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World Journal of Gastroenterology 2023年第20期29卷 3168-3184页

作者： Jia-lin Wu Jun-Yang Luo Zai-Bo Jiang Si-Bo Huang Ge-Run Chen Hui-Ying Ran Qi-Yue liang Ming-Sheng Huang li-sha lai Jun-Wei Chen Department of Interventional Radiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina The First Clinical Medical College Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Radiology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510010Guangdong ProvinceChina

BACKGROUND The efficacy of conversion therapy for patients with unresectable hepatocellular carcinoma(HCC)is a common clinical *** To analyse the prognostic factors of overall survival(OS)in patients with unresectable HCC who received conversion *** One hundred and fifty patients who met the inclusion criteria were enrolled and divided into a training cohort(n=120)and a validation cohort(n=30).Using the independent risk factors in the training cohort,a nomogram model was constructed to predict OS for patients treated with transarterial chemoembolization following hepatic *** nomogram was internally validated with the bootstrapping *** predictive performance of nomogram was assessed by Harrell’s concordance index(C-index),calibration plot and timedependent receiver operating characteristic curves and compared with six other conventional HCC staging *** Multivariate Cox analysis identified that albumin,blood urea nitrogen,gamma-glutamyl transpeptidase to platelet ratio,platelet to lymphocyte ratio,macrovascular invasion and tumour number were the six independent prognostic factors correlated with OS in nomogram *** C-index in the training cohort and validation cohort were 0.752 and 0.807 for predicting OS,which were higher than those of the six conventional HCC staging systems(0.563 to 0.715 for the training cohort and 0.458 to 0.571 for the validation cohort).The calibration plots showed good consistency between the nomogram prediction of OS and the actual observations of *** curve analyses indicated satisfactory clinical *** a total nomogram score of 196,patients were accurately classified into low-risk and high-risk ***,we have deployed the model into online calculators that can be accessed for free at https://***/DynNomapp/.CONCLUSION The nomogram achieved optimal individualized prognostication of OS in HCC patients who received conversion ther

关键词： Hepatocellular carcinoma Conversion therapy Nomogram Inflammation Transarterial chemoembolization

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完备与不完备背景关系中蕴含的系统功能结构分析

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计算机科学 2017年第3期44卷 268-273,306页

作者：崔铁军李莎莎王来贵辽宁工程技术大学安全科学与工程学院阜新123000 矿山热动力灾害与防治教育部重点实验室阜新123000 大连交通大学辽宁省隧道与地下结构工程技术研究中心大连116028 辽宁工程技术大学力学与工程学院阜新123000

考虑完备或不完备背景关系中蕴含的元件与系统功能结构关系,提出了基于因素空间理论中因素逻辑的系统功能结构分析法,给出了该方法的严谨的数学定义系统及分析过程的逻辑数学描述。对完备和不完备两个例子进行分析后得到了两个不同的系... 详细信息

考虑完备或不完备背景关系中蕴含的元件与系统功能结构关系,提出了基于因素空间理论中因素逻辑的系统功能结构分析法,给出了该方法的严谨的数学定义系统及分析过程的逻辑数学描述。对完备和不完备两个例子进行分析后得到了两个不同的系统功能结构表达式,说明完备背景关系可得到唯一确定的系统功能结构,不完备背景关系可以得到一族确定的系统功能结构。如果不完备背景关系是完备背景关系的子集,那么在不完备背景关系中一定能找到功能之间的线性关系,以补充不完备背景关系。该方法是严谨的逻辑数学推理,可用于广泛领域类似问题的分析。

关键词：因素空间因素逻辑空间故障树系统功能结构背景关系

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Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-Yu liu sha-sha Cui Ting-Ting li Xiao-Meng Yang Zhijuan liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

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数媒时代焦虑、抑郁与社会比较的关系

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心理科学进展 2025年第1期33卷 92-106,I0001-I0007页

作者：赵立白莎首都经济贸易大学工商管理学院北京100070

社会焦虑和抑郁现象日益严重。为理解与探索数媒时代焦虑、抑郁的引致因素及应对策略,研究采用系统性文献综述方法,基于情感事件理论和社会比较理论构建框架,梳理了社会比较的不同亚型与焦虑、抑郁的关系以及网络媒体环境的权变作用。... 详细信息

社会焦虑和抑郁现象日益严重。为理解与探索数媒时代焦虑、抑郁的引致因素及应对策略,研究采用系统性文献综述方法,基于情感事件理论和社会比较理论构建框架,梳理了社会比较的不同亚型与焦虑、抑郁的关系以及网络媒体环境的权变作用。研究发现,消极社会比较(传统上行比较和下行同化比较)可能会引发焦虑和抑郁,社交网络平台对此负面影响具有催化作用;而情绪比较和下行对比比较可以缓解焦虑和抑郁,网络健康社区促进了情绪比较的积极作用的发挥。研究推进了社会比较理论在情绪情感领域的应用,确定了焦虑、抑郁与网络健康社区可供性的关联,也为网络社区服务、运营和设计的原则提供参考和借鉴以帮助个体应对心理健康问题。研究还指出焦虑、抑郁和社会比较关系后续研究的可能路径和方向。

关键词：社会比较焦虑抑郁社交网络平台网络健康社区

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Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng liao sha liao Yu-Jiao Gao Xi Wang li-Hong Guo Su Zheng Wu Yang Yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu liang Ni-Hui Zhang Zhi-lai Zhan Guang-Lu Chang Yan Gao Xia li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Nomograms predicting long-term survival in patients with invasive intraductal papillary mucinous neoplasms of the pancreas: A population-based study

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World Journal of Gastroenterology 2020年第5期26卷 535-549页

作者： Jia-Yuan Wu Yu-Feng Wang Huan Ma sha-sha li Hui-lai Miao Department of Clinical Research the Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina School of Public Health Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina Department of Hepatobiliary Surgery the Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina Department of Hepatobiliary Surgery the Second Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524003Guangdong ProvinceChina

BACKGROUND There are few effective tools to predict survival in patients with invasive intraductal papillary mucinous neoplasms of the *** To develop comprehensive nomograms to individually estimate the survival outcome of patients with invasive intraductal papillary mucinous neoplasms of the *** Data of 1219 patients with invasive intraductal papillary mucinous neoplasms after resection were extracted from the Surveillance,Epidemiology,and End Results database,and randomly divided into the training(n=853)and the validation(n=366)*** on the Cox regression model,nomograms were constructed to predict overall survival and cancer-specific survival for an individual *** performance of the nomograms was measured according to discrimination,calibration,and clinical ***,we compared the predictive accuracy of the nomograms with that of the traditional staging *** In the training cohort,age,marital status,histological type,T stage,N stage,M stage,and chemotherapy were selected to construct *** with the American Joint Committee on Cancer 7th staging system,the nomograms were generally more *** nomograms passed the calibration steps by showing high consistency between actual probability and nomogram *** net classification improvements and integrated discrimination improvements suggested that the predictive accuracy of the nomograms exceeded that of the American Joint Committee on Cancer staging *** respect to decision curve analyses,the nomograms exhibited more preferable net benefit gains than the staging system across a wide range of threshold *** The nomograms show improved predictive accuracy,discrimination capability,and clinical utility,which can be used as reliable tools for risk classification and treatment recommendations.

关键词： Invasive intraductal papillary mucinous neoplasm Pancreas Nomogram Overall survival Cancer-specific survival Surgical resection

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Biosorption of Cr（VI） by carbonized Eupatorium adenophorum and Buckwheat straw： thermodynamics and mechanism

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Frontiers of Environmental Science & Engineering 2014年第6期8卷 960-966页

作者： Jinfa CHEN Ping YANG Dagang SONG sha YANG li ZHOU Lei HAN Bo lai Department of Agricultural Science Xichang College Xichang 615013 China College of Architecture & Environment Sichuan University Chengdu 610065 China

