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One-pot synthesis of network supported catalyst using supramolecular gel as template

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Chinese Chemical Letters 2010年第8期21卷 991-994页

作者： Yong liang li ming Tang Yu xia Kai Chen Bo Tian li Xin Jin Laboratory of Advanced Materials Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

A simple and general strategy is described for preparing network supported catalyst through a one-pot synthetic procedure using supramolecular gel as *** procedure directly attaches ligand to support during fabricating the *** this strategy,supported CuBr/di-（2-picolyl） amine catalyst with U-shaped fibrillar network was prepared and used in atom transfer radical polymerization of methyl *** and SEM characterization of the catalyst revealed homogeneous distribution of ligand,sufficient reactive sites,adequate mechanical strength and *** polymerization results demonstrated high activity and reusability of such *** strategy might be extended to other supported catalysts used in column reactors.

关键词： One-pot synthesis Network supported catalyst Supramolecular gel Atom transfer radical polymerization

Feasibility of Subtraction Coronary Computed Tomographic Angiography and Influencing Factor Analysis: a Retrospective Study

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Current Medical Science 2021年第4期41卷 821-826页

作者： Chao HUANG Wei-jia WAN Yu-huan YAO li-ming xia Wen-hua HUANG Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective To investigate the feasibility of subtraction coronary computed tomographic(CT)angiography(SubCCTA)to decline calcium artifacts and improve diagnostic accuracy in the presence of coronary calcification and analyze the factors that influence *** A total of 294 patients suspected of having coronary artery diseases underwent coronary computed tomographic angiography(CCTA)and *** stenoses were blindly evaluated by two experienced radiologists,which were compared with invasive coronary angiography(ICA).Multiple statistical indexes were adopted to analyze the value of SubCCTA for the diagnosis of calcium *** The diagnosable rate of SubCCTA was 67.2%(n=197),and the non-diagnosable rate was 32.8%(n=97).Using SubCCTA,the false positive rate decreased from 56.5%to 17.4%,and the corresponding diagnostic accuracy was increased from 83.6%to 92.9%.Univariate logistic regression analysis showed that height(OR=1.029,95%CI=1.001–1.058),weight(OR=1.025,95%CI=1.004–1.046),left ventricular size(OR=1.018,95%CI=1.007–1.030),cardiothoracic ratio(OR=39.917,95%CI=1.244–1281.098),the average heart rate(OR=0.866,95%CI=0.836–0.896)and heart rate range(OR=0.882,95%CI=0.853–0.912)might be the factors influencing *** This study suggested that SubCCTA could help improve diagnostic accuracy in the presence of calcium ***,several factors were discovered for the first time to possibly influence SubCCTA,which will be helpful in improving the subtracted image quality.

关键词： coronary computed tomographic angiography calcification artifacts coronary subtraction diagnosis accuracy influencing factors

Efficacy and Safety of Jianpi Jieyu Decoction for Patients with Mild-to-Moderate Depression of Xin(Heart)-Pi(Spleen)Deficiency Syndrome:A Multi-centre Randomized Controlled Study

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Chinese Journal of Integrative Medicine 2023年第4期29卷 299-307页

作者： CHEN Xu CHEN Jiu-xi HAN Xue-yan ZHAO Yang CAO Jing JIAO Xiu-zhen liU Hong-mei GUO Chun-li MENG Shuo liANG Shuai QI Jiang-xia CHEN Dong li ming-xia JIAO Yun-xia WANG Ting-ting HONG xia Xiyuan Clinical Medical College Beijing University of Chinese MedicineBeijing 100091China Department of Encephalopathy Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China First College of Clinical Medicine Shandong University of Traditional Chinese MedicineJinan 250355China Institute of Clinical Pharmacology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Encephalopathy Botou Traditional Chinese Medicine Hospital of Hebei ProvinceBotou 062150China Institute of Basic Medicine Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Nephrology Pinggu HospitalBeijing Hospital of Traditional Chinese MedicineBeijing 101299China

Objective:To evaluate the efficacy and safety of Jianpi Jieyu Decoction(JJD)for treating patients with mild-to-moderate depression of Xin(Heart)-Pi(Spleen)deficiency(XPD)***:In this multi-center,randomized,controlled study,140 patients with mild-to-moderate depression of XPD syndrome were included from Xiyuan Hospital of China Academy of Chinese Medical Sciences and Botou Hospital of Traditional Chinese Medicine from December 2017 to December *** were randomly divided into JJD group and paroxetine group by using a random number table,with 70 cases in each *** patients in the JJD group were given JJD one dose per day(twice daily at morning and evening,100 m L each time),and the patients in the paroxetine group were given paroxetine(10 mg/d in week 1;20 mg/d in weeks 2-6),both orally administration for a total of 6 *** primary outcome was the change of 17-item Hamilton Depression Rating Scale(HAMD-17)score at week 6 from *** secondary outcomes included the Hamilton Anxiety Scale(HAMA)score,Traditional Chinese Medicine Symptom Scale(TCMSS),and Clinlcal Global Impression(CGI)scores at the 2nd,4th,and 6th weekends of treatment,HAMD-17 response(defined as a reduction in score of>50%)and HAMD-17 remission(defined as a score of 7)at the end of the 6th week of *** events(AEs)were also ***:From baseline to week 6,the HAMD-17 scores decreased 10.2±4.0 and 9.1±4.9 points in the JJD and paroxetine groups,respectively(P=0.689).The HAMD-17 response occurred in 60%of patients in the JJD group and in 50%of those in the paroxetine group(P=0.292);HAMD-17 remission occurred in 45.7%and 30%of patients,respectively(P=0.128).The differences of CGI scores at the 6th week were not statistically significant(P>0.05).There were significant differences in HAMD-17 scores between the two groups at 2nd and 4th week(P=0.001 and P=0.014).The HAMA scores declined 8.1±3.0 and 6.9±4.3 points from baseline to week 6 in the JJD and paroxe

关键词： depression Xin(Heart)-Pi(Spleen)deficiency syndrome Chinese medicine Jianpi Jieyu Decoction depression efficacy safety

Study on the Aesthetic Deformation of Micro Short Drama Audience from the Perspective of Media Ecology

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Journal of literature and Art Studies 2024年第10期14卷 908-915页

作者： li ming-xia li Jia-xin University of Shanghai for Science and Technology Shanghai 200093China

Micro short drama is a new form of fictional narrative in the environment of digital intelligent media,which attracts the attention of the audience in the era of fragmentation and forms an explosive growth of the industrial market with the characteristics of short content,concentrated dramatic conflict and quick plot ***,the“viral”dissemination of micro short drama makes the audience’s aesthetics show the aesthetic deformation characteristics of earthy,ugly and *** article applies media ecology Neil Postman’s theories of“entertainment to death”and“technological monopoly”to observe the impact of micro short dramas on audience aesthetics in order to optimize the market of micro short dramas and guide the healthy development of audience aesthetics.

关键词： micro short drama media ecology aesthetic deformation

The Number of Positive Pelvic Lymph Nodes and Multiple Groups of Pelvic Lymph Node Metastasis Influence Prognosis in Stage ⅠA-ⅡB Cervical Squamous Cell Carcinoma

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Chinese Medical Journal 2015年第15期128卷 2084-2089页

作者： Yu liu li-Jon Zhao ming-Zho li ming-xia li Jian-liu Wang li-Hui Wei Department of Obstetrics and Gynecology Peking University People's Hospital Beijing 100044 China

Background：Pelvic lymph node metastasis （LNM） is an important prognostic factor in cervical *** squamous cell carcinoma accounts for approximately 75-80% of all cervical *** of the effects of the number of positive lymph nodes （LNs）,unilateral vcrsus bilateral pelvic LNM and a single group versus multiple groups of pelvic LNM on survival and recurrence of cervical squamous cell carcinoma are still *** study aimed to analyze the effects of the number of positive pelvic LNs and a single group versus multiple groups of pelvic LNM on survival and ***：We performed a retrospective review of 296 patients diagnosed with Stage ⅠA-ⅡB cervical squamous cell carcinoma who received extensive/sub-extensive hysterectomy with pelvic lymphadenectomy/pelvic LN sampling at Peking University People＇s Hospital from November 2004 to July *** clinicopathological variables were evaluated as risk factors for pelvic LNM：Age at diagnosis,gravidity,clinical stage,histological grade,tumor diameter,lymph-vascular space involvement （LVSI）,depth of cervical stromal invasion,uterine invasion,parametrial invasion,and neoadjuvant ***：The incidence of pelvic LNM was 20.27% （60/296 cases）.Pelvic LNM （P =0.00） was significantly correlated with *** LNM （P =0.00）,the number of positive pelvic LNs （P =0.04） and a single group versus multiple groups of pelvic LNM （P =0.03）had a significant influence on *** analysis revealed that LVSI （P =0.00）,depth of cervical stromal invasion （P =0.00）and parametrial invasion （P =0.03） were independently associated with pelvic ***：Patients with pelvic LNM had a higher recurrence rate and poor survival ***,more than 2 positive pelvic LNs and multiple groups of pelvic LNM appeared to identify patients with worse survival outcomes in node-positive ⅠA-ⅡB cervical squamous cell ***,parametrial invasion,and depth of cervical stromal invas

关键词： Cervical Squamous Cell Carcinoma Pelvic Lymph Node Metastasis Prognosis

Comparison of Various Parameters of DWI in Distinguishing Solitary Pulmonary Nodules

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Current Medical Science 2018年第5期38卷 920-924页

作者： Han-xiong GUAN Yue-ying pAN Yu-jin WANG Da-zong TANG Shu-chang ZHOU li-ming xia Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

In order to prospectively assess various parameters of diffusion weighted imaging (DWI)in differential diagnosis of benign and malignant solitary pulmonary nodules (SPNs),58 patients (40 men and 18 women,and mean age of 48.1±10.4years old) with SPNs undergoing conventional MR,DWI using b=500s/mm^2 on a 1.5T MR scanner, were *** DWI parameters [apparent diffusion coefficient (ADC),lesion-to-spinal cord signal intensity ratio (LSR),signal intensity (SI)score] were calculated and compared between malignant and benign SPNs groups.A receiver operating characteristic (ROC)curve analysis was employed to compare the diagnostic capabilities of all the parameters for discrimination between benign and malignant *** results showed that there were 42 malignant and 16 benign *** ADC was significantly,lower in malignant SPNs (1.40±0.44)×10^-3mm^2/s than in benign SPNs (1.81±0.58)×10^-3mm^2/ *** LSR and SI scores were significantly increased in malignant SPNs (0.90±0.37 and 2.8±1.2)as compared with those in benign SPNs (0.68±0.39 and 2.2±1.2).The area under the ROC curves (AUC)of all parameters was not significantly different between malignant SPNs and benign *** was suggested that as three reported parameters for DWI,ADC,LSR and SI scores are all feasible for discrimination of malignant and benign *** three parameters have equal diagnostic performance.

关键词： magnetic resonance imaging diffusion weighted imaging solitary pulmonary nodules differential diagnosis

Prospective Study of Low-and Standard-dose Chest CT for Pulmonary Nodule Detection:A Comparison of Image Quality,Size Measurements and Radiation Exposure

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Current Medical Science 2021年第5期41卷 966-973页

作者： Qiong-jie HU Yi-wen liU Chong CHEN Shi-chao KANG Zi-yan SUN Yu-jin WANG Min xiaNG li-ming xia Han-xiong GUAN Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Radiology Shenzhen Maternity&Child Healthcare Hospital Southern Medical UniversityShenzhen 518028China

Objective:To comprehensively and accurately analyze the out-performance of low-dose chest CT(LDCT)***-dose CT(SDCT).Methods:The image quality,size measurements and radiation exposure for LDCT and SDCT protocols were evaluated.A total of 117 patients with extra-thoracic malignancies were prospectively enrolled for non-enhanced CT scanning using LDCT and SDCT *** experienced radiologists evaluated subjective image quality independently using a 5-point score *** detection efficiency was compared between LDCT and SDCT based on nodule characteristics(size and volume).Radiation metrics and organ doses were analyzed using ***:The images acquired with the LDCT protocol yielded comparable quality to those acquired with the SDCT *** sensitivity of LDCT for the detection of pulmonary nodules(n=650)was lower than that of SDCT(n=660).There was no significant difference in the diameter and volume of pulmonary nodules between LDCT and SDCT(for BMI22 kg/m^(2),4.3 vs.4.41 mm,and 41.66 vs.44.86 mm^(3))(P>0.05).The individualized volume CT dose index(CTDI_(vol)),the size specific dose estimate and effective dose were significantly reduced in the LDCT group compared with the SDCT group(all P22 kg/m^(2),1.62 vs.9.79 mSV)and the breast(for BMI22 kg/m^(2),1.53 vs.9.01 mSV)(Plity and *** LDCT protocol for chest scans may reduce radiation exposure by about 80% compared to the SDCT protocol.

关键词： pulmonary nodules tomography,X-ray computed radiation dosage lung breast

Stroke-like Migraine Attacks after Radiation Therapy Syndrome

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Chinese Medical Journal 2015年第15期128卷 2097-2101页

作者： Qian Zheng li Yang li-ming Tan li-xia Qin Chun-Yu Wang Hai-Nan Zhang Department of Neurology Second Xiangya Hospital Central South University Changsha Hunan 410011 China

Objective：To summarize the clinical presentation,pathogenesis,neuroimaging,treatment,and outcome of stroke-like migraine attacks after radiation therapy （SMART） syndrome,and to propose diagnostic criteria for this *** Sources：We searched the PubMed database for articles in English published from 1995 to 2015 using the terms of ＂stroke-like AND migraine AND radiation.＂ Reference lists of the identified articles and reviews were used to retrieve additional *** Selection：Data and articles related to late-onset effects of cerebral radiation were selected and ***：SMART is a rare condition that involves complex migraines with focal neurologic deficits following cranial irradiation for central nervous system *** recovery,which ranges from hours to days to weeks,can be partial or *** propose the following diagnostic criteria for SMART：（1） Remote history of therapeutic external beam cranial irradiation for malignancy;（2） prolonged,reversible clinical manifestations mostly years after irradiation,which may include migraine,seizures,hemiparesis,hemisensory deficits,visuospatial defect,aphasia,confusion and so on;（3） reversible,transient,unilateral cortical gadolinium enhancement correlative abnormal T2 and fluid-attenuated inversion recovery signal of the affected cerebral region;（4） eventual complete or partial recovery,the length of duration of recovery ranging from hours to days to weeks;（5） no evidence of residual or recurrent tumor;（6） not attributable to another *** date,no specific treatment has been identified for this ***：SMART is an extremely rare delayed complication of brain ***,improvements in cancer survival rates have resulted in a rise in its ***,awareness and recognition of the syndrome is important to make a rapid diagnosis and avoid aggressive interventions such as brain biopsy and cerebral angiography.

关键词： Cranial Irradiation Epilepsy Migraine Stroke-like Migraine Attacks after Radiation Therapy

Fludarabine and cytarabine combined chemotherapy followed by transfusion of donor blood stem cells for treating relapse of acute leukaemia after allogeneic haematopoietic stem cell transplantation

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Chinese Medical Journal 2008年第18期121卷 1770-1774页

作者： YOU Yong li Qiu-bai CHEN Zhi-chao li Wei-ming xia ling-hui ZHOU Hao ZOU Ping Institute of Haematology Union Hospital Tongji Medical College of Huazhong University of Science and Technology WuhanHubei 430022 China

Background Relapse remains an obstacle to successful allogeneic haematopoietic stem cell transplantation （allo-HSCT） for patients with acute leukaemia and no standard treatment is available. We assessed fludarabine and cytarabine with transfusion of donor haematopoietic stem cell in treating the relapse of acute leukaemia after allo-HSCT. Methods Seven patients, median age 34 years, with relapse of acute leukaemia after allo-HSCT received combination chemotherapy of fludarabine with cytarabine for 5 days. Five patients suffered from acute myeloid leukaemia （2 refractory） and 2 refractory acute lymphoblastic leukaemia. After the transplantation, the median relapse time was 110 days （range, 38-185 days）. Two days after chemotherapy, 5 patients received infusion of donor＇s peripheral blood stem cells, mobilized by granulocyte colony stimulating factor. No prophylactic agents of graft versus host diseases were administered, Results Six patients achieved haematopoietic reconstitution. DNA sequence analysis at day 30 after treatment identified all as full donor chimera type. The median observation time was 189 days. After the treatment, the median time for neutrophilic granulocyte value 〉0.5×10^9/L and for platelet value 〉20×10^9/L were 13 days （range, 10-18 days） and 15 days （range, 11-24 days）, respectively. Graft versus host disease occurred in 2 patients （acute） and 3 （chronic）. Five patients suffered from pulmonary fungal infection （2 died）, 3 haemorrhagic cystitis and 2 cytomegalovirus viraemia. The other patients died of leukaemia related deaths. Three patients with chronic graft versus host disease who had received donor peripheral blood stem cells reinfusion have survived for 375 days, 232 days and 195 days, respectively. Conclusions Fludarabine with cytarabine plus the donor haematopoietic stem cell should be considered as an effective therapeutic regimen for relapse of acute leukaemia after alio-HSCT. The disease free state of patients may increase, though with

关键词： fludarabine allogeneic haematopoietic stem cell transplantation relapse acute leukaemia