status of a population[1,2].Nutrition is one of the most important components of children’s well-being[3].The Chinese government attaches great importance to children’s health and development,with a clear statement and consistent practice for“Children are the future and hope of the motherland”.

关键词： mother statement children

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Effect of Cr_(2)O_(3) on properties of CaO-SiO_(2)-Fe_(t)O-MgO system and dissolution behavior of lime

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Journal of Iron and Steel Research(International) 2024年第4期31卷 870-881页

作者： Shan-nan li Jian-li li Yue Yu Hang-yu Zhu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The productivity of the chrome-containing semi-steel converter smelting process is directly affected by the slag-forming speed during the converter preliminary *** effects of Cr_(2)O_(3) content on the physicochemical properties of the CaO-SiO_(2)-Fe_(t)O-MgO system,such as melting temperature,solidification behavior,mineral composition,and lime dissolution rate,were *** results showed that the slag was an amorphous phase at 1500℃.When Cr_(2)O_(3) was added,Ca(Fe,Mg)Si_(2)O_(6) and spinel were formed in the *** the increase in Cr_(2)O_(3) content,the amount of spinel precipitation increased,and the dendritic FegO_(4) crystal gradually changed into the granular(Fe,Mg)(Fe,Cr)2O_(4) *** the Cr_(2)O_(3) content increased from O to 2.91 wt.%,the melting temperature of the slag rose,and the melting range of the slag expanded slightly,but the lime dissolution rate did not *** the Cr_(2)O_(3) content further increased to 9.09 wt.%,the melting temperature continued to rise,the melting range rapidly expanded,and the lime dissolution rate decreased.

关键词： Cr_(2)O_(3) Vanadium-titanium magnetite Converter Slag lime dissolution

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Tailoring microenvironment for efficient CO_(2)electroreduction through nanoconfinement strategy

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nano Research 2024年第9期17卷 7880-7899页

作者： Lulu Chen Minhan li Jia-nan Zhang Key Laboratory of Advanced Energy Catalytic and Functional Materials Preparation Country College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

The electrocatalytic conversion of CO_(2)to produce fuels and chemicals holds great promise,not only to provide an alternative to fossil feedstocks,but also to use renewable electricity to convert and recycle the greenhouse gas CO_(2)to mitigate climate ***,the selectivity and reaction rates for the conversion of CO_(2)into desirable carbon-based products,especially multicarbon products with high added value,are still insufficient for commercial applications,which is attributed to insufficiently favourable microenvironmental conditions in the vicinity of the *** construction of catalysts/electrodes with confined structures can effectively improve the reaction microenvironment in the vicinity of the electrodes and thus effectively direct the reaction towards the desired *** this review,we firstly introduce the effects of the microenvironment at the electrode-electrolyte interface including local pH,local intermediate concentration,and local cation concentration on CO_(2)reduction reaction(CO_(2)RR)as well as the mechanism of action,and then shed light on the microenvironmental modulation within the confined space,and finally and most importantly,introduce the design strategy of CO_(2)RR catalyst/electrode based on the confinement effect.

关键词： CO_(2)reduction reaction microenvironment confinement effect catalyst design

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Screening the optimal Co_(x)/CeO_(2)(110)(x=1–6)catalyst for methane activation in coalbed gas

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International Journal of Coal Science & Technology 2024年第3期11卷 256-271页

作者： li’nan Huang Danyang li Lei Jiang Zhiqiang li Dong Tian Kongzhai li Engineering Research Center of Metallurgical Energy Conservation and Emission Reduction Ministry of EducationKunming University of Science and TechnologyKunming650093China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093China State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and TechnologyKunming650093China

The challenges posed by energy and environmental issues have forced mankind to explore and utilize unconventional energy *** is imperative to convert the abundant coalbed gas(CBG)into high value-added products,i.e.,selective and efficient conversion of methane from *** activation,known as the“holy grail”,poses a challenge to the design and development of *** structural complexity of the active metal on the carrier is of particular *** this work,we have studied the nucleation growth of small Co clusters(up to Co_(6))on the surface of CeO_(2)(110)using density functional theory,from which a stable loaded Co/CeO_(2)(110)structure was selected to investigate the methane activation *** the relatively small size of the selected Co clusters,the obtained Co_(x)/CeO_(2)(110)exhibits interesting *** optimized Co_(5)/CeO_(2)(110)structure was selected as the optimal structure to study the activation mechanism of methane due to its competitive electronic structure,adsorption energy and binding *** energy barriers for the stepwise dissociation of methane to form CH3^(*),CH2^(*),CH^(*),and C^(*)radical fragments are 0.44,0.55,0.31,and 1.20 eV,respectively,indicating that CH^(*)dissociative dehydrogenation is the rate-determining step for the system under investigation *** fundamental study of metal-support interactions based on Co growth on the CeO_(2)(110)surface contributes to the understanding of the essence of Co/CeO_(2) catalysts with promising catalytic *** provides theoretical guidance for better designing the optimal Co/CeO_(2) catalyst for tailored catalytic reactions.

关键词： Co cluster growth Ce-based catalysts Methane activation DFT

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Investigating the Absorption and Desorption Behavior of Methylene Chloride in the Poly(aryl ether ketone) Film with Different Crystallinities

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Chinese Journal of Polymer Science 2024年第2期42卷 239-246,I0009页

作者： Hong-Ru Yang Jin-Dong Zhang Dong-ting Gao Gang liu Chun-Hai Chen Jia-nan Yao Center for Advanced Low-Dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai201620China

Poly(aryl ether keton e)(PAEK) films with different crystallinities were obtained by controlling the cooling rate,which were subjected to the absorption and desorption of methylene chloride(CH_(2)Cl_(2)).We employed attenuated total reflection Fourier transform infrared(ATR-FTIR)spectroscopy analyses to investigate the diffusion behavior of CH_(2)Cl_(2) in PAEK films with different *** to the Fickian diffusion model,the calculated diffu sion coefficients of CH_(2)Cl_(2) in PAEK films were observed to decrease with increasing *** effect of CH_(2)Cl_(2)absorption and desorption on the mechanical properties of PAEK films with different crystallinity was further analyzed using tensile *** tensile tests exhibited that CH_(2)Cl_(2) has two concurrent effects:plasticization and solvent-induced *** scanning calorimetry(DSC) and wide-angle X-ray diffraction(WXRD) techniques further confirmed solvent-induced crystallization *** results would be beneficial to understand the solvent resistance of PAEK materials and consequently provide the practical application conditions of PAEK with a theoretical basis.

关键词： Poly(aryl ether ketone) Diffusion behavior Infrared spectra Solvent-induced crystallization Mechanical properties

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