High quality and low cost carbon can be prepared from Eupatorium adenophorum （E. adenophorum） and Buckwheat straw. The biosorbent was used for Cr（VI） removal. The effect of experimental parameters, such as pH, sorbent dosage and temperature were examined and the optimal experimental condition was determned. Solution pH is found influencing the adsorp- tion. Cr（VI） removal efficiency is found to be maximum （98%） at pH= 1. Langmuir and Freundlich adsorption isotherms were applicable to the adsorption process and their constants were evaluated. The adsorption data obtained agreed well with the Langmuir sorption isotherm model. The maximum adsorption capacities for Cr（VI） ranged from 46.23 to 55.19mg.g^-1 for temperature between 298 K and 308 K under the condition of pH = 1.0. Thermodynamic parameters such as free energy change （AG）, enthalpy （AH） and entropy （AS） indicate a spontaneous, endothermic and increased randomness nature of Cr（VI） adsorption. Studies found that the raw E. adenophorum and buckwheat straw mixed materials with simple treatment had a high efficiency for the removal of Cr（VI） and would be a promising adsorbent.

关键词： Eupatorium adenophorum buckwheat straw adsorption Cr(VI) thermodynamics

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结合Udwadia-Kalaba控制理论的下肢外骨骼步态轨迹跟踪控制

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西安交通大学学报 2025年第1期59卷 148-158页

作者：肖志毅沙连森邹学坤黄锟李永斌刘斌中国科学技术大学生物医学工程学院(苏州) 江苏苏州215000 中国科学院苏州生物医学工程技术研究所江苏苏州215000

针对现有轨迹跟踪控制方法较难兼顾控制精度与稳定性的问题,提出一种基于Udwadia-Kalaba(U-K)控制理论的鲁棒控制方法。基于拉格朗日法建立机器人动力学模型,将动力学参数分为确定的名义部分与不确定部分;结合U-K理论与系统名义部分参... 详细信息

针对现有轨迹跟踪控制方法较难兼顾控制精度与稳定性的问题,提出一种基于Udwadia-Kalaba(U-K)控制理论的鲁棒控制方法。基于拉格朗日法建立机器人动力学模型,将动力学参数分为确定的名义部分与不确定部分;结合U-K理论与系统名义部分参数确定外骨骼机器人系统理想运动轨迹约束下的名义部分控制力矩;为消除机器人系统不确定部分的影响,引入鲁棒控制器,通过划分不确定性边界确定其应输出的额外控制力矩。仿真结果表明:相较于传统PID算法,基于U-K控制理论的鲁棒控制的外骨骼机器人髋关节、膝关节角度的轨迹跟踪控制精度分别提高了76.4%和96.8%。基于设计的下肢外骨骼机器人样机进行轨迹跟踪对比实验,实验结果表明:基于该方法的下肢外骨骼髋关节、膝关节角度的轨迹跟踪精度为0.467 0°和0.114 1°,相比作为对照的PID算法,分别提高了82.6%和86.8%,同时系统整体控制周期缩短了56.6%,该控制方法具有更高的同步性、控制精度与稳定性。

关键词：下肢外骨骼机器人 Udwadia-Kalaba控制理论鲁棒控制轨迹跟踪控制

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Gastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function

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World Journal of Psychiatry 2024年第7期14卷 1095-1105页

作者： sha li Nan Zhang Wang li Han-lai Zhang Xiao-Xi Wang Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100000China Institute of Basic Theory for Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100000China

BACKGROUND Autism spectrum disorder(ASD)is a developmental disorder characterized by social deficits and repetitive ***(GI)problems,such as constipation,diarrhea,and inflammatory bowel disease,commonly occur in patients with ***,GI problems of ASD patients were attributed to intestinal inflammation and vertical mother-to-infant microbiome *** To explore whether GI problems in ASD are related to maternal intestinal inflam-mation and gut microbiota *** An ASD rat model was developed using valproic acid(VPA).Enzyme-linked immunosorbent assay and fecal 16S rRNA sequencing were used to test GI *** VPA exposure during pregnancy led to pathological maternal intestinal changes,resulting in alterations in maternal gut ***,the levels of inflammatory factors also ***,prenatal exposure to VPA resulted in impaired duodenal motility in the offspring as well as increased levels of infla-mmatory *** GI problems in ASD may be associated with maternal intestinal inflammation and microbiota *** research is required to find more evidence on the etiology and treatment of GI problems in ASD.

关键词： Autism spectrum disorder Gastrointestinal problems Gut microbiota Intestinal inflammation Intestinal motility

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