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Chinese Journal of Polymer Science 2012年第5期30卷 719-726页

作者： li-li xie 仝维鋆 Jian-quan Xu Chang-you Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

To improve the colloidal stability of bovine serum albumin （BSA） nanoparticles （hiPs） in diverse mediums, poly（allylamine hydrochloride）（PAH）/sodium poly（4-styrene sulfonate）（PSS） multilayers and poly（allylamine hydrochloride）-graft-poly（ethylene glycol）（PAH-g-PEG） coating were coated on the surface of BSA NPs. Stabilities of the BSA NPs in diverse mediums with different surfaces were detected by dynamic light scattering （DLS）. Multilayers and PAH-g-PEG coated BSA NPs can be well dispersed in various mediums with a narrow polydispersity index （PDI）. The BSA NPs with the highest surface density of PEG show the best stability. The multilayers and PAH-g-PEG coating do not deter the pH-dependent loading and release property of BSA NPs. At pH 9, the encapsulation efficiency of doxorubicin reaches almost 99%, and the release rate at pH 5.5 is significantly higher than that at pH 7.4.

关键词： BSA nanoparticle PEG LBL Drug delivery pH-responsive.

Simple and effective method for treating severe adult skeletal class II malocclusion: A case report

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World Journal of Orthopedics 2024年第10期15卷 965-972页

作者： li-li xie Dan-Yang Chu Xiao-Feng Wu Department of Stomatology Hebei General HospitalShijiazhuang 050057Hebei ProvinceChina Chengde Medical University Chengde 067000Hebei ProvinceChina

BACKGROUND Severe skeletal class II malocclusion is the indication for combined orthodontic and orthognathic *** SUMMARY A woman with a chief complaint of a protruding chin and an inability to close her lips requested orthodontic *** treatment plan consisted of extracting the right upper third molar,right lower third molar,left lower second molar,and left upper third molar and moving the maxillary dentition distally using a convenient method involving microimplant nail anchors,push springs,long arm traction hooks,and elastic traction *** 52 months of treatment,her overbite and overjet were normal,and her facial profile was *** This method can be used for distal movement of the maxillary dentition and to correct severe skeletal class II malocclusion in adults.

关键词： Skeletal class II malocclusion Maxillary dentition Microimplant nail Simple and effective method Case report

In vivo anti-tumor effect of hybrid vaccine of dendritic cells and esophageal carcinoma cells on esophageal carcinoma cell line 109 in mice with severe combined immune deficiency

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World Journal of Gastroenterology 2008年第8期14卷 1167-1174页

作者： Guang-Hua Guo Su-Zuan Chen Jing Yu Juan Zhang li-li Luo li-Hua xie Zhong-Jing Su Hong-Mei Dong Hong Xu li-Biao Wu Department of Gastroenterology The First Affiliatecl Hospital of Shantou University Medical College Shantou 515041Guangdong Province China

AIM： To develop a fusion vaccine of esophageal carcinoma cells and dendritic cells （DC） and observe its protective and therapeutic effect against esophageal carcinoma cell line 109 （EC109）. METHODS： The fusion vaccine was produced by fusing traditional polyethyleneglycol （PEG）, inducing cytokine, sorting CD34＋ magnetic microbead marker and magnetic cell system （MACS）. The liver, spleen and lung were pathologically tested after injection of the fusion vaccine. To study the therapeutic and protective effect of the fusion vaccine against tumor EC109, mice were divided immune group and therapeutic group. The immune group was divided into P, E, D and ED subgroups, immunized by phosphate buffered solution （PBS）, inactivated EC109, DC and the fusion vaccine respectively, and attacked by EC109 cells. The tumor size, weight, latent period and mouse survival period were recorded and statistically analyzed. The therapeutic group was divided into four subgroups： P, inactivated EC109, D and ED subgroups, which were attacked by EC109 and then treated with PBS, inactivated EC109, DC, and EC109-DC respectively. Pathology and flow cytometry were also used to study the therapeutic effect of the fusion vaccine against EC109 cells.RESULTS： Flow cytometry showed that the expression of folate receptor （FR）, EC109 （C）, Des （D） in human nasopharyngeal carcinoma cell line （HNE1）（B） was 78.21%, 89.50%, and 0.18%, respectively. The fusion cells （C） were highly expressed. No tumor was found in the spleen, lung and liver after injection of the fusion vaccine. Human IgG was tested in peripheral blood lymphocytes （PBL）. In the immune group, the latent period was longer in EC109-DC subgroup than in other subgroups, while the tumor size and weight were also smaller than those in ED subgroup. In the therapeutic group, the tumor size and weight were smaller in ED subgroup than in P, inactivated EC109 and DC subgroups. CONCLUSION： Fusion cells are highly expressed not only in FR but also in CD8

关键词： Dendritic cells Esophageal carcinoma cells Cell fusion Immune protection Immunotherapy

Spaceflight alters the gene expression profile of cervical cancer cells

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Chinese Journal of Cancer 2011年第12期30卷 842-852页

作者： Zhi-Jie Zhang Yong-Qing Tong Jia-Jia Wang Cheng Yang Guo-Hua Zhou Yue-Hui li Ping-li xie Jin-Yue Hu Guan-Cheng li Cancer Research Inst tute Xiangya Schoo of Med c neCentral South University Changsha Hunan 410078 P. R. China

Our previous study revealed that spaceflight induced biological changes in human cervical carcinoma Caski cells. Here, we report that 48A9 cells, which were subcloned from Caski cells, experienced significant growth suppression and exhibited low tumorigenic ability after spaceflight. To further understand the potential mechanism at the transcriptional level, we compared gene expression between 48A9 cells and ground control Caski cells with suppression subtractive hybridization (SSH) and reverse Northern blotting methods, and analyzed the relative gene network and molecular functions with the Ingenuity Pathways Analysis (IPA) program. We found 5 genes, SUB1, SGEF, MALAT-1, MYL6, and MT-CO2, to be up-regulated and identified 3 new cDNAs, termed B4, B5, and C4, in 48A9 cells. In addition, we also identified the two most significant gene networks to indicate the function of these genes using the IPA program. To our knowledge, our results show for the first time that spaceflight can reduce the growth of tumor cells, and we also provide a new model for oncogenesis study.

关键词：基因表达谱航天飞行癌细胞宫颈癌 Northern 抑制性消减杂交生长抑制基因网络

Reconstruction of meandering paleo-channels using dense well data,Daqing Oil Field,Songliao Basin,China

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Petroleum Science 2018年第4期15卷 722-743页

作者： Jing-Fu Shan Zhi-Peng lin Le Chen Bin Zhang Shi-Xiang Fang Xue Yan Wei Fang li-li xie Bo liu Le Zhang Key Laboratory of Exploration Technologies for Oil and Gas Resources Ministry of EducationYangtze University School of Geosciences Yangtze University State Key Laboratory of Biogeology and Environmental Geology School of Earth Sciences and ResourcesChina University of Geosciences International Publishing and Distribution Headquarter China Academic Journal (CD) Electronic Publishing House CO.Ltd.

Reconstructing meandering paleo-channels is attracting global research attention. We implemented a novel method by comprehensively integrating migration models and sedimentary structures. Firstly, the migration architectures of the corresponding characteristics in planform and cross-sectional models were summarised as expansion, translation, expansion and translation, expansion and downstream rotation, constriction and downstream rotation, and expansion and countercurrent rotation models. Secondly, full continuous core data from 270 dense drilling wells were collected from the Daqing Oil Field in the Songliao Basin, China, providing information on rock textures, sedimentary cycles, and boundary information for the two layers being studied. Through a comprehensive analysis of dense drill cores and logging data, the abandoned channels and the initial and final channel centrelines were identified. Consequently, four profiles, including one longitudinal and three transverse sections, were constructed to reveal the cross-sectional structures and planform migration architecture. Profile interpretation revealed the evolution from the initial channel centreline to the final centreline. Using a method of rational interpolation, we were able to reconstruct the migration architecture of the meandering channels. The results showed that the average ancient bankfull width(Wc) was approximately 100 m, a single meandering belt was800 m, the radius of the curvature was 250 m, the length of the channel bend was 700 m, the average meander wavelength was 1300 m, the sinuosity was 3.0, and the annual average discharge rate was 450 m3/s. Furthermore, we compared the results from empirical equations, which verified that our reconstruction is both feasible and potentially widely applicable.

关键词： Songliao Basin Reconstruction Meandering paleo-channels Meandering rivers Point bar Planform Migration architectures

A method to extend wavelength into middle-wavelength infrared based on InAsSb/(Al)GaSb interband transition quantum well infrared photodetector

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Chinese Physics B 2020年第3期29卷 468-472页

作者： Xuan-Zhang li ling Sun Jin-Lei Lu Jie liu Chen Yue li-li xie Wen-Xin Wang Hong Chen Hai-Qiang Jia Lu Wang Key Laboratory for Renewable Energy Beijing Key Laboratory for New Energy Materials and DevicesBeijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Detector Technology Laboratory Beijing Institute of Space Mechanics&ElectricityBeijing 100076China Songshan Lake Materials Laboratory Dongguan 523808China

We present a method to extend the operating wavelength of the interband transition quantum well photodetector from an extended short-wavelength infrared region to a middle-wavelength infrared region. In the modified In As Sb quantum well, Ga Sb is replaced with Al Sb/Al Ga Sb, the valence band of the barrier material is lowered, the first restricted energy level is higher than the valence band of the barrier material, the energy band structure forms type-II structure. The photocurrent spectrum manifest that the fabricated photodetector exhibits a response range from 1.9 μm to 3.2 μm with two peaks at 2.18 μm and 3.03 μm at 78 K.

关键词： photodetector energy band calculation InAsSb/AlSb/AlGaSb quantum well interband transition

High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

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Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng Bai Yi li Yabo xie Qiancheng Chen Xin Zhang Jian-Rong li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU lin li Xue xie Jun DONG Ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

Spectroscopic Diagnostics of Rotational Temperature in the Pulsed Atmospheric Air Plasma

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高电压技术 2013年第10期39卷 2568-2572页

作者： DONG Pan li Jie li Xi xie Yutong LONG Jidong ZHANG linwen Key Laboratory of Pulsed Power Institute of Fluid Physics China Academy of Engineering Physics Mianyang 621900 China

Dielectric barrier discharge(DBD) attracts lots of attentions for its great application promises,and the rotational temperature is one of its mostly important *** order to measure the rotational temperature of a pulsed DBD in atmospheric air,the temperature is studied by using optical emission spectroscopy(OES).The discharge is excited by a high voltage pulse with 124 ns rise time and 230 ns full width at half maximum(FWHM) at a repetition rate of a few hundred *** rotational temperatures are studied using different voltages,different repetition rates of the pulse power supply,and different gaps between dielectrics: They are in the range from 390 K to 500 K during the whole *** the gap between dielectrics increases,the rotational temperature initially decreases and then *** rotational temperature changes complexly when the pulse repetition rate *** the voltage increases,the rotational temperature always decreases,which is not *** results allow one to predict the rotational temperature at different supply power parameters and electrode configurations,which is useful for the DBD's industrial application.

关键词：转动温度高压脉冲空气等离子光谱诊断大气介质阻挡放电光学发射光谱脉冲重复频率

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： Zhi-Jun xie Jia-lin li ling Gong Xiang-li Zhong Hong-Jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